Detailed information for compound 1409866

Basic information

Technical information
  • TDR Targets ID: 1409866
  • Name: N-(5-diethylaminopentan-2-yl)-4-(trifluoromet hyl)benzamide hydrochloride
  • MW: 366.849 | Formula: C17H26ClF3N2O
  • H donors: 1 H acceptors: 1 LogP: 4.8 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCC(NC(=O)c1ccc(cc1)C(F)(F)F)C)CC.Cl
  • InChi: 1S/C17H25F3N2O.ClH/c1-4-22(5-2)12-6-7-13(3)21-16(23)14-8-10-15(11-9-14)17(18,19)20;/h8-11,13H,4-7,12H2,1-3H3,(H,21,23);1H
  • InChiKey: FQWFDIXEXJMVCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-diethylamino-1-methyl-butyl)-4-(trifluoromethyl)benzamide hydrochloride
  • N-(4-diethylamino-1-methylbutyl)-4-(trifluoromethyl)benzamide hydrochloride
  • T0510-1845

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.078 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1478 0.1478
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0495 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0019 0.0363 0.4405
Onchocerca volvulus 0.0054 0.1427 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0026 0.0582 0.0472
Brugia malayi Pleckstrin Homology Domain 0.0027 0.061 0.061
Onchocerca volvulus 0.0042 0.1056 0.6939
Onchocerca volvulus 0.0031 0.0729 0.4241
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1151 1
Trypanosoma brucei unspecified product 0.0023 0.0495 0.4301
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.0622
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0243
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1151 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0802 0.0802
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Brugia malayi diacylglycerol kinase 0.0026 0.0582 0.0582
Onchocerca volvulus 0.0033 0.078 0.4664
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0824 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0495 0.0495
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Echinococcus multilocularis lamin 0.0033 0.078 0.0724
Leishmania major DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0033 0.0802 0.0802
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0495 0.4301
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0824 1
Brugia malayi Cam kinase protein 1 0.0034 0.0823 0.0823
Brugia malayi proprotein convertase 2 0.0209 0.6201 0.6201
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.019
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.1151 1
Echinococcus multilocularis Furin 1 0.0078 0.2192 0.2532
Echinococcus granulosus neuroendocrine convertase 2 0.0209 0.6201 0.6118
Echinococcus granulosus Rac GTPase activating protein 1 0.0026 0.0582 0.0376
Loa Loa (eye worm) raf kinase 0.0026 0.0582 0.0582
Leishmania major subtilisin-like serine peptidase 0.0014 0.0214 0.1862
Toxoplasma gondii subtilisin SUB9 0.0014 0.0214 0.1862
Echinococcus multilocularis N chimaerin 0.0029 0.0659 0.057
Echinococcus multilocularis myotubularin protein 13 0.0027 0.061 0.0507
Giardia lamblia Kinase, AGC PKA 0.0019 0.0363 0.1015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0363 0.0363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0078 0.2192 0.3423
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0031 0.0729 0.0659
Schistosoma mansoni growth factor receptor-bound protein 0.0063 0.1703 0.1703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1478 0.1478
Loa Loa (eye worm) inositol-1 0.0045 0.1151 0.1151
Echinococcus granulosus dna polymerase eta 0.0023 0.0495 0.0287
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0014 0.0214 0.0214
Echinococcus granulosus serine:threonine protein kinase N2 0.0023 0.0473 0.0264
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0495 0.3541
Schistosoma mansoni atypical protein kinase C 0.0059 0.1607 0.1607
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0078 0.2192 0.3423
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0202 0.599 0.7397
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0802 0.0802
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1151 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0495 0.0495
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0163 0.4805 0.4805
Leishmania major DNA polymerase eta, putative 0.0023 0.0495 0.4301
Echinococcus multilocularis serine:threonine protein kinase N2 0.0033 0.0802 0.0753
Plasmodium vivax subtilisin-like serine protease, putative 0.0014 0.0214 0.26
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0495 0.0486
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0659 0.0659
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0823 0.0823
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0014 0.0214 0.1862
Echinococcus granulosus Diacylglycerol kinase theta 0.0026 0.0582 0.0376
Schistosoma mansoni rac gtpase activating protein 0.0026 0.0582 0.0582
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0014 0.0214 0.1862
Schistosoma mansoni furin-1 (S08 family) 0.0144 0.4224 0.4224
Brugia malayi RhoGAP domain containing protein 0.0029 0.0659 0.0659
Toxoplasma gondii AGC kinase 0.0019 0.0363 0.3154
Toxoplasma gondii subtilisin SUB8 0.0014 0.0214 0.1862
