Detailed information for compound 141150

Basic information

Technical information
  • TDR Targets ID: 141150
  • Name: 3-[[(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy- 3-[[3-[(4-methylpyridin-2-yl)carbamoyl]phenyl ]methyl]-2-oxo-1,3-diazepan-1-yl]methyl]-N-(4 -methylpyridin-2-yl)benzamide
  • MW: 774.905 | Formula: C47H46N6O5
  • H donors: 4 H acceptors: 7 LogP: 6.23 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(C(=O)N([C@@H]1Cc1ccccc1)Cc1cccc(c1)C(=O)Nc1nccc(c1)C)Cc1cccc(c1)C(=O)Nc1nccc(c1)C
  • InChi: 1S/C47H46N6O5/c1-31-19-21-48-41(23-31)50-45(56)37-17-9-15-35(25-37)29-52-39(27-33-11-5-3-6-12-33)43(54)44(55)40(28-34-13-7-4-8-14-34)53(47(52)58)30-36-16-10-18-38(26-36)46(57)51-42-24-32(2)20-22-49-42/h3-26,39-40,43-44,54-55H,27-30H2,1-2H3,(H,48,50,56)(H,49,51,57)/t39-,40-,43+,44+/m1/s1
  • InChiKey: VFYUAUUEVXEJCV-RRHZFJGQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[[(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-3-[[3-[(4-methyl-2-pyridyl)carbamoyl]phenyl]methyl]-2-oxo-1,3-diazepan-1-yl]methyl]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[[(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-3-[[3-[[(4-methyl-2-pyridyl)amino]-oxomethyl]phenyl]methyl]-2-oxo-1,3-diazepan-1-yl]methyl]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[[(4R,5S,6S,7R)-5,6-dihydroxy-3-[[3-[(4-methylpyridin-2-yl)carbamoyl]phenyl]methyl]-2-oxo-4,7-bis(phenylmethyl)-1,3-diazepan-1-yl]methyl]-N-(4-methylpyridin-2-yl)benzamide
  • 3-[[(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-2-keto-3-[3-[(4-methyl-2-pyridyl)carbamoyl]benzyl]-1,3-diazepan-1-yl]methyl]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[[(4R,5S,6S,7R)-5,6-dihydroxy-3-[[3-[(4-methyl-2-pyridyl)carbamoyl]phenyl]methyl]-2-oxo-4,7-bis(phenylmethyl)-1,3-diazepan-1-yl]methyl]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[[(4R,5S,6S,7R)-5,6-dihydroxy-3-[[3-[[(4-methyl-2-pyridyl)amino]-oxomethyl]phenyl]methyl]-2-oxo-4,7-bis(phenylmethyl)-1,3-diazepan-1-yl]methyl]-N-(4-methyl-2-pyridyl)benzamide
  • 3-[[(4R,5S,6S,7R)-4,7-bis(benzyl)-5,6-dihydroxy-2-keto-3-[3-[(4-methyl-2-pyridyl)carbamoyl]benzyl]-1,3-diazepan-1-yl]methyl]-N-(4-methyl-2-pyridyl)benzamide
  • 183854-99-1
  • (4aalpha,5alpha,6beta,7beta)-3,3'-(Tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethy)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene)bis(N-(4-methyl-2-pyridinyl)benzamide)
  • Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-(4-methyl-2-pyridinyl)-
  • (4a.alpha.,5.alpha.,6.beta.,7.beta.)-3,3'-[Tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethy)-1H-1,3-diazepine-1,3(2H)-diyl]bis(methylene)bis[N-(4-methyl-2-pyridinyl)benzamide]
  • AIDS-042919
  • AIDS042919
  • Benzamide, 3,3'-[[(4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl]bis(methylene)]bis[N-(4-methyl-2-pyridinyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0114 0.0196 0.0197
Plasmodium falciparum thioredoxin reductase 0.0055 0.0081 0.5184
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0106 0.0254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0188 0.0339 0.0808
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0046 0.0064 0.0169
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0118 0.5204
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0399 0.0748 0.0779
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0012 0.0174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0057 0.2335
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0049 0.1611
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0003
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0075 0.0164
Brugia malayi nuclear hormone receptor 0.0399 0.0748 0.0779
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0016 0.0384
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0046 0.0064 0.2525
Brugia malayi Nuclear hormone receptor-like 1 0.0399 0.0748 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0035 0.0658
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0188 0.0339 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0019 0.0507
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0075 0.319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0196 0.0355 0.0831
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.001 0.0025
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0089 0.0147 0.5664
Schistosoma mansoni coup transcription factor 0.0399 0.0748 0.1769
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0179
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0055 0.2212
Loa Loa (eye worm) hypothetical protein 0.0049 0.0069 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.004 0.077
Plasmodium vivax vivapain-2 0.0019 0.0012 0.0174
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.0219 1
Echinococcus granulosus nuclear receptor nhr 48 0.0188 0.0339 0.0808
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0012 0.0032
Onchocerca volvulus 0.0117 0.0202 0.0195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0055 0.0131
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.001 0.0023
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0105 0.4613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0543
Loa Loa (eye worm) nuclear hormone receptor 0.0188 0.0339 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0064 0.1241
Loa Loa (eye worm) hypothetical protein 0.0211 0.0383 0.0393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0399 0.0748 0.1769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0541
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0399 0.0748 0.0779
Schistosoma mansoni hypothetical protein 0.0056 0.0083 0.0181
Plasmodium falciparum glutathione reductase 0.0055 0.0081 0.5184
Leishmania major cathepsin L-like protease 0.0074 0.0118 0.5204
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.014 0.0369
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0211 0.0383 0.0898
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0399 0.0748 0.1974
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0089 0.0147 0.0151
Brugia malayi ecdysteroid receptor 0.0399 0.0748 0.0779
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0055 0.0146
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0069 0.0065
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.0219 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0035 0.0658
