Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1709 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0015 | 0.205 | 0.7641 |
Mycobacterium leprae | putative cytochrome p450 | 0.0015 | 0.205 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.1121 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0015 | 0.205 | 0.7641 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0015 | 0.205 | 0.7641 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1709 |
Loa Loa (eye worm) | cytochrome P450 | 0.0015 | 0.205 | 0.3851 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.5239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2107 | 0.396 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5132 | 0.9794 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.2667 | 0.5 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0015 | 0.205 | 0.7641 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8867 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.1121 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0015 | 0.205 | 0.2266 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0109 | 0.0056 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 0.1969 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.2667 | 0.504 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.2667 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0015 | 0.205 | 0.7641 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.205 | 0.7641 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.2667 | 1 |
Echinococcus multilocularis | 0.0015 | 0.205 | 0.3851 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.5239 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.2667 | 0.2628 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.2667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2214 | 0.4166 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.8369 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.8369 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0015 | 0.205 | 0.7641 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0015 | 0.205 | 0.7641 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.2667 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.2214 | 0.4166 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0015 | 0.205 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0015 | 0.205 | 0.7641 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.5239 | 1 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.205 | 0.3851 |
Onchocerca volvulus | 0.0028 | 0.4393 | 0.8369 | |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0015 | 0.205 | 0.7641 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.2667 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.2667 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0015 | 0.205 | 0.7641 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.1709 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0015 | 0.205 | 0.7641 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0015 | 0.205 | 0.7641 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.5239 | 0.5214 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0015 | 0.205 | 0.7641 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1671 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.2667 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0015 | 0.205 | 0.7641 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.2667 | 0.504 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4393 | 0.4363 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.205 | 0.7641 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.1121 |
Brugia malayi | cytochrome P450 | 0.0015 | 0.205 | 0.3851 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0015 | 0.205 | 0.7641 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.4678 | 0.8918 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.2667 | 0.504 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4678 | 0.465 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0015 | 0.205 | 0.7641 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.205 | 0.7641 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5239 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0015 | 0.205 | 0.7641 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0015 | 0.205 | 0.3851 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0015 | 0.205 | 0.7641 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.1121 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.4678 | 0.8918 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0015 | 0.205 | 0.7641 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0584 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.5239 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.5239 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.5239 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.5239 | 0.5214 |
Onchocerca volvulus | 0.0033 | 0.5239 | 1 | |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2107 | 0.396 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0015 | 0.205 | 0.7641 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.2667 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.2524 | 0.4765 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.2524 | 0.4765 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0015 | 0.205 | 0.7641 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0015 | 0.205 | 0.7641 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.2667 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.205 | 0.7641 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0015 | 0.205 | 0.7641 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4678 | 0.465 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.2667 | 0.504 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.2667 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0015 | 0.205 | 0.7641 |
Onchocerca volvulus | 0.0033 | 0.5239 | 1 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Echinococcus multilocularis | lamin | 0.0033 | 0.5239 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.205 | 0.7641 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Echinococcus multilocularis | musashi | 0.0033 | 0.5239 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0015 | 0.205 | 0.2008 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.205 | 0.3851 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.2667 | 0.2628 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.5239 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.2667 | 0.2966 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.205 | 0.2008 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.5239 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.2214 | 0.4166 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.2667 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.5239 | 0.5214 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.205 | 0.7641 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.2667 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0015 | 0.205 | 0.7641 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.