Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0391 | 0.0312 |
Trypanosoma cruzi | hexokinase, putative | 0.0784 | 1 | 0.5 |
Onchocerca volvulus | 0.0784 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0047 | 1 |
Onchocerca volvulus | 0.0784 | 1 | 1 | |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.6284 | 0.6263 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.3142 | 0.3085 |
Echinococcus granulosus | hexokinase | 0.0784 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0084 | 0.0027 |
Loa Loa (eye worm) | hexokinase type II | 0.0784 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0391 | 0.0086 | |
Trypanosoma cruzi | hexokinase, putative | 0.0784 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0784 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0784 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0784 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0784 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0307 | 0.0298 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.0878 |
Loa Loa (eye worm) | hexokinase | 0.0784 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.0878 |
Echinococcus granulosus | hexokinase | 0.0784 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0242 | 0.3057 | 0.3 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0887 | 0.0835 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0784 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0784 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0047 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0242 | 0.3057 | 0.2998 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0307 | 0.0226 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.5 |
Onchocerca volvulus | 0.0492 | 0.6253 | 0.6135 | |
Brugia malayi | Hexokinase family protein | 0.0492 | 0.6253 | 0.6223 |
Trypanosoma brucei | hexokinase, putative | 0.0784 | 1 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0416 | 0.0362 |
Echinococcus granulosus | hexokinase | 0.0784 | 1 | 1 |
Brugia malayi | SEA domain containing protein | 0.0028 | 0.0307 | 0.0228 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0047 | 1 |
Brugia malayi | hexokinase type II | 0.0249 | 0.3142 | 0.3086 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0047 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0416 | 0.0407 |
Brugia malayi | Hexokinase family protein | 0.0784 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0887 | 0.0835 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0047 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0784 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0307 | 0.0226 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0047 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0416 | 0.0407 |
Onchocerca volvulus | 0.0784 | 1 | 1 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0416 | 0.0362 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.0106 |
Trypanosoma brucei | hexokinase | 0.0784 | 1 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0056 | 0.0047 |
Schistosoma mansoni | hexokinase | 0.0784 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0492 | 0.6253 | 0.6222 |
Leishmania major | hexokinase, putative | 0.0784 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0047 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0784 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0784 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.3142 | 0.3085 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0391 | 0.0382 |
Echinococcus multilocularis | hexokinase | 0.0784 | 1 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.6284 | 0.6263 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0005 | 0.0014 | 0.0004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0007 | 0.0038 | 0.0029 |
Onchocerca volvulus | Hexokinase homolog | 0.0492 | 0.6253 | 0.6135 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0887 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0047 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0028 | 0.0307 | 0.0228 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.089 | 0.0881 |
Echinococcus granulosus | hexokinase type 2 | 0.0784 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0784 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0084 | 0.0027 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0028 | 0.0307 | 0.0226 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.6803 | 0.6776 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0784 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.6284 | 0.628 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0391 | 0.031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0047 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0784 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.