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0019 0.0363 0.3154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1478 0.1618
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.0152
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0495 0.0287
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0017 0.0312 0.0125
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0201 0.5976 0.7379
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0028 0.0634 0.0537
Entamoeba histolytica protein kinase, putative 0.0034 0.0823 0.5695
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0033 0.0802 0.0601
Echinococcus multilocularis serine:threonine protein kinase 38 0.0033 0.0802 0.0753
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0261 0.0048
Schistosoma mansoni growth factor receptor-bound protein 0.0063 0.1703 0.1703
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0014 0.0214 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0802 0.0802
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.1151 1
Loa Loa (eye worm) hypothetical protein 0.0332 1 1
Schistosoma mansoni protein kinase C 0.0031 0.0729 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0314 0.0314
Toxoplasma gondii subtilisin SUB2 0.0014 0.0214 0.1862
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0314 0.0314
Echinococcus granulosus Furin 1 0.0078 0.2192 0.2021
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.019
Toxoplasma gondii AGC kinase 0.0019 0.0363 0.3154
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0029 0.0659 0.0455
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0495 0.0495
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Toxoplasma gondii subtilisin SUB1 0.0014 0.0214 0.1862
Onchocerca volvulus 0.0042 0.1056 0.6939
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Schistosoma mansoni site-1 peptidase (S08 family) 0.0014 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0968 0.0968
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0659 0.0659
Trichomonas vaginalis hypothetical protein 0.0064 0.1755 0.2667
Entamoeba histolytica hypothetical protein 0.0026 0.0582 0.2526
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0495 0.1373
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0078 0.2192 0.3423
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0802 0.1018
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0823 0.7156
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Schistosoma mansoni vav2 0.003 0.0687 0.0687
Schistosoma mansoni hypothetical protein 0.0064 0.1755 0.1755
Toxoplasma gondii AGC kinase 0.0033 0.0802 0.6973
Brugia malayi Protein kinase domain containing protein 0.0028 0.0634 0.0634
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.0243
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Leishmania major protein kinase, putative 0.0034 0.0823 0.7156
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0802 0.0802
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0029 0.0659 0.0659
Plasmodium falciparum subtilisin-like protease 2 0.0014 0.0214 0.26
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0363 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0019 0.0363 0.3154
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.019
Echinococcus granulosus dna polymerase kappa 0.0023 0.0495 0.0287
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0495 0.0359
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0659 0.0659
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.1151 0.1621
Loa Loa (eye worm) hypothetical protein 0.0053 0.14 0.14
Echinococcus multilocularis protein kinase c iota type 0.0059 0.1607 0.1784
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0495 0.0495
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0019 0.0363 0.0363
Echinococcus granulosus protein kinase c iota type 0.0059 0.1607 0.1424
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0634 0.0634
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0495 0.0495
Schistosoma mansoni protein kinase 0.0034 0.0823 0.0823
Loa Loa (eye worm) AGC/PKA protein kinase 0.0019 0.0363 0.0363
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0064 0.1755 0.2667
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.1151 0.1199
Echinococcus multilocularis Diacylglycerol kinase theta 0.0026 0.0582 0.0472
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.078 0.078
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.5976 0.5976
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0078 0.2192 0.3423
Plasmodium vivax subtilisin-like protease 2, putative 0.0014 0.0214 0.26
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0823 0.0823
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0823 0.0823
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0064 0.1755 0.2667
Loa Loa (eye worm) RasGEF domain-containing protein 0.0026 0.0582 0.0582
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0032 0.0751 0.093
Loa Loa (eye worm) subtilase 0.0014 0.0214 0.0214
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0019 0.0363 0.4405
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0495 0.0486
