Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.1864 | 0.9863 | 0.9862 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.2016 | 0.1998 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0347 | 0.1573 | 0.1554 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0965 | 0.0945 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0165 | 0.0577 | 0.0556 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0876 | 0.4465 | 0.6517 |
Onchocerca volvulus | 0.1541 | 0.8101 | 1 | |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0099 | 0.0212 | 0.0066 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1048 | 0.5401 | 0.789 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0338 | 0.1521 | 0.9452 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0347 | 0.1573 | 0.2274 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0432 | 0.2033 | 0.2016 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0347 | 0.1573 | 0.2274 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0965 | 0.0945 |
Echinococcus granulosus | N chimaerin | 0.0236 | 0.0965 | 0.1383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1051 | 0.5419 | 0.7923 |
Schistosoma mansoni | protein kinase C | 0.0263 | 0.1112 | 0.1625 |
Entamoeba histolytica | hypothetical protein | 0.0236 | 0.0965 | 0.2477 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0965 | 0.0945 |
Entamoeba histolytica | protein kinase, putative | 0.0354 | 0.1607 | 0.4317 |
Brugia malayi | diacylglycerol kinase | 0.0236 | 0.0965 | 0.0841 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0432 | 0.2033 | 0.1941 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0099 | 0.0212 | 0.1079 |
Brugia malayi | Protein kinase c protein 2 | 0.0713 | 0.3571 | 0.3523 |
Echinococcus granulosus | protein kinase C gamma type | 0.0815 | 0.4127 | 0.6021 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0529 | 0.2566 | 0.3731 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0347 | 0.1573 | 0.23 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0347 | 0.1573 | 0.23 |
Brugia malayi | protein kinase C II. | 0.1311 | 0.6839 | 0.6887 |
Brugia malayi | Hr1 repeat family protein | 0.0876 | 0.4465 | 0.4444 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0347 | 0.1573 | 0.2274 |
Brugia malayi | RhoGEF domain containing protein | 0.0236 | 0.0965 | 0.0841 |
Brugia malayi | Protein kinase domain containing protein | 0.0246 | 0.1017 | 0.0894 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1051 | 0.5419 | 0.7916 |
Schistosoma mansoni | rac gtpase activating protein | 0.0236 | 0.0965 | 0.1412 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0236 | 0.0965 | 0.0945 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1311 | 0.6839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1541 | 0.8101 | 0.8097 |
Brugia malayi | C1-like domain containing protein | 0.0432 | 0.2033 | 0.1941 |
Echinococcus granulosus | NDR protein kinase | 0.0347 | 0.1573 | 0.2274 |
Echinococcus granulosus | unc 13 munc13 | 0.0263 | 0.1112 | 0.1598 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0347 | 0.1573 | 0.2274 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0347 | 0.1573 | 0.2274 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0347 | 0.1573 | 0.1554 |
Schistosoma mansoni | protein kinase C mu | 0.0432 | 0.2033 | 0.2973 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0263 | 0.1112 | 0.1598 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.2081 | 0.2063 |
Entamoeba histolytica | protein kinase, putative | 0.0347 | 0.1573 | 0.4219 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0236 | 0.0965 | 0.1383 |
Brugia malayi | Fes/CIP4 homology domain containing protein | 0.0293 | 0.1275 | 0.116 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1311 | 0.6839 | 1 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0236 | 0.0965 | 0.1412 |
Brugia malayi | RhoGAP domain containing protein | 0.0236 | 0.0965 | 0.0841 |
Brugia malayi | Variant SH3 domain containing protein | 0.0236 | 0.0965 | 0.0841 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0605 | 0.2984 | 0.4362 |
Onchocerca volvulus | 0.0422 | 0.1982 | 0.1743 | |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0099 | 0.0212 | 0.5 |
Schistosoma mansoni | vav2 | 0.0243 | 0.1 | 0.1462 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0354 | 0.1607 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0347 | 0.1573 | 0.4219 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0091 | 0.0169 | 0.0021 |
Loa Loa (eye worm) | raf kinase | 0.0236 | 0.0965 | 0.0945 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0246 | 0.1017 | 0.1487 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0236 | 0.0965 | 0.1383 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0236 | 0.0965 | 0.2477 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0347 | 0.1573 | 0.1466 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0263 | 0.1112 | 0.1598 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0236 | 0.0965 | 0.0945 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0347 | 0.1573 | 0.2274 |
Schistosoma mansoni | unc-13 (munc13) | 0.0263 | 0.1112 | 0.1625 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.044 | 0.2081 | 0.302 |
Echinococcus multilocularis | protein kinase c eta type | 0.0236 | 0.0965 | 0.1383 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0236 | 0.0965 | 0.1383 |
Trichomonas vaginalis | AGC family protein kinase | 0.0347 | 0.1573 | 0.9781 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0263 | 0.1112 | 0.1598 |
Echinococcus multilocularis | protein kinase c iota type | 0.0584 | 0.2865 | 0.4169 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.0965 | 0.1412 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1051 | 0.5419 | 0.7923 |
