Detailed information for compound 1408218

Basic information

Technical information
  • TDR Targets ID: 1408218
  • Name: 5-[5-[3-(4-methoxyphenyl)-1-phenylpyrazol-4-y l]-3-thiophen-2-yl-4,5-dihydropyrazol-1-yl]-5 -oxopentanoic acid
  • MW: 514.595 | Formula: C28H26N4O4S
  • H donors: 1 H acceptors: 4 LogP: 4.11 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)c1nn(cc1C1CC(=NN1C(=O)CCCC(=O)O)c1cccs1)c1ccccc1
  • InChi: 1S/C28H26N4O4S/c1-36-21-14-12-19(13-15-21)28-22(18-31(30-28)20-7-3-2-4-8-20)24-17-23(25-9-6-16-37-25)29-32(24)26(33)10-5-11-27(34)35/h2-4,6-9,12-16,18,24H,5,10-11,17H2,1H3,(H,34,35)
  • InChiKey: BLGRDCIMLYXWFQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[5-[3-(4-methoxyphenyl)-1-phenyl-pyrazol-4-yl]-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-5-oxo-pentanoic acid
  • 5-[5-[3-(4-methoxyphenyl)-1-phenyl-4-pyrazolyl]-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]-5-oxopentanoic acid
  • 5-keto-5-[5-[3-(4-methoxyphenyl)-1-phenyl-pyrazol-4-yl]-3-(2-thienyl)-4,5-dihydropyrazol-1-yl]valeric acid
  • 5-[5-[3-(4-methoxyphenyl)-1-phenyl-pyrazol-4-yl]-3-thiophen-2-yl-4,5-dihydropyrazol-1-yl]-5-oxo-pentanoic acid
  • STOCK2S-63968
  • MLS000550966
  • 5-[3'-(4-Methoxy-phenyl)-1'-phenyl-5-thiophen-2-yl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-yl]-5-oxo-pentanoi c acid
  • Oprea1_861859
  • SMR000145094
  • ChemDiv1_007668

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 1 0.0111 0.0266 0.0682
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Brugia malayi G protein-coupled receptor F59B2.13 0.0111 0.0266 0.0682
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0112 0.027 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0096 0.0096
Toxoplasma gondii subtilisin SUB7 0.0065 0.0125 0.372
Echinococcus granulosus neuropeptide receptor 0.0111 0.0266 0.0266
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0111 0.0266 0.0266
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0111 0.0266 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0125 0.0292
Trichomonas vaginalis cyclin B, putative 0.0182 0.0484 0.226
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0266 0.0266
Giardia lamblia Furin precursor putative serine protease 0.0341 0.0969 1
Schistosoma mansoni amine GPCR 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Giardia lamblia Cyclin A 0.0076 0.0159 0.098
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0266 0.0266
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Echinococcus multilocularis fmrfamide receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Echinococcus granulosus g protein coupled receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis cyclin b3 0.0076 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni myosin xvIII 0.0111 0.0266 0.0266
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0065 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0096 0.0258
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0087 0.0192 0.0516
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Onchocerca volvulus 0.0111 0.0266 0.5107
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0484 0.124
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus membrane bound transcription factor site 1 0.0065 0.0125 0.0125
Echinococcus multilocularis membrane bound transcription factor site 1 0.0065 0.0125 0.0125
Echinococcus multilocularis cyclin dependent kinase 5 0.0088 0.0195 0.0195
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0088 0.0195 0.1929
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus multilocularis neuropeptide s receptor 0.0667 0.1964 0.1964
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus granulosus cyclins 0.0076 0.0159 0.0159
Onchocerca volvulus 0.0111 0.0266 0.5107
Echinococcus multilocularis neuropeptide receptor 0.0111 0.0266 0.0266
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.0266 0.0266
Mycobacterium leprae Possible secreted protease 0.0065 0.0125 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Toxoplasma gondii subtilisin SUB2 0.0065 0.0125 0.372
Toxoplasma gondii subtilisin SUB8 0.0065 0.0125 0.372
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0071 0.0269
Onchocerca volvulus 0.0111 0.0266 0.5107
Echinococcus multilocularis cyclin B 0.0182 0.0484 0.0484
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Onchocerca volvulus 0.0111 0.0266 0.5107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Onchocerca volvulus 0.0111 0.0266 0.5107
Schistosoma mansoni furin-1 (S08 family) 0.066 0.1945 0.1945
Echinococcus granulosus cyclin dependent kinase 1 0.0088 0.0195 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0125 0.0292
Loa Loa (eye worm) hypothetical protein 0.0194 0.0521 0.1403
