Detailed information for compound 1408952

Basic information

Technical information
  • TDR Targets ID: 1408952
  • Name: 3,6-dichloro-N-(2,2,6,6-tetramethylpiperidin- 4-yl)-1-benzothiophene-2-carboxamide
  • MW: 385.351 | Formula: C18H22Cl2N2OS
  • H donors: 2 H acceptors: 1 LogP: 5.17 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)sc(c2Cl)C(=O)NC1CC(C)(C)NC(C1)(C)C
  • InChi: 1S/C18H22Cl2N2OS/c1-17(2)8-11(9-18(3,4)22-17)21-16(23)15-14(20)12-6-5-10(19)7-13(12)24-15/h5-7,11,22H,8-9H2,1-4H3,(H,21,23)
  • InChiKey: CUYBPDXPQYEAIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,6-dichloro-N-(2,2,6,6-tetramethyl-4-piperidyl)benzothiophene-2-carboxamide
  • 3,6-dichloro-N-(2,2,6,6-tetramethyl-4-piperidinyl)-2-benzothiophenecarboxamide
  • T0504-7887
  • MLS001018441
  • SMR000354716
  • Oprea1_675309

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.003 0.2681 0.2676
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Leishmania major DNA polymerase eta, putative 0.0023 0.1002 0.0995
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0007 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.1002 0.0995
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.1002 0.1002
Trypanosoma brucei unspecified product 0.0023 0.1002 0.0995
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1002 0.0995
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.2681 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0007 0.0007
Echinococcus multilocularis mitogen activated protein kinase 0.0062 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.2681 0.2676
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1002 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1002 0.1002
Leishmania major DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0007 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.1002 0.0995
Brugia malayi isocitrate dehydrogenase 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Schistosoma mansoni hypothetical protein 0.0041 0.5203 0.5203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.2681 0.2676
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0007 0.0007
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.1002 0.0995
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.2681 0.2676
Schistosoma mansoni serine/threonine protein kinase 0.0062 1 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.1002 0.1002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.1002 0.5
Schistosoma mansoni DNA polymerase eta 0.0023 0.1002 0.1002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Echinococcus granulosus mitogen activated protein kinase 0.0062 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.2681 0.2676
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.2681 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.9686 0.9686
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.5203 0.5203
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0007 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0007 0.0007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.1002 0.1002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.2681 1
Echinococcus granulosus dna polymerase eta 0.0023 0.1002 0.1002
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1002 0.0995
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.9686 0.9686
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0007 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.1002 0.1002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.1002 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.0041 0.5203 0.5203
Loa Loa (eye worm) hypothetical protein 0.0023 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.006 0.9686 0.9686
Brugia malayi hypothetical protein 0.003 0.2681 0.2681
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.9686 0.9686
Echinococcus granulosus dna polymerase kappa 0.0023 0.1002 0.1002
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 1 1
Trypanosoma brucei protein kinase, putative 0.0062 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1002 0.0995
Echinococcus multilocularis dna polymerase kappa 0.0023 0.1002 0.1002
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1002 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.1002 0.1002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.1002 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0007 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.1002 0.1002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1002 0.0995
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.2681 0.2681
Brugia malayi hypothetical protein 0.002 0.0142 0.0142

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.