Detailed information for compound 1410374

Basic information

Technical information
  • TDR Targets ID: 1410374
  • Name: 1-di(morpholin-4-yl)phosphoryl-3-methyl-2-phe nylindolizine
  • MW: 425.46 | Formula: C23H28N3O3P
  • H donors: 0 H acceptors: 1 LogP: 3.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c(c2ccccc2)c(c2n1cccc2)P(=O)(N1CCOCC1)N1CCOCC1
  • InChi: 1S/C23H28N3O3P/c1-19-22(20-7-3-2-4-8-20)23(21-9-5-6-10-26(19)21)30(27,24-11-15-28-16-12-24)25-13-17-29-18-14-25/h2-10H,11-18H2,1H3
  • InChiKey: ACSVKBSAEBANRV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-dimorpholinophosphoryl-3-methyl-2-phenyl-indolizine
  • 1-dimorpholinophosphoryl-3-methyl-2-phenylindolizine
  • 1-di(morpholin-4-yl)phosphoryl-3-methyl-2-phenyl-indolizine
  • T0504-4325
  • Oprea1_435838
  • MLS000055663
  • ZINC03123921
  • SMR000060672

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica thioredoxin reductase, putative 0.0009 0.0122 0.023
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.3443 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0157 0.0113
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0157 0.0113
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0836 0.2329
Schistosoma mansoni glutamate synthase 0.0009 0.0122 0.0122
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.3443 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.6257 0.8958
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.6257 0.8958
Plasmodium vivax ferrodoxin reductase, putative 0.0009 0.0122 0.0298
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0122 0.023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2329
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.697 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0563 0.1527
Schistosoma mansoni glutamate synthase 0.0009 0.0122 0.0122
Loa Loa (eye worm) glutathione reductase 0.0103 0.2667 0.2634
Toxoplasma gondii selenide, water dikinase 0.0009 0.0122 0.0298
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0836 0.2148
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0836 0.0795
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0831 0.9941
Schistosoma mansoni ran 0.0026 0.0563 0.0563
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0153 0.0321
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.3443 0.485
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3443 1
Plasmodium falciparum importin beta, putative 0.0035 0.0814 0.2935
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0814 0.2265
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0122 0.0079
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0122 0.0079
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0836 0.2329
Plasmodium vivax importin-beta 2, putative 0.0035 0.0814 0.2935
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0836 0.3018
Plasmodium falciparum thioredoxin reductase 0.0036 0.0836 0.3018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0836 0.2329
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3443 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0831 0.3002
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0831 0.3002
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0009 0.0122 0.0298
Trypanosoma brucei NADH dehydrogenase 0.0009 0.0122 0.023
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0122 0.0079
Echinococcus multilocularis glutamate synthase 0.0009 0.0122 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2148
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0836 0.3018
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0122 0.0079
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0122 0.0079
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0831 0.3002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0122 0.0079
Echinococcus multilocularis snurportin 1 0.0372 1 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0122 0.023
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0122 0.0079
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0122 0.0298
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.3443 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0814 0.0773
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.3443 0.3443
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0122 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0831 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0122 0.023
Entamoeba histolytica hypothetical protein 0.0028 0.0634 0.1736
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0836 0.2148
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0836 0.3018
Brugia malayi Importin beta-1 subunit 0.0035 0.0814 0.2265
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0831 0.2135
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.081 0.0769
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.3443 1
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0122 0.0122
Brugia malayi 6-phosphofructokinase 0.0131 0.3443 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0122 0.0079
Leishmania major hypothetical protein, conserved 0.0009 0.0122 0.023
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0831 0.2316
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0122 0.0298
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0831 0.3002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0634 0.1736
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0079 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Echinococcus granulosus importin subunit beta 1 0.0035 0.0814 0.0773
Schistosoma mansoni hypothetical protein 0.0372 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0079 0.0102
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0122 0.023
Brugia malayi 6-phosphofructokinase 0.0131 0.3443 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.187 0.187
Loa Loa (eye worm) phosphofructokinase 0.0131 0.3443 0.3414
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.697 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0009 0.0122 0.023
Leishmania major trypanothione reductase 0.0103 0.2667 0.7716
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0563 0.1979
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0122 0.023
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0563 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0099 0.0056
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0836 0.2148
Brugia malayi phosphofructokinase 0.0131 0.3443 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0634 0.1736
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0122 0.023
Leishmania major NADH dehydrogenase, putative 0.0009 0.0122 0.023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2148
Loa Loa (eye worm) hypothetical protein 0.0009 0.0122 0.0079
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.3443 1
Brugia malayi glutathione reductase 0.0103 0.2667 0.7716
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0122 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0831 0.2316
Toxoplasma gondii thioredoxin reductase 0.0103 0.2667 1
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0122 0.023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0836 0.2329
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0563 0.1979
Echinococcus multilocularis cpg binding protein 0.0037 0.0864 0.0824
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0009 0.0122 0.023
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0122 0.0298
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2329
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.6257 0.8958
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0836 0.2329
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0836 0.2148
Trypanosoma brucei trypanothione reductase 0.0103 0.2667 0.7716
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0836 0.2148
Leishmania major hypothetical protein, conserved 0.0009 0.0122 0.023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.697 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0122 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2148
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0831 0.3002
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3443 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2684 0.2651
Schistosoma mansoni importin-beta 2 0.0007 0.0044 0.0044
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0122 0.023
