Detailed information for compound 1410647

Basic information

Technical information
  • TDR Targets ID: 1410647
  • Name: 5-methyl-2-phenyl-N-(1,3-thiazol-2-yl)-1,3-ox azole-4-carboxamide
  • MW: 285.321 | Formula: C14H11N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nc(oc1C)c1ccccc1)Nc1nccs1
  • InChi: 1S/C14H11N3O2S/c1-9-11(12(18)17-14-15-7-8-20-14)16-13(19-9)10-5-3-2-4-6-10/h2-8H,1H3,(H,15,17,18)
  • InChiKey: LABOTDLEMVNZHH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-methyl-2-phenyl-N-thiazol-2-yl-oxazole-4-carboxamide
  • 5-methyl-2-phenyl-N-(2-thiazolyl)-4-oxazolecarboxamide
  • T5332426
  • ZINC03379257
  • MLS000056945
  • SMR000064483

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0061 0.0142 0.0133
Mycobacterium ulcerans aminopeptidase N PepN 0.0153 0.0464 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0153 0.0464 0.0456
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0153 0.0464 0.3201
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.003 0.0035 0.0058
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0061 0.0142 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.003 0.0035 0.0058
Loa Loa (eye worm) RNA binding protein 0.0076 0.0197 0.0193
Echinococcus granulosus potassium voltage gated channel subfamily A 0.003 0.0035 0.0026
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0153 0.0464 0.0456
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0081 0.0073
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0061 0.0142 0.0292
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0035 0.0026
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0061 0.0142 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0455
Toxoplasma gondii transporter, cation channel family protein 0.003 0.0035 0.0579
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0061 0.0142 0.0133
Onchocerca volvulus 0.0061 0.0142 0.2581
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0153 0.0464 1
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0091 0.0248 0.0239
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0429 0.1432 1
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0035 0.0026
Trypanosoma cruzi cAMP binding protein, putative 0.0061 0.0142 0.2919
Treponema pallidum cyclic nucleotide binding protein 0.0061 0.0142 1
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0061 0.0142 0.0133
Trichomonas vaginalis adenylate cyclase type III, putative 0.0042 0.0077 0.048
Leishmania major calcium channel protein, putative,ion transporter, putative 0.003 0.0035 0.0579
Echinococcus granulosus sodium channel protein 0.003 0.0035 0.0026
Brugia malayi N-terminal motif family protein 0.0061 0.0142 0.0292
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0061 0.0142 0.0133
Leishmania major hypothetical protein, unknown function 0.003 0.0035 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.003 0.0035 0.0058
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0061 0.0142 0.2919
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.003 0.0035 0.0058
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3356 0.335
Trichomonas vaginalis hypothetical protein 0.0042 0.0077 0.048
Brugia malayi hypothetical protein 0.003 0.0035 0.0058
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0145 0.0136
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0035 0.0026
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0153 0.0464 0.0456
Leishmania major hypothetical protein, conserved 0.0061 0.0142 0.2919
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Trypanosoma brucei protein kinase A regulatory subunit 0.0061 0.0142 0.2919
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0061 0.0142 0.2919
Echinococcus granulosus patatin phospholipase domain containing protein 0.0061 0.0142 0.0133
Brugia malayi cation channel family protein 0.003 0.0035 0.0058
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0061 0.0142 0.0934
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0043 0.0079 0.1542
Mycobacterium ulcerans transcriptional regulatory protein 0.0061 0.0142 0.299
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0061 0.0142 0.299
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0091 0.0248 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Toxoplasma gondii hypothetical protein 0.003 0.0035 0.0579
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0153 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.055
Echinococcus multilocularis hyperpolarization activated cyclic 0.0091 0.0248 0.0239
Loa Loa (eye worm) calcium channel 0.003 0.0035 0.0031
Loa Loa (eye worm) voltage-dependent calcium channel 0.003 0.0035 0.0031
Echinococcus granulosus cGMP dependent protein kinase 1 0.0061 0.0144 0.0135
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0029 0.2076
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0145 0.2982
Echinococcus granulosus sodium leak channel non selective protein 0.003 0.0035 0.0026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Leishmania major hypothetical protein, conserved 0.0061 0.0142 0.2919
Brugia malayi hypothetical protein 0.1323 0.4559 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Echinococcus granulosus single minded 2 0.0042 0.0077 0.0068
Schistosoma mansoni hypothetical protein 0.0042 0.0077 0.0068
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0061 0.0142 1
Toxoplasma gondii transporter, cation channel family protein 0.003 0.0035 0.0579
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0091 0.0248 0.1678
