Detailed information for compound 1409061

Basic information

Technical information
  • TDR Targets ID: 1409061
  • Name: N-[2-[[2-(cyclohexylamino)-2-oxoethyl]-(4-met hoxyphenyl)amino]-2-oxoethyl]furan-2-carboxam ide
  • MW: 413.467 | Formula: C22H27N3O5
  • H donors: 2 H acceptors: 3 LogP: 2.81 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N(C(=O)CNC(=O)c1ccco1)CC(=O)NC1CCCCC1
  • InChi: 1S/C22H27N3O5/c1-29-18-11-9-17(10-12-18)25(15-20(26)24-16-6-3-2-4-7-16)21(27)14-23-22(28)19-8-5-13-30-19/h5,8-13,16H,2-4,6-7,14-15H2,1H3,(H,23,28)(H,24,26)
  • InChiKey: QGPXPKYTKOICJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[[2-(cyclohexylamino)-2-oxo-ethyl]-(4-methoxyphenyl)amino]-2-oxo-ethyl]furan-2-carboxamide
  • N-[2-[[2-(cyclohexylamino)-2-oxoethyl]-(4-methoxyphenyl)amino]-2-oxoethyl]-2-furancarboxamide
  • N-[2-[[2-(cyclohexylamino)-2-keto-ethyl]-(4-methoxyphenyl)amino]-2-keto-ethyl]-2-furamide
  • MLS000677419
  • SMR000286205
  • ZINC04875947
  • ASN 05586090

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0019 0.0165
Brugia malayi RNA binding protein 0.0076 0.0043 0.0374
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0012 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0101 0.0064 0.0538
Loa Loa (eye worm) hypoxia-induced factor 1 0.0115 0.0076 0.0661
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0022 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.0019 0.0157
Loa Loa (eye worm) hypothetical protein 0.006 0.0028 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.0019 0.0157
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0613 0.051 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0019 0.0165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0019 0.0165
Brugia malayi Cytochrome P450 family protein 0.0042 0.0012 0.0109
Echinococcus granulosus bloom syndrome protein 0.0056 0.0025 0.0395
Schistosoma mansoni jumonji/arid domain-containing protein 0.0272 0.0213 0.187
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0005 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0003 0.0031
Loa Loa (eye worm) hypothetical protein 0.006 0.0028 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.0019 0.0165
Echinococcus multilocularis transcription factor btf3 0.009 0.0055 0.087
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0072 0.0039 0.062
Onchocerca volvulus 0.0048 0.0018 0.0167
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0003 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Trypanosoma brucei hypothetical protein, conserved 0.0101 0.0064 0.124
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0056 0.0025 0.0395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0076 0.1696
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0076 0.0656
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0124 0.0084 0.008
Echinococcus multilocularis jumonji domain containing 1A 0.0073 0.0039 0.0627
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0168 0.0122 0.1049
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0076 0.0639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.0019 0.0157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0046 0.0016 0.0252
Brugia malayi nuclear receptor NHR-88 0.0049 0.0019 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Echinococcus granulosus transcription factor btf3 0.009 0.0055 0.087
Schistosoma mansoni cellular tumor antigen P53 0.0039 0.001 0.0089
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0005 0.0032
Mycobacterium ulcerans cysteinyl-tRNA synthetase 1.1509 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.009 0.0055 0.1047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.0019 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0024 0.0464
Echinococcus multilocularis bloom syndrome protein 0.0056 0.0025 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.002 0.0368
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0076 0.0639
Echinococcus granulosus beta LACTamase domain containing family member 0.0101 0.0064 0.1024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0043 0.0367
Onchocerca volvulus Serine\/threonine kinase homolog 0.0072 0.0039 0.0371
Brugia malayi exodeoxyribonuclease III family protein 0.0124 0.0084 0.0738
Loa Loa (eye worm) hypothetical protein 0.0101 0.0064 0.0556
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0003 0.0248
Onchocerca volvulus 0.0039 0.001 0.0096
Mycobacterium tuberculosis Conserved protein 0.0101 0.0064 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0019 0.03
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0019 0.0165
Loa Loa (eye worm) hypothetical protein 0.0101 0.0064 0.0556
Loa Loa (eye worm) RNA binding protein 0.0076 0.0043 0.0367
Loa Loa (eye worm) hypothetical protein 0.0032 0.0004 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0001 0.0077
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0003 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0012 0.0101
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0168 0.0122 0.1065
Brugia malayi cytoplasmic intermediate filament protein 0.0086 0.0051 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0039 0.0341
Echinococcus multilocularis JmjC domain containing protein 4 0.0073 0.0039 0.0627
Onchocerca volvulus 0.0161 0.0116 0.1109
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0001 0.0008
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.0019 0.03
Leishmania major cathepsin L-like protease 0.0058 0.0027 0.0453
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0073 0.0039 0.075
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0102 0.0884
