Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.013 | 0.0917 | 0.0917 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.013 | 0.0917 | 0.0917 |
Echinococcus granulosus | neuroligin | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0771 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.0917 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.013 | 0.0917 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Schistosoma mansoni | acetylcholinesterase | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.4035 | 0.4035 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.013 | 0.0917 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 0.0917 | 0.0917 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.013 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.013 | 0.0917 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.013 | 0.0917 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.013 | 0.0917 | 0.5 | |
Onchocerca volvulus | 0.013 | 0.0917 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0771 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0771 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | carboxylesterase | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.2289 | 0.2289 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.013 | 0.0917 | 0.0917 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.013 | 0.0917 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.013 | 0.0917 | 0.0917 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0771 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | carboxylesterase | 0.0771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0771 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0771 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | carboxylesterase | 0.013 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.013 | 0.0917 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Echinococcus multilocularis | neuroligin | 0.013 | 0.0917 | 0.0917 |
Echinococcus multilocularis | acetylcholinesterase | 0.0771 | 1 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.2289 | 0.2289 |
Echinococcus multilocularis | acetylcholinesterase | 0.0771 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.013 | 0.0917 | 0.0917 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.013 | 0.0917 | 0.5 |
Brugia malayi | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0917 | 0.0917 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0771 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 0.0917 | 0.0917 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 0.0917 | 0.0917 |
Echinococcus granulosus | BC026374 protein S09 family | 0.013 | 0.0917 | 0.0917 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.013 | 0.0917 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.013 | 0.0917 | 0.0917 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.013 | 0.0917 | 0.0917 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0891 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.5221 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.