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0429 0.1432 1
Mycobacterium ulcerans transmembrane transport protein 0.0061 0.0142 0.299
Echinococcus multilocularis potassium large conductance calcium activated 0.003 0.0035 0.0026
Echinococcus granulosus tumor protein p63 0.0408 0.1357 0.135
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.003 0.0035 0.0058
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0061 0.0144 0.0135
Loa Loa (eye worm) TATA binding protein associated factor 0.0153 0.0464 0.046
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0061 0.0142 0.2919
Echinococcus multilocularis hyperpolarization activated cyclic 0.0091 0.0248 0.0239
Mycobacterium ulcerans regulatory protein 0.0061 0.0142 0.299
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0061 0.0142 0.0133
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0042 0.0077 0.048
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.046 0.1538 0.1534
Leishmania major cyclic nucleotide-binding protein-like protein 0.0061 0.0142 0.2919
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0004 0.0289
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Leishmania major regulatory subunit of protein kinase a-like protein 0.0061 0.0142 0.2919
Echinococcus multilocularis shaker cognate 0.003 0.0035 0.0026
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0035 0.0026
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.0248 0.0239
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Brugia malayi RNA binding protein 0.0076 0.0197 0.0414
Echinococcus granulosus two pore calcium channel protein 2 0.003 0.0035 0.0026
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0145 1
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0042 0.0077 0.015
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0061 0.0142 0.0934
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0061 0.0142 0.299
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0035 0.0026
Brugia malayi Transient-receptor-potential like protein 0.003 0.0035 0.0058
Trypanosoma cruzi aminopeptidase, putative 0.0153 0.0464 1
Mycobacterium ulcerans hypothetical protein 0.0061 0.0142 0.299
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Toxoplasma gondii transporter, cation channel family protein 0.003 0.0035 0.0579
Echinococcus multilocularis sodium channel protein 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Echinococcus granulosus short transient receptor potential channel 6 0.003 0.0035 0.0026
Loa Loa (eye worm) voltage-gated potassium channel 0.003 0.0035 0.0031
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0464 1
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0042 0.0077 0.048
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0061 0.0142 0.0133
Schistosoma mansoni voltage-gated potassium channel 0.0502 0.1686 0.1678
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.003 0.0035 0.0026
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0145 0.0141
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.003 0.0035 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0144 0.0135
Loa Loa (eye worm) AGC/PKG protein kinase 0.0061 0.0144 0.014
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0183 0.0174
Trypanosoma brucei Flagellar Member 6 0.0061 0.0142 0.2919
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0061 0.0142 0.0133
Trypanosoma cruzi aminopeptidase, putative 0.0153 0.0464 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.003 0.0035 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0133 0.0395 0.0387
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0035 0.0026
Trypanosoma cruzi cAMP response protein 1, putative 0.0061 0.0142 0.2919
Echinococcus multilocularis transient receptor potential gamma protein 0.003 0.0035 0.0026
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0061 0.0142 0.2919
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus multilocularis two pore calcium channel protein 2 0.003 0.0035 0.0026
Echinococcus multilocularis voltage dependent calcium channel 0.003 0.0035 0.0026
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.046 0.1538 0.1531
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0142 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0061 0.0142 0.0133
Echinococcus granulosus voltage gated potassium channel 0.003 0.0035 0.0026
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0145 0.0136
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0042 0.0077 0.048
Echinococcus multilocularis sodium leak channel non selective protein 0.003 0.0035 0.0026
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0042 0.0077 0.048
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.003 0.0035 0.0026
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0061 0.0142 0.0133
Trypanosoma brucei aminopeptidase, putative 0.0153 0.0464 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0197 0.0188
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0035 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0035 0.0579
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0153 0.0464 0.3201
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0145 0.2982
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0145 0.0136
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0061 0.0142 0.2919
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0061 0.0142 0.0133
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0042 0.0077 0.048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0025