Onchocerca volvulus 0.0101 0.0064 0.0613
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0076 0.006
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0003 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0076 0.1208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.0019 0.0157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0003 0.0054
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0005 0.0041
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0076 0.0656
Brugia malayi beta-lactamase family protein 0.0101 0.0064 0.0563
Schistosoma mansoni jumonji/arid domain-containing protein 0.0272 0.0213 0.187
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0076 0.0639
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0056 0.0025 0.0415
Brugia malayi hypoxia-induced factor 1 0.0115 0.0076 0.0668
Treponema pallidum exodeoxyribonuclease (exoA) 0.0124 0.0084 0.0597
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0004 0.0053
Echinococcus granulosus lamin 0.0161 0.0116 0.1852
Echinococcus granulosus jumonji domain containing 1A 0.0073 0.0039 0.0627
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0025 0.2029
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.0019 0.03
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0101 0.0064 0.0563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Giardia lamblia DINP protein human, muc B family 0.0038 0.001 0.0147
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0342 0.0274 0.0269
Leishmania major cathepsin L-like protease 0.0058 0.0027 0.0453
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0168 0.0122 0.2373
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0056 0.0025 0.021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0124 0.0084 0.1832
Loa Loa (eye worm) hypothetical protein 0.0101 0.0064 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Echinococcus granulosus geminin 0.0747 0.0626 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0005 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0043 0.0375
Plasmodium falciparum cysteine--tRNA ligase 0.0168 0.0122 1
Echinococcus granulosus intermediate filament protein 0.0161 0.0116 0.1852
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.0028 0.0532
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0061 0.003 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0004 0.0005
Echinococcus granulosus lysine specific demethylase 6a 0.0073 0.0039 0.0627
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0003 0.0248
Echinococcus multilocularis Protein lozenge 0.0154 0.011 0.1761
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0073 0.0039 0.0754
Schistosoma mansoni coup transcription factor 0.0049 0.0019 0.0166
Entamoeba histolytica hypothetical protein 0.009 0.0055 0.1222
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.0019 0.03
Brugia malayi Intermediate filament tail domain containing protein 0.0161 0.0116 0.1017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Brugia malayi follicle stimulating hormone receptor 0.0396 0.0321 0.2816
Loa Loa (eye worm) hypothetical protein 0.0073 0.0039 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Treponema pallidum fructose-bisphosphate aldolase 0.054 0.0446 0.319
Schistosoma mansoni hypothetical protein 0.0268 0.0209 0.1837
Loa Loa (eye worm) hypothetical protein 0.0101 0.0064 0.0556
Brugia malayi jmjC domain containing protein 0.0073 0.0039 0.0345
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0094 0.0058 0.0058
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0617 0.0513 1
Brugia malayi jmjC domain containing protein 0.0073 0.0039 0.0345
Chlamydia trachomatis transglycolase/transpeptidase 0.1126 0.0957 1
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0504 0.0415 0.04
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0012 0.0101
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0168 0.0122 0.1073
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0076 0.1464
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0055 0.0024 0.0019
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0076 0.1414
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0124 0.0084 0.1344
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0264 0.0206 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.0019 0.0165
Leishmania major mitochondrial DNA polymerase beta 0.0617 0.0513 1
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0335 0.0268 0.0268
Mycobacterium leprae conserved hypothetical protein 0.0101 0.0064 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0003 0.0054
Mycobacterium leprae conserved hypothetical protein 0.0055 0.0024 0.0008
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0012 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Toxoplasma gondii hypothetical protein 0.0099 0.0063 0.513
Loa Loa (eye worm) hypothetical protein 0.0031 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.0044 0.0375
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0099 0.087
Brugia malayi serine/threonine-protein kinase plk-2 0.0072 0.0039 0.0341
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0617 0.0513 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.0019 0.03
Loa Loa (eye worm) glutaminase 0.1337 0.114 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0264 0.0206 0.0191
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0008 0.0679
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0973 0.0823 0.0819
Loa Loa (eye worm) hypothetical protein 0.1229 0.1046 0.9176
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.0019 0.0165
Schistosoma mansoni protein phosphatase 2C 0.0073 0.0039 0.0345
