Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1539 | 0.4395 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1091 | 0.1091 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0968 | 0.183 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3413 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1412 | 0.4014 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1091 | 0.1091 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.202 | 0.4979 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0071 | 0.0071 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.202 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1254 | 0.3541 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1249 | 0.2673 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2916 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0968 | 0.2684 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2677 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.202 | 0.5833 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0198 | 0.0198 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2677 | 0.2677 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0968 | 0.0968 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3698 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.202 | 0.4979 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2818 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.