TDR Targets

Basic information

Technical information

TDR Targets ID: 1408485
Name: [2-(4-chlorophenyl)-2-oxoethyl] 5-methylpyraz ine-2-carboxylate
MW: 290.702 | Formula: C14H11ClN2O3
H donors: 0 H acceptors: 4 LogP: 2.41 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(=O)COC(=O)c1ncc(nc1)C
InChi: 1S/C14H11ClN2O3/c1-9-6-17-12(7-16-9)14(19)20-8-13(18)10-2-4-11(15)5-3-10/h2-7H,8H2,1H3
InChiKey: WLGXOJNQVGUTNQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-(4-chlorophenyl)-2-oxo-ethyl] 5-methylpyrazine-2-carboxylate
5-methyl-2-pyrazinecarboxylic acid [2-(4-chlorophenyl)-2-oxoethyl] ester
5-methylpyrazinic acid [2-(4-chlorophenyl)-2-keto-ethyl] ester
ZINC06349069

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	opsin-like receptor	0.0048	0.6285	0.6244
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.6285	1
Schistosoma mansoni	cpg binding protein	0.0037	0.4678	0.4619
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.8867	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0048	0.6285	0.6244
Brugia malayi	sulfakinin receptor protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0048	0.6285	0.6244
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Echinococcus granulosus	allatostatin A receptor	0.0048	0.6285	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Echinococcus granulosus	serotonin receptor	0.0048	0.6285	1
Brugia malayi	Dopamine receptor	0.0048	0.6285	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0048	0.6285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Brugia malayi	Serotonin receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.6285	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.6285	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0048	0.6285	1
Echinococcus granulosus	G protein coupled receptor 139	0.0048	0.6285	1
Schistosoma mansoni	myosin xvIII	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	hypothetical protein	0.0048	0.6285	0.6244
Brugia malayi	Dopamine receptor protein 1	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0048	0.6285	0.6244
Onchocerca volvulus		0.0048	0.6285	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	hypothetical protein	0.0048	0.6285	0.6244
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0048	0.6285	0.6244
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0048	0.6285	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.6285	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0048	0.6285	0.6244
Brugia malayi	GnHR receptor homolog	0.0048	0.6285	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0048	0.6285	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0048	0.6285	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0048	0.6285	1
Echinococcus granulosus	g protein coupled receptor	0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Schistosoma mansoni	amine GPCR	0.0048	0.6285	0.6244
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.6285	1
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.6285	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0048	0.6285	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	sex peptide receptor	0.0048	0.6285	1
Schistosoma mansoni	amine GPCR	0.0048	0.6285	0.6244
Schistosoma mansoni	amine GPCR	0.0048	0.6285	0.6244
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	hypothetical protein	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	cpg binding protein	0.0037	0.4678	0.7157
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0048	0.6285	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	neuropeptide receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0634	0.0531
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.6285	1
Schistosoma mansoni	neuropeptide receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	biogenic amine receptor	0.0048	0.6285	0.6244
Onchocerca volvulus		0.0048	0.6285	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0048	0.6285	0.6244
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0048	0.6285	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.6285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Onchocerca volvulus		0.0048	0.6285	1
Brugia malayi	follicle stimulating hormone receptor	0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Echinococcus granulosus	sex peptide receptor	0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus granulosus	fmrfamide receptor	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.6285	1
Schistosoma mansoni	adenoreceptor	0.0048	0.6285	0.6244
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	orexin receptor type 2	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0048	0.6285	1
Schistosoma mansoni	amine GPCR	0.0048	0.6285	0.6244
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0048	0.6285	1
Loa Loa (eye worm)	TYRA-2 protein	0.0048	0.6285	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.6285	0.6244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.6285	0.6244
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.6285	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Echinococcus granulosus	neuropeptide receptor	0.0048	0.6285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Onchocerca volvulus		0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0939	0.054
Echinococcus multilocularis	g-protein coupled receptor	0.0048	0.6285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.6285	1
Echinococcus granulosus	cpg binding protein	0.0037	0.4678	0.7157
Trichomonas vaginalis	helicase, putative	0.0008	0.0525	1
Brugia malayi	G-protein coupled receptor	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.6285	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	CXXC zinc finger family protein	0.0035	0.4393	0.6474
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.6285	1