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Brugia malayi RNA, U transporter 1 0.0071 0.0038 0.0335
Trypanosoma brucei polo-like protein kinase 0.0072 0.0039 0.0745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.0019 0.0157
Brugia malayi hypothetical protein 0.0048 0.0018 0.0159
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.0019 0.03
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.0019 0.018
Giardia lamblia Fructose-bisphosphate aldolase 0.054 0.0446 1
Onchocerca volvulus 0.0161 0.0116 0.1109
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0004 0.0057
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0076 0.0071
Onchocerca volvulus 0.1229 0.1046 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0124 0.0084 0.1626
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0168 0.0122 0.1056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0092 0.0056 0.0899
Schistosoma mansoni glutaminase 0.1337 0.114 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0055 0.0024 0.0216
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0073 0.0039 0.3217
Loa Loa (eye worm) runx1 0.0154 0.011 0.0961
Trichomonas vaginalis DNA helicase recq1, putative 0.0056 0.0025 0.0192
Mycobacterium ulcerans lipoprotein LpqF 0.0045 0.0016 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0027 0.0504
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0025 0.021
Trypanosoma cruzi polo-like protein kinase, putative 0.0072 0.0039 0.0741
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0061 0.003 0.0473
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.0019 0.0166
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0007 0.0056
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0272 0.0213 0.3403
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0004 0.0031
Echinococcus granulosus FTZ F1 alpha 0.0049 0.0019 0.03
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0073 0.0039 0.075
Schistosoma mansoni ap endonuclease 0.0124 0.0084 0.0739
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0003 0.0248
Brugia malayi Cytochrome P450 family protein 0.0042 0.0012 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0043 0.0375
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0003 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0646 0.0539 0.0535
Loa Loa (eye worm) hypothetical protein 0.0101 0.0064 0.0556
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0193 0.1672
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.0019 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0027 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.0019 0.0157
Onchocerca volvulus 0.0049 0.0019 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0076 0.0656
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0168 0.0122 0.0122
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0012 0.023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0124 0.0084 0.1887
Brugia malayi beta-lactamase family protein 0.0101 0.0064 0.0563
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0055 0.0024 0.1731
Loa Loa (eye worm) glutaminase 2 0.1337 0.114 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0004 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0003 0.0031
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0076 0.0664
Loa Loa (eye worm) hypothetical protein 0.0101 0.0064 0.0556
Trypanosoma cruzi transcription factor btf3, putative 0.009 0.0055 0.1047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Mycobacterium ulcerans glutaminase 0.1337 0.114 0.114
Schistosoma mansoni hypothetical protein 0.0048 0.0018 0.0154
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0005 0.0104
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0004 0.0057
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0024 0.0024
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0004 0.0057
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0979 0.0829 0.0815
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0124 0.0084 0.1626
Echinococcus granulosus leucyl tRNA synthetase 0.0168 0.0122 0.1951
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.0019 0.0165
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0504 0.0415 0.0411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.0019 0.0157
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0335 0.0268 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Echinococcus granulosus dna polymerase eta 0.006 0.0028 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Echinococcus granulosus snurportin 1 0.0268 0.0209 0.3342
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0124 0.0084 0.6808
Plasmodium falciparum basic transcription factor 3b, putative 0.009 0.0055 0.432
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.0019 0.03
Echinococcus multilocularis geminin 0.0747 0.0626 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0004 0.0005
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0359 0.0289 0.0285
Schistosoma mansoni jumonji domain containing protein 0.0272 0.0213 0.187
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1296 0.1105 0.1105
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0052 0.099
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0979 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0028 0.0001 0.0000000001762
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0076 0.1696
Brugia malayi Pre-SET motif family protein 0.0031 0.0003 0.003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0025 0.0217
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.054 0.0446 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0292 0.023 0.448
