TDR Targets

Basic information

Technical information

TDR Targets ID: 1408315
Name: 3,4-dihydro-1H-isoquinolin-2-yl-[1-(3H-imidaz ol-4-ylsulfonyl)piperidin-4-yl]methanone
MW: 374.457 | Formula: C18H22N4O3S
H donors: 1 H acceptors: 4 LogP: 1.03 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCc2c(C1)cccc2)C1CCN(CC1)S(=O)(=O)c1c[nH]cn1
InChi: 1S/C18H22N4O3S/c23-18(21-8-5-14-3-1-2-4-16(14)12-21)15-6-9-22(10-7-15)26(24,25)17-11-19-13-20-17/h1-4,11,13,15H,5-10,12H2,(H,19,20)
InChiKey: GYZAYHSANFPNCD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3,4-dihydro-1H-isoquinolin-2-yl-[1-(3H-imidazol-4-ylsulfonyl)-4-piperidyl]methanone
3,4-dihydro-1H-isoquinolin-2-yl-[1-(3H-imidazol-4-ylsulfonyl)-4-piperidinyl]methanone
MLS000092069
2-{[1-(1H-imidazol-4-ylsulfonyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline
EU-0026551
SMR000026981

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0008	0.0508	0.1931
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/EPH protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.002	0.2178	0.2638
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0008	0.0508	0.1163
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.8256	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0012	0.1005	0.1218
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0008	0.0508	0.1931
Schistosoma mansoni	ap endonuclease	0.0023	0.2628	0.2628
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	suppressor of cytokine signaling	0.0012	0.1005	0.1005
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	hypothetical protein	0.0008	0.0508	0.0615
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Brugia malayi	Protein kinase domain containing protein	0.002	0.2178	0.2638
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0009	0.0588	0.0664
Loa Loa (eye worm)	STAT protein	0.0012	0.1005	0.1218
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Brugia malayi	Furin-like cysteine rich region family protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	protein kinase	0.0009	0.0588	0.0588
Echinococcus granulosus	hypothetical protein	0.0012	0.1005	0.1218
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0012	0.1005	0.1218
Entamoeba histolytica	hypothetical protein, conserved	0.0008	0.0508	0.1931
Schistosoma mansoni	SH2A	0.0012	0.1005	0.1005
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.2628	0.3183
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.0508	0.1931
Schistosoma mansoni	cpg binding protein	0.0037	0.465	0.465
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0012	0.1005	0.1218
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0008	0.0508	0.0615
Leishmania major	protein kinase, putative	0.0008	0.0508	0.0615
Onchocerca volvulus		0.002	0.2178	0.4991
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	SH2 motif	0.0012	0.1005	0.1218
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.1005	0.1218
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Echinococcus multilocularis	tyrosine protein kinase Srms	0.002	0.2178	0.2638
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.2628	0.5
Echinococcus multilocularis	SH2 motif	0.0012	0.1005	0.1218
Brugia malayi	Protein kinase domain containing protein	0.002	0.2178	0.2638
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus		0.002	0.2178	0.4991
Echinococcus multilocularis	SHC transforming protein 3	0.0012	0.1005	0.1218
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0012	0.1005	0.1218
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0474	0.0575
Brugia malayi	integrin-linked kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.0508	0.1931
Brugia malayi	hypothetical protein	0.0008	0.0508	0.0615
Echinococcus granulosus	activin receptor type	0.0009	0.0588	0.0713
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0008	0.0508	0.1163
Schistosoma mansoni	tensin	0.0012	0.1005	0.1005
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Giardia lamblia	Kinase, NEK	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Schistosoma mansoni	signal transduction protein lnk-related	0.0012	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	integrin linked protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0008	0.0508	0.1163
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	helicase, putative	0.0008	0.0474	0.0575
Echinococcus multilocularis	tyrosine protein kinase Abl	0.002	0.2178	0.2638
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.002	0.2178	0.2638
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0008	0.0508	0.0508
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Onchocerca volvulus		0.0008	0.0508	0.1163
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0474	0.0575
Trypanosoma brucei	protein kinase, putative	0.0062	0.8256	1
Schistosoma mansoni	tensin-related	0.0012	0.1005	0.1005
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0008	0.0508	0.1163
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.2628	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	protein tyrosine kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	cpg binding protein	0.0037	0.465	0.5632
Echinococcus granulosus	receptor type guanylyl cyclase	0.0008	0.0508	0.0615
Brugia malayi	Tensin	0.0012	0.1005	0.1218
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0009	0.0588	0.0713
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0584	0.0584
Echinococcus granulosus	signal transduction protein lnk realted	0.0012	0.1005	0.1218
Onchocerca volvulus		0.0008	0.0508	0.1163
Entamoeba histolytica	protein kinase, putative	0.0012	0.1086	0.4133
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0012	0.1005	0.1218
Entamoeba histolytica	ankyrin repeat protein	0.0008	0.0508	0.1931
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0008	0.0508	0.0615
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	SH2 motif	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0008	0.0508	0.0615
