Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.3064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.2792 | 0.2792 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0289 | 0.0289 |
Onchocerca volvulus | 0.0808 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0808 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0154 | 0.0154 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0808 | 1 | 1 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0185 | 0.0185 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0154 | 0.0154 |
Trypanosoma cruzi | hexokinase, putative | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0154 | 0.0154 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0 | 0.5 |
Leishmania major | hexokinase, putative | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.664 | 0.664 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0147 | 0.0147 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0058 | 0.0185 | 0.0185 |
Echinococcus granulosus | hexokinase type 2 | 0.0808 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0808 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0808 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0808 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0808 | 1 | 1 |
Onchocerca volvulus | 0.0808 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.2792 | 0.2792 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0154 | 0.0154 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0058 | 0.0185 | 0.0185 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0058 | 0.0185 | 0.0185 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0289 | 0.0289 |
Echinococcus granulosus | hexokinase | 0.0808 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0154 | 0.0154 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0154 | 0.0154 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | Hexokinase homolog | 0.0507 | 0.6062 | 0.6062 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0185 | 0.0185 |
Brugia malayi | Hexokinase family protein | 0.025 | 0.2702 | 0.2702 |
Onchocerca volvulus | 0.0808 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0808 | 1 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0185 | 0.0185 |
Leishmania major | hexokinase, putative | 0.0808 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0154 | 0.0154 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0289 | 0.0289 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0154 | 0.0154 |
Trypanosoma brucei | hexokinase | 0.0808 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.401 | 0.401 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0058 | 0.0185 | 0.0185 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0289 | 0.0289 |
Brugia malayi | Hexokinase family protein | 0.0808 | 1 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0058 | 0.0185 | 0.0185 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0289 | 0.0289 |
Trypanosoma brucei | hexokinase | 0.0808 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0808 | 1 | 0.5 |
Onchocerca volvulus | 0.0507 | 0.6062 | 0.6062 | |
Brugia malayi | Hexokinase family protein | 0.0507 | 0.6062 | 0.6062 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0289 | 0.0289 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.24 | 0.24 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0289 | 0.0289 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0058 | 0.0185 | 0.0185 |
Plasmodium vivax | hexokinase, putative | 0.0808 | 1 | 1 |
Onchocerca volvulus | 0.0058 | 0.0185 | 0.0185 | |
Brugia malayi | hexokinase type II | 0.0257 | 0.2792 | 0.2792 |
Loa Loa (eye worm) | hexokinase | 0.025 | 0.2702 | 0.2702 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0058 | 0.0185 | 0.0185 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0154 | 0.0154 |
Schistosoma mansoni | hexokinase | 0.0808 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0185 | 0.0185 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hexokinase | 0.0507 | 0.6062 | 0.6062 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.24 | 0.24 |
Trypanosoma cruzi | hexokinase, putative | 0.0808 | 1 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0808 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0147 | 0.0147 |
Entamoeba histolytica | hexokinase 2 | 0.0808 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0808 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0808 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0147 | 0.0147 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.