Schistosoma mansoni	opsin-like receptor	0.0048	0.6285	0.6244
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Echinococcus granulosus	orexin receptor type 2	0.0048	0.6285	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Brugia malayi	RE15519p	0.0048	0.6285	1
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.6285	1
Brugia malayi	Dopamine receptor protein 2	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.6285	1
Schistosoma mansoni	cpg binding protein	0.0035	0.4393	0.4331
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.6285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Echinococcus granulosus	g protein coupled receptor	0.0048	0.6285	1
Brugia malayi	larval opioid receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.6285	1
Brugia malayi	putative neuropeptide receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0525	1
Echinococcus granulosus	somatostatin receptor	0.0048	0.6285	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0048	0.6285	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	hypothetical protein	0.0048	0.6285	0.6244
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.6285	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0048	0.6285	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Schistosoma mansoni	amine GPCR	0.0048	0.6285	0.6244
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.6285	1
Echinococcus multilocularis	allatostatin A receptor	0.0048	0.6285	1
Schistosoma mansoni	neuropeptide receptor	0.0048	0.6285	0.6244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.6285	1
Echinococcus granulosus	g-protein coupled receptor	0.0048	0.6285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.6285	1
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	neuropeptide F receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0048	0.6285	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0048	0.6285	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Echinococcus granulosus	neuropeptide receptor	0.0048	0.6285	1
Echinococcus granulosus	neuropeptide receptor A26	0.0048	0.6285	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0525	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0048	0.6285	0.6244
Brugia malayi	G-protein coupled receptor	0.0048	0.6285	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0939	0.054
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.6285	0.6244
Onchocerca volvulus		0.0048	0.6285	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	neuropeptide F receptor	0.0048	0.6285	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0048	0.6285	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0048	0.6285	1
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0048	0.6285	1
Echinococcus granulosus	g protein coupled receptor	0.0048	0.6285	1
Echinococcus multilocularis	serotonin receptor	0.0048	0.6285	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0048	0.6285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Schistosoma mansoni	opsin-like receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	biogenic amine receptor	0.0048	0.6285	0.6244
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0048	0.6285	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.6285	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0048	0.6285	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0048	0.6285	0.6244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Brugia malayi	AKH receptor	0.0048	0.6285	1
Echinococcus multilocularis	serotonin receptor	0.0048	0.6285	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.6285	0.6244
Schistosoma mansoni	cpg binding protein	0.0037	0.4678	0.4619
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	Serotonin receptor	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0048	0.6285	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.6285	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0048	0.6285	1
Echinococcus granulosus	neuropeptide s receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	neuropeptide receptor	0.0048	0.6285	0.6244
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.6285	1
Brugia malayi	ORL1-like opioid receptor	0.0048	0.6285	1
Brugia malayi	Melatonin receptor type 1A	0.0048	0.6285	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0048	0.6285	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0048	0.6285	1
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.6285	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Brugia malayi	G protein-coupled receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0048	0.6285	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0525	1
Onchocerca volvulus		0.0048	0.6285	1
Schistosoma mansoni	biogenic amine receptor	0.0048	0.6285	0.6244
Brugia malayi	hypothetical protein	0.0048	0.6285	1
Onchocerca volvulus		0.0048	0.6285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.6285	1
Echinococcus granulosus	hypothetical protein	0.0048	0.6285	1
Echinococcus multilocularis	neuropeptide s receptor	0.0048	0.6285	1
Echinococcus multilocularis	somatostatin receptor	0.0048	0.6285	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.6285	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0048	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6285	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.6285	0.6244
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0048	0.6285	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.4393	0.6461
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0525	1
Schistosoma mansoni	histamine h1 receptor	0.0048	0.6285	0.6244

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.0787 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1541913

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1408485