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0508	0.0508
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0012	0.1005	0.2304
Brugia malayi	Protein kinase domain containing protein	0.002	0.2178	0.2638
Toxoplasma gondii	STE kinase	0.0008	0.0508	0.0573
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Plasmodium vivax	protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Giardia lamblia	Kinase, NEK	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0012	0.1005	0.1005
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0891	0.1079
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	SH2 motif	0.0012	0.1005	0.1218
Schistosoma mansoni	GTPase activating protein	0.0012	0.1005	0.1005
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine kinase	0.002	0.2178	0.2638
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.8256	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Brugia malayi	Receptor family ligand binding region containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	ephrin type A receptor 4 A	0.0008	0.0508	0.0615
Trichomonas vaginalis	CAMK family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.2628	0.3183
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0008	0.0508	0.0615
Loa Loa (eye worm)	SRC-1	0.002	0.2178	0.2638
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0012	0.1005	0.1218
Schistosoma mansoni	tensin	0.0012	0.1005	0.1005
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0584	0.0708
Giardia lamblia	Kinase	0.0008	0.0508	0.0615
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.2628	0.3183
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Onchocerca volvulus		0.0012	0.1005	0.2304
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0008	0.0508	0.0615
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0008	0.0508	0.0615
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0008	0.0508	0.0508
Schistosoma mansoni	vav2	0.0012	0.1005	0.1005
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.1005	0.1218
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Brugia malayi	protein-tyrosine kinase	0.002	0.2178	0.2638
Schistosoma mansoni	tensin	0.0012	0.1005	0.1005
Schistosoma mansoni	ap endonuclease	0.0023	0.2628	0.2628
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.2628	1
Brugia malayi	SRC-1	0.002	0.2178	0.2638
Trichomonas vaginalis	protein kinase atn1, putative	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase Src42A	0.002	0.2178	0.2638
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	growth factor receptor-bound protein	0.0012	0.1005	0.1005
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Trichomonas vaginalis	STE family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	CXXC zinc finger family protein	0.0035	0.4363	0.5285
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TK family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.002	0.2178	0.2638
Echinococcus granulosus	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.0508	0.1931
Plasmodium falciparum	protein kinase, putative	0.0008	0.0508	0.1931
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0012	0.1005	0.1005
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0009	0.0588	0.0713
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Brugia malayi	RhoGAP domain containing protein	0.0012	0.1005	0.1218
Loa Loa (eye worm)	TK/FAK protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.4363	0.5285
Entamoeba histolytica	receptor protein kinase, putative	0.0008	0.0508	0.1931
Brugia malayi	ephrin receptor 1 precursor	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Echinococcus multilocularis	N chimaerin	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0012	0.1005	0.1218
Onchocerca volvulus		0.0012	0.1005	0.2304
Onchocerca volvulus		0.0012	0.1005	0.2304
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0008	0.0508	0.0508
Onchocerca volvulus		0.002	0.2178	0.4991
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0008	0.0508	0.0573
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0891	0.1079
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.8256	1
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0008	0.0508	0.0615
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0012	0.1005	0.1218
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.8256	1
Echinococcus multilocularis	NCK adaptor protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	epidermal growth factor receptor	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/ROR protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Schistosoma mansoni	serine/threonine RGC	0.0008	0.0508	0.0508
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0584	0.0708
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus granulosus	protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	ephrin receptor	0.0008	0.0508	0.0508
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0008	0.0508	0.0615
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.0508	0.1931
Entamoeba histolytica	ankyrin repeat protein	0.0008	0.0508	0.1931
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.002	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0008	0.0508	0.0615
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0012	0.1005	0.1218
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Echinococcus granulosus	raf serine:threonine protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.8256	1
Echinococcus granulosus	tyrosine kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	activated cdc42 kinase 1	0.0008	0.0508	0.0615
Plasmodium falciparum	tyrosine kinase-like protein	0.0008	0.0508	0.1931
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0012	0.1005	0.1218
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0008	0.0508	0.0615