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0033 0.0802 0.0601
Loa Loa (eye worm) intermediate filament protein 0.0033 0.078 0.078
Loa Loa (eye worm) proprotein convertase 2 0.0078 0.2192 0.2192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0202 0.599 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0824 1
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.5976 0.5976
Brugia malayi celfurPC protein 0.0268 0.8023 0.8023
Echinococcus multilocularis protein kinase c epsilon type 0.0085 0.2398 0.2797
Echinococcus multilocularis lamin dm0 0.0033 0.078 0.0724
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0363 0.0363
Brugia malayi Protein kinase domain containing protein 0.0033 0.0802 0.0802
Entamoeba histolytica diacylglycerol kinase, putative 0.0026 0.0582 0.2526
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Entamoeba histolytica protein kinase, putative 0.0033 0.0802 0.5418
Leishmania major protein kinase A catalytic subunit isoform 2 0.0019 0.0363 0.3154
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0026 0.0582 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0773 0.0571
Plasmodium vivax subtilisin-like protease 1 0.0014 0.0214 0.26
Brugia malayi C1-like domain containing protein 0.0054 0.1451 0.1451
Loa Loa (eye worm) hypothetical protein 0.0027 0.0595 0.0595
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.0152
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0495 0.4301
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0019 0.0363 0.3154
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0824 0.7161
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1151 0.1621
Echinococcus granulosus N chimaerin 0.0029 0.0659 0.0455
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0033 0.0802 0.0802
Loa Loa (eye worm) hypothetical protein 0.0137 0.4 0.4
Schistosoma mansoni protein kinase C mu 0.0026 0.0582 0.0582
Schistosoma mansoni lamin 0.0033 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0054 0.1427 0.1427
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.1151 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0824 1
Brugia malayi Variant SH3 domain containing protein 0.0008 0.0028 0.0028
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0014 0.0214 0.0214
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0031 0.0729 0.0526
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.2398 0.2398
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0495 0.0495
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1151 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0261 0.006
Schistosoma mansoni protein kinase 0.0034 0.0823 0.0823
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0078 0.2192 0.3423
Loa Loa (eye worm) hypothetical protein 0.0027 0.0595 0.0595
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0033 0.0802 0.0753
Echinococcus multilocularis growth factor receptor bound protein 2 0.0063 0.1703 0.1906
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Schistosoma mansoni diacylglycerol kinase theta 0.0026 0.0582 0.0582
Toxoplasma gondii subtilisin SUB12 0.0014 0.0214 0.1862
Brugia malayi RhoGEF domain containing protein 0.0026 0.0582 0.0582
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.083 0.7213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1478 0.1478
Brugia malayi Subtilase family protein 0.0014 0.0214 0.0214
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.078
Echinococcus granulosus lamin dm0 0.0033 0.078 0.0578
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0495 0.4301
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Toxoplasma gondii subtilisin SUB7 0.0014 0.0214 0.1862
Echinococcus multilocularis protein kinase c eta type 0.0026 0.0582 0.0472
Giardia lamblia High cysteine membrane protein Group 2 0.0123 0.3576 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0824 0.7161
Trypanosoma brucei subtilisin peptidase 0.0014 0.0214 0.1862
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0363 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0272 0.2365
Onchocerca volvulus 0.0053 0.14 0.9773
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0029 0.0659 0.057
Echinococcus granulosus furin 0.0332 1 1
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0773 0.0715
Toxoplasma gondii subtilisin SUB4 0.0014 0.0214 0.1862
Echinococcus granulosus growth factor receptor bound protein 2 0.0063 0.1703 0.1521
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0078 0.2192 0.2192
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0272 0.2365
Echinococcus multilocularis Rac GTPase activating protein 1 0.0026 0.0582 0.0472
Brugia malayi Inositol-1 0.0045 0.1151 0.1151
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0054 0.1451 0.1451
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Echinococcus multilocularis neuroendocrine convertase 2 0.0209 0.6201 0.7668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1478 0.1291
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0033 0.0802 0.0753
Loa Loa (eye worm) AGC/PKN protein kinase 0.0033 0.0802 0.0802
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0008 0.0028 0.0028
