Detailed information for compound 1408765

Basic information

Technical information
  • TDR Targets ID: 1408765
  • Name: 2-(4-methylphenyl)sulfanyl-N-(1-phenylethyl)a cetamide
  • MW: 285.404 | Formula: C17H19NOS
  • H donors: 1 H acceptors: 1 LogP: 4.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(c1ccccc1)C)CSc1ccc(cc1)C
  • InChi: 1S/C17H19NOS/c1-13-8-10-16(11-9-13)20-12-17(19)18-14(2)15-6-4-3-5-7-15/h3-11,14H,12H2,1-2H3,(H,18,19)
  • InChiKey: LLLMPTXKIGLDPC-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(4-methylphenyl)thio]-N-(1-phenylethyl)acetamide
  • 2-(4-methylphenyl)sulfanyl-N-(1-phenylethyl)ethanamide
  • Oprea1_863505
  • BAS 02194652
  • N-(1-Phenyl-ethyl)-2-p-tolylsulfanyl-acetamide
  • IBS-0013667

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0149 0.3691 0.5417
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0034 0.0383 0.0562
Loa Loa (eye worm) hypothetical protein 0.0221 0.5779 0.8481
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0687 0.0687
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0257 0.6813 1
Entamoeba histolytica protein kinase, putative 0.0194 0.5004 0.7345
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0128 0.3103 0.4555
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.1669 0.1669
Giardia lamblia 20S proteasome alpha subunit 3 0.0136 0.3325 0.4879
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0103 0.2364 0.347
Schistosoma mansoni tyrosine kinase 0.0047 0.0751 0.0751
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0158 0.3971 0.5828
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0023 0.0072 0.0106
Schistosoma mansoni hypothetical protein 0.0031 0.0298 0.0298
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0149 0.3691 0.5417
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.013 0.3153 0.4628
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0354 0.0354
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0128 0.3103 0.4555
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0099 0.2257 0.3312
Schistosoma mansoni 26S proteasome subunit S9 0.0037 0.0482 0.0482
Trypanosoma brucei proteasome beta 3 subunit, putative 0.013 0.3153 0.4628
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.004 0.0546 0.0546
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0135 0.331 0.4858
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.004 0.0564 0.0564
Echinococcus granulosus insulin receptor 0.0047 0.0751 0.0751
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.2274 0.2274
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0482 0.0708
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0128 0.3103 0.3103
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0141 0.3473 0.5097
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0194 0.5004 0.5004
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0379 0.0379
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0036 0.0036
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0136 0.3338 0.4898
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.004 0.0564 0.0564
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0257 0.6813 1
Echinococcus granulosus proteasome subunit alpha type 6 0.0149 0.3691 0.3691
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0187 0.4789 0.4789
Loa Loa (eye worm) proteasome subunit beta type 2 0.013 0.3153 0.4628
Brugia malayi mbt repeat family protein 0.0058 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0097 0.2207 0.324
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0383 0.0562
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.004 0.0564 0.0564
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0158 0.3971 0.3971
Toxoplasma gondii proteasome subunit alpha type, putative 0.0136 0.3325 0.4879
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0037 0.0482 0.0708
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0298 0.0437
Loa Loa (eye worm) hypothetical protein 0.003 0.0257 0.0377
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0148 0.3663 0.5376
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.003 0.0257 0.0377
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0303 0.0302
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0037 0.0482 0.0482
Schistosoma mansoni tyrosine kinase 0.0078 0.1645 0.1645
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0136 0.3338 0.4898
Giardia lamblia 26S protease regulatory subunit 6A 0.0022 0.0036 0.0053
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0021 0.0018 0.0026
Plasmodium vivax proteasome subunit beta type-2, putative 0.013 0.3153 0.4628
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0303 0.0444
Plasmodium vivax proteasome subunit beta type-3, putative 0.013 0.3153 0.4628
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0136 0.3325 0.4879
Echinococcus multilocularis insulin receptor 0.0047 0.0751 0.0751
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0031 0.0303 0.0444
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0141 0.3473 0.5097
Schistosoma mansoni tyrosine kinase 0.0146 0.3622 0.3622
Leishmania major proteasome beta 3 subunit, putative 0.013 0.3153 0.4628
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0031 0.0298 0.0437
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0044 0.0687 0.1009
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0124 0.299 0.4388
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0257 0.6813 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.013 0.3153 0.3153
Leishmania major proteasome alpha 7 subunit, putative 0.0138 0.3373 0.4951
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0022 0.0035 0.0051
Leishmania major proteasome beta 7 subunit, putative 0.0128 0.3103 0.4555
Loa Loa (eye worm) hypothetical protein 0.0021 0.0000046893 0.0000068824
Schistosoma mansoni tyrosine kinase 0.0079 0.1669 0.1669