Echinococcus granulosus alpha 1A adrenergic receptor 0.0111 0.0266 0.0266
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) acetyltransferase 0.0175 0.0462 0.1243
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni growth hormone secretagogue receptor 0.0111 0.0266 0.0266
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0065 0.0125 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0294 0.0825 0.4126
Giardia lamblia High cysteine membrane protein Group 2 0.0286 0.08 0.8113
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0088 0.0195 1
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.0266 0.0266
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0065 0.0125 1
Echinococcus granulosus neuropeptide receptor 0.026 0.0721 0.0721
Echinococcus multilocularis sex peptide receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.0011 0.0011
Toxoplasma gondii kringle domain-containing protein 0.0069 0.0137 0.4763
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0194 0.0521 0.0521
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Onchocerca volvulus 0.0111 0.0266 0.5107
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0111 0.0266 0.0682
Trichomonas vaginalis cyclin D, putative 0.0076 0.0159 0.0478
Trichomonas vaginalis cyclin A, putative 0.0182 0.0484 0.226
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus orexin receptor type 2 0.0111 0.0266 0.0266
Echinococcus granulosus sex peptide receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis neuroendocrine convertase 2 0.1001 0.2988 0.2988
Echinococcus granulosus allatostatin A receptor 0.0111 0.0266 0.0266
Brugia malayi Protein kinase domain containing protein 0.0069 0.0137 0.0351
Echinococcus multilocularis 0.0946 0.2818 0.2818
Echinococcus granulosus epidermal growth factor receptor 0.0249 0.0687 0.0687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0096 0.0096
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0065 0.0125 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0111 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0125 0.0292
Echinococcus multilocularis cyclin B3 1 0.0076 0.0159 0.0159
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Trichomonas vaginalis cyclin B, putative 0.0182 0.0484 0.226
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0111 0.0266 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0195 0.0195
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0484 0.124
Giardia lamblia Hypothetical protein 0.0076 0.0159 0.098
Brugia malayi G protein-coupled receptor 0.0111 0.0266 0.0682
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0111 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0104 0.0246 0.0246
Toxoplasma gondii subtilisin SUB5 0.0065 0.0125 0.372
Onchocerca volvulus 0.0065 0.0125 0.2406
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Brugia malayi Kringle domain containing protein 0.0069 0.0137 0.0351
Trichomonas vaginalis cyclins, putative 0.0182 0.0484 0.226
Schistosoma mansoni neuropeptide receptor 0.026 0.0721 0.0721
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.0266 0.0717
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.124 0.3715 0.3715
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.1168 0.6008
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.0266 0.0266
Schistosoma mansoni amine GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0111 0.0266 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.1168 0.6008
Brugia malayi putative neuropeptide receptor 0.0111 0.0266 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Schistosoma mansoni amine GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Onchocerca volvulus 0.0048 0.0072 0.1387
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0065 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0111 0.0266 0.0266
Echinococcus granulosus neuropeptide receptor A26 0.0667 0.1964 0.1964
Echinococcus granulosus g protein coupled receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0347 0.0988 0.266
Schistosoma mansoni opsin-like receptor 0.0111 0.0266 0.0266
Echinococcus granulosus 7tm_1 domain containing protein 0.0111 0.0266 0.0266
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.0266 0.0266
Brugia malayi putative neuropeptide receptor NPR1 0.0111 0.0266 0.0682
Echinococcus granulosus cyclin dependent kinase 5 0.0088 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0106 0.0252 0.0678
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Trypanosoma cruzi cdc2-related kinase 1 0.0088 0.0195 0.1929
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0096 0.0096
Leishmania major hypothetical protein, conserved 0.0069 0.0137 0.032