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0032 0.0004 0.0082
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0168 0.0122 0.1073
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0007 0.0037
Brugia malayi polk-prov protein 0.0033 0.0005 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.001 0.0173
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0028 0.0001 0.0077
Mycobacterium tuberculosis Probable esterase LipL 0.0101 0.0064 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Mycobacterium leprae Probable lipase LipE 0.0101 0.0064 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.0019 0.0166
Brugia malayi jmjC domain containing protein 0.0073 0.0039 0.0345
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0101 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0019 0.0166
Echinococcus granulosus tar DNA binding protein 0.0076 0.0043 0.0682
Echinococcus granulosus tumor protein p63 0.0267 0.0208 0.3327
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.0019 0.0165
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0039 0.0345
Plasmodium vivax SET domain protein, putative 0.0031 0.0003 0.0284
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0335 0.0268 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0076 0.0639
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0019 0.03
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0101 0.0064 0.0563
Giardia lamblia Kinase, PLK 0.0072 0.0039 0.0809
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.0019 0.018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.0019 0.03
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0019 0.0166
Mycobacterium ulcerans esterase/lipase LipP 0.0101 0.0064 0.0064
Treponema pallidum penicillin-binding protein (pbp-1) 0.1126 0.0957 0.6849
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0064 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0055 0.0453
Chlamydia trachomatis transglycolase/transpeptidase 0.0674 0.0563 0.5872
Leishmania major hypothetical protein, conserved 0.0073 0.0039 0.0701
Brugia malayi jmjC domain containing protein 0.0272 0.0213 0.1869
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0973 0.0823 0.0823
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0073 0.0039 0.0345
Trichomonas vaginalis esterase, putative 0.0101 0.0064 0.0538
Loa Loa (eye worm) hypothetical protein 0.0158 0.0113 0.0988
Trypanosoma brucei transcription factor BTF3, putative 0.009 0.0055 0.1051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Mycobacterium ulcerans lipase LipD 0.0101 0.0064 0.0064
Mycobacterium tuberculosis Conserved hypothetical protein 0.0325 0.0259 0.0254
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0168 0.0122 0.274
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0016 0.0292
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.0019 0.03
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0004 0.0057
Plasmodium falciparum JmjC domain-containing protein, putative 0.0073 0.0039 0.3045
Trichomonas vaginalis DNA helicase recq, putative 0.0056 0.0025 0.0192
Echinococcus multilocularis dna polymerase eta 0.006 0.0028 0.0445
Loa Loa (eye worm) hypothetical protein 0.0073 0.0039 0.0337
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0194 0.0145 0.1273
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.0019 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0005 0.0081
Brugia malayi hypothetical protein 0.1229 0.1046 0.9177
Trypanosoma brucei beta lactamase 0.0045 0.0016 0.0289
Mycobacterium ulcerans beta-lactamase 0.0101 0.0064 0.0064
Mycobacterium ulcerans hypothetical protein 0.0101 0.0064 0.0064
Entamoeba histolytica recQ family DNA helicase 0.0028 0.0001 0.0021
Leishmania major DNA polymerase eta, putative 0.006 0.0028 0.0477
Leishmania major cathepsin L-like protease 0.0058 0.0027 0.0453
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0043 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0019 0.0165
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0032 0.0004 0.0014
Brugia malayi Pre-SET motif family protein 0.0219 0.0167 0.1462
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0039 0.0337
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0005 0.0073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0124 0.0084 0.1344
Schistosoma mansoni lozenge 0.0154 0.011 0.0968
Brugia malayi phosphofructokinase 0.0114 0.0076 0.0663
Toxoplasma gondii exonuclease III APE 0.0124 0.0084 0.6887
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Leishmania major DNA polymerase kappa, putative 0.0038 0.001 0.0116
Entamoeba histolytica hypothetical protein 0.0055 0.0024 0.053
Plasmodium vivax cysteine--tRNA ligase, putative 0.0168 0.0122 1
Toxoplasma gondii NAC domain-containing protein 0.009 0.0055 0.4461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Brugia malayi beta-NAC-like protein 0.009 0.0055 0.0478
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.0019 0.03
Plasmodium vivax basic transcription factor 3b, putative 0.009 0.0055 0.4461
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0099 0.087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.0019 0.0165
Onchocerca volvulus 0.0101 0.0064 0.0613
Trichomonas vaginalis glutaminase, putative 0.1337 0.114 1
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0027 0.0504
Onchocerca volvulus 0.0168 0.0122 0.1168
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0396 0.0321 0.2811
Mycobacterium tuberculosis Probable hydrolase 0.0101 0.0064 0.006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0124 0.0084 0.163
