Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.3144 | 0.3089 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0045 | 1 |
Brugia malayi | Hexokinase family protein | 0.0512 | 0.6254 | 0.6225 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Brugia malayi | Hexokinase family protein | 0.0253 | 0.3058 | 0.3003 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.008 | 0.0026 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.6027 | 0.6005 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0045 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0054 | 0.0045 |
Onchocerca volvulus | 0.0512 | 0.6254 | 0.6108 | |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0399 | 0.039 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0045 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0375 | 0.0297 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0375 | 0.0366 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0045 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0558 | 0.6821 | 0.6803 |
Loa Loa (eye worm) | hexokinase | 0.0512 | 0.6254 | 0.6224 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.6027 | 0.6023 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0558 | 0.6821 | 0.6803 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.3144 | 0.3089 |
Loa Loa (eye worm) | hexokinase | 0.0253 | 0.3058 | 0.3002 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0045 | 1 |
Brugia malayi | hexokinase type II | 0.026 | 0.3144 | 0.309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0045 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0399 | 0.0347 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0558 | 0.6821 | 0.6803 |
Onchocerca volvulus | Hexokinase homolog | 0.0512 | 0.6254 | 0.6108 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0399 | 0.0347 |
Echinococcus granulosus | neuropeptide s receptor | 0.0558 | 0.6821 | 0.6803 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0045 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0399 | 0.039 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0375 | 0.0299 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.008 | 0.0026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0045 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.6027 | 0.6005 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0045 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.6804 | 0.6778 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0853 | 0.0845 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0045 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.