Entamoeba histolytica cyclin family protein 0.0076 0.0159 0.2344
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus fmrfamide receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.292 0.292
Schistosoma mansoni site-1 peptidase (S08 family) 0.0065 0.0125 0.0125
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0065 0.0125 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0111 0.0266 0.0266
Echinococcus granulosus cyclins 0.0076 0.0159 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0125 0.0292
Echinococcus multilocularis dro:myosuppressin receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Brugia malayi neuropeptide F receptor 0.0111 0.0266 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0065 0.0125 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Onchocerca volvulus 0.0194 0.0521 1
Trypanosoma brucei cdc2-related kinase 1 0.0088 0.0195 0.1929
Echinococcus multilocularis allatostatin A receptor 0.0111 0.0266 0.0266
Schistosoma mansoni amine GPCR 0.0111 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0111 0.0266 0.0266
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0266 0.0266
Brugia malayi Subtilase family protein 0.0065 0.0125 0.0321
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0182 0.0484 1
Echinococcus multilocularis epidermal growth factor receptor 0.0249 0.0687 0.0687
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0065 0.0125 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni biogenic amine receptor 0.0111 0.0266 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0644 0.1896 0.1896
Echinococcus multilocularis cyclin dependent kinase 0.0088 0.0195 0.0195
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Toxoplasma gondii hypothetical protein 0.0058 0.0103 0.1712
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0065 0.0125 0.0321
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus dro:myosuppressin receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.0266 0.0717
Schistosoma mansoni biogenic amine receptor 0.0111 0.0266 0.0266
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0069 0.0137 0.4763
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus granulosus cyclin B3 1 0.0076 0.0159 0.0159
Onchocerca volvulus 0.0069 0.0137 0.2626
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.0266 0.0266
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0111 0.0266 0.0266
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0065 0.0125 0.0321
Trichomonas vaginalis cyclins, putative 0.0076 0.0159 0.0478
Schistosoma mansoni opsin-like receptor 0.0111 0.0266 0.0266
Echinococcus granulosus hypothetical protein 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0462 0.1183
Echinococcus granulosus Furin 1 0.0406 0.1168 0.1168
Leishmania major cyclin 0.0182 0.0484 1
Trichomonas vaginalis cyclin B3, putative 0.0076 0.0159 0.0478
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0111 0.0266 0.0717
Echinococcus multilocularis Furin 1 0.0406 0.1168 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Schistosoma mansoni hypothetical protein 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0111 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0125 0.0292
Brugia malayi Cyclin, N-terminal domain containing protein 0.0076 0.0159 0.0408
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.0266 0.0266
Brugia malayi G-protein coupled receptor 0.0111 0.0266 0.0682
Brugia malayi ORL1-like opioid receptor 0.0111 0.0266 0.0682
Toxoplasma gondii subtilisin SUB1 0.0065 0.0125 0.372
Onchocerca volvulus 0.0182 0.0484 0.9286
Brugia malayi larval opioid receptor 0.0111 0.0266 0.0682
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0137 0.032
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0462 0.0462
Echinococcus granulosus cyclins 0.0076 0.0159 0.0159
Giardia lamblia Kinase, CMGC CDK 0.0088 0.0195 0.1373
Plasmodium falciparum cyclin 0.0076 0.0159 0.7137
Brugia malayi GnHR receptor homolog 0.0111 0.0266 0.0682
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0111 0.0266 0.5107
Echinococcus multilocularis G-protein coupled receptor, putative 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Loa Loa (eye worm) proprotein convertase 2 0.0406 0.1168 0.3143
Trypanosoma cruzi cyclin 6, putative 0.0182 0.0484 1
Loa Loa (eye worm) TYRA-2 protein 0.0111 0.0266 0.0717
Schistosoma mansoni hypothetical protein 0.0069 0.0137 0.0137
Echinococcus granulosus tachykinin peptides receptor 99D 0.0111 0.0266 0.0266
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus g protein coupled receptor 0.0111 0.0266 0.0266
Onchocerca volvulus 0.0111 0.0266 0.5107
Echinococcus multilocularis serotonin receptor 0.0111 0.0266 0.0266