Treponema pallidum penicillin-binding protein (pbp-3) 0.1632 0.1397 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0004 0.0053
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0002 0.0038
Brugia malayi jmjC domain containing protein 0.0272 0.0213 0.1869
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.001 0.0005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0056 0.0025 0.0466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Brugia malayi Cytochrome P450 family protein 0.0036 0.0007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Echinococcus multilocularis lamin 0.0161 0.0116 0.1852
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0024 0.046
Brugia malayi hypothetical protein 0.0125 0.0085 0.0742
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0027 0.0504
Brugia malayi PAS domain containing protein 0.0037 0.0008 0.0074
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.0028 0.0527
Echinococcus multilocularis snurportin 1 0.0268 0.0209 0.3342
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.0016 0.1349
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0055 0.0024 0.1936
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0025 0.0217
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.0016 0.0262
Echinococcus multilocularis lysine specific demethylase 6a 0.0073 0.0039 0.0627
Schistosoma mansoni hypothetical protein 0.005 0.002 0.0172
Loa Loa (eye worm) RecQ helicase 0.0056 0.0025 0.021
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0272 0.0213 0.3403
Echinococcus multilocularis phd:f box containing protein 0.0073 0.0039 0.0627
Echinococcus multilocularis tumor protein p63 0.0267 0.0208 0.3327
Brugia malayi ecdysteroid receptor 0.0049 0.0019 0.0165
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0043 0.0367
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0613 0.051 0.051
Schistosoma mansoni hypothetical protein 0.0092 0.0056 0.0495
Onchocerca volvulus 0.0194 0.0145 0.1387
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0124 0.0084 0.0649
Loa Loa (eye worm) beta-lactamase 0.0101 0.0064 0.0556
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0073 0.0039 0.0627
Trichomonas vaginalis DNA helicase recq, putative 0.0056 0.0025 0.0192
Giardia lamblia Sgs1 DNA helicase, putative 0.0056 0.0025 0.0491
Brugia malayi 6-phosphofructokinase 0.0114 0.0076 0.0663
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0018 0.0154
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0086 0.0051 0.044
Loa Loa (eye worm) hypothetical protein 0.1229 0.1046 0.9176
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0168 0.0122 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0124 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0125 0.0085 0.0734
Echinococcus granulosus lamin dm0 0.0161 0.0116 0.1852
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0161 0.0116 0.101
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0055 0.0453
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0052 0.099
Trypanosoma brucei unspecified product 0.005 0.002 0.0368
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0168 0.0122 0.2369
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0055 0.0453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Leishmania major phosphopantetheinyl transferase-like protein 0.0055 0.0024 0.0393
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0124 0.0084 0.0731
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0052 0.099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0019 0.0165
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.0016 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.054 0.0446 1
Schistosoma mansoni single-minded 0.0037 0.0008 0.0074
Schistosoma mansoni lamin 0.0161 0.0116 0.1018
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0043 0.0375
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.0019 0.03
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0056 0.0025 0.0395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.0019 0.0165
Leishmania major DNA polymerase eta, putative 0.0037 0.0008 0.0091
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0008 0.0144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.0019 0.03
Echinococcus multilocularis beta LACTamase domain containing family member 0.0101 0.0064 0.1024
Treponema pallidum hypothetical protein 0.0335 0.0268 0.1913
Schistosoma mansoni DNA helicase recq1 0.0056 0.0025 0.0218
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.023 0.4448
Treponema pallidum penicillin-binding protein (pbp-2) 0.0979 0.0829 0.5931
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0024 0.0464
Brugia malayi 6-phosphofructokinase 0.0114 0.0076 0.0663
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0264 0.0206 0.0206
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0005 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0068 0.1312
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0124 0.0084 0.6887
Schistosoma mansoni intermediate filament proteins 0.0161 0.0116 0.1018
Loa Loa (eye worm) hypothetical protein 0.0233 0.0179 0.1566
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0025 0.2029
Loa Loa (eye worm) hypothetical protein 0.0194 0.0145 0.1266
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0167 0.1456
Brugia malayi steroid hormone receptor 0.0049 0.0019 0.0165
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.0019 0.0166
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0078 0.0044 0.0696
Schistosoma mansoni phd/f-box containing protein 0.0073 0.0039 0.0345