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0061 0.0142 0.0133
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0091 0.0248 0.0239
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0145 0.0136
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0061 0.0142 0.2919
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Schistosoma mansoni hypothetical protein 0.0043 0.0081 0.0073
Schistosoma mansoni voltage-dependent calcium channel 0.003 0.0035 0.0026
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0029 0.0455
Entamoeba histolytica hypothetical protein 0.0043 0.0081 0.1593
Toxoplasma gondii aminopeptidase n, putative 0.0153 0.0464 1
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus multilocularis calcium activated potassium channel 0.0031 0.0037 0.0028
Echinococcus granulosus cGMP dependent protein kinase 0.0061 0.0144 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0197 0.0193
Echinococcus granulosus calcium activated potassium channel 0.0031 0.0037 0.0028
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0153 0.0464 1
Echinococcus multilocularis tumor protein p63 0.0408 0.1357 0.135
Echinococcus granulosus two pore calcium channel protein 1 0.003 0.0035 0.0026
Leishmania major hypothetical protein, conserved 0.0061 0.0142 0.2919
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0035 0.0026
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.003 0.0035 0.013
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0091 0.0248 0.0244
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0035 0.0026
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0061 0.0142 0.0133
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.003 0.0035 0.0026
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Trichomonas vaginalis adenylate cyclase type, putative 0.0042 0.0077 0.048
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0035 0.0026
Schistosoma mansoni transient receptor potential channel 4 0.003 0.0035 0.0026
Brugia malayi ion channel NompC 0.003 0.0035 0.0058
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Schistosoma mansoni ryanodine receptor related 0.003 0.0035 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni voltage-gated ion channel 0.003 0.0035 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0197 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0144 0.0135
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0061 0.0142 0.0133
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0042 0.0077 0.048
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.0455
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.0455
Echinococcus multilocularis aminopeptidase N 0.0153 0.0464 0.0456
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2878 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0091 0.0248 0.0244
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus granulosus hypothetical protein 0.003 0.0035 0.0026
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0091 0.0248 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0145 0.0136
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0142 0.0934
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0042 0.0077 0.048
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0455
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Entamoeba histolytica hypothetical protein 0.0043 0.0081 0.1593
Brugia malayi MAP kinase sur-1 0.0062 0.0145 0.0299
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Echinococcus multilocularis transfer RNA-Gly 0.003 0.0035 0.0026
Schistosoma mansoni 60S ribosomal protein L21 0.0072 0.0183 0.0174
Schistosoma mansoni voltage-gated potassium channel 0.0502 0.1686 0.1678
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0061 0.0142 1
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0035 0.0026
Echinococcus granulosus short transient receptor potential channel 6 0.003 0.0035 0.0026
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.003 0.0035 0.0026
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.003 0.0035 0.0026
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0035 0.0026
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0035 0.0026
Toxoplasma gondii hypothetical protein 0.003 0.0035 0.0579
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0025
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0061 0.0142 0.2919
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0134
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0035 0.0026
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0042 0.0077 0.048
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.003 0.0035 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Schistosoma mansoni calcium-activated potassium channel 0.003 0.0035 0.0026
Loa Loa (eye worm) peptidase family M1 containing protein 0.0153 0.0464 0.046
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Mycobacterium tuberculosis Conserved protein 0.0061 0.0142 1
Mycobacterium ulcerans hypothetical protein 0.0061 0.0142 0.299
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0061 0.0142 0.0133
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0061 0.0142 0.0133
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus granulosus ryanodine receptor 44f 0.003 0.0035 0.0026
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2878 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0142 0.0138
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.0248 0.0239
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Entamoeba histolytica hypothetical protein 0.0043 0.0081 0.1593
