TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.433 | Formula: C20H27NO4
H donors: 1 H acceptors: 1 LogP: 3.62 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCO/C(=C/C1=NC2(CCCCC2)Cc2c1cc(OC)c(c2)OC)/O
InChi: 1S/C20H27NO4/c1-4-25-19(22)12-16-15-11-18(24-3)17(23-2)10-14(15)13-20(21-16)8-6-5-7-9-20/h10-12,22H,4-9,13H2,1-3H3/b19-12+
InChiKey: NRDKSWNJZODTMP-XDHOZWIPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	allatostatin A receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0025	0.0284
Schistosoma mansoni	opsin-like receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	serotonin receptor	0.0061	0.0103	0.0977
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	voltage-gated potassium channel	0.003	0.0008	0.0072
Loa Loa (eye worm)	glutaminase 2	0.0318	0.0885	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0036	0.0025	0.0233
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0036	0.0025	0.0247
Echinococcus granulosus	g protein coupled receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	snurportin 1	0.0315	0.0875	0.8377
Schistosoma mansoni	amine GPCR	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0073	0.0827
Brugia malayi	larval opioid receptor	0.0061	0.0103	0.1162
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0061	0.0103	0.0977
Schistosoma mansoni	hypothetical protein	0.0061	0.0103	0.0977
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0061	0.0103	0.0977
Schistosoma mansoni	neuropeptide receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.0103	0.0977
Brugia malayi	neuropeptide F receptor	0.0061	0.0103	0.1162
Loa Loa (eye worm)	intermediate filament protein	0.0052	0.0073	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0155
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0048	0.0063	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0014	0.0131
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0032	0.0298
Brugia malayi	intermediate filament protein	0.0052	0.0073	0.0827
Echinococcus multilocularis	fmrfamide receptor	0.0061	0.0103	0.0977
Brugia malayi	Importin beta-1 subunit	0.0029	0.0006	0.0062
Brugia malayi	putative neuropeptide receptor NPR1	0.0061	0.0103	0.1162
Echinococcus granulosus	G protein coupled receptor 139	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus granulosus	fmrfamide receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0032	0.0298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	voltage-gated potassium channel	0.0056	0.0086	0.0815
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0048	0.0063	0.0651
Schistosoma mansoni	phosphatidylserine receptor	0.0036	0.0025	0.0233
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0038	0.0032	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Brugia malayi	G protein-coupled receptor	0.0061	0.0103	0.1162
Echinococcus granulosus	leucyl tRNA synthetase	0.0048	0.0063	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	neuropeptide F receptor	0.0061	0.0103	0.1162
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0032	0.0298
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.034	0.0952	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.0103	0.0977
Echinococcus granulosus	biogenic amine 5HT receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	beta LACTamase domain containing family member	0.0032	0.0014	0.0123
Onchocerca volvulus		0.0061	0.0103	1
Schistosoma mansoni	jumonji domain containing protein	0.0036	0.0025	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Brugia malayi	beta-lactamase family protein	0.0032	0.0014	0.0155
Brugia malayi	ORL1-like opioid receptor	0.0061	0.0103	0.1162
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0061	0.0103	0.1162
Brugia malayi	jmjC domain containing protein	0.0135	0.0326	0.3686
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Echinococcus granulosus	geminin	0.037	0.1045	1
Brugia malayi	Melatonin receptor type 1A	0.0061	0.0103	0.1162
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0038	0.0032	0.0298
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Leishmania major	mitochondrial DNA polymerase beta	0.0351	0.0986	1
Echinococcus granulosus	somatostatin receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	neuropeptides capa receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0061	0.0103	0.0977
Echinococcus granulosus	serotonin receptor	0.0061	0.0103	0.0977
Mycobacterium ulcerans	hypothetical protein	0.0185	0.048	0.0467
Echinococcus granulosus	orexin receptor type 2	0.0061	0.0103	0.0977
Echinococcus multilocularis	phd:f box containing protein	0.0036	0.0025	0.0233
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0032	0.036
Loa Loa (eye worm)	TYRA-2 protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Echinococcus granulosus	sex peptide receptor	0.0061	0.0103	0.0977
Treponema pallidum	fructose-bisphosphate aldolase	0.034	0.0952	1
Echinococcus granulosus	lamin dm0	0.0052	0.0073	0.0693
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0061	0.0103	0.0977
Echinococcus granulosus	neuropeptide Y receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	voltage-gated potassium channel	0.0056	0.0086	0.0815
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0036	0.0025	0.0233
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0032	0.0298
Brugia malayi	GnHR receptor homolog	0.0061	0.0103	0.1162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0048	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trichomonas vaginalis	glutaminase, putative	0.0318	0.0885	0.9295
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Plasmodium falciparum	cysteine--tRNA ligase	0.0048	0.0063	1
Echinococcus multilocularis	fmrfamide receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.006	0.0099	0.0998
Loa Loa (eye worm)	melatonin receptor type 1A	0.0061	0.0103	0.1162
Brugia malayi	Dopamine receptor protein 2	0.0061	0.0103	0.1162
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0048	0.0063	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Wolbachia endosymbiont of Brugia malayi	cysteinyl-tRNA synthetase	0.0048	0.0063	0.5
Brugia malayi	Dopamine receptor protein 1	0.0061	0.0103	0.1162
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0193	0.0503	0.5687
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	importin beta-1	0.0029	0.0006	0.0045
