Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Neprilysin | Starlite/ChEMBL | No references |
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | Endothelin-converting enzyme 2, putative | Neprilysin | 750 aa | 787 aa | 21.2 % |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 33.7 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 773 aa | 20.7 % |
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.4 % | |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.2588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1338 | 0.1338 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.2588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2588 | 0.2588 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1338 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1338 | 0.1338 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.2588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1249 | 0.1249 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.2588 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0128 | 0.3225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1338 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2588 | 0.2588 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.2588 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1338 | 0.1338 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2588 | 0.2588 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1338 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1249 | 0.1249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.005 uM | Inhibitory activity against recombinant human Leukotriene A4 hydrolase | ChEMBL. | No reference |
IC50 (binding) | = 0.005 uM | Inhibitory activity against recombinant human Leukotriene A4 hydrolase | ChEMBL. | No reference |
IC50 (binding) | = 0.01 uM | Inhibitory activity against aminopeptidase | ChEMBL. | No reference |
IC50 (binding) | = 2 uM | Inhibitory activity against rabbit kidney neutral endopeptidase(NEP) | ChEMBL. | No reference |
IC50 (binding) | = 2 uM | Inhibitory activity against rabbit kidney neutral endopeptidase(NEP) | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE) | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.