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0012 0.0029
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0141
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0211 0.0383 0.0898
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0057 0.2335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Echinococcus granulosus neuropeptide s receptor 0.0539 0.1018 0.2426
Onchocerca volvulus 0.0188 0.0339 0.0333
Brugia malayi nuclear hormone receptor family member odr-7 0.0188 0.0339 0.0352
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0064 0.2659
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.001 0.0065
Echinococcus multilocularis cysteine protease 0.0019 0.0012 0.0032
Schistosoma mansoni nuclear receptor nhr-48 0.0188 0.0339 0.0794
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0399 0.0748 0.1782
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0083 0.0085
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0069 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0041 0.0083
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0104 0.0176 0.0405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.218 0.4199 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0217 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0399 0.0748 0.0779
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0188 0.0339 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0134
Onchocerca volvulus 0.0019 0.0012 0.0005
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0075 0.319
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.2092
Schistosoma mansoni thyroid hormone receptor 0.0399 0.0748 0.1769
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.001 0.0023
Trypanosoma brucei trypanothione reductase 0.0055 0.0081 0.3441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Brugia malayi Uncoordinated protein 44 0.0017 0.0007 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0081 0.5184
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0011 0.0115
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0055 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0011 0.0115
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0104 0.0176 0.0465
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0399 0.0748 0.1782
Brugia malayi nuclear receptor NHR-67 0.0188 0.0339 0.0352
Loa Loa (eye worm) hypothetical protein 0.0211 0.0383 0.0393
Schistosoma mansoni inositol monophosphatase 0.0043 0.0057 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0217 0.8837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0399 0.0748 0.0774
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0019 0.0507
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.0219 0.8918
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0219 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0244 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0019 0.0345
Onchocerca volvulus 0.0056 0.0083 0.0076
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0057 0.2226
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0012 0.0006
Echinococcus multilocularis protein dispatched 1 0.0056 0.0083 0.0218
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0003
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.001 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0064 0.1241
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0007 0.0018
Brugia malayi nuclear hormone receptor family member nhr-6 0.0188 0.0339 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0118 0.5204
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.004 0.077
Brugia malayi Nuclear hormone receptor E75 0.0188 0.0339 0.0352
Echinococcus multilocularis FTZ F1 alpha 0.0399 0.0748 0.1974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0061 0.117
Loa Loa (eye worm) hypothetical protein 0.0211 0.0383 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0075 0.3066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0067 0.0144
Brugia malayi hypothetical protein 0.0188 0.0339 0.0352
Loa Loa (eye worm) nuclear receptor NHR-67 0.0188 0.0339 0.0347
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0134
Echinococcus granulosus phd:f box containing protein 0.0018 0.001 0.0023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0064 0.0065
Brugia malayi hypothetical protein 0.0042 0.0055 0.0056
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0049 0.291
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0118 0.5204
Brugia malayi jmjC domain containing protein 0.0018 0.001 0.0009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0057 0.1107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0399 0.0748 0.1769
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0003
Schistosoma mansoni hypothetical protein 0.0042 0.0055 0.0116
Plasmodium vivax glutathione reductase, putative 0.0055 0.0081 0.5184
Loa Loa (eye worm) inositol-1 0.0043 0.0057 0.0053
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0179
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0011 0.014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0244 1
Echinococcus multilocularis neuropeptide s receptor 0.0539 0.1018 0.2687
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0399 0.0748 0.1782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0035 0.0658
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.004 0.2244
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0046 0.0064 0.8258
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0399 0.0748 0.1974
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0011 0.014
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0041 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Loa Loa (eye worm) fibroinase 0.0019 0.0012 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0399 0.0748 0.1769
Plasmodium falciparum glutathione reductase 0.0019 0.0011 0.0115
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0012 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0012 0.0208
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0012 0.0032
Loa Loa (eye worm) ctsf protein 0.0019 0.0012 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0041 0.0083
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0244 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.0219 0.8877
Echinococcus granulosus Ankyrin 0.0017 0.0007 0.0017
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0007 0.0018
