Detailed information for compound 1411077

Basic information

Technical information
  • TDR Targets ID: 1411077
  • Name: 1-benzyl-4-[1-[1-(2-methoxyethyl)tetrazol-5-y l]pentyl]piperazine hydrochloride
  • MW: 408.969 | Formula: C20H33ClN6O
  • H donors: 0 H acceptors: 3 LogP: 3.16 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(c1nnnn1CCOC)N1CCN(CC1)Cc1ccccc1.Cl
  • InChi: 1S/C20H32N6O.ClH/c1-3-4-10-19(20-21-22-23-26(20)15-16-27-2)25-13-11-24(12-14-25)17-18-8-6-5-7-9-18;/h5-9,19H,3-4,10-17H2,1-2H3;1H
  • InChiKey: SDCCDLUQUDJRKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-benzyl-4-[1-[1-(2-methoxyethyl)-5-tetrazolyl]pentyl]piperazine hydrochloride
  • 1-[1-[1-(2-methoxyethyl)-1,2,3,4-tetrazol-5-yl]pentyl]-4-(phenylmethyl)piperazine hydrochloride
  • MLS000121298
  • SMR000118693
  • 1-Benzyl-4-{1-[1-(2-methoxy-ethyl)-1H-tetrazol-5-yl]-pentyl}-piperazine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tailless protein 0.0262 0.1767 0.0608
Brugia malayi nuclear receptor NHR-88 0.0556 0.7533 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0294 0.2384 0.075
Schistosoma mansoni RAR-like nuclear receptor 0.0556 0.7533 0.7003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0556 0.7533 0.7003
Echinococcus multilocularis snurportin 1 0.0372 0.391 0.2603
Echinococcus granulosus ecdysone induced protein 78C 0.0556 0.7533 0.7003
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Brugia malayi hypothetical protein 0.0262 0.1767 0.0608
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0439 0.5225 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0556 0.7533 1
Brugia malayi nuclear receptor NHR-67 0.0262 0.1767 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0556 0.7533 1
Brugia malayi conserved hypotetical protein 0.0262 0.1767 0.0608
Trypanosoma cruzi glutamine synthetase, putative 0.0682 1 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0262 0.1767 0.0608
Echinococcus multilocularis glutamine synthetase 0.0682 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0556 0.7533 0.7003
Brugia malayi Nuclear hormone receptor-like 1 0.0294 0.2384 0.1614
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3541 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 0.2384 0.1071
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0682 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0556 0.7533 1
Toxoplasma gondii glutamine synthetase, type I, putative 0.0439 0.5225 0.5
Schistosoma mansoni thyroid hormone receptor 0.0556 0.7533 0.7003
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0556 0.7533 0.7003
Brugia malayi hypothetical protein 0.0294 0.2384 0.1614
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0556 0.7533 0.7003
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Brugia malayi Nuclear hormone receptor-like 1 0.0556 0.7533 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0556 0.7533 0.7003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0556 0.7533 0.7003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0556 0.7533 0.7003
Brugia malayi ecdysteroid receptor 0.0556 0.7533 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0294 0.2384 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0556 0.7533 0.7003
Brugia malayi ecdysone receptor 0.0262 0.1767 0.0608
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0556 0.7533 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0556 0.7533 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0294 0.2384 0.075
Schistosoma mansoni nuclear hormone receptor 0.0556 0.7533 0.7003
Plasmodium falciparum glutamine synthetase, putative 0.0439 0.5225 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 0.2384 0.1071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0556 0.7533 0.7003
Brugia malayi steroid hormone receptor 0.0556 0.7533 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0556 0.7533 0.7003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0556 0.7533 0.7003
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3541 0.5
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0439 0.5225 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0556 0.7533 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0556 0.7533 0.7003
Plasmodium vivax glutamine synthetase, putative 0.0439 0.5225 0.5
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0556 0.7533 0.7003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0294 0.2384 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0556 0.7533 1
Brugia malayi nuclear hormone receptor 0.0262 0.1767 0.0608
Leishmania major glutamine synthetase, putative 0.0682 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 0.2384 0.1071
Loa Loa (eye worm) steroid hormone receptor 0.0556 0.7533 1
Brugia malayi Nuclear hormone receptor E75 0.0262 0.1767 0.0608
Onchocerca volvulus 0.0556 0.7533 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Brugia malayi hypothetical protein 0.0294 0.2384 0.1614
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 0.2384 0.1071
Brugia malayi nuclear receptor NHR-88 0.0262 0.1767 0.0608
Echinococcus granulosus snurportin 1 0.0372 0.391 0.2603
Trypanosoma brucei glutamine synthetase, putative 0.0682 1 0.5
Schistosoma mansoni thyroid hormone receptor 0.0556 0.7533 0.7003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0294 0.2384 0.075
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0556 0.7533 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0556 0.7533 0.7003
Brugia malayi hypothetical protein 0.0262 0.1767 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0556 0.7533 1
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Brugia malayi nuclear receptor RXR 0.0262 0.1767 0.0608
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0556 0.7533 1
Echinococcus granulosus FTZ F1 alpha 0.0556 0.7533 0.7003
Schistosoma mansoni hypothetical protein 0.0372 0.391 0.2603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0556 0.7533 1
Onchocerca volvulus Bile acid receptor homolog 0.0556 0.7533 1
Brugia malayi nuclear receptor RXR 0.0294 0.2384 0.1614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0556 0.7533 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0556 0.7533 0.7003
Loa Loa (eye worm) Gln-2 protein 0.0439 0.5225 0.5997
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0556 0.7533 0.7003
Mycobacterium ulcerans glutamine synthetase 0.0439 0.5225 1
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0556 0.7533 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0556 0.7533 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0556 0.7533 0.7003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0556 0.7533 0.7003
Brugia malayi orphan nuclear receptor NR2E1 0.0262 0.1767 0.0608
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0556 0.7533 1
Brugia malayi nuclear hormone receptor 0.0556 0.7533 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0556 0.7533 1
Echinococcus multilocularis FTZ F1 alpha 0.0556 0.7533 0.7003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0262 0.1767 0.0608
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0556 0.7533 0.7003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0556 0.7533 0.7003
Brugia malayi Steroid receptor seven-up type 2 0.0556 0.7533 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0556 0.7533 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0556 0.7533 1
Trypanosoma cruzi glutamine synthetase, putative 0.0682 1 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0556 0.7533 0.7003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0556 0.7533 1
Loa Loa (eye worm) hypothetical protein 0.0556 0.7533 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.2384 0.1071
Schistosoma mansoni retinoic acid receptor RXR 0.0556 0.7533 0.7003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0556 0.7533 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3541 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0556 0.7533 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0262 0.1767 0.0608
Onchocerca volvulus Glutamine synthetase homolog 0.0439 0.5225 0.5997
Echinococcus multilocularis ecdysone induced protein 78C 0.0556 0.7533 0.7003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0556 0.7533 1
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0439 0.5225 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0556 0.7533 1
Brugia malayi Nuclear hormone receptor-like 1 0.0294 0.2384 0.1614
Brugia malayi Nuclear hormone receptor E75 0.0262 0.1767 0.0608
Schistosoma mansoni coup transcription factor 0.0556 0.7533 0.7003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.391 0.3717

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.92 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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