Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | methylated-DNA--protein-cysteine methyltransferase Ogt | 0.0838 | 1 | 1 |
Trichomonas vaginalis | methylated-DNA--protein-cysteine methyltransferase, putative | 0.0276 | 0.2253 | 0.5 |
Treponema pallidum | methylated-DNA-protein-cysteine S-methyltransferase (dat) | 0.0276 | 0.2253 | 0.5 |
Chlamydia trachomatis | methylated-DNA protein-cysteine methyltransferase | 0.0276 | 0.2253 | 0.5 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0276 | 0.2253 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0112 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0276 | 0.2253 | 0.5 |
Mycobacterium tuberculosis | Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra | 0.0838 | 1 | 0.5 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0276 | 0.2253 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.9 nM | Binding affinity towards human estrogen receptor alpha | ChEMBL. | 15109649 |
IC50 (binding) | = 3.9 nM | Binding affinity towards human estrogen receptor alpha | ChEMBL. | 15109649 |
IC50 (binding) | = 40 nM | Binding affinity towards human estrogen receptor beta (ERbeta) | ChEMBL. | 15109649 |
IC50 (binding) | = 40 nM | Binding affinity towards human estrogen receptor beta (ERbeta) | ChEMBL. | 15109649 |
IC50 (functional) | = 67 nM | In vivo inhibition of human ERalpha/ERbeta co-expressed in HEK 293 cells; 67/1213 | ChEMBL. | 15109649 |
IC50 (functional) | = 67 nM | In vivo inhibition of human ERalpha/ERbeta co-expressed in HEK 293 cells; 67/1213 | ChEMBL. | 15109649 |
Inhibition (functional) | = 78 % | Anti-estrogenic activity as percent inhibtion/control in uterotrophic assay on co-administration with subcutaneous 17-beta-estradiol in rats; 78/26 | ChEMBL. | 15109649 |
Inhibition (functional) | = 78 % | Anti-estrogenic activity as percent inhibtion/control in uterotrophic assay on co-administration with subcutaneous 17-beta-estradiol in rats; 78/26 | ChEMBL. | 15109649 |
Selectivity (binding) | = 10 | Selectivity of IC50[ERbeta] / IC50[ERalpha] | ChEMBL. | 15109649 |
Selectivity (binding) | = 10 | Selectivity of IC50[ERbeta] / IC50[ERalpha] | ChEMBL. | 15109649 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.