Detailed information for compound 1409942

Basic information

Technical information
  • TDR Targets ID: 1409942
  • Name: N-(oxolan-2-ylmethyl)-4-(propylsulfamoyl)benz amide
  • MW: 326.411 | Formula: C15H22N2O4S
  • H donors: 2 H acceptors: 3 LogP: 1.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNS(=O)(=O)c1ccc(cc1)C(=O)NCC1CCCO1
  • InChi: 1S/C15H22N2O4S/c1-2-9-17-22(19,20)14-7-5-12(6-8-14)15(18)16-11-13-4-3-10-21-13/h5-8,13,17H,2-4,9-11H2,1H3,(H,16,18)
  • InChiKey: DXGXMAUDWQNDMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(propylsulfamoyl)-N-(tetrahydrofuran-2-ylmethyl)benzamide
  • 4-(propylsulfamoyl)-N-(2-tetrahydrofuranylmethyl)benzamide
  • 4-(propylsulfamoyl)-N-(tetrahydrofurfuryl)benzamide
  • MLS000075809
  • SMR000008152
  • ASN 07848637
  • 4-Propylsulfamoyl-N-(tetrahydro-furan-2-ylmethyl)-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cathepsin L homolog 0.0273 1 1
Leishmania major cathepsin L-like protease 0.0273 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0273 1 1
Brugia malayi Cathepsin L-like precursor 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0273 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0142 0.4054 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Brugia malayi cathepsin L-like precursor 0.0184 0.5946 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Loa Loa (eye worm) cysteine protease 0.0273 1 1
Onchocerca volvulus 0.0184 0.5946 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.1888 0.1888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0273 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0273 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0095 0.1888 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Leishmania major cathepsin L-like protease 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.6104 0.6104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Toxoplasma gondii cathepsin CPL 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Giardia lamblia Cathepsin B precursor 0.0095 0.1888 1
Loa Loa (eye worm) ctsf protein 0.0273 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Echinococcus granulosus cathepsin b 0.0187 0.6104 0.6104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0273 1 1
Onchocerca volvulus 0.0273 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0089 0.1602 0.1602
Plasmodium vivax vivapain-3 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0273 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0273 1 1
Echinococcus multilocularis cathepsin b 0.0187 0.6104 0.6104
Onchocerca volvulus 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.5946 0.5946
Giardia lamblia Cathepsin B precursor 0.0095 0.1888 1
Brugia malayi Papain family cysteine protease containing protein 0.0273 1 1
Leishmania major cathepsin L-like protease 0.0273 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0089 0.1602 0.1602
Loa Loa (eye worm) hypothetical protein 0.0089 0.1602 0.1602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.4054 0.267
Brugia malayi cathepsin B-like cysteine proteinase 0.0187 0.6104 0.6104
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.4054 0.4054
Brugia malayi Cathepsin L-like precursor 0.0273 1 1
Echinococcus granulosus cathepsin b 0.0187 0.6104 0.6104
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Loa Loa (eye worm) hypothetical protein 0.0187 0.6104 0.6104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine proteinase 2 0.0142 0.4054 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.4054 0.4054
Echinococcus granulosus cysteine protease 0.0142 0.4054 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0187 0.6104 0.6104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Leishmania major cathepsin L-like protease 0.0273 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0273 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0273 1 1
Echinococcus multilocularis cathepsin b 0.0187 0.6104 0.6104
Echinococcus multilocularis cysteine protease 0.0273 1 1
Leishmania major cathepsin L-like protease 0.0273 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0187 0.6104 0.6104
Echinococcus granulosus cathepsin l1 0.0184 0.5946 0.5946
Echinococcus multilocularis cathepsin L cysteine protease 0.0273 1 1
Brugia malayi Cathepsin L-like precursor 0.0089 0.1602 0.1602
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0142 0.4054 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0273 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.1602 0.1602
Brugia malayi Cathepsin L-like precursor 0.0273 1 1
Plasmodium vivax unspecified product 0.0089 0.1602 0.1602
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.4054 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Onchocerca volvulus 0.0273 1 1
Giardia lamblia Cathepsin B precursor 0.0095 0.1888 1
Plasmodium vivax vivapain-2 0.0273 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0089 0.1602 0.1602
Loa Loa (eye worm) hypothetical protein 0.0089 0.1602 0.1602
Plasmodium falciparum cysteine proteinase falcipain 1 0.0142 0.4054 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0273 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0273 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0273 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.4054 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Trypanosoma cruzi cysteine protease, putative 0.0142 0.4054 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0273 1 1
Onchocerca volvulus 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Plasmodium vivax vivapain-1 0.0142 0.4054 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Toxoplasma gondii cathepsin B 0.0095 0.1888 0.1888
Onchocerca volvulus Cathepsin F homolog 0.0273 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0273 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0184 0.5946 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Loa Loa (eye worm) cathepsin B 0.0095 0.1888 0.1888
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0273 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.6104 0.6104
Loa Loa (eye worm) hypothetical protein 0.0184 0.5946 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Schistosoma mansoni cathepsin s 0.0089 0.1602 0.1602
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.4054 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Brugia malayi Cathepsin L-like precursor 0.0273 1 1
Brugia malayi Cathepsin L-like precursor 0.0273 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.4054 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0273 1 1
Loa Loa (eye worm) hypothetical protein 0.0273 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.4054 0.4054
Loa Loa (eye worm) fibroinase 0.0273 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0273 1 1
Brugia malayi Cathepsin L-like precursor 0.0184 0.5946 0.5946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.1888 0.1888
Leishmania major cathepsin L-like protease 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.4054 0.267
Brugia malayi Cathepsin L-like cysteine proteinase 0.0184 0.5946 0.5946
Plasmodium vivax vivapain-2 0.0273 1 1
Echinococcus granulosus cathepsin l1 0.0273 1 1
Onchocerca volvulus 0.0273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.5946 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.4054 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine protease, putative 0.0142 0.4054 0.4054
Loa Loa (eye worm) hypothetical protein 0.0184 0.5946 0.5946
Echinococcus granulosus cathepsin L 0.0142 0.4054 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.5946 0.5946
Echinococcus multilocularis cysteine protease 0.0273 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0142 0.4054 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.4054 0.4054
Onchocerca volvulus 0.0273 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0273 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.4054 0.4054
Plasmodium vivax unspecified product 0.0142 0.4054 0.4054
Echinococcus multilocularis cathepsin L 0.0142 0.4054 0.4054
Leishmania major cathepsin L-like protease 0.0273 1 1
Leishmania major cathepsin L-like protease 0.0273 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0273 1 1
Brugia malayi Cathepsin L-like precursor 0.0184 0.5946 0.5946
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.1602 0.1602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.5946 0.5946
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.4054 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0184 0.5946 0.5946
Onchocerca volvulus 0.0273 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1602 0.1602
Trypanosoma cruzi cysteine peptidase, putative 0.0273 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.6104 0.6104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.01 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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