Echinococcus multilocularis	lamin	0.0052	0.0073	0.0693
Onchocerca volvulus		0.0061	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0135	0.0326	0.3117
Echinococcus multilocularis	somatostatin receptor	0.0061	0.0103	0.0977
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0032	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0032	0.0327
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0166	0.0422	0.4278
Schistosoma mansoni	hypothetical protein	0.0315	0.0875	0.8377
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0061	0.0103	0.1162
Echinococcus multilocularis	neuropeptide receptor	0.0061	0.0103	0.0977
Plasmodium falciparum	importin beta, putative	0.0029	0.0006	0.0763
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0025	0.0284
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.0103	0.0977
Schistosoma mansoni	lamin	0.0052	0.0073	0.0693
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0061	0.0103	0.0977
Schistosoma mansoni	neuropeptide receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	lamin dm0	0.0052	0.0073	0.0693
Mycobacterium ulcerans	glutaminase	0.0318	0.0885	0.0872
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0014	0.0136
Brugia malayi	beta-NAC-like protein	0.0028	0.0001	0.0009
Echinococcus multilocularis	neuropeptide receptor A26	0.0061	0.0103	0.0977
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0166	0.0422	0.4278
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.0103	0.0977
Schistosoma mansoni	intermediate filament proteins	0.0052	0.0073	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0135	0.0326	0.3117
Echinococcus granulosus	dro:myosuppressin receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0048	0.0063	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0061	0.0103	0.0977
Schistosoma mansoni	opsin-like receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	biogenic amine receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	neuropeptides capa receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	neuropeptide s receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0032	0.0014	0.0123
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0351	0.0986	1
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	hypothetical protein	0.0061	0.0103	0.0977
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0351	0.0986	1
Schistosoma mansoni	glutaminase	0.0318	0.0885	0.8469
Loa Loa (eye worm)	beta-lactamase	0.0032	0.0014	0.0155
Leishmania major	hypothetical protein, conserved	0.0032	0.0014	0.0131
Echinococcus granulosus	allatostatin A receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Loa Loa (eye worm)	G-protein coupled receptor	0.0061	0.0103	0.1162
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0038	0.0032	0.0298
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.034	0.0952	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.007	0.0794
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0048	0.0063	0.0651
Echinococcus granulosus	lysine specific demethylase 6a	0.0036	0.0025	0.0233
Schistosoma mansoni	jumonji domain containing protein	0.0135	0.0326	0.3117
Brugia malayi	Intermediate filament tail domain containing protein	0.0052	0.0073	0.0827
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0135	0.0326	0.3117
Brugia malayi	glutaminase DH11.1	0.0318	0.0885	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Echinococcus granulosus	7TM GPCR rhodopsin	0.0061	0.0103	0.0977
Echinococcus multilocularis	neuropeptide receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	geminin	0.037	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0006	0.0062
Onchocerca volvulus		0.0061	0.0103	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	lamin	0.0052	0.0073	0.0693
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0315	0.0875	0.9892
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0048	0.0063	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	neuropeptide receptor	0.0061	0.0103	0.0977
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0061	0.0103	0.1162
Giardia lamblia	Fructose-bisphosphate aldolase	0.034	0.0952	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Brugia malayi	neuropeptide F receptor	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	lysine specific demethylase 5A	0.0135	0.0326	0.3117
Echinococcus granulosus	snurportin 1	0.0315	0.0875	0.8377
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0014	0.2082
Onchocerca volvulus		0.0061	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.0066	0.0663
Echinococcus granulosus	jumonji domain containing 1A	0.0036	0.0025	0.0233
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0048	0.0063	0.0593
Schistosoma mansoni	opsin-like receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0056	0.0086	0.0815
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0061	0.0103	0.1162
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0006	0.0048
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0014	0.0136
Echinococcus multilocularis	musashi	0.0052	0.0073	0.0693
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0193	0.0503	0.5687
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0006	0.0045
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0014	0.0136
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0061	0.0103	0.0977
Onchocerca volvulus		0.0052	0.0073	0.6673
Onchocerca volvulus		0.0061	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	neuropeptide FF receptor 2	0.0061	0.0103	0.0977
Loa Loa (eye worm)	ICD-1 protein	0.0028	0.0001	0.0009
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0056	0.0086	0.0815
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Echinococcus granulosus	phd:f box containing protein	0.0036	0.0025	0.0233
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0061	0.0103	0.0977
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0061	0.0103	0.1162
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0048	0.0063	0.0628
Brugia malayi	RE15519p	0.0061	0.0103	0.1162
Echinococcus multilocularis	neuropeptide Y receptor	0.0061	0.0103	0.0977
Brugia malayi	jmjC domain containing protein	0.0036	0.0025	0.0284
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0351	0.0986	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0155