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0014 0.0214 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0824 0.7161
Trypanosoma cruzi subtilisin peptidase 0.0014 0.0214 0.1862
Onchocerca volvulus 0.0027 0.0595 0.3135
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0019 0.0363 0.3154
Echinococcus multilocularis serine:threonine protein kinase N2 0.0054 0.1447 0.1578
Schistosoma mansoni serine/threonine kinase 0.0033 0.0802 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Entamoeba histolytica protein kinase, putative 0.0039 0.0969 0.7618
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0582 0.0582
Leishmania major protein kinase A catalytic subunit 0.0019 0.0363 0.3154
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0363 0.0363
Schistosoma mansoni unc-13 (munc13) 0.0031 0.0729 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Loa Loa (eye worm) AGC/PKA protein kinase 0.0019 0.0363 0.0363
Echinococcus granulosus RNA directed DNA polymerase 0.0137 0.4 0.3869
Echinococcus granulosus raf serine:threonine protein kinase 0.0026 0.0582 0.0376
Brugia malayi intermediate filament protein 0.0033 0.078 0.078
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0019 0.0363 0.3154
Echinococcus granulosus protein kinase c eta type 0.0026 0.0582 0.0376
Schistosoma mansoni inositol monophosphatase 0.0045 0.1151 0.1151
Schistosoma mansoni site-1 peptidase (S08 family) 0.0014 0.0214 0.0214
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0802 0.0802
Entamoeba histolytica protein kinase, putative 0.0033 0.0802 0.5418
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0014 0.0214 0.1862
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.0622
Echinococcus multilocularis musashi 0.0033 0.078 0.0724
Echinococcus granulosus Protein kinase C brain isozyme 0.0201 0.5976 0.5888
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.1151 0.5
Trypanosoma brucei unspecified product 0.0016 0.0272 0.2365
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0028 0.0634 0.0429
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0261
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0824 1
Brugia malayi RhoGAP domain containing protein 0.0026 0.0582 0.0582
Brugia malayi Protein kinase domain containing protein 0.0034 0.083 0.083
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.078
Giardia lamblia Furin precursor putative serine protease 0.0064 0.1755 0.4907
Schistosoma mansoni intermediate filament proteins 0.0033 0.078 0.078
Leishmania major protein kinase A catalytic subunit isoform 1 0.0019 0.0363 0.3154
Toxoplasma gondii subtilisin SUB10 0.0014 0.0214 0.1862
Brugia malayi neuroendocrine convertase 1 precursor 0.0209 0.6201 0.6201
Brugia malayi Protein kinase c protein 2 0.017 0.5002 0.5002
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Entamoeba histolytica diacylglycerol kinase, putative 0.0026 0.0582 0.2526
Brugia malayi protein kinase C3,putative 0.0028 0.0634 0.0634
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0495 0.4301
Echinococcus multilocularis serine threonine protein kinase 0.0175 0.5171 0.6348
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0014 0.0214 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0272 0.2365
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0332 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.061 0.061
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.1007 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0033 0.0802 0.0802
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0028 0.0646 0.0646
Giardia lamblia DINP protein human, muc B family 0.0023 0.0495 0.1384
Echinococcus granulosus myotubularin protein 13 0.0027 0.061 0.0404
Echinococcus multilocularis dna polymerase eta 0.0023 0.0495 0.0359
Schistosoma mansoni protein kinase 0.0034 0.0823 0.0823
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.0622
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0495 0.4301
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0802 0.1018
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0495 0.4301
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0042 0.1056 0.1056
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0019 0.0363 0.019
Brugia malayi Ras association domain family 1 isoform A 0.0026 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.0032 0.0762 0.0762
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0634 0.0634
Echinococcus granulosus protein kinase C gamma type 0.0175 0.5171 0.5065
Brugia malayi Hr1 repeat family protein 0.0033 0.0802 0.0802
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0495 0.4301
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0014 0.0214 0.1862
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0014 0.0214 0.0214
Entamoeba histolytica protein kinase, putative 0.0034 0.083 0.5781
Echinococcus granulosus protein kinase c epsilon type 0.0085 0.2398 0.2232
Loa Loa (eye worm) hypothetical protein 0.0042 0.1056 0.1056
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1478 0.1291
Toxoplasma gondii subtilisin SUB5 0.0014 0.0214 0.1862
Brugia malayi Sex muscle abnormal protein 5 0.0063 0.1703 0.1703