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0004 0.0057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0056 0.0025 0.047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0101 0.0064 0.006
Schistosoma mansoni survival motor neuron protein 0.0048 0.0018 0.0154
Loa Loa (eye worm) ICD-1 protein 0.009 0.0055 0.0471
Schistosoma mansoni lamin 0.0161 0.0116 0.1018
Echinococcus granulosus dna polymerase kappa 0.0056 0.0024 0.039
Chlamydia trachomatis cysteine--tRNA ligase 0.0168 0.0122 0.125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0003 0.0284
Brugia malayi jmjC domain containing protein 0.0073 0.0039 0.0345
Loa Loa (eye worm) hypothetical protein 0.0075 0.0041 0.0352
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0194 0.0145 0.1273
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0064 0.5252
Trichomonas vaginalis D-aminoacylase, putative 0.0101 0.0064 0.0538
Echinococcus granulosus phd:f box containing protein 0.0073 0.0039 0.0627
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0055 0.0024 0.1936
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0019 0.03
Brugia malayi MH2 domain containing protein 0.0144 0.0102 0.0891
Brugia malayi Bloom's syndrome protein homolog 0.0056 0.0025 0.0217
Loa Loa (eye worm) hypothetical protein 0.0161 0.0116 0.101
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.0019 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0003 0.0031
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0052 0.0994
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0039 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Mycobacterium tuberculosis Probable lipase LipE 0.0101 0.0064 0.006
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0094 0.0058 0.0054
Brugia malayi beta-lactamase 0.0101 0.0064 0.0563
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0046 0.0016 0.0262
Trichomonas vaginalis ap endonuclease, putative 0.0124 0.0084 0.0714
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0055 0.0024 0.1936
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.0019 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0101 0.0064 0.0538
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0268 0.0209 0.183
Schistosoma mansoni phosphatidylserine receptor 0.0073 0.0039 0.0345
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0359 0.0289 0.0274
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0617 0.0513 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0073 0.0039 0.0627
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0101 0.0064 0.0563
Loa Loa (eye worm) hypothetical protein 0.0049 0.0019 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0016 0.0016
Schistosoma mansoni DNA helicase recq5 0.0056 0.0025 0.0218
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0072 0.0039 0.0333
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0055 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0075 0.0041 0.0352
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0072 0.0039 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0005 0.0081
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0073 0.0039 0.3217
Leishmania major cysteinyl-tRNA synthetase, putative 0.0168 0.0122 0.2329
Brugia malayi hypothetical protein 0.0233 0.0179 0.1572
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0092 0.0056 0.0899
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.001 0.0116
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0056 0.0025 0.0395
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.023 0.4477
Leishmania major cytochrome p450-like protein 0.0042 0.0012 0.0173
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0179 0.2862
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0004 0.0005
Onchocerca volvulus 0.0249 0.0193 0.1845
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 1.1509 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0024 0.0464
Echinococcus multilocularis lysine specific demethylase 5A 0.0272 0.0213 0.3403
Schistosoma mansoni transcription factor btf3 0.009 0.0055 0.0478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.0099 0.1582
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0168 0.0122 0.1072
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0043 0.0375
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0076 0.146
Onchocerca volvulus 0.0048 0.0018 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0019 0.0165
Schistosoma mansoni hypothetical protein 0.0747 0.0626 0.5494
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0055 0.0024 0.0024
Leishmania major basic transcription factor 3a, putative 0.009 0.0055 0.0999
Entamoeba histolytica transcription factor BTF3, putative 0.009 0.0055 0.1222
Trypanosoma cruzi polo-like protein kinase, putative 0.0072 0.0039 0.0741
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0168 0.0122 0.2369
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.0019 0.03
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0056 0.0025 0.1826
Echinococcus granulosus lysine specific demethylase 5A 0.0272 0.0213 0.3403
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0028 0.0245
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0504 0.0415 0.0415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.054 0.0446 0.3898
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0039 0.0315
Mycobacterium ulcerans hypothetical protein 0.0325 0.0259 0.0259
Echinococcus multilocularis musashi 0.0161 0.0116 0.1852
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.0019 0.0166
Trichomonas vaginalis D-aminoacylase, putative 0.0101 0.0064 0.0538
Schistosoma mansoni hypothetical protein 0.0747 0.0626 0.5494
Brugia malayi nuclear hormone receptor 0.0049 0.0019 0.0165