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0006	0.054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0025	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0048	0.0063	0.0628
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.3306	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0025	0.0284
Echinococcus granulosus	neuropeptides capa receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0032	0.0298
Echinococcus granulosus	intermediate filament protein	0.0052	0.0073	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Onchocerca volvulus		0.0061	0.0103	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Onchocerca volvulus		0.0048	0.0063	0.5501
Brugia malayi	putative neuropeptide receptor	0.0061	0.0103	0.1162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.0103	0.0977
Loa Loa (eye worm)	G-protein coupled receptor	0.0061	0.0103	0.1162
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0056	0.0086	0.097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0025	0.0284
Echinococcus granulosus	biogenic amine 5HT receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0061	0.0103	0.0977
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Brugia malayi	jmjC domain containing protein	0.0036	0.0025	0.0284
Echinococcus granulosus	neuropeptide receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0086	0.097
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0049	0.0066	0.0663
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0166	0.0422	0.0409
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0036	0.0025	0.0247
Echinococcus granulosus	lysine specific demethylase 5A	0.0135	0.0326	0.3117
Brugia malayi	G protein-coupled receptor F59B2.13	0.0061	0.0103	0.1162
Echinococcus granulosus	g-protein coupled receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	orexin receptor type 2	0.0061	0.0103	0.0977
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	voltage-gated potassium channel	0.021	0.0557	0.533
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	neuropeptide F-like receptor	0.0061	0.0103	0.0977
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Schistosoma mansoni	histamine h1 receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	voltage gated potassium channel	0.0056	0.0086	0.0815
Brugia malayi	Dopamine receptor	0.0061	0.0103	0.1162
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0061	0.0103	0.0977
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.018	0.0464	0.4876
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	protein phosphatase 2C	0.0036	0.0025	0.0233
Echinococcus granulosus	JmjC domain containing protein 4	0.0036	0.0025	0.0233
Echinococcus multilocularis	neuropeptides capa receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	neuropeptide receptor A26	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0155
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0166	0.0422	0.0409
Brugia malayi	jmjC domain containing protein	0.0135	0.0326	0.3686
Schistosoma mansoni	neuropeptide receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	voltage-gated potassium channel	0.021	0.0557	0.533
Onchocerca volvulus		0.0061	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	voltage gated potassium channel	0.0056	0.0086	0.0815
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0032	0.0298
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0061	0.0103	0.0977
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0014	0.0131
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0006	0.0048
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0061	0.0103	0.0977
Schistosoma mansoni	neuropeptide F-like receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	neuropeptide f receptor 76f	0.0061	0.0103	0.0977
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	amine GPCR	0.0061	0.0103	0.0977
Brugia malayi	G-protein coupled receptor	0.0061	0.0103	0.1162
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0061	0.0103	0.1162
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0036	0.0025	0.2776
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0032	0.0014	0.0155
Onchocerca volvulus		0.0061	0.0103	1
Schistosoma mansoni	myosin xvIII	0.0061	0.0103	0.0977
Echinococcus granulosus	g protein coupled receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0038	0.0032	0.036
Toxoplasma gondii	hypothetical protein	0.0057	0.0088	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0032	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	amine GPCR	0.0061	0.0103	0.0977
Brugia malayi	beta-lactamase family protein	0.0032	0.0014	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0185	0.048	0.0467
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0061	0.0103	0.1162
Schistosoma mansoni	biogenic amine receptor	0.0061	0.0103	0.0977
Brugia malayi	Serotonin receptor	0.0061	0.0103	0.1162
Echinococcus granulosus	7tm_1 domain containing protein	0.0061	0.0103	0.0977
Plasmodium vivax	JmjC domain containing protein	0.0036	0.0025	0.3925
Onchocerca volvulus		0.0061	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0061	0.0103	0.1162
Schistosoma mansoni	lamin	0.0052	0.0073	0.0693
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0032	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Onchocerca volvulus		0.0061	0.0103	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0166	0.0422	0.4278
Echinococcus multilocularis	sex peptide receptor	0.0061	0.0103	0.0977
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0061	0.0103	0.1162
Schistosoma mansoni	phd/f-box containing protein	0.0036	0.0025	0.0233
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0048	0.0063	0.0628
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0061	0.0103	0.0977
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0036	0.0025	0.3925
Plasmodium falciparum	cysteine--tRNA ligase	0.0048	0.0063	1
Onchocerca volvulus		0.0061	0.0103	1
Schistosoma mansoni	hypothetical protein	0.0061	0.0103	0.0977
Leishmania major	hypothetical protein, conserved	0.0036	0.0025	0.0247
Brugia malayi	jmjC domain containing protein	0.0036	0.0025	0.0284
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0032	0.0298
Brugia malayi	RNA, U transporter 1	0.0084	0.0171	0.1935
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	jmjC domain-containing protein	0.0135	0.0326	0.3686