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0133 0.0395 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Echinococcus multilocularis short transient receptor potential channel 6 0.003 0.0035 0.0026
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.003 0.0035 0.0058
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.003 0.0035 0.0058
Plasmodium falciparum cGMP-dependent protein kinase 0.0061 0.0144 0.3032
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0153 0.0464 1
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0061 0.0142 0.0133
Echinococcus granulosus cGMP dependent protein kinase 1 0.0061 0.0144 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0197 0.0188
Treponema pallidum catabolite gene activator 0.0061 0.0142 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0153 0.0464 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.003 0.0035 0.0026
Brugia malayi TAR-binding protein 0.0076 0.0197 0.0414
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0138 0.013
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0464 0.1001
Mycobacterium leprae Conserved hypothetical protein 0.0061 0.0142 1
Schistosoma mansoni vesicular amine transporter 0.003 0.0035 0.0026
Brugia malayi hypothetical protein 0.0153 0.0464 0.1001
Mycobacterium ulcerans hypothetical protein 0.0061 0.0142 0.299
Trypanosoma brucei Aminopeptidase M1, putative 0.0153 0.0464 1
Leishmania major protein kinase, putative 0.0061 0.0144 0.2961
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0142 1
Treponema pallidum cyclic nucleotide binding protein 0.0061 0.0142 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.003 0.0035 0.0026
Trypanosoma cruzi Aminopeptidase M1, putative 0.0153 0.0464 1
Mycobacterium leprae Possible transporter protein 0.0042 0.0077 0.424
Echinococcus granulosus hyperpolarization activated cyclic 0.0091 0.0248 0.0239
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0464 1
Trypanosoma brucei cAMP binding protein, putative 0.0061 0.0142 0.2919
Toxoplasma gondii aminopeptidase N protein 0.0153 0.0464 1
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0061 0.0142 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0061 0.0142 0.9787
Loa Loa (eye worm) hypothetical protein 0.0153 0.0464 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0153 0.0464 1
Schistosoma mansoni hypothetical protein 0.0061 0.0142 0.0133
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0145 0.2982
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.003 0.0035 0.0026
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0091 0.0248 0.1678
Loa Loa (eye worm) hypothetical protein 0.0091 0.0248 0.0244
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0061 0.0144 0.2961
Echinococcus granulosus voltage gated potassium channel 0.0133 0.0395 0.0387
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0133 0.0395 0.085
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0197 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni voltage-gated cation channel 0.003 0.0035 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.2076
Echinococcus granulosus voltage dependent calcium channel 0.003 0.0035 0.0026
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0061 0.0142 0.2581
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0035 0.0026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Trypanosoma brucei cAMP response protein 1, putative 0.0061 0.0142 0.2919
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0142 0.2919
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0042 0.0077 0.048
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0061 0.0142 0.0133
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0042 0.0077 0.048
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0035 0.0026
Leishmania major hypothetical protein, conserved 0.003 0.0035 0.0579
Echinococcus granulosus potassium voltage gated channel subfamily D 0.003 0.0035 0.0026
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0035 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0046
Onchocerca volvulus 0.0153 0.0464 1
Trypanosoma cruzi protein kinase A regulatory subunit 0.0061 0.0142 0.2919
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0042 0.0077 0.048
Brugia malayi cation channel family protein 0.003 0.0035 0.0058
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.003 0.0035 0.0026
Echinococcus multilocularis conserved hypothetical protein 0.003 0.0035 0.0026
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0153 0.0464 1
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0153 0.0464 0.0456
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Onchocerca volvulus 0.003 0.0035 0.013
Echinococcus granulosus transient receptor potential gamma protein 0.003 0.0035 0.0026
Mycobacterium ulcerans aminopeptidase N PepN 0.0153 0.0464 1
Onchocerca volvulus 0.0061 0.0142 0.2581
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Schistosoma mansoni two-pore calcium channel 0.003 0.0035 0.0026
Loa Loa (eye worm) ion channel NompC 0.003 0.0035 0.0031
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2878 1 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.003 0.0035 0.0058
Loa Loa (eye worm) voltage-gated calcium channel 0.003 0.0035 0.0031
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni transient receptor potential channel 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0399 0.1325 0.1322
Echinococcus multilocularis ryanodine receptor 44f 0.003 0.0035 0.0026