Brugia malayi ecdysone receptor 0.0188 0.0339 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Leishmania major cathepsin L-like protease 0.0074 0.0118 0.5204
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0019 0.0678
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0219 0.4299
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.029 0.0692
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0041 0.2324
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0106 0.0238
Echinococcus multilocularis nuclear receptor nhr 48 0.0188 0.0339 0.0896
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0012 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0219 0.4299
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0022 0.066
Brugia malayi jmjC domain containing protein 0.0068 0.0106 0.011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0011 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0034 0.0646
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0211 0.0383 0.0398
Echinococcus granulosus cathepsin l1 0.0019 0.0012 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0399 0.0748 0.0779
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0106 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0399 0.0748 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0055 0.1054
Schistosoma mansoni retinoic acid receptor RXR 0.218 0.4199 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Brugia malayi Death domain containing protein 0.0017 0.0007 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0011 0.014
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.001 0.0003
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0012 0.0013
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0081 0.0192
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0019 0.1202
Onchocerca volvulus 0.0399 0.0748 0.0742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0041 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0399 0.0748 0.0779
Brugia malayi Inositol-1 0.0043 0.0057 0.0058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0075 0.319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0399 0.0748 0.0774
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0188 0.0339 0.0896
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.001 0.0007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0188 0.0339 0.0808
Brugia malayi Thioredoxin reductase 0.0055 0.0081 0.0083
Echinococcus granulosus tumor protein p63 0.0392 0.0733 0.1747
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0046 0.0064 0.0137
Leishmania major trypanothione reductase 0.0055 0.0081 0.3441
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0057 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0399 0.0748 0.0779
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Schistosoma mansoni hypothetical protein 0.0196 0.0355 0.0831
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0399 0.0748 0.1769
Loa Loa (eye worm) phosphofructokinase 0.0126 0.0219 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0055 0.1054
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Schistosoma mansoni DNA helicase recq1 0.0023 0.0019 0.0029
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0019 0.005
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.029 0.0766
Brugia malayi 6-phosphofructokinase 0.0126 0.0219 0.0226
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0219 1
Mycobacterium ulcerans endonuclease IV 0.0089 0.0147 0.6528
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Brugia malayi hypothetical protein 0.0118 0.0202 0.0209
Echinococcus multilocularis phd:f box containing protein 0.0018 0.001 0.0025
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0141
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.004 0.2244
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0141
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0217 0.8837
Echinococcus multilocularis ecdysone induced protein 78C 0.0399 0.0748 0.1974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0134
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.001 0.0025
Toxoplasma gondii endonuclease IV APN 0.0089 0.0147 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0543
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.004 0.2244
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0188 0.0339 0.0333
Onchocerca volvulus 0.0057 0.0085 0.0079
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0008 0.0022
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0019 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0019 0.0678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0075 0.1463
Brugia malayi tailless protein 0.0188 0.0339 0.0352
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0211 0.0383 0.0393
Echinococcus multilocularis ubiquitin specific protease 41 0.0046 0.0064 0.0169
Loa Loa (eye worm) glutathione reductase 0.0055 0.0081 0.0077
Echinococcus granulosus expressed conserved protein 0.0107 0.0182 0.0434
Schistosoma mansoni phd/f-box containing protein 0.0018 0.001 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0041 0.0109
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.004 0.1373
Loa Loa (eye worm) RecQ helicase 0.0023 0.0019 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Brugia malayi Protein kinase domain containing protein 0.0017 0.0007 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0399 0.0748 0.0779
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0217 0.8837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0179
Schistosoma mansoni nuclear receptor 0.0188 0.0339 0.0794
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0399 0.0748 0.0774
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0008 0.0004
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0106 0.0104
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0055 0.2212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0019 0.005
Echinococcus multilocularis geminin 0.0196 0.0355 0.0937
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0019 0.0345
Schistosoma mansoni nuclear receptor 0.0188 0.0339 0.0794
Schistosoma mansoni DNA helicase recq5 0.0023 0.0019 0.0029
Brugia malayi phosphofructokinase 0.0126 0.0219 0.0226
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0012 0.0174
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0069 0.0165