Giardia lamblia Proteasome subunit beta type 1 0.0158 0.3971 0.5828
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0037 0.0482 0.0708
Plasmodium vivax proteasome subunit beta type-6, putative 0.0136 0.3338 0.4898
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.3622 0.5315
Loa Loa (eye worm) proteasome regulatory particle 0.0037 0.0482 0.0708
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0149 0.3691 0.5417
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0367 1 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0148 0.3663 0.3663
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0022 0.0036 0.0053
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0141 0.3473 0.5097
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0097 0.2207 0.2207
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0379 0.0556
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0687 0.0687
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.1669 0.1669
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0158 0.3971 0.5828
Brugia malayi RNA binding protein 0.0076 0.1611 0.1611
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.004 0.0546 0.0546
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0136 0.3338 0.4898
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0687 0.1009
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0034 0.005
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0128 0.3103 0.4555
Toxoplasma gondii proteasome 26S regulatory subunit 0.0021 0.0018 0.0026
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0136 0.3325 0.3325
Loa Loa (eye worm) RPN-3 protein 0.004 0.0564 0.0828
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0037 0.0482 0.0708
Giardia lamblia 20S proteasome alpha subunit 6 0.0135 0.331 0.4858
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0138 0.3373 0.3373
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0128 0.3103 0.4555
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0148 0.3663 0.5376
Leishmania major proteasome alpha 7 subunit, putative 0.0187 0.4789 0.7028
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0034 0.0034
Loa Loa (eye worm) PCI domain-containing protein 0.0034 0.0383 0.0562
Plasmodium vivax proteasome subunit beta type-7, putative 0.0124 0.299 0.4388
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0023 0.0072 0.0106
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0687 0.0687
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0257 0.6813 1
Schistosoma mansoni hypothetical protein 0.0221 0.5779 0.5779
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0138 0.3373 0.4951
Giardia lamblia Proteasome subunit beta type 2 0.013 0.3153 0.4628
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0298 0.0437
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0103 0.2364 0.5
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0257 0.6813 0.6813
Brugia malayi 20S proteasome alpha5 subunit 0.0148 0.3663 0.3663
Schistosoma mansoni tyrosine kinase 0.0047 0.0751 0.0751
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.003 0.0257 0.0377
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0124 0.299 0.4388
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0148 0.3663 0.3663
Brugia malayi 26S protease regulatory subunit 6A 0.0022 0.0036 0.0036
Schistosoma mansoni tyrosine kinase 0.0078 0.1645 0.1645
Entamoeba histolytica proteasome regulatory subunit, putative 0.004 0.0564 0.0828
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0034 0.0383 0.0562
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0036 0.0053
Giardia lamblia 20S proteasome alpha subunit 2 0.0141 0.3473 0.5097
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0141 0.3473 0.5097
Schistosoma mansoni multiubiquitin binding protein S5a 0.0022 0.0034 0.0034
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0257 0.6813 1
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0034 0.0383 0.0383
Trypanosoma brucei proteasome subunit beta type-2, putative 0.013 0.3153 0.4628
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0037 0.0482 0.0708
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0128 0.3103 0.4555
Echinococcus multilocularis proteasome (prosome, macropain) 0.0257 0.6813 0.6813
Echinococcus multilocularis adhesion regulating molecule 1 0.0097 0.2207 0.2207
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0221 0.5779 0.5779
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1296 0.1296
Leishmania major proteasome alpha 1 subunit, putative 0.0149 0.3691 0.5417
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.5957 0.5957
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.013 0.3153 0.4628
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0303 0.0444
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0149 0.3691 0.5417
Toxoplasma gondii peptidase, T1 family protein 0.0138 0.3373 0.4951
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0135 0.331 0.331
Toxoplasma gondii proteasome beta subunit 0.013 0.3153 0.4628
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0124 0.299 0.4388
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0149 0.3691 0.5417
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0022 0.0036 0.0053
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0044 0.0687 0.1009
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.004 0.0564 0.0564
Loa Loa (eye worm) proteasome subunit beta type 1 0.0158 0.3971 0.5828
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0034 0.0379 0.0556
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0022 0.0036 0.0053
Trypanosoma brucei proteasome beta 6 subunit 0.0158 0.3971 0.5828
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.004 0.0564 0.0828
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0037 0.0482 0.0482