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	AGC family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	signal transduction protein lnk realted	0.0012	0.1005	0.1218
Onchocerca volvulus		0.0012	0.1005	0.2304
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Giardia lamblia	Protein 21.1	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0012	0.1005	0.1218
Echinococcus multilocularis	protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	SH2 domain containing protein 7	0.0012	0.1005	0.1218
Schistosoma mansoni	protein tyrosine kinase	0.0008	0.0508	0.0508
Brugia malayi	Tyrosine-protein kinase PR2	0.0008	0.0508	0.0615
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.002	0.2178	0.2638
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.8256	1
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0508	0.0508
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.1005	0.1005
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0871	0.1055
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.2628	0.5
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.2628	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus		0.002	0.2178	0.4991
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/DDR protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	hypothetical protein	0.0008	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0009	0.0588	0.2239
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0012	0.1005	0.1218
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Schistosoma mansoni	hypothetical protein	0.0012	0.1005	0.1005
Leishmania major	protein kinase, putative	0.0009	0.0588	0.0713
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0012	0.1005	0.2304
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Schistosoma mansoni	cpg binding protein	0.0035	0.4363	0.4363
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0008	0.0508	0.0615
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.2628	0.3183
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0474	0.0575
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.8256	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.2628	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.8256	1
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK protein kinase	0.002	0.2178	0.2638
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0012	0.1005	0.1218
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0012	0.1005	0.1218
Echinococcus multilocularis	tensin	0.0012	0.1005	0.1218
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.8256	0.8256
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0008	0.0508	0.0615
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.8256	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0008	0.0508	0.1163
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tensin-related	0.0012	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Plasmodium falciparum	protein kinase, putative	0.0009	0.0588	0.2239
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0009	0.0588	0.0713
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0008	0.0508	0.0615
Toxoplasma gondii	protein kinase domain-containing protein	0.0008	0.0508	0.0573
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0474	0.0575
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0891	0.1079
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.002	0.2178	0.2638
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Onchocerca volvulus		0.002	0.2178	0.4991
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Onchocerca volvulus		0.0008	0.0508	0.1163
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.2628	1
Echinococcus granulosus	integrin linked protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0012	0.1005	0.1218
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.2628	0.3183
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0012	0.1005	0.1218
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	protein tyrosine kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase shark	0.002	0.2178	0.2638
Schistosoma mansoni	adapter molecule crk	0.0012	0.1005	0.1005
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0012	0.1005	0.1005
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Plasmodium falciparum	protein kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	hypothetical protein	0.002	0.2178	0.2638
Echinococcus multilocularis	tensin	0.0012	0.1005	0.1218
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Schistosoma mansoni	tyrosine kinase	0.002	0.2178	0.2178
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0474	0.0575
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0008	0.0508	0.0615
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0474	0.0575
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.8256	1
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Onchocerca volvulus		0.002	0.2178	0.4991
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0012	0.1005	0.1218
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.002	0.2178	0.2638
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trypanosoma cruzi	protein kinase, putative	0.0008	0.0508	0.0615
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0008	0.0508	0.0573
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Echinococcus granulosus	epidermal growth factor receptor	0.0008	0.0508	0.0615
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Brugia malayi	Raf kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	serine/threonine protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	TK/CSK protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	nck2/grb4	0.0012	0.1005	0.1005
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.2628	0.3183
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.8256	1
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase shark	0.002	0.2178	0.2638
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0008	0.0508	0.0615