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0075 0.3066
Onchocerca volvulus Protein ultraspiracle homolog 0.0399 0.0748 0.0742
Onchocerca volvulus 0.0019 0.0012 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0012 0.0011
Mycobacterium ulcerans epimerase 0.0023 0.002 0.0409
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.0219 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0011 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0069 0.1343
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0019 0.0018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0106 0.0281
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.001 0.0065
Echinococcus multilocularis protein patched 0.0049 0.0069 0.0183
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.004 0.2244
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.014 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.004 0.2244
Schistosoma mansoni inositol monophosphatase 0.0043 0.0057 0.0121
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.004 0.2244
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0011
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.004 0.2244
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0075 0.319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0399 0.0748 0.0774
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0217 0.8793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0399 0.0748 0.0774
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0188 0.0339 0.0794
Onchocerca volvulus 0.0019 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0117 0.0202 0.0204
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.0442 0.0454
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0011 0.014
Brugia malayi nuclear hormone receptor 0.4963 0.9591 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0055 0.1054
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0019 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0011 0.0115
Brugia malayi jmjC domain containing protein 0.0018 0.001 0.0009
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.004 0.077
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0057 0.2335
Loa Loa (eye worm) steroid hormone receptor 0.0399 0.0748 0.0774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0055 0.1054
Brugia malayi steroid hormone receptor 0.0399 0.0748 0.0779
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.001 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0399 0.0748 0.0774
Echinococcus granulosus ecdysone induced protein 78C 0.0399 0.0748 0.1782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0081 0.3441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0029 0.0543
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.0506 0.1334
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0188 0.0339 0.0896
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0089 0.0147 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0188 0.0339 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0134
Echinococcus multilocularis expressed conserved protein 0.0107 0.0182 0.0481
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0211 0.0383 0.0913
Toxoplasma gondii cathepsin CPL 0.0019 0.0012 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0399 0.0748 0.1769
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0219 0.0221
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0179
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Schistosoma mansoni steroid hormone receptor ad4bp 0.0399 0.0748 0.1769
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0075 0.0072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0012 0.0032
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.002 0.0013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0011 0.0115
Echinococcus granulosus neuropeptide receptor A26 0.0539 0.1018 0.2426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.004 0.0761
Brugia malayi Pre-SET motif family protein 0.0035 0.0041 0.0042
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0399 0.0748 0.1769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0055 0.1054
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0219 1
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0081 0.0077
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0019 0.0018
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0075 0.0199
Brugia malayi M-phase phosphoprotein, mpp8 0.0117 0.0202 0.0209
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0014
Mycobacterium ulcerans hypothetical protein 0.0023 0.002 0.0409
Brugia malayi nuclear receptor NHR-88 0.0188 0.0339 0.0352
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0057 0.3486
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0019 0.0678
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0399 0.0748 0.1974
Onchocerca volvulus 0.0117 0.0202 0.0195
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Echinococcus multilocularis Ankyrin 0.0017 0.0007 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0399 0.0748 0.1769
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0012 0.0005
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0211 0.0383 0.1011
Brugia malayi jmjC domain containing protein 0.0018 0.001 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0033 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0399 0.0748 0.0779
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0244 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.004 0.077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0399 0.0748 0.0779
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.004 0.077
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0106 0.0254
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.0506 0.1204
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0057 0.1107
Brugia malayi CHE-14 protein 0.0049 0.0069 0.0071
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0118 0.5204
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0046 0.0064 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.2092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0085 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0106 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0008 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0011 0.0115
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0012 0.0013