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0031 0.0303 0.0444
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0034 0.0383 0.0562
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0034 0.0383 0.0562
Onchocerca volvulus 0.0058 0.1066 0.3159
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.013 0.3153 0.4628
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0124 0.299 0.4388
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0136 0.3325 0.4879
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0136 0.3325 0.4879
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0044 0.0687 0.0687
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0303 0.0302
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0031 0.0298 0.0437
Echinococcus granulosus geminin 0.0205 0.5311 0.5311
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0141 0.3473 0.3473
Echinococcus granulosus adhesion regulating molecule 1 0.0097 0.2207 0.2207
Schistosoma mansoni tyrosine kinase 0.0078 0.1645 0.1645
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.004 0.0546 0.0802
Plasmodium vivax proteasome subunit beta type-1, putative 0.0158 0.3971 0.5828
Echinococcus multilocularis proteasome subunit beta type 7 0.0367 1 1
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0136 0.3338 0.4898
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0482 0.0708
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0128 0.3103 0.3103
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0158 0.3971 0.5828
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.013 0.3153 0.4628
Brugia malayi mbt repeat family protein 0.0058 0.1066 0.1066
Entamoeba histolytica proteasome subunit beta type 3, putative 0.013 0.3153 0.4628
Trypanosoma cruzi 20S proteasome subunit 0.013 0.3153 0.4628
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1296 0.1296
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0148 0.3663 0.5376
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0136 0.3325 0.3325
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0051 0.0863 0.1267
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.004 0.0564 0.0828
Brugia malayi Protein kinase domain containing protein 0.0047 0.0751 0.0751
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0482 0.0708
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0257 0.0377
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0131 0.318 0.318
Brugia malayi proteasome subunit alpha type 6 0.0149 0.3691 0.3691
Loa Loa (eye worm) MBCTL1 0.0066 0.1296 0.1902
Toxoplasma gondii hypothetical protein 0.0027 0.0191 0.028
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0097 0.2207 0.324
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0031 0.0303 0.0302
Trichomonas vaginalis 26S proteasome subunit, putative 0.0031 0.0298 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.2257 0.3312
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0354 0.0354
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0257 0.6813 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0158 0.3971 0.5828
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0124 0.299 0.4388
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0135 0.331 0.4858
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0148 0.3663 0.5376
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0149 0.3691 0.5417
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0148 0.3663 0.5376
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0158 0.3971 0.3971
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0303 0.0444
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.004 0.0564 0.0828
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0128 0.3103 0.4555
Toxoplasma gondii proteasome subunit alpha1, putative 0.0149 0.3691 0.5417
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0257 0.6813 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1611 0.1611
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0031 0.0298 0.0298
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0379 0.0556
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0187 0.4789 0.7028
Loa Loa (eye worm) RNA binding protein 0.0076 0.1611 0.2365
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0034 0.0379 0.0556
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0379 0.0556
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.013 0.3153 0.3153
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0303 0.0444
Leishmania major proteasome alpha 1 subunit, putative 0.0135 0.331 0.4858
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.009 0.2 0.2
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0257 0.0377
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0031 0.0298 0.0298
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.1066 0.1066
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0136 0.3325 0.4879
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0124 0.299 0.4388
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0158 0.3971 0.5828
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0031 0.0303 0.0444
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0149 0.3691 0.5417
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.004 0.0546 0.0546
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0194 0.5004 0.5004
Echinococcus granulosus proteasome prosome macropain subunit beta 0.013 0.3153 0.3153
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0021 0.0018 0.0026
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0187 0.4789 0.7028
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0135 0.331 0.4858
Schistosoma mansoni hypothetical protein 0.0205 0.5311 0.5311
Giardia lamblia 20S proteasome alpha subunit 4 0.0187 0.4789 0.7028
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0751 0.0751
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0034 0.0383 0.0562
