Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein patched | 0.0378 | 0.3968 | 0.3968 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0918 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0378 | 0.3968 | 0.3968 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0378 | 0.3968 | 0.3968 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0918 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0918 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.043 | 0.4557 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0918 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0378 | 0.3968 | 0.3968 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0378 | 0.3968 | 0.3968 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0378 | 0.3968 | 0.3968 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0918 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.043 | 0.4557 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0918 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0378 | 0.3968 | 0.8707 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0918 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0918 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0378 | 0.3968 | 0.3968 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.043 | 0.4557 | 1 |
Brugia malayi | CHE-14 protein | 0.0378 | 0.3968 | 0.3968 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0378 | 0.3968 | 0.3968 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0918 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.043 | 0.4557 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3968 | 0.3968 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0378 | 0.3968 | 0.3968 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0378 | 0.3968 | 0.3968 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.9466 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.