Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8645 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Brugia malayi | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.4775 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.4775 | 0.4775 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.4775 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.8645 | 0.8645 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.2319 | 0.2319 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.8645 | 0.8645 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8645 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.8645 | 0.8645 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0047 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.8645 | 0.8645 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.8645 | 0.8645 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8645 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8645 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.