Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0602 | 1 | 1 |
Onchocerca volvulus | 0.0602 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0602 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | 0.0602 | 1 | 1 | |
Onchocerca volvulus | 0.0602 | 1 | 1 | |
Echinococcus granulosus | peroxidasin | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0602 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0195 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0602 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0602 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0195 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0602 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0602 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0602 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0602 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0602 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0602 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 12 nM | 50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes | ChEMBL. | 2585443 |
IC50 (binding) | = 12 nM | 50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes | ChEMBL. | 2585443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.