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0148 0.3663 0.5376
Echinococcus granulosus tar DNA binding protein 0.0076 0.1611 0.1611
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0135 0.331 0.331
Plasmodium falciparum proteasome subunit beta type-4 0.0128 0.3103 0.4555
Brugia malayi Proteasome subunit alpha type 1 0.0119 0.2827 0.2827
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0036 0.0053
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0044 0.0687 0.0687
Leishmania major proteasome beta 5 subunit, putative 0.0257 0.6813 1
Brugia malayi proteasome subunit beta type 2 0.013 0.3153 0.3153
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0303 0.0444
Brugia malayi proteasome subunit alpha type 4 0.0119 0.2842 0.2841
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0136 0.3325 0.4879
Echinococcus multilocularis proteasome subunit alpha type 6 0.0149 0.3691 0.3691
Loa Loa (eye worm) PAS-3 protein 0.0119 0.2842 0.417
Leishmania major proteasome beta-1 subunit, putative 0.0136 0.3338 0.4898
Schistosoma mansoni proteasome regulatory subunit-related 0.0034 0.0383 0.0383
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0135 0.331 0.4858
Toxoplasma gondii PCI domain-containing protein 0.004 0.0564 0.0828
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0148 0.3663 0.5376
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0034 0.0383 0.0562
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0138 0.3373 0.4951
Entamoeba histolytica proteasome regulatory subunit, putative 0.0022 0.0034 0.005
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0482 0.0708
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0187 0.4789 0.7028
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0187 0.4789 0.7028
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0097 0.2207 0.2207
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.1066 0.1066
Mycobacterium ulcerans proteasome PrcB 0.0257 0.6813 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0136 0.3338 0.4898
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0298 0.0437
Brugia malayi proteasome subunit beta type 3 0.013 0.3153 0.3153
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0036 0.0036
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0687 0.1009
Brugia malayi Proteasome A-type and B-type family protein 0.0136 0.3338 0.3338
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0031 0.0298 0.0437
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0138 0.3373 0.4951
Plasmodium falciparum proteasome subunit beta type-2, putative 0.013 0.3153 0.4628
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0022 0.0036 0.0036
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.1669 0.1669
Brugia malayi TAR-binding protein 0.0076 0.1611 0.1611
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0034 0.0379 0.0379
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0031 0.0303 0.0302
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0138 0.3373 0.4951
Giardia lamblia 20S proteasome alpha subunit 1 0.0149 0.3691 0.5417
Echinococcus granulosus subfamily T1A non peptidase ue 0.0148 0.3663 0.3663
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0257 0.6813 1
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0148 0.3663 0.3663
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.004 0.0564 0.0828
Toxoplasma gondii proteasome subunit alpha type, putative 0.0084 0.1827 0.2681
Entamoeba histolytica protein kinase, putative 0.0194 0.5004 0.7345
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0103 0.2364 0.347
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0022 0.0036 0.0053
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0148 0.3663 0.5376
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0000046893 0.0000068824
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0257 0.0377
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0148 0.3663 0.5376
Brugia malayi Proteasome A-type and B-type family protein 0.0128 0.3103 0.3103
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1066 0.1066
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.009 0.2 0.2
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0136 0.3325 0.3325
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0103 0.2364 0.347
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0187 0.4789 0.4789
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0034 0.0379 0.0556
Brugia malayi Ubiquitin interaction motif family protein 0.0022 0.0034 0.0034
Echinococcus multilocularis proteasome subunit beta type 6 0.0136 0.3338 0.3338
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0031 0.0303 0.0444
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.013 0.3153 0.4628
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.1066 0.1066
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0044 0.0687 0.1009
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0031 0.0303 0.0302
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0135 0.331 0.4858
Brugia malayi proteasome subunit alpha type 1 0.0135 0.331 0.331
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0257 0.0377
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0158 0.3971 0.5828
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0187 0.4789 0.7028
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.004 0.0546 0.0802
Toxoplasma gondii SAC3/GANP family protein 0.003 0.0257 0.0377
Trypanosoma brucei proteasome beta 7 subunit 0.0128 0.3103 0.4555
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0124 0.299 0.4388
Echinococcus granulosus proteasome subunit alpha type 2 0.0141 0.3473 0.3473
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0187 0.4789 0.7028
Brugia malayi proteasome subunit alpha type 3 0.0138 0.3373 0.3373
Giardia lamblia 20S proteasome alpha subunit 5 0.0148 0.3663 0.5376