Schistosoma mansoni aminopeptidase A (M01 family) 0.0153 0.0464 0.0456
Trypanosoma brucei protein kinase, putative 0.0062 0.0145 0.2982
Echinococcus granulosus potassium voltage gated channel subfamily D 0.003 0.0035 0.0026
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0035 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0091 0.0248 0.0239
Loa Loa (eye worm) voltage-gated potassium channel 0.003 0.0035 0.0031
Entamoeba histolytica aminopeptidase, putative 0.0153 0.0464 1
Entamoeba histolytica hypothetical protein 0.0043 0.0081 0.1593
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.01
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0145 0.2982
Mycobacterium ulcerans hypothetical protein 0.0029 0.0029 0.055
Leishmania major protein kinase A regulatory subunit, putative 0.0061 0.0142 0.2919
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0153 0.0464 0.3201
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.055
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0035 0.0026
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0035 0.0026
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0061 0.0142 0.2919
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0061 0.0142 0.0292
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0046
Brugia malayi Egg laying defective protein 4 0.0061 0.0144 0.0296
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0061 0.0142 0.0292
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0197 0.0188
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0061 0.0142 0.0133
Echinococcus granulosus potassium voltage gated channel subfamily D 0.003 0.0035 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Toxoplasma gondii aminopeptidase N, putative 0.0153 0.0464 1
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0035 0.0026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0029 0.055
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0144 0.0135
Echinococcus multilocularis expressed conserved protein 0.0061 0.0144 0.0135
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.003 0.0035 0.0026
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0464 0.1001
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus granulosus hyperpolarization activated cyclic 0.0091 0.0248 0.0239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0009 0.0614
Loa Loa (eye worm) aminopeptidase N 0.0153 0.0464 0.046
Echinococcus granulosus voltage gated hydrogen channel 1 0.003 0.0035 0.0026
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0029 0.055
Trichomonas vaginalis adenylate cyclase type, putative 0.0042 0.0077 0.048
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0091 0.0248 0.0239
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.0455
Echinococcus multilocularis TRP (transient receptor potential) channel 0.003 0.0035 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0197 0.0188
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0061 0.0142 0.0133
Echinococcus granulosus potassium voltage gated channel subfamily H 0.046 0.1538 0.1531
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0035 0.0579
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.055
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0153 0.0464 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.003 0.0035 0.0026
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0197 0.0193
Trypanosoma cruzi Flagellar Member 6 0.0061 0.0142 0.2919
Brugia malayi olfactory channel protein osm-9 0.003 0.0035 0.0058
Trypanosoma brucei Aminopeptidase M1, putative 0.0153 0.0464 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.003 0.0035 0.0026
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0042 0.0077 0.048
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0061 0.0142 0.0133
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0145 0.0954
Trichomonas vaginalis adenylate cyclase, putative 0.0042 0.0077 0.048
Mycobacterium ulcerans hypothetical protein 0.0061 0.0142 0.299
Loa Loa (eye worm) hypothetical protein 0.0153 0.0464 0.046
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0464 1
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0464 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0142 0.0934
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0142 0.0934
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0153 0.0464 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0133 0.0395 0.0387
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.003 0.0035 0.0026
Brugia malayi TATA binding protein associated factor 0.0153 0.0464 0.1001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0029 0.055
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0035 0.0026
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0061 0.0142 0.0138
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.003 0.0035 0.0026
Echinococcus granulosus shaker cognate 0.003 0.0035 0.0026
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0035 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0081 0.0073
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Brugia malayi voltage-dependent calcium channel 0.003 0.0035 0.0058
Echinococcus multilocularis two pore calcium channel protein 1 0.003 0.0035 0.0026
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.003 0.0035 0.0058
Echinococcus granulosus tar DNA binding protein 0.0076 0.0197 0.0188
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.003 0.0035 0.0026
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.01