Loa Loa (eye worm) hypothetical protein 0.0073 0.0039 0.0337
Trichomonas vaginalis penicillin-binding protein, putative 0.0101 0.0064 0.0538
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0024 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0064 0.1236
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.0019 0.0166
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0012 0.0012
Schistosoma mansoni kinase 0.0037 0.0008 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0024 0.046
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0043 0.0375
Mycobacterium tuberculosis Probable lipase LipD 0.0101 0.0064 0.006
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0076 0.1696
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0016 0.0145
Echinococcus multilocularis L aminoadipate semialdehyde 0.0194 0.0145 0.2316
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0078 0.0044 0.0696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Brugia malayi glutaminase DH11.1 0.1337 0.114 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0101 0.0064 0.006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.0019 0.0166
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.0019 0.0157
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1126 0.0957 1
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0179 0.2862
Loa Loa (eye worm) intermediate filament protein 0.0161 0.0116 0.101
Brugia malayi TAR-binding protein 0.0076 0.0043 0.0374
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0012 0.0225
Toxoplasma gondii ABC1 family protein 0.0101 0.0064 0.5252
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0007 0.0037
Brugia malayi intermediate filament protein 0.0161 0.0116 0.1017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0024 0.046
Giardia lamblia Cysteinyl-tRNA synthetase 0.0168 0.0122 0.269
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0072 0.0039 0.0692
Onchocerca volvulus 0.0101 0.0064 0.0613
Echinococcus granulosus jun protein 0.0061 0.003 0.0473
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0056 0.0025 0.0395
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0045 0.0016 0.0011
Echinococcus multilocularis jun protein 0.0061 0.003 0.0473
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0973 0.0823 0.0809
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0076 0.0664
Brugia malayi bZIP transcription factor family protein 0.0061 0.003 0.026
Mycobacterium tuberculosis Conserved protein 0.0101 0.0064 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0272 0.0213 0.1863
Schistosoma mansoni DNA polymerase eta 0.006 0.0028 0.0245
Leishmania major hypothetical protein, conserved 0.0101 0.0064 0.1189
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0124 0.0084 0.1582
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0076 0.0076
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0004 0.0032
Schistosoma mansoni ap endonuclease 0.0124 0.0084 0.0739
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0003 0.0068
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0613 0.051 0.0506
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0168 0.0122 0.1951
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0039 0.0337
Echinococcus granulosus JmjC domain containing protein 4 0.0073 0.0039 0.0627
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0056 0.0025 0.1826
Trichomonas vaginalis DNA polymerase eta, putative 0.0056 0.0024 0.0189
Echinococcus granulosus L aminoadipate semialdehyde 0.0194 0.0145 0.2316
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0101 0.0064 0.0556
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0016 0.0145
Schistosoma mansoni aryl hydrocarbon receptor 0.0037 0.0008 0.0074
Echinococcus multilocularis lamin dm0 0.0161 0.0116 0.1852
Plasmodium vivax JmjC domain containing protein 0.0073 0.0039 0.3217
Trichomonas vaginalis conserved hypothetical protein 0.0979 0.0829 0.7263
Entamoeba histolytica serine/threonine protein kinase, putative 0.0072 0.0039 0.0871
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0056 0.0024 0.0189
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0055 0.0024 0.0163
Echinococcus multilocularis dna polymerase kappa 0.0056 0.0024 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0027 0.0508
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0004 0.0057
Mycobacterium tuberculosis Conserved protein 0.0101 0.0064 0.006
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0043 0.0374
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0076 0.0535
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0024 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0101 0.0064 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0024 0.046
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0003 0.0015
Treponema pallidum cysteinyl-tRNA synthetase 0.0168 0.0122 0.0869
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0019 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0124 0.0084 0.0714
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0076 0.1208
Onchocerca volvulus 0.0031 0.0003 0.0033
Schistosoma mansoni jun-related protein 0.005 0.002 0.0172
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0168 0.0122 0.1065
Entamoeba histolytica recQ family helicase, putative 0.0056 0.0025 0.0556
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0102 0.0884
Plasmodium falciparum cysteine--tRNA ligase 0.0168 0.0122 1
Echinococcus granulosus cysteinyl tRNA synthetase 0.0168 0.0122 0.1951

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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