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0008	0.0508	0.0615
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus multilocularis	protein kinase	0.0008	0.0508	0.0615
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.8256	1
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.1005	0.1218
Schistosoma mansoni	protein kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	insulin receptor	0.0008	0.0508	0.0615
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.002	0.2178	0.2638
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0008	0.0508	0.0615
Entamoeba histolytica	SH2 domain containing protein	0.0012	0.1005	0.3826
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0474	0.0575
Echinococcus multilocularis	tyrosine kinase	0.002	0.2178	0.2638
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0012	0.1005	0.1218
Brugia malayi	Protein kinase domain containing protein	0.002	0.2178	0.2638
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	tyrosine protein kinase Lyn	0.002	0.2258	0.2735
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Brugia malayi	Guanylyl cyclase protein 23	0.0008	0.0508	0.0615
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Brugia malayi	Tyrosine-protein kinase abl-1	0.002	0.2178	0.2638
Schistosoma mansoni	tyrosine kinase	0.002	0.2178	0.2178
Entamoeba histolytica	cysteine surface protein, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0008	0.0508	0.1931
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0008	0.0508	0.0508
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.1005	0.1218
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.002	0.2178	0.2638
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0008	0.0508	0.0615
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	FL cytokine receptor	0.0008	0.0508	0.0615
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0008	0.0508	0.0615
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.8256	0.9317
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	expressed conserved protein	0.0012	0.1005	0.1218
Brugia malayi	C-terminal src kinase protein 1	0.0008	0.0508	0.0615
Echinococcus granulosus	tyrosine protein kinase ABL1	0.002	0.2178	0.2638
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0008	0.0508	0.0615
Echinococcus granulosus	natriuretic peptide receptor 1	0.0008	0.0508	0.0615
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.8256	1
Echinococcus granulosus	SHC transforming protein 3	0.0012	0.1005	0.1218
Schistosoma mansoni	ephrin receptor	0.0008	0.0508	0.0508
Schistosoma mansoni	shc transforming protein	0.0012	0.1005	0.1005
Echinococcus granulosus	tyrosine protein kinase pr2	0.0008	0.0508	0.0615
Echinococcus granulosus	NCK adaptor protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	insulin receptor	0.0008	0.0508	0.0615
Leishmania major	hypothetical protein, conserved	0.0008	0.0508	0.0615
Entamoeba histolytica	receptor protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	tyrosine kinase	0.002	0.2178	0.2638
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.002	0.2178	0.8287
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0584	0.0708
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.002	0.2178	0.2638
Schistosoma mansoni	tyrosine kinase	0.002	0.2178	0.2178
Echinococcus granulosus	tyrosine protein kinase csk	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.002	0.2178	0.2638
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Loa Loa (eye worm)	TK/RYK protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Loa Loa (eye worm)	TK/Met protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.1005	0.1218
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	cpg binding protein	0.0037	0.465	0.465
Echinococcus granulosus	epidermal growth factor receptor	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Brugia malayi	MAP kinase sur-1	0.0062	0.8256	1
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Echinococcus granulosus	growth factor receptor bound protein 2	0.0012	0.1005	0.1218
Loa Loa (eye worm)	TK/ABL protein kinase	0.002	0.2178	0.2638
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0012	0.1086	0.4133
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.8256	1
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.2628	0.3183
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.8256	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.002	0.2178	0.2638
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	SH2 domain containing protein 7	0.0012	0.1005	0.1218
Onchocerca volvulus	Tyrosine kinase homolog	0.0008	0.0508	0.1163
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0012	0.1005	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trypanosoma cruzi	protein kinase, putative	0.0008	0.0508	0.0615
Brugia malayi	Sex muscle abnormal protein 5	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.8861	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.1005	0.1005
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.2628	0.3183
Echinococcus multilocularis	epidermal growth factor receptor	0.0008	0.0508	0.0615
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0508	0.0508
Brugia malayi	hypothetical protein	0.002	0.2178	0.2638
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Echinococcus multilocularis	tyrosine protein kinase Blk	0.002	0.2178	0.2638
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0508	0.0615
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0008	0.0508	0.1163
Schistosoma mansoni	growth factor receptor-bound protein	0.0012	0.1005	0.1005
Entamoeba histolytica	hypothetical protein	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0008	0.0508	0.0615
Brugia malayi	SH2 domain containing protein	0.002	0.2178	0.2638
Loa Loa (eye worm)	TK/ACK protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0012	0.1005	0.2304
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	c src tyrosine kinase	0.002	0.2178	0.2638