Echinococcus granulosus aminopeptidase N 0.0153 0.0464 0.0456
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.048
Echinococcus multilocularis short transient receptor potential channel 6 0.003 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0153 0.0464 0.046
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0197 0.0188
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0061 0.0142 0.2919
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0009 0.01
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0009 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0145 0.2982
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.046 0.1538 0.336
Echinococcus multilocularis voltage dependent calcium channel 0.003 0.0035 0.0026
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0091 0.0248 0.0239
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0035 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0395 0.0387
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0035 0.0026
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.003 0.0035 0.0579
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.003 0.0035 0.0579
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Trichomonas vaginalis adenylate cyclase type III, putative 0.0042 0.0077 0.048
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0035 0.0026
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.003 0.0035 0.0026
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Schistosoma mansoni transient receptor potential channel 0.003 0.0035 0.0026
Treponema pallidum catabolite gene activator (Crp) 0.0061 0.0142 1
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0042 0.0077 0.048
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0145 0.0954
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0042 0.0077 0.048
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0145 0.0954
Echinococcus granulosus TRP transient receptor potential channel 0.003 0.0035 0.0026
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0142 0.0133
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0153 0.0464 1
Brugia malayi hypothetical protein 0.0153 0.0464 0.1001
Trichomonas vaginalis guanylate cyclase, putative 0.0042 0.0077 0.048
Echinococcus granulosus voltage dependent calcium channel 0.003 0.0035 0.0026
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.003 0.0035 0.0026
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0091 0.0248 0.0239
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0029 0.055
Brugia malayi hypothetical protein 0.0043 0.0081 0.0159
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0009 0.0005
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0042 0.0077 0.048
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0061 0.0142 0.299
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0061 0.0142 0.2919
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0091 0.0248 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0145 0.0954
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0035 0.0026
Schistosoma mansoni transient receptor potential channel 0.003 0.0035 0.0026
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.003 0.0035 0.0579
Echinococcus granulosus potassium large conductance calcium activated 0.003 0.0035 0.0026
Leishmania major protein kinase, putative 0.0061 0.0144 0.2961
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0061 0.0142 0.0133
Trichomonas vaginalis adenylate cyclase type, putative 0.0042 0.0077 0.048
Brugia malayi Cyclic-nucleotide gated cation channel 0.0091 0.0248 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0031
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0026
Echinococcus granulosus potassium voltage gated channel subfamily C 0.003 0.0035 0.0026
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0061 0.0144 0.0135
Leishmania major hypothetical protein, unknown function 0.0061 0.0142 0.2919
Onchocerca volvulus 0.0153 0.0464 1
Loa Loa (eye worm) ryanodine receptor 0.003 0.0035 0.0031
Onchocerca volvulus 0.006 0.0138 0.2502
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.003 0.0035 0.0579
Loa Loa (eye worm) hypothetical protein 0.0061 0.0142 0.0138
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0145 0.2982
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0395 0.0387
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0153 0.0464 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Echinococcus multilocularis voltage gated potassium channel 0.0133 0.0395 0.0387
Trypanosoma cruzi cAMP response protein 1 0.0061 0.0142 0.2919
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0081 0.0073
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.003 0.0035 0.0026
Onchocerca volvulus 0.0153 0.0464 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0091 0.0248 0.0239
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0091 0.0248 0.0239
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.003 0.0035 0.013
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0046
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0145 0.2982
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.003 0.0035 0.0058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0145 0.2982
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0153 0.0464 0.0456
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.003 0.0035 0.0058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.2512 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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