Schistosoma mansoni hypothetical protein 0.0205 0.5311 0.5311
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0303 0.0444
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.1066 0.1066
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0135 0.331 0.331
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.003 0.0257 0.0377
Brugia malayi Proteasome subunit alpha type 7-1 0.0187 0.4789 0.4789
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.028
Loa Loa (eye worm) PCI domain-containing protein 0.0031 0.0298 0.0437
Brugia malayi proteasome subunit alpha type 2 0.0141 0.3473 0.3473
Toxoplasma gondii proteasome subunit 0.0136 0.3338 0.4898
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0187 0.4789 0.7028
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0379 0.0556
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0037 0.0482 0.0482
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0022 0.0036 0.0053
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0034 0.0034
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1296 0.1296
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0124 0.299 0.4388
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0128 0.3103 0.4555
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0187 0.4789 0.7028
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1296 0.1296
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0303 0.0444
Plasmodium vivax proteasome subunit beta type-4, putative 0.0128 0.3103 0.4555
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1611 0.2365
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0187 0.4789 0.4789
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.013 0.3153 0.3153
Loa Loa (eye worm) proteasome subunit beta type 3 0.013 0.3153 0.4628
Echinococcus granulosus proteasome subunit beta type 6 0.0136 0.3338 0.3338
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0103 0.2382 0.3496
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0031 0.0303 0.0444
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0044 0.0687 0.1009
Plasmodium falciparum proteasome subunit beta type-3, putative 0.013 0.3153 0.4628
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0148 0.3663 0.5376
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0257 0.0257
Echinococcus granulosus Proteasome subunit alpha type 7 0.0187 0.4789 0.4789
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0128 0.3103 0.4555
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0187 0.4789 0.4789
Brugia malayi Ribonuclease 2-5A family protein 0.0194 0.5004 0.5004
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0022 0.0036 0.0036
Onchocerca volvulus Notchless protein homolog 0.0138 0.3373 1
Giardia lamblia Hypothetical protein 0.0037 0.0482 0.0708
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.013 0.3153 0.3153
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0136 0.3338 0.4898
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0257 0.0377
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0103 0.2364 0.347
Echinococcus granulosus proteasome subunit beta type 7 0.0367 1 1
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0031 0.0303 0.0302
Schistosoma mansoni hypothetical protein 0.009 0.2 0.2
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.003 0.0272 0.04
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0022 0.0034 0.0034
Leishmania major proteasome beta 2 subunit, putative 0.013 0.3153 0.4628
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.004 0.0546 0.0802
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0128 0.3103 0.3103
Loa Loa (eye worm) hypothetical protein 0.0058 0.1066 0.1564
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0303 0.0444
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0128 0.3103 0.4555
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0031 0.0303 0.0302
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0751 0.1102
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0022 0.0036 0.0053
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0034 0.0379 0.0556
Toxoplasma gondii proteasome subunit beta type, putative 0.0257 0.6813 1
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0033 0.0354 0.052
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.3622 0.3622
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.003 0.0257 0.0377
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1066 0.1066
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0044 0.0687 0.0687
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0141 0.3473 0.5097
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.004 0.0546 0.0802
Loa Loa (eye worm) hypothetical protein 0.0066 0.1296 0.1902
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0158 0.3971 0.3971
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.1066 0.3159
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0136 0.3338 0.3338
Leishmania major proteasome alpha 3 subunit, putative 0.0136 0.3325 0.4879
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0034 0.005
Entamoeba histolytica hypothetical protein 0.004 0.0546 0.0802
Brugia malayi PCI domain containing protein 0.0034 0.0383 0.0383
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0136 0.3338 0.4898
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0103 0.2364 0.347
Echinococcus multilocularis 0.0045 0.0708 0.0708
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1611 0.2365
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.1066 0.1564
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0136 0.3325 0.4879
Schistosoma mansoni hypothetical protein 0.035 0.9514 0.9514
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0149 0.3691 0.3691
Brugia malayi Proteasome A-type and B-type family protein 0.0257 0.6813 0.6813