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0141
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0089 0.0147 1
Brugia malayi jmjC domain containing protein 0.0018 0.001 0.0009
Brugia malayi nuclear receptor NHR-88 0.0399 0.0748 0.0779
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0219 0.4299
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.2092
Onchocerca volvulus 0.0019 0.0012 0.0005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0057 0.1107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0399 0.0748 0.1974
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0069 0.0165
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0064 0.2659
Plasmodium vivax SET domain protein, putative 0.0035 0.0041 0.2324
Plasmodium vivax vivapain-2 0.0019 0.0012 0.0174
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0075 0.0077
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0057 0.0137
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0011 0.014
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0011 0.014
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0057 0.0151
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0011 0.014
Brugia malayi hypothetical protein 0.0274 0.0506 0.0526
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0196 0.0466
Schistosoma mansoni protein phosphatase 2C 0.0018 0.001 0.0007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0012 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0399 0.0748 0.1782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0019 0.0345
Mycobacterium tuberculosis Probable reductase 0.0125 0.0217 0.8837
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Echinococcus granulosus Nuclear hormone receptor HR96 0.0188 0.0339 0.0808
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0012 0.0179
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0087 0.3746
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0188 0.0339 0.0352
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0399 0.0748 0.0779
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0196 0.8886
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0019 0.0334
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.001 0.0023
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0104 0.0176 0.0405
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0399 0.0748 0.1974
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0057 0.2335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Brugia malayi 6-phosphofructokinase 0.0126 0.0219 0.0226
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0011 0.0193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0399 0.0748 0.0774
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.001 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0042 0.0805
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0196 0.0516
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0011 0.0115
Brugia malayi Nuclear hormone receptor E75 0.0188 0.0339 0.0352
Onchocerca volvulus 0.0275 0.0507 0.05
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0046 0.0064 0.2659
Onchocerca volvulus Bile acid receptor homolog 0.0399 0.0748 0.0742
Loa Loa (eye worm) DR-78 0.0188 0.0339 0.0347
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0075 0.1463
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0199 0.0459
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0019 0.0678
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.2935 0.6986
Brugia malayi glutathione reductase 0.0055 0.0081 0.0083
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0007 0.0001
Echinococcus granulosus death domain containing protein 0.0017 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0211 0.0383 0.0393
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.004 0.4546
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.002 0.0364
Toxoplasma gondii thioredoxin reductase 0.0055 0.0081 0.5184
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0196 0.0202
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0399 0.0748 0.1974
Brugia malayi hypothetical protein 0.0211 0.0383 0.0398
Echinococcus granulosus bloom syndrome protein 0.0023 0.0019 0.0045
Brugia malayi SET domain containing protein 0.0014 0.0002 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0188 0.0339 0.0794
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0011 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0046 0.0064 0.0153
Echinococcus granulosus FTZ F1 alpha 0.0399 0.0748 0.1782
Onchocerca volvulus 0.0019 0.0012 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0081 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0049 0.1294
Schistosoma mansoni nuclear hormone receptor 0.0399 0.0748 0.1769
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0217 0.8837
Brugia malayi conserved hypotetical protein 0.0188 0.0339 0.0352
Loa Loa (eye worm) hypothetical protein 0.0274 0.0506 0.0521
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0075 0.319
Loa Loa (eye worm) hypothetical protein 0.0211 0.0383 0.0393
Onchocerca volvulus 0.0019 0.0012 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0012 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.004 0.077
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0089 0.0147 0.5822
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0007 0.0000000201
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0104 0.0176 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0007 0.0016
Schistosoma mansoni patched 1 0.0049 0.0069 0.0149
Brugia malayi Pre-SET motif family protein 0.0241 0.0442 0.0459
Brugia malayi Cytochrome P450 family protein 0.003 0.0033 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0039 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.0211 0.0383 0.0398
Loa Loa (eye worm) hypothetical protein 0.0057 0.0085 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0399 0.0748 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0049 0.095
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0399 0.0748 0.1782
Loa Loa (eye worm) hypothetical protein 0.006 0.0091 0.0088
Trichomonas vaginalis set domain proteins, putative 0.0275 0.0506 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0012 0.0029
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0019 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0018 0.001 0.0007