Loa Loa (eye worm) | hypothetical protein | 0.1541 | 0.8101 | 0.8097 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0347 | 0.1573 | 0.1554 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0347 | 0.1573 | 0.1554 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0236 | 0.0965 | 0.1383 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.1982 | 0.1964 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0815 | 0.4127 | 0.6021 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.069 | 0.0669 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0716 | 0.3587 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0246 | 0.1017 | 0.0997 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0185 | 0.0687 | 0.0975 |
Trichomonas vaginalis | AGC family protein kinase | 0.0347 | 0.1573 | 0.9781 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 0.3373 | 0.3358 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1311 | 0.6839 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0185 | 0.0687 | 0.1004 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0236 | 0.0965 | 0.0945 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0605 | 0.2984 | 0.4344 |
Onchocerca volvulus | 0.0263 | 0.1112 | 0.0569 | |
Brugia malayi | Pleckstrin Homology Domain | 0.0243 | 0.1 | 0.0877 |
Loa Loa (eye worm) | thyroid receptor interactor | 0.0293 | 0.1275 | 0.1255 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0099 | 0.0212 | 0.0316 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0236 | 0.0965 | 0.1383 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0354 | 0.1607 | 0.1588 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Toxoplasma gondii | AGC kinase | 0.0347 | 0.1573 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0347 | 0.1573 | 0.1466 |
Onchocerca volvulus | 0.0605 | 0.2984 | 0.3095 | |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0965 | 0.0945 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0236 | 0.0965 | 0.1383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0236 | 0.0965 | 0.1412 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0236 | 0.0965 | 0.1383 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0876 | 0.4465 | 0.4452 |
Echinococcus granulosus | protein kinase c iota type | 0.0584 | 0.2865 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.1541 | 0.8101 | 0.8097 |
Brugia malayi | RhoGAP domain containing protein | 0.0236 | 0.0965 | 0.0841 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1311 | 0.6839 | 0.6832 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.044 | 0.2081 | 0.302 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0185 | 0.0687 | 0.0975 |
Onchocerca volvulus | 0.0596 | 0.2932 | 0.3025 | |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0246 | 0.1017 | 0.1459 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0347 | 0.1573 | 0.1554 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.1112 | 0.1092 |
Brugia malayi | protein kinase C3,putative | 0.0246 | 0.1017 | 0.0894 |
Trichomonas vaginalis | AGC family protein kinase | 0.0354 | 0.1607 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0195 | 0.0742 | 0.0721 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0347 | 0.1573 | 0.2274 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0099 | 0.0212 | 0.1079 |
Schistosoma mansoni | serine/threonine kinase | 0.0347 | 0.1573 | 0.23 |
Loa Loa (eye worm) | hypothetical protein | 0.1778 | 0.9393 | 0.9391 |
Echinococcus granulosus | protein kinase c eta type | 0.0236 | 0.0965 | 0.1383 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.044 | 0.2081 | 0.302 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0099 | 0.0212 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1051 | 0.5419 | 0.7916 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0099 | 0.0212 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1 | 0.0979 |
Schistosoma mansoni | atypical protein kinase C | 0.0584 | 0.2865 | 0.4189 |
Brugia malayi | Protein kinase domain containing protein | 0.0347 | 0.1573 | 0.1466 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0347 | 0.1573 | 0.23 |
Schistosoma mansoni | unc-13 (munc13) | 0.0263 | 0.1112 | 0.1625 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.071 | 0.3553 | 0.5179 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0236 | 0.0965 | 0.2477 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0236 | 0.0965 | 0.1412 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0236 | 0.0965 | 0.1412 |
Brugia malayi | Protein kinase domain containing protein | 0.0354 | 0.1607 | 0.1502 |
Entamoeba histolytica | protein kinase, putative | 0.0354 | 0.1607 | 0.4317 |
Trichomonas vaginalis | AGC family protein kinase | 0.0347 | 0.1573 | 0.9781 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0243 | 0.1 | 0.1434 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0096 | 0.0196 | 0.027 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0236 | 0.0965 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0965 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0965 | 0.0945 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0246 | 0.1017 | 0.1487 |
Echinococcus multilocularis | rho associated protein kinase | 0.0605 | 0.2984 | 0.4344 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0236 | 0.0965 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.069 | 0.0669 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0477 | 0.2279 | 0.2262 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0876 | 0.4465 | 0.6528 |
Brugia malayi | Protein kinase domain containing protein | 0.1864 | 0.9863 | 1 |
Brugia malayi | diacylglycerol kinase | 0.0236 | 0.0965 | 0.0841 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0236 | 0.0965 | 0.0841 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0876 | 0.4465 | 0.6517 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0529 | 0.2566 | 0.3731 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0246 | 0.1017 | 0.1459 |
Onchocerca volvulus | 0.0428 | 0.2016 | 0.179 | |
Schistosoma mansoni | protein kinase C mu | 0.0236 | 0.0965 | 0.1412 |
Echinococcus multilocularis | N chimaerin | 0.0236 | 0.0965 | 0.1383 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0236 | 0.0965 | 0.1383 |
Echinococcus granulosus | myotubularin protein 13 | 0.0243 | 0.1 | 0.1434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.