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0141 0.3473 0.5097
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0044 0.0687 0.1009
Toxoplasma gondii heat shock protein hslv, putative 0.0103 0.2364 0.347
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1296 0.1296
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0751 0.0751
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0149 0.3691 0.5417
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0034 0.0383 0.0383
Loa Loa (eye worm) IRE protein kinase 0.0194 0.5004 0.7345
Leishmania major proteasome alpha 2 subunit, putative 0.0141 0.3473 0.5097
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0158 0.3971 0.5828
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0034 0.0379 0.0556
Plasmodium falciparum proteasome subunit beta type-5 0.0257 0.6813 1
Loa Loa (eye worm) proteasome Regulatory Particle 0.0034 0.0379 0.0556
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0148 0.3663 0.5376
Schistosoma mansoni tyrosine kinase 0.0079 0.1669 0.1669
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0138 0.3373 0.3373
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0135 0.331 0.4858
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.003 0.0257 0.0257
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0103 0.2364 0.347
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0128 0.3103 0.4555
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1611 0.1611
Leishmania major proteasome beta 2 subunit, putative 0.0124 0.299 0.4388
Echinococcus multilocularis proteasome subunit alpha type 2 0.0141 0.3473 0.3473
Giardia lamblia Proteasome subunit beta type 3 0.013 0.3153 0.4628
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0033 0.0354 0.052
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0124 0.299 0.4388
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.013 0.3153 0.3153
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.013 0.3153 0.4628
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0036 0.0036
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.5957 0.5957
Plasmodium vivax proteasome subunit beta type-5, putative 0.0257 0.6813 1
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0022 0.0036 0.0053
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0303 0.0444
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1296 0.1296
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0187 0.4789 0.7028
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.2847 0.4179
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0303 0.0302
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0044 0.0687 0.1009
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.003 0.0257 0.0257
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0257 0.0257
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0022 0.0036 0.0053
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0257 0.0257
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.013 0.3153 0.4628
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0128 0.3103 0.4555
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.3622 0.3622
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.299 0.4388
Echinococcus multilocularis geminin 0.0205 0.5311 0.5311
Toxoplasma gondii proteasome subunit beta type 2, putative 0.013 0.3153 0.4628
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0128 0.3103 0.4555
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0062 0.1183 0.3508
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0034 0.0383 0.0562
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0298 0.0437
Leishmania major hypothetical protein, conserved 0.0051 0.0863 0.1267
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0136 0.3325 0.4879
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0136 0.3338 0.4898
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.003 0.0257 0.0377
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.013 0.3153 0.3153
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0379 0.0379
Echinococcus granulosus proteasome subunit beta t family 0.013 0.3153 0.3153
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0138 0.3373 0.4951
Brugia malayi proteasome subunit beta type 1 0.0158 0.3971 0.3971
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0135 0.331 0.4858
Echinococcus granulosus Proteasome subunit alpha beta 0.0138 0.3373 0.3373
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0257 0.6813 1
Trypanosoma brucei proteasome alpha 7 subunit 0.0138 0.3373 0.4951
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0138 0.3373 0.4951
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0138 0.3373 0.4951
Brugia malayi PCI domain containing protein 0.0031 0.0298 0.0298
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0303 0.0444
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.3622 0.3622
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0379 0.0379
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.004 0.0564 0.0564
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0135 0.331 0.4858
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0138 0.3373 0.4951
Echinococcus granulosus proteasome prosome macropain 0.0257 0.6813 0.6813
Giardia lamblia 20S proteasome alpha subunit 7 0.0138 0.3373 0.4951
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0141 0.3473 0.5097
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.0034 0.005
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0103 0.2364 0.2364
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0298 0.0437
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0136 0.3325 0.4879
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Toxoplasma gondii proteasome regulatory subunit 0.0031 0.0303 0.0444

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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