Trypanosoma brucei unspecified product 0.0016 0.0272 0.2365
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0495 0.3541
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0823 0.1054
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Echinococcus granulosus lamin 0.0033 0.078 0.0578
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Onchocerca volvulus 0.0042 0.1056 0.6939
Echinococcus granulosus intermediate filament protein 0.0033 0.078 0.0578
Brugia malayi protein kinase C II. 0.0085 0.2398 0.2398
Loa Loa (eye worm) hypothetical protein 0.0042 0.1056 0.1056
Loa Loa (eye worm) AGC/NDR protein kinase 0.0033 0.0802 0.0802
Echinococcus multilocularis RNA directed DNA polymerase 0.0137 0.4 0.4848
Toxoplasma gondii subtilisin SUB6 0.0014 0.0214 0.1862
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0582 0.0582
Onchocerca volvulus 0.0033 0.078 0.4664
Brugia malayi diacylglycerol kinase 0.0026 0.0582 0.0582
Schistosoma mansoni unc-13 (munc13) 0.0031 0.0729 0.0729
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Loa Loa (eye worm) endoprotease bli-4 0.0332 1 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0033 0.0802 0.0601
Entamoeba histolytica protein kinase, putative 0.0034 0.083 0.5781
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.05 0.1446
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0017 0.0312 0.01
Echinococcus granulosus NDR protein kinase 0.0033 0.0802 0.0601
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0063 0.1703 0.1703
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0033 0.0802 0.0601
Schistosoma mansoni inositol monophosphatase 0.0045 0.1151 0.1151
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0014 0.0214 0.1862
Plasmodium falciparum subtilisin-like protease 3 0.0014 0.0214 0.26
Brugia malayi p70 ribosomal S6 kinase beta 0.0033 0.0802 0.0802
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0802 0.1018
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0823 0.0823
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0823 0.0622
Loa Loa (eye worm) hypothetical protein 0.013 0.3787 0.3787
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0019 0.0363 0.3154
Schistosoma mansoni protein kinase C mu 0.0054 0.1451 0.1451
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0064 0.1755 0.2667
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0054 0.1451 0.1451
Schistosoma mansoni diacylglycerol kinase theta 0.0026 0.0582 0.0582
Schistosoma mansoni hypothetical protein 0.0026 0.0582 0.0582
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0019 0.0363 0.3154
Toxoplasma gondii diacylglycerol kinase, putative 0.0026 0.0582 0.5063
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0019 0.0363 0.3154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1478 0.1618
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0028 0.0634 0.0634
Plasmodium falciparum subtilisin-like protease 1 0.0014 0.0214 0.26
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0042 0.1056 0.1056
Echinococcus multilocularis unc 13 (munc13) 0.0031 0.0729 0.0659
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0085 0.2398 0.2398
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.083 0.083
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0078 0.2192 0.3423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0824 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0823 0.078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0582 0.0582
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0495 0.4301
Brugia malayi Cation transporter family protein 0.0042 0.1056 0.1056
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.1151 0.0957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1151 0.1621
Schistosoma mansoni lamin 0.0033 0.078 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1755 0.2667
Brugia malayi Protein kinase domain containing protein 0.0033 0.0802 0.0802
Trichomonas vaginalis AGC family protein kinase 0.0034 0.083 0.1066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0729 0.0729
Echinococcus multilocularis 0.0268 0.8023 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0014 0.0214 0.0214
Schistosoma mansoni DNA polymerase eta 0.0023 0.0495 0.0495
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0033 0.0802 0.0753
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0495 0.4301
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0202 0.599 0.5903
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0202 0.599 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0137 0.4 0.4848
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0033 0.0802 0.0802
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1478 0.1478
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0824 1
Toxoplasma gondii subtilisin SUB11 0.0014 0.0214 0.1862
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0144 0.4197 0.4197
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0824 1
Echinococcus granulosus unc 13 munc13 0.0031 0.0729 0.0526

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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