Detailed information for compound 1412148

Basic information

Technical information
  • TDR Targets ID: 1412148
  • Name: (4S,6S)-4-(4-fluorophenyl)-6-(4-hydroxybutoxy )-5,6-dihydro-4H-pyran-2-carboxylic acid
  • MW: 310.317 | Formula: C16H19FO5
  • H donors: 2 H acceptors: 3 LogP: 2.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCCO[C@@H]1C[C@@H](C=C(O1)C(=O)O)c1ccc(cc1)F
  • InChi: 1S/C16H19FO5/c17-13-5-3-11(4-6-13)12-9-14(16(19)20)22-15(10-12)21-8-2-1-7-18/h3-6,9,12,15,18H,1-2,7-8,10H2,(H,19,20)/t12-,15+/m1/s1
  • InChiKey: NJPABYQXFFFBJI-DOMZBBRYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000849495
  • SMR000451214

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0914 0.1452
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.099 0.099
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3407 0.3263
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0456 0.046
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0102 0.0163
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0456 0.0724
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0456 0.0456
Brugia malayi latrophilin 2 splice variant baaae 0.0245 0.4876 0.4876
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0097 0.1744 0.1744
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Echinococcus granulosus lamin 0.0026 0.026 0.0414
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0017 0.006 0.0095
Brugia malayi TAR-binding protein 0.0313 0.6296 0.6296
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0256 0.1468
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0359 0.7268 0.7268
Schistosoma mansoni lamin 0.0026 0.026 0.0414
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.0795
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.3041 0.4829
Brugia malayi nuclear receptor RXR 0.0017 0.006 0.006
Brugia malayi MH1 domain containing protein 0.0033 0.0408 0.0408
Echinococcus granulosus sodium and chloride dependent glycine 0.0052 0.0795 0.1262
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Echinococcus multilocularis Smad4 0.0033 0.0408 0.0648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.006 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0102 0.0163
Echinococcus multilocularis isocitrate dehydrogenase 0.0097 0.1744 0.2769
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0497 0.0035
Onchocerca volvulus 0.0249 0.4952 0.5214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2668
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.006 0.0095
Onchocerca volvulus 0.0036 0.0456 0.046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0456 0.0456
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0052 0.0795 0.1262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0456 0.0456
Brugia malayi steroid hormone receptor 0.0036 0.0456 0.0456
Leishmania major hypothetical protein, conserved 0.0026 0.0256 0.1468
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0616 0.0979
Loa Loa (eye worm) hypothetical protein 0.0304 0.6115 0.6115
Schistosoma mansoni tar DNA-binding protein 0.0313 0.6296 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0547 0.0547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.006 0.0095
Schistosoma mansoni sodium/chloride dependent transporter 0.0304 0.6115 0.9713
Brugia malayi Isocitrate dehydrogenase 0.0097 0.1744 0.1744
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3407 0.3263
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0408 0.0648
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0938 0.149
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0753 0.0319
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.8292 0.8292
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0456 0.0456
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0456 0.0724
Brugia malayi nuclear receptor NHR-88 0.0017 0.006 0.006
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0456 0.046
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5058 0.5095
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0753 0.1196
Echinococcus granulosus jun protein 0.0083 0.1447 0.2298
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0697 0.0697
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.006 0.0095
Echinococcus granulosus smad 0.0033 0.0408 0.0648
Echinococcus granulosus intermediate filament protein 0.0026 0.026 0.0414
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.1447 0.2298
Echinococcus multilocularis tar DNA binding protein 0.0313 0.6296 1
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0029 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0456 0.0456
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0456 0.0724
Schistosoma mansoni hypothetical protein 0.0047 0.0697 0.1107
Toxoplasma gondii hypothetical protein 0.0052 0.0795 0.4557
Brugia malayi Nuclear hormone receptor E75 0.0017 0.006 0.006
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0029 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0456 0.0456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0938 0.149
Schistosoma mansoni Smad4 0.0033 0.0408 0.0648
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0256 0.1325
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0009 0.0014
Toxoplasma gondii hypothetical protein 0.0052 0.0795 0.4557
Schistosoma mansoni nuclear hormone receptor 0.0017 0.006 0.0095
Schistosoma mansoni hypothetical protein 0.0123 0.2292 0.364
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0465 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0249 0.4952 0.4952
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0009 0.0014
Brugia malayi Latrophilin receptor protein 2 0.0114 0.2099 0.2099
Loa Loa (eye worm) intermediate filament protein 0.0026 0.026 0.026
Treponema pallidum sodium- and chloride- dependent transporter 0.0304 0.6115 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0456 0.0724
Brugia malayi jmjC domain containing protein 0.0015 0.0029 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0456 0.0724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0753 0.0753
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0408 0.0408
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0456 0.0724
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0914 0.1452
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0097 0.1744 0.2769
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0456 0.0456
Onchocerca volvulus 0.0052 0.0795 0.0819
