Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3036 | 0.3036 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0047 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 0.3036 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 0.3036 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 0.3036 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 0.3036 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0077 | 0.3036 | 0.3036 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 0.3036 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 0.3036 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.