Echinococcus multilocularis	activated cdc42 kinase 1	0.0008	0.0508	0.0615
Schistosoma mansoni	suppressor of cytokine signaling	0.0012	0.1005	0.1005
Echinococcus multilocularis	activin receptor type	0.0009	0.0588	0.0713
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0008	0.0508	0.0508
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Schistosoma mansoni	protein kinase	0.0009	0.0588	0.0588
Onchocerca volvulus		0.0035	0.4363	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0012	0.1005	0.1218
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0056	0.0056
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.002	0.2178	0.2638
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Plasmodium falciparum	tyrosine kinase-like protein	0.0008	0.0508	0.1931
Toxoplasma gondii	exonuclease III APE	0.0023	0.2628	0.2966
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	SH2 motif	0.0012	0.1005	0.1218
Onchocerca volvulus		0.0008	0.0508	0.1163
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.002	0.2178	0.2638
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Toxoplasma gondii	protein kinase	0.0008	0.0508	0.0573
Echinococcus granulosus	N chimaerin	0.0012	0.1005	0.1218
Echinococcus multilocularis		0.0012	0.1005	0.1218
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Echinococcus granulosus	tyrosine protein kinase Srms	0.002	0.2178	0.2638
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0008	0.0508	0.0615
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218
Trypanosoma brucei	Pseudokinase, putative	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus granulosus	cpg binding protein	0.0037	0.465	0.5632
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0008	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0012	0.1005	0.1218
Schistosoma mansoni	tyrosine protein kinase	0.0008	0.0508	0.0508
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0584	0.0708
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.2628	0.3183
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Loa Loa (eye worm)	TK/ALK protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.0508	0.1931
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0012	0.1005	0.1218
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.8256	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.002	0.2178	0.2638
Schistosoma mansoni	tyrosine kinase	0.0008	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0008	0.0508	0.0615
Schistosoma mansoni	tyrosine kinase	0.002	0.2178	0.2178
Loa Loa (eye worm)	TK/INSR protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0508	0.1931
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0009	0.0588	0.0713
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0008	0.0508	0.0615
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.8256	1
Brugia malayi	hypothetical protein	0.0012	0.1005	0.1218
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0012	0.1005	0.2304
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.2628	0.3183
Echinococcus granulosus	tensin	0.0012	0.1005	0.1218
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Echinococcus granulosus	tyrosine protein kinase HCK	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK protein kinase	0.0008	0.0508	0.0615
Schistosoma mansoni	hypothetical protein	0.0012	0.1005	0.1005
Schistosoma mansoni	tyrosine kinase	0.002	0.2178	0.2178
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0008	0.0508	0.0615
Onchocerca volvulus		0.0008	0.0508	0.1163
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.002	0.2178	0.2178
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0012	0.1005	0.1218
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0012	0.1005	0.1218
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.002	0.2178	0.2638
Echinococcus multilocularis	heat shock protein 70	0.0008	0.0508	0.0615
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0474	0.0575
Echinococcus granulosus	activated cdc42 kinase 1	0.0008	0.0508	0.0615
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0008	0.0508	0.0615
Brugia malayi	SH2 domain containing protein	0.002	0.2178	0.2638
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.0508	0.1931
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	transfer RNA-Thr	0.0008	0.0508	0.0615
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0508	0.0615
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0008	0.0508	0.0615
Trypanosoma brucei	protein kinase, putative	0.0009	0.0588	0.0713
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0508	0.0615
Echinococcus granulosus	kinase suppressor of Ras 1	0.0008	0.0508	0.0615
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.0508	0.1931
Schistosoma mansoni	protein kinase	0.0009	0.0588	0.0588
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.002	0.2178	0.2638
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.2628	0.3183
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0008	0.0508	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.2178	0.2638
Echinococcus granulosus	tyrosine protein kinase Blk	0.002	0.2178	0.2638
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0009	0.0588	0.0713
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0508	0.0615
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0008	0.0508	0.0615
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.1005	0.1218
Entamoeba histolytica	protein kinase, putative	0.0008	0.0508	0.1931
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0474	0.0575
Echinococcus granulosus	c src tyrosine kinase	0.002	0.2178	0.2638
Brugia malayi	SH2 domain containing protein	0.0012	0.1005	0.1218

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0501 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.3162 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1563638

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1408315