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.2099 0.2099
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0938 0.149
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0009 0.0014
Plasmodium vivax amine transporter, putative 0.0052 0.0795 0.4466
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Schistosoma mansoni tar DNA-binding protein 0.0313 0.6296 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0489 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.1447 0.2298
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.006 0.0095
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0408 0.0408
Schistosoma mansoni nuclear receptor 0.0017 0.006 0.0095
Schistosoma mansoni single-minded 0.0048 0.0715 0.1135
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.006 0.0095
Schistosoma mansoni smad1 5 8 and 0.0033 0.0408 0.0648
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Echinococcus multilocularis lamin dm0 0.0026 0.026 0.0414
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.2099 0.2099
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0795 0.1262
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0029 0.0046
Schistosoma mansoni Smad4 0.0015 0.002 0.0032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0456 0.0724
Brugia malayi Cytochrome P450 family protein 0.0033 0.0395 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0313 0.6296 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.1207 0.1207
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0456 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0456 0.0456
Plasmodium vivax SET domain protein, putative 0.0058 0.0938 0.5303
Loa Loa (eye worm) nuclear factor I 0.0018 0.0095 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0456 0.0456
Schistosoma mansoni gabp alpha 0.0071 0.1207 0.1917
Leishmania major hypothetical protein, conserved 0.0015 0.0029 0.0165
Loa Loa (eye worm) hypothetical protein 0.023 0.4562 0.4562
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0029 0.0165
Loa Loa (eye worm) serotonin transporter b 0.0304 0.6115 0.6115
Brugia malayi nuclear receptor RXR 0.0019 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0456 0.0456
Schistosoma mansoni inositol monophosphatase 0.0036 0.0465 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0395 0.0395
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0256 0.1468
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0456 0.0724
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0914 0.1452
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Onchocerca volvulus 0.0026 0.026 0.0254
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0009 0.0014
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.1207 0.1917
Brugia malayi jmjC domain containing protein 0.0015 0.0029 0.0029
Onchocerca volvulus 0.0017 0.006 0.0042
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0182 0.1041
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5058 0.5095
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0456 0.0724
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0102 0.0102
Brugia malayi jmjC domain containing protein 0.0057 0.0914 0.0914
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0408 0.0648
Loa Loa (eye worm) hypothetical protein 0.0304 0.6115 0.6115
Onchocerca volvulus 0.0065 0.1073 0.1113
Schistosoma mansoni intermediate filament proteins 0.0026 0.026 0.0414
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.002 0.0032
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0097 0.1744 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0938 0.0938
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.4557
Loa Loa (eye worm) hypothetical protein 0.0304 0.6115 0.6115
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Loa Loa (eye worm) hypothetical protein 0.008 0.1399 0.1399
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0456 0.0456
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0753 0.4319
Brugia malayi MH2 domain containing protein 0.0015 0.002 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0182 0.0182
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0753 0.4319
Echinococcus multilocularis smad 0.0033 0.0408 0.0648
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0029 0.0165
Schistosoma mansoni hypothetical protein 0.0114 0.2099 0.3334
Schistosoma mansoni lamin 0.0026 0.026 0.0414
Brugia malayi hypothetical protein 0.0065 0.1073 0.1073
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.006 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0029 0.0029
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0795 0.1262
Schistosoma mansoni smad 0.0015 0.002 0.0032
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.0795
Brugia malayi hypothetical protein 0.0017 0.0061 0.0061
Toxoplasma gondii isocitrate dehydrogenase 0.0097 0.1744 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0029 0.0046
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.006 0.006
Brugia malayi tailless protein 0.0017 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0453 0.0719
Schistosoma mansoni survival motor neuron protein 0.0047 0.0697 0.1107
Brugia malayi nuclear hormone receptor 0.0036 0.0456 0.0456
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0182 0.1041
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.4557
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0456 0.0724
Brugia malayi MH1 domain containing protein 0.0018 0.0095 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0456 0.0456
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0456 0.0456
Onchocerca volvulus 0.0026 0.026 0.0254
Schistosoma mansoni coup transcription factor 0.0036 0.0456 0.0724
Brugia malayi jmjC domain containing protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0893 0.1418
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0547 0.0547
Brugia malayi Cytochrome P450 family protein 0.0023 0.0182 0.0182
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0453 0.9732
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0456 0.0724
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0914 0.1452
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0456 0.0724
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Loa Loa (eye worm) fli-1 protein 0.0216 0.4262 0.4262
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0386 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0097 0.1744 0.2769
