Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0193 | 0.2314 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.1314 | 0.4658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0056 | 0.0581 | 0.0387 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.406 | 0.5676 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0045 | 0.0441 | 0.0617 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0045 | 0.0441 | 0.0617 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0045 | 0.0441 | 0.0617 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0193 | 0.2314 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.1314 | 0.4658 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0193 | 0.2314 | 0.3236 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.1314 | 0.1837 |
Echinococcus granulosus | prolyl endopeptidase | 0.0045 | 0.0441 | 0.0617 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.2635 | 0.3684 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.1314 | 0.1837 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0193 | 0.2314 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0172 | 0.2055 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 1 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.406 | 0.3786 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0441 | 0.5 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1736 | 0.2428 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.1314 | 0.5405 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0627 | 0.7835 | 0.7735 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.1314 | 0.4658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.1314 | 0.1837 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.1314 | 0.1837 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.1314 | 0.1837 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0045 | 0.0441 | 0.0617 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0045 | 0.0441 | 0.0617 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0573 | 0.7152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1736 | 0.2428 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0045 | 0.0441 | 0.0617 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.1314 | 0.5405 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0573 | 0.7152 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0627 | 0.7835 | 0.7735 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0441 | 0.0617 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0193 | 0.2314 | 0.3236 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.406 | 0.5676 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.406 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0193 | 0.2314 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0045 | 0.0441 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0441 | 0.0617 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0045 | 0.0441 | 0.0563 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.406 | 0.5676 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0193 | 0.2314 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0045 | 0.0441 | 0.0563 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0045 | 0.0441 | 0.0617 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0627 | 0.7835 | 1 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0045 | 0.0441 | 0.0617 |
Schistosoma mansoni | kinase | 0.0058 | 0.0601 | 0.084 |
Brugia malayi | N-terminal motif family protein | 0.0218 | 0.2635 | 0.3684 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0056 | 0.0581 | 0.0387 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0193 | 0.2314 | 0.3236 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 0.2635 | 0.3684 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0441 | 0.0617 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0193 | 0.2314 | 0.2954 |
Toxoplasma gondii | prolyl endopeptidase | 0.0045 | 0.0441 | 0.0563 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.1314 | 0.4658 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0627 | 0.7835 | 0.7735 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0573 | 0.7152 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0573 | 0.7152 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0573 | 0.7152 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0573 | 0.7152 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0172 | 0.2055 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0193 | 0.2314 | 0.3236 |
Plasmodium falciparum | peptidase, putative | 0.0045 | 0.0441 | 0.5 |
Schistosoma mansoni | glutaminase | 0.033 | 0.406 | 0.5676 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1314 | 0.2411 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.1314 | 0.1837 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0045 | 0.0441 | 0.0617 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0045 | 0.0441 | 0.0617 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0045 | 0.0441 | 0.0617 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0172 | 0.2055 | 0.446 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 23.7558 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.