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) cyclin domain-containing protein 0.0076 0.0159 0.0429
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.1168 0.6008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0111 0.0266 0.0266
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0065 0.0125 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0159 0.0478
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.0266 0.0266
Schistosoma mansoni neuropeptide receptor 0.0111 0.0266 0.0266
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0111 0.0266 0.0266
Schistosoma mansoni neuropeptide receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Plasmodium vivax subtilisin-like protease 2, putative 0.0065 0.0125 0.372
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Plasmodium falciparum subtilisin-like protease 2 0.0065 0.0125 0.4388
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0111 0.0266 0.0266
Brugia malayi Dopamine receptor protein 2 0.0111 0.0266 0.0682
Loa Loa (eye worm) hypothetical protein 0.0643 0.1892 0.5092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0096 0.0096
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.0266 0.0266
Echinococcus granulosus neuroendocrine convertase 2 0.1001 0.2988 0.2988
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0195 0.0672
Schistosoma mansoni hypothetical protein 0.0294 0.0825 0.0825
Brugia malayi neuroendocrine convertase 1 precursor 0.1301 0.3904 1
Echinococcus granulosus cyclins 0.0076 0.0159 0.0159
Echinococcus multilocularis cyclins 0.0076 0.0159 0.0159
Onchocerca volvulus 0.0111 0.0266 0.5107
Trypanosoma cruzi cyclin, putative 0.0182 0.0484 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus multilocularis cyclin dependent kinase 1 0.0088 0.0195 0.0195
Echinococcus multilocularis serotonin receptor 0.0111 0.0266 0.0266
Brugia malayi cell division control protein 2 homolog 0.0088 0.0195 0.0499
Brugia malayi Melatonin receptor type 1A 0.0111 0.0266 0.0682
Schistosoma mansoni alpha-1 adrenergic receptor 0.0111 0.0266 0.0266
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0644 0.1896 1
Toxoplasma gondii subtilisin SUB4 0.0065 0.0125 0.372
Loa Loa (eye worm) hypothetical protein 0.0182 0.0484 0.1303
Onchocerca volvulus 0.0111 0.0266 0.5107
Plasmodium falciparum subtilisin-like protease 3 0.0065 0.0125 0.4388
Trichomonas vaginalis cyclins, putative 0.0182 0.0484 0.226
Echinococcus multilocularis neuropeptide receptor A26 0.0667 0.1964 0.1964
Brugia malayi proprotein convertase 2 0.1001 0.2988 0.7653
Trichomonas vaginalis cyclins, putative 0.0182 0.0484 0.226
Trypanosoma cruzi cdc2-related kinase 3 0.0088 0.0195 0.1929
Loa Loa (eye worm) melatonin receptor type 1A 0.0111 0.0266 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.1168 0.6008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0112 0.027 0.1087
Echinococcus granulosus peptide allatostatin:somatostatin 0.0111 0.0266 0.0266
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Brugia malayi neuropeptide F receptor 0.0111 0.0266 0.0682
Onchocerca volvulus 0.0111 0.0266 0.5107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0341 0.0969 0.4921
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0111 0.0266 0.0682
Schistosoma mansoni biogenic amine receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis orexin receptor type 2 0.0111 0.0266 0.0266
Brugia malayi hypothetical protein 0.0043 0.006 0.0153
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni neuropeptide receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0195 0.0672
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0111 0.0266 0.0266
Brugia malayi Furin-like cysteine rich region family protein 0.0249 0.0687 0.1761
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0341 0.0969 0.4921
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0194 0.0521 0.0521
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Plasmodium falciparum subtilisin-like protease 1 0.0065 0.0125 0.4388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0084 0.0084
Brugia malayi Tachykinin-like peptides receptor 99D 0.0819 0.2429 0.6223
Toxoplasma gondii subtilisin SUB6 0.0065 0.0125 0.372
Schistosoma mansoni hypothetical protein 0.0111 0.0266 0.0266
Echinococcus granulosus neuropeptide s receptor 0.0667 0.1964 0.1964
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0088 0.0195 0.0524
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Echinococcus granulosus 7TM GPCR rhodopsin 0.0111 0.0266 0.0266
Onchocerca volvulus 0.0171 0.0448 0.8602
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus furin 0.124 0.3715 0.3715
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0088 0.0195 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Toxoplasma gondii subtilisin SUB10 0.0065 0.0125 0.372