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0032	0.0298
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0061	0.0103	0.0977
Echinococcus multilocularis	JmjC domain containing protein 4	0.0036	0.0025	0.0233
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0048	0.0063	0.0709
Echinococcus multilocularis	dro:myosuppressin receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0061	0.0103	0.0977
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0063	0.0709
Loa Loa (eye worm)	glutaminase	0.0318	0.0885	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0032	0.036
Brugia malayi	jmjC domain containing protein	0.0036	0.0025	0.0284
Trichomonas vaginalis	esterase, putative	0.0032	0.0014	0.0136
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0014	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0032	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0155
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0061	0.0103	0.0977
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0061	0.0103	0.1162
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0205	0.0542	0.0529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0014	0.0123
Toxoplasma gondii	ABC1 family protein	0.0032	0.0014	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0036	0.0025	0.0247
Echinococcus granulosus	g protein coupled receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0006	0.0045
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0025	0.0284
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.3306	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0061	0.0103	0.1162
Schistosoma mansoni	growth hormone secretagogue receptor	0.0061	0.0103	0.0977
Onchocerca volvulus		0.0052	0.0073	0.6673
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0061	0.0103	1
Echinococcus granulosus	neuropeptide Y receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	neuropeptide receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	lysine specific demethylase 6a	0.0036	0.0025	0.0233
Brugia malayi	AKH receptor	0.0061	0.0103	0.1162
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0166	0.0422	0.0409
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0061	0.0103	0.0977
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Onchocerca volvulus		0.0061	0.0103	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0032	0.036
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0036	0.0025	0.0233
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0061	0.0103	0.0977
Brugia malayi	Serotonin receptor	0.0061	0.0103	0.1162
Echinococcus granulosus	neuropeptide s receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0061	0.0103	0.0977
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.0952	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	g-protein coupled receptor	0.0061	0.0103	0.0977
Onchocerca volvulus		0.0061	0.0103	1
Echinococcus multilocularis	serotonin receptor	0.0061	0.0103	0.0977
Brugia malayi	sulfakinin receptor protein	0.0061	0.0103	0.1162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0066	0.0663
Onchocerca volvulus		0.0061	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.0103	0.0977
Brugia malayi	G-protein coupled receptor	0.0061	0.0103	0.1162
Brugia malayi	beta-lactamase	0.0032	0.0014	0.0155
Schistosoma mansoni	adenoreceptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0048	0.0063	0.0593
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0061	0.0103	0.0977
Brugia malayi	hypothetical protein	0.0061	0.0103	0.1162
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0014	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0014	0.0136
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0052	0.0073	0.0827
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0061	0.0103	1
Schistosoma mansoni	amine GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	hypothetical protein	0.0061	0.0103	0.0977
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0193	0.0503	0.4813
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0006	0.0763
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0426	0.481
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	biogenic amine receptor	0.0061	0.0103	0.0977
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0014	0.0136
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0036	0.0025	0.2776
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0032	0.0014	0.0155
Onchocerca volvulus		0.0061	0.0103	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0032	0.0298
Onchocerca volvulus		0.0061	0.0103	1
Schistosoma mansoni	hypothetical protein	0.037	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	amine GPCR	0.0061	0.0103	0.0977
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0135	0.0326	0.3117
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0061	0.0103	0.0977
Schistosoma mansoni	60S ribosomal protein L21	0.003	0.0008	0.0072
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0048	0.0063	0.0628
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0066	0.0663
Schistosoma mansoni	hypothetical protein	0.037	0.1045	1
Chlamydia trachomatis	cysteine--tRNA ligase	0.0048	0.0063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0155
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.018	0.0464	0.4876
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0193	0.0503	0.4813
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0061	0.0103	0.0977
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0032	0.0298
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0048	0.0063	0.7073
Loa Loa (eye worm)	neuropeptide F receptor	0.0061	0.0103	0.1162
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0032	0.0298
Echinococcus granulosus	hypothetical protein	0.0061	0.0103	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0103	0.1162
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0061	0.0103	0.0977
Onchocerca volvulus		0.0061	0.0103	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0061	0.0103	0.0977
Echinococcus multilocularis	jumonji domain containing 1A	0.0036	0.0025	0.0233

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.9433 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1548998

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1409149