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0563 0.0521
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0836 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0122 0.023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0079 0.0102
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0836 0.0836
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0122 0.023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2667 0.3716
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0563 0.1328
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2148
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.3443 0.3414
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0009 0.0122 0.023
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0563 0.1328
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0836 0.1042
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0831 0.2316
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0122 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0079 0.0102
Schistosoma mansoni glutamate synthase 0.0009 0.0122 0.0122
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.3443 0.485
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0831 0.9941
Echinococcus granulosus glutamate synthase 0.0009 0.0122 0.0079
Trichomonas vaginalis ran, putative 0.0026 0.0563 0.1527
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0836 0.2329
Brugia malayi glutamate synthase 0.0009 0.0122 0.023
Brugia malayi RNA, U transporter 1 0.0099 0.2564 0.7414
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0079 0.0102
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0122 0.023
Schistosoma mansoni hypothetical protein 0.0009 0.0122 0.0122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0099 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3443 1
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.3443 0.3414
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.697 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0157 0.0113
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2667 0.7662
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0122 0.0122
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.6257 0.8958
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0122 0.023
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0122 0.023
Echinococcus granulosus cpg binding protein 0.0037 0.0864 0.0824
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0814 0.2265
Schistosoma mansoni ran 0.0026 0.0563 0.0563
Plasmodium falciparum glutathione reductase 0.0103 0.2667 1
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.3443 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0099 0.0056
Schistosoma mansoni cpg binding protein 0.0035 0.081 0.081
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1656 0.6146
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0563 0.1527
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0079 0.0102
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0836 0.3018
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0836 0.2148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2148
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0836 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0009 0.0122 0.023
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0009 0.0122 0.023
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0122 0.0122
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0831 0.2316
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0563 0.6182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0634 0.1736
Onchocerca volvulus 0.0035 0.081 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0079 0.0102
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0122 0.023
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0836 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0122 0.023
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0578 0.157
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2667 0.2634
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0122 0.0079
Plasmodium vivax glutathione reductase, putative 0.0103 0.2667 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0122 0.023
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0814 0.2935
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0831 0.2316
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0831 0.3002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0122 0.023
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.3443 0.3443
Schistosoma mansoni cpg binding protein 0.0037 0.0864 0.0864
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0122 0.0079
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Treponema pallidum NADH oxidase 0.0036 0.0836 0.2148
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0122 0.023
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2684 0.2651
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0836 0.0795
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0009 0.0122 0.0298
Leishmania major GTP-binding protein, putative 0.0026 0.0563 0.1527
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0009 0.0122 0.0298
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0099 0.0056
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.3443 0.3414
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0836 0.2329
Entamoeba histolytica disulphide oxidoreductase, putative 0.0009 0.0122 0.023
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.3443 0.3414
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0079 0.0102
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0578 0.157
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0122 0.023
Leishmania major hypothetical protein, conserved 0.0009 0.0122 0.023
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.3443 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.081 0.2253
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0831 0.2316
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0009 0.0122 0.0298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.6257 0.8958
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0634 0.1542
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.3443 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0836 0.3018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0836 0.2148
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0836 0.2329
Plasmodium falciparum thioredoxin reductase 0.0103 0.2667 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0122 0.023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0836 0.2329
Trichomonas vaginalis helicase, putative 0.0008 0.0079 0.0102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0122 0.023
Mycobacterium tuberculosis Probable reductase 0.0234 0.6257 0.8958
Brugia malayi Thioredoxin reductase 0.0103 0.2667 0.7716
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0836 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.6257 0.8958
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0563 0.1979
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0563 0.1527
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0122 0.0298
Plasmodium falciparum ferrodoxin reductase-like protein 0.0009 0.0122 0.0298
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0563 0.0521
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0122 0.0298
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0814 0.0773
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0122 0.023
Schistosoma mansoni importin beta-1 0.0035 0.0814 0.0814
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0634 0.1736
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0831 0.2316
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0099 0.0056
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0831 0.9941
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0079 0.0102
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0836 0.3018
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0831 0.3002
Plasmodium falciparum glutathione reductase 0.0036 0.0836 0.3018
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2667 1
Schistosoma mansoni cpg binding protein 0.0037 0.0864 0.0864
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0122 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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