Trichomonas vaginalis cyclin B, putative 0.0076 0.0159 0.0478
Trypanosoma cruzi cyclin, putative 0.0182 0.0484 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.0266 0.0266
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) hypothetical protein 0.0819 0.2429 0.6539
Trypanosoma brucei RNA helicase, putative 0.0104 0.0246 0.3363
Echinococcus multilocularis somatostatin receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.0266 0.0266
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0111 0.0266 0.0682
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0011 0.0011
Echinococcus granulosus cyclins 0.0076 0.0159 0.0159
Schistosoma mansoni cyclins 0.0076 0.0159 0.0159
Trichomonas vaginalis hypothetical protein 0.0294 0.0825 0.4126
Echinococcus granulosus serotonin receptor 0.0111 0.0266 0.0266
Echinococcus granulosus cyclin b3 0.0076 0.0159 0.0159
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.1168 0.6008
Toxoplasma gondii subtilisin SUB11 0.0065 0.0125 0.372
Toxoplasma gondii subtilisin SUB12 0.0065 0.0125 0.372
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Trichomonas vaginalis cyclin B, putative 0.0182 0.0484 0.226
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Giardia lamblia G2/mitotic-specific cyclin B 0.0182 0.0484 0.4596
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0076 0.0159 0.0159
Schistosoma mansoni tyrosine kinase 0.0249 0.0687 0.0687
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.006 0.006
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0088 0.0195 0.0195
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0088 0.0195 0.1929
Brugia malayi sulfakinin receptor protein 0.0111 0.0266 0.0682
Echinococcus multilocularis fmrfamide receptor 0.0111 0.0266 0.0266
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0084 0.0068
Trypanosoma cruzi cdc2-related kinase 1 0.0088 0.0195 0.1929
Schistosoma mansoni opsin-like receptor 0.0111 0.0266 0.0266
Brugia malayi RE15519p 0.0111 0.0266 0.0682
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0266 0.0266
Entamoeba histolytica cell division protein kinase 2, putative 0.0088 0.0195 0.3176
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0195 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0195 0.0672
Brugia malayi follicle stimulating hormone receptor 0.0111 0.0266 0.0682
Onchocerca volvulus Neuropeptide F receptor homolog 0.0111 0.0266 0.5107
Echinococcus granulosus tm gpcr rhodopsin 0.0648 0.1908 0.1908
Brugia malayi Trypsin family protein 0.0194 0.0521 0.1336
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0065 0.0125 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0644 0.1896 1
Onchocerca volvulus 0.0111 0.0266 0.5107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus multilocularis neuropeptide receptor 0.026 0.0721 0.0721
Brugia malayi Protein kinase domain containing protein 0.0088 0.0195 0.0499
Echinococcus granulosus cyclin dependent kinase 0.0088 0.0195 0.0195
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0462 0.0462
Brugia malayi G-protein coupled receptor 0.0111 0.0266 0.0682
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.006 0.006
Entamoeba histolytica cell division protein kinase 2, putative 0.0088 0.0195 0.3176
Echinococcus granulosus somatostatin receptor 0.0111 0.0266 0.0266
Brugia malayi endoprotease bli-4 precursor 0.124 0.3715 0.9518
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0065 0.0125 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0125 0.0338
Loa Loa (eye worm) hypothetical protein 0.124 0.3715 1
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.0266 0.0717
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.0266 0.0266
Plasmodium falciparum protein kinase 5 0.0088 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis G protein coupled receptor 139 0.026 0.0721 0.0721
Plasmodium falciparum cysteine repeat modular protein 1 0.0069 0.0137 0.5319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0406 0.1168 0.6008
Loa Loa (eye worm) hypothetical protein 0.0069 0.0137 0.0368
Trichomonas vaginalis cyclin D, putative 0.0076 0.0159 0.0478
Loa Loa (eye worm) TK/ROR protein kinase 0.0069 0.0137 0.0368
Toxoplasma gondii subtilisin SUB9 0.0065 0.0125 0.372
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0406 0.1168 0.1168
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis cyclin dependent kinase 1 0.0088 0.0195 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Entamoeba histolytica cyclin, putative 0.0182 0.0484 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Schistosoma mansoni cyclin B3 0.0076 0.0159 0.0159
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0266 0.0266
