Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2099 | 0.2945 |
Echinococcus multilocularis | geminin | 0.0182 | 0.7127 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.2605 | 0.2969 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1178 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1178 | 0.1342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2099 | 0.2945 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2099 | 0.2945 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2605 | 0.3656 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2099 | 0.2945 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.1131 | 0.1587 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.2605 | 0.2969 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.2605 | 0.2969 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1178 | 0.1653 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2099 | 0.2945 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1178 | 0.1653 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7127 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.8775 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2099 | 0.2945 |
Onchocerca volvulus | 0.0032 | 0.1178 | 0.1178 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2099 | 0.2392 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.1178 | 0.1342 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.2605 | 0.2969 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2099 | 0.2945 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2605 | 0.3656 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7127 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2605 | 0.3656 |
Echinococcus granulosus | geminin | 0.0182 | 0.7127 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2099 | 0.2392 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.8775 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.1178 | 0.1653 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.1178 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.1178 | 0.1653 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.1178 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.2605 | 0.3656 |
Onchocerca volvulus | 0.0015 | 0.0485 | 0.0485 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.1178 | 0.1653 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.2605 | 0.3656 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2605 | 0.3656 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2605 | 0.3656 |
Brugia malayi | RNA binding protein | 0.0068 | 0.2605 | 0.2969 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.1178 | 0.1653 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0002 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.2605 | 0.2969 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.