Brugia malayi jmjC domain containing protein 0.0068 0.0106 0.011
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.004 0.1406
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0064 0.2659
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.2092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0064 0.1241
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0008 0.0134
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0007 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0188 0.0339 0.0794
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0081 0.2985
Echinococcus multilocularis tumor protein p63 0.0392 0.0733 0.1935
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0399 0.0748 0.1782
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0513 0.1207
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.001 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0012 0.0208
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0089 0.0147 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0034 0.0646
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.014
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0011 0.0193
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0219 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0012 0.0032
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0046 0.0064 0.0169
Loa Loa (eye worm) hypothetical protein 0.4774 0.9226 0.9619
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.0219 0.0521
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0008 0.0002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.004 0.2154
Brugia malayi hypothetical protein 0.0211 0.0383 0.0398
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0219 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0075 0.1463
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0011 0.001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.004 0.2154
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1969 0.379 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0219 0.0221
Schistosoma mansoni RAR-like nuclear receptor 0.0399 0.0748 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0399 0.0748 0.0779
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.0219 1
Onchocerca volvulus 0.0188 0.0339 0.0333
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.002 0.0019
Echinococcus multilocularis neuropeptide receptor A26 0.0539 0.1018 0.2687
Echinococcus multilocularis thyroid hormone receptor alpha 0.0399 0.0748 0.1974
Onchocerca volvulus 0.0019 0.0012 0.0005
Brugia malayi nuclear receptor RXR 0.0188 0.0339 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Schistosoma mansoni zinc finger protein 0.0188 0.0339 0.0794
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0019 0.0507
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0019 0.005
Brugia malayi nuclear receptor RXR 0.0211 0.0383 0.0398
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0057 0.2196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0075 0.319
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0188 0.0339 0.0333
Echinococcus granulosus geminin 0.0196 0.0355 0.0846
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0019 0.0018
Plasmodium falciparum thioredoxin reductase 0.0019 0.0011 0.0115
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.001 0.0023
Leishmania major cathepsin L-like protease 0.0074 0.0118 0.5204
Echinococcus granulosus ubiquitin specific protease 41 0.0046 0.0064 0.0153
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0046 0.0064 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Loa Loa (eye worm) cysteine protease 0.0019 0.0012 0.0006
Loa Loa (eye worm) nuclear receptor nhr-7B 0.4963 0.9591 1
Brugia malayi orphan nuclear receptor NR2E1 0.0188 0.0339 0.0352
Loa Loa (eye worm) hypothetical protein 0.0118 0.0202 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.004 0.077
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0188 0.0339 0.0808
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0075 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0118 0.5204
Onchocerca volvulus 0.0048 0.0067 0.006
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0219 0.0505
Giardia lamblia GTOR 0.0052 0.0075 1
Echinococcus multilocularis cysteine protease 0.0019 0.0012 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0399 0.0748 0.0779
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0219 1
Brugia malayi hypothetical protein 0.0188 0.0339 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0012 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0219 0.4299
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0012 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0012 0.0208
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0106 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0399 0.0748 0.0779
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0036
Chlamydia trachomatis endonuclease IV 0.0089 0.0147 1
Schistosoma mansoni survival motor neuron protein 0.0056 0.0083 0.0181
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0055 0.2212
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0041 0.0109
Loa Loa (eye worm) hypothetical protein 0.0399 0.0748 0.0774
Loa Loa (eye worm) hypothetical protein 0.0188 0.0339 0.0347
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.002 0.0409
Echinococcus granulosus thyroid hormone receptor alpha 0.0188 0.0339 0.0808
Leishmania major hypothetical protein, conserved 0.0018 0.001 0.0065

Activities

Activity type Activity value Assay description Source Reference
clogP = 7.7 Calculated partition coefficient (clogP) ChEMBL. 8863807
IC90 (functional) = 7.7 nM The concentration required to inhibit HIV-1 RNA synthesis by 90%. Viral RNA quantified by a sandwich hybridisation assay ChEMBL. 8863807
Ki (binding) = 0.027 nM Inhibition of HIV-1 protease ChEMBL. 9925730
Ki (binding) = 0.027 nM Inhibitory activity against HIV-1 protease ChEMBL. 8863807
Ki (binding) = 0.027 nM Inhibition of HIV-1 protease ChEMBL. 9925730
Ki (binding) = 0.027 nM Inhibitory activity against HIV-1 protease ChEMBL. 8863807
Ki (binding) = 0.03 nM Binding affinity for HIV-1 protease ChEMBL. 8863807
Ki (binding) = 0.03 nM Binding affinity for HIV-1 protease ChEMBL. 8863807

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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