Detailed information for compound 1410993

Basic information

Technical information
  • TDR Targets ID: 1410993
  • Name: 3'-Methylthio-4',5',6',7'-tetrahydrospiro(1,3 -dithiane-2,4'-benzo[c]thiophene)-1-carboxhyd razide
  • MW: 332.528 | Formula: C12H16N2OS4
  • H donors: 2 H acceptors: 1 LogP: 2.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)c1sc(c2c1CCCC12SCCS1)SC
  • InChi: 1S/C12H16N2OS4/c1-16-11-8-7(9(19-11)10(15)14-13)3-2-4-12(8)17-5-6-18-12/h2-6,13H2,1H3,(H,14,15)
  • InChiKey: QZWYADYTGKLZQS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000860713
  • SMR000459497
  • Maybridge4_002182
  • ZINC04351386

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0059 0.0084 0.0084
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0099 0.0305 1
Echinococcus multilocularis voltage gated potassium channel 0.0086 0.0234 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0064 0.0064
Echinococcus multilocularis hyperpolarization activated cyclic 0.0059 0.0084 0.0084
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0059 0.0084 0.0084
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0305 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0086 0.0234 0.0234
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0059 0.0084 0.0084
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0099 0.0305 0.5
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0099 0.0305 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0064 0.0064
Brugia malayi hypothetical protein 0.0099 0.0305 0.0682
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0163 0.0163
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Brugia malayi hypothetical protein 0.0858 0.4468 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0305 0.0305
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0298 0.1396 0.1396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0163 0.5343
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0234 0.0234
Trypanosoma brucei Aminopeptidase M1, putative 0.0099 0.0305 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0059 0.0084 0.0084
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0305 0.0682
Loa Loa (eye worm) hypothetical protein 0.0099 0.0305 0.0305
Echinococcus granulosus hyperpolarization activated cyclic 0.0059 0.0084 0.0084
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0305 0.0682
Loa Loa (eye worm) hypothetical protein 0.0099 0.0305 0.0305
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0298 0.1396 0.3125
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0163 0.0163
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0099 0.0305 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0064 0.0064
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0305 0.2363
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0099 0.0305 0.0305
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0084 0.0084
Loa Loa (eye worm) aminopeptidase N 0.0099 0.0305 0.0305
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0099 0.0305 0.0305
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0099 0.0305 1
Echinococcus multilocularis aminopeptidase N 0.0099 0.0305 0.0305
Trypanosoma cruzi aminopeptidase, putative 0.0099 0.0305 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0298 0.1396 0.1396
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0099 0.0305 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0086 0.0234 0.0234
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0059 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0259 0.118 0.118
Toxoplasma gondii aminopeptidase n, putative 0.0099 0.0305 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1867 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0163 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0305 0.2363
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0099 0.0305 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0298 0.1396 0.1396
Onchocerca volvulus 0.0114 0.0385 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.084 0.084
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0163 0.0163
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0305 1
Brugia malayi TATA binding protein associated factor 0.0099 0.0305 0.0682
Loa Loa (eye worm) TATA binding protein associated factor 0.0099 0.0305 0.0305
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.084 0.084
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0059 0.0084 0.0084
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0084 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0064 0.0064
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0099 0.0305 0.0305
Schistosoma mansoni aminopeptidase A (M01 family) 0.0099 0.0305 0.0305
Schistosoma mansoni alpha-glucosidase 0.0169 0.0689 0.0689
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0059 0.0084 0.0084
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0064 0.0064
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1867 1 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.0689 0.0689
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Brugia malayi Cyclic-nucleotide gated cation channel 0.0059 0.0084 0.0188
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0305 0.2363
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0059 0.0084 0.0084
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0059 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0059 0.0084 0.0084
Loa Loa (eye worm) peptidase family M1 containing protein 0.0099 0.0305 0.0305
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0086 0.0234 0.0525
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0305 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0059 0.0084 0.0084
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0305 0.0682
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0099 0.0305 0.5
Toxoplasma gondii aminopeptidase N protein 0.0099 0.0305 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0059 0.0084 0.0653
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0084 0.0084
Toxoplasma gondii aminopeptidase N, putative 0.0099 0.0305 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0064 0.0064
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0086 0.0234 0.0234
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0099 0.0305 1
Echinococcus granulosus voltage gated potassium channel 0.0086 0.0234 0.0234
Trypanosoma cruzi Aminopeptidase M1, putative 0.0099 0.0305 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0064 0.0142
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0018 0.0018
Schistosoma mansoni 60S ribosomal protein L21 0.0047 0.0018 0.0018
Entamoeba histolytica aminopeptidase, putative 0.0099 0.0305 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0279 0.1289 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0064 0.0064
Mycobacterium ulcerans aminopeptidase N PepN 0.0099 0.0305 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.084 0.084
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Schistosoma mansoni voltage-gated potassium channel 0.0326 0.1546 0.1546
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0059 0.0084 0.0653
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0305 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0099 0.0305 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0163 0.5343
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0084 0.0084
Brugia malayi hypothetical protein 0.0099 0.0305 0.0682
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1867 1 1
Trypanosoma cruzi aminopeptidase, putative 0.0099 0.0305 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0099 0.0305 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.084 0.084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.084 0.1879
Trypanosoma brucei Aminopeptidase M1, putative 0.0099 0.0305 1
Schistosoma mansoni voltage-gated potassium channel 0.0326 0.1546 0.1546
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0234 0.0234
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0099 0.0305 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Echinococcus granulosus aminopeptidase N 0.0099 0.0305 0.0305
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Trypanosoma brucei aminopeptidase, putative 0.0099 0.0305 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0059 0.0084 0.0084
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0279 0.1289 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0305 0.0305
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0059 0.0084 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0163 0.0163
Echinococcus multilocularis hyperpolarization activated cyclic 0.0059 0.0084 0.0084

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.