Trypanosoma cruzi cdc2-related kinase 3 0.0088 0.0195 0.1929
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.0266 0.0266
Plasmodium vivax subtilisin-like serine protease, putative 0.0065 0.0125 0.372
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.0266 0.0717
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0266 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Schistosoma mansoni site-1 peptidase (S08 family) 0.0065 0.0125 0.0125
Echinococcus granulosus neuropeptide FF receptor 2 0.0819 0.2429 0.2429
Entamoeba histolytica cyclin family protein 0.0076 0.0159 0.2344
Loa Loa (eye worm) subtilase 0.0065 0.0125 0.0338
Echinococcus multilocularis g-protein coupled receptor 0.0111 0.0266 0.0266
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0644 0.1896 0.1896
Loa Loa (eye worm) hypothetical protein 0.0194 0.0521 0.1403
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0111 0.0266 0.0682
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.0266 0.0266
Onchocerca volvulus 0.0111 0.0266 0.5107
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0111 0.0266 0.0266
Onchocerca volvulus 0.0111 0.0266 0.5107
Schistosoma mansoni histamine h1 receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis cyclins, putative 0.0125 0.0308 0.1294
Schistosoma mansoni cyclin B 0.0182 0.0484 0.0484
Onchocerca volvulus 0.0111 0.0266 0.5107
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Echinococcus granulosus G protein coupled receptor 139 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Brugia malayi hypothetical protein 0.0111 0.0266 0.0682
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0648 0.1908 0.1908
Trypanosoma brucei mitotic cyclin 6 0.0182 0.0484 1
Brugia malayi Serotonin receptor 0.0111 0.0266 0.0682
Trichomonas vaginalis cyclins, putative 0.0182 0.0484 0.226
Trypanosoma cruzi CYC2-like cyclin, putative 0.0182 0.0484 1
Echinococcus granulosus g-protein coupled receptor 0.0111 0.0266 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0266 0.0266
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0111 0.0266 0.0266
Brugia malayi celfurPC protein 0.0946 0.2818 0.7219
Onchocerca volvulus 0.0111 0.0266 0.5107
Echinococcus multilocularis tissue type plasminogen activator 0.0069 0.0137 0.0137
Echinococcus granulosus cyclin B 0.0182 0.0484 0.0484
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.0266 0.0266
Brugia malayi Serotonin receptor 0.0111 0.0266 0.0682
Schistosoma mansoni neuropeptide f receptor 76f 0.0111 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Brugia malayi AKH receptor 0.0111 0.0266 0.0682
Loa Loa (eye worm) hypothetical protein 0.0111 0.0266 0.0717
Plasmodium vivax protein kinase Crk2 0.0088 0.0195 1
Onchocerca volvulus 0.0111 0.0266 0.5107
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Trichomonas vaginalis cyclin B, putative 0.0182 0.0484 0.226
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0825 0.4126
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) TK/EGFR protein kinase 0.0249 0.0687 0.185
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0111 0.0266 0.0266
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0065 0.0125 0.5
Onchocerca volvulus 0.0111 0.0266 0.5107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0096 0.0096
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0088 0.0195 0.0524
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0011 0.0011
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0076 0.0159 0.0159
Trypanosoma brucei cdc2-related kinase 3 0.0088 0.0195 0.1929
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0096 0.0246
Brugia malayi Dopamine receptor 0.0111 0.0266 0.0682
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0111 0.0266 0.0266
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0084 0.0068
Plasmodium vivax subtilisin-like protease 1 0.0065 0.0125 0.372
Schistosoma mansoni adenoreceptor 0.0111 0.0266 0.0266
Loa Loa (eye worm) endoprotease bli-4 0.124 0.3715 1
Echinococcus granulosus tissue type plasminogen activator 0.0069 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0182 0.0484 0.1303
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0065 0.0125 0.0292
Giardia lamblia Kinase, CMGC CDK 0.0088 0.0195 0.1373
Entamoeba histolytica cyclin, putative 0.0076 0.0159 0.2344
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0111 0.0266 0.0717
Echinococcus multilocularis neuropeptide FF receptor 2 0.0819 0.2429 0.2429
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0111 0.0266 0.0717
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0043 0.006 0.006

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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