Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0606 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0606 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0606 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0606 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0428 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | fibroinase | 0.0606 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0409 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0409 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0428 | 0.3846 | 0.3846 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0409 | 0.3182 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0428 | 0.3846 | 0.3846 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0428 | 0.3846 | 0.3846 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0428 | 0.3846 | 0.3846 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0606 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0409 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0409 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0606 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0409 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0606 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0606 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0409 | 0.3182 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0409 | 0.3182 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.3846 | 0.0974 |
Toxoplasma gondii | cathepsin CPL | 0.0606 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0428 | 0.3846 | 0.3846 |
Brugia malayi | Cathepsin L-like precursor | 0.0409 | 0.3182 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Loa Loa (eye worm) | cysteine protease | 0.0606 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0606 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0606 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0428 | 0.3846 | 0.3846 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0606 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0428 | 0.3846 | 0.3846 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0409 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0606 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0428 | 0.3846 | 0.3846 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0428 | 0.3846 | 0.3846 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0606 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0606 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.