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.006 0.0042
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0052 0.0795 0.1262
Brugia malayi Ets-domain containing protein 0.0071 0.1207 0.1207
Brugia malayi hypothetical protein 0.0052 0.0795 0.0795
Brugia malayi hypothetical protein 0.0017 0.006 0.006
Echinococcus granulosus phd:f box containing protein 0.0015 0.0029 0.0046
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0408 0.0648
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0753 0.4319
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.0795
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.006 0.0095
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.006 0.0095
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0256 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0456 0.0456
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0052 0.0795 0.0795
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0753 0.1196
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) norepinephrine transporter 0.0304 0.6115 0.6115
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0009 0.0014
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.006 0.0095
Onchocerca volvulus 0.0052 0.0795 0.0819
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0029 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0313 0.6296 0.6296
Brugia malayi nuclear hormone receptor 0.0017 0.006 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0489 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.006 0.006
Schistosoma mansoni smad1 5 8 and 0.0033 0.0408 0.0648
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.002 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0753 0.0319
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0753 0.0319
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0753 0.4319
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Onchocerca volvulus 0.0464 0.9479 1
Echinococcus multilocularis jun protein 0.0083 0.1447 0.2298
Plasmodium falciparum transporter, putative 0.0052 0.0795 0.4466
Brugia malayi Ets-domain containing protein 0.0071 0.1207 0.1207
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0182 0.1041
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.006 0.0095
Schistosoma mansoni hypothetical protein 0.0114 0.2099 0.3334
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0456 0.0724
Brugia malayi MH1 domain containing protein 0.0033 0.0408 0.0408
Brugia malayi hypothetical protein 0.0019 0.0102 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0456 0.0724
Brugia malayi conserved hypotetical protein 0.0017 0.006 0.006
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.3218 0.338
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2292 0.364
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0456 0.0724
Echinococcus granulosus serotonin transporter 0.0304 0.6115 0.9713
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.2099 0.3334
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0026 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0026 0.026 0.026
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0753 0.1196
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0102 0.0163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0097 0.1744 0.2769
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.002 0.0032
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.0795
Plasmodium falciparum amino acid transporter, putative 0.0052 0.0795 0.4466
Loa Loa (eye worm) inositol-1 0.0036 0.0465 0.0465
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0097 0.1744 0.2769
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0753 0.4319
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0914 0.1452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0456 0.0724
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.002 0.002
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0914 0.1452
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2668
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0029 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Schistosoma mansoni tar DNA-binding protein 0.0313 0.6296 1
Echinococcus multilocularis serotonin transporter 0.0304 0.6115 0.9713
Brugia malayi hypothetical protein 0.016 0.3088 0.3088
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Brugia malayi Inositol-1 0.0036 0.0465 0.0465
Schistosoma mansoni ets-related 0.0216 0.4262 0.6769
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0753 0.4319
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0029 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0456 0.0456
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0456 0.0456
Echinococcus multilocularis lamin 0.0026 0.026 0.0414
Brugia malayi hypothetical protein 0.023 0.4562 0.4562
Brugia malayi MH2 domain containing protein 0.0033 0.0408 0.0408
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2292 0.364
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0456 0.0724
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.006 0.0095
Loa Loa (eye worm) hypothetical protein 0.0114 0.2099 0.2099
Brugia malayi Calcitonin receptor-like protein seb-1 0.0359 0.7268 0.7268
Leishmania major cytochrome p450-like protein 0.0023 0.0182 0.1041
Brugia malayi MAP kinase sur-1 0.005 0.0753 0.0753
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0456 0.0456
Schistosoma mansoni nuclear receptor 0.0017 0.006 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0456 0.0724
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0456 0.0724
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0029 0.0029
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0408 0.0648
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0465 0.0739
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0456 0.0724
Brugia malayi Pre-SET motif family protein 0.0058 0.0938 0.0938
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.2099 0.3334
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0456 0.0724
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5058 0.5095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0456 0.0456
Brugia malayi hypothetical protein 0.0026 0.0256 0.0256
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0465 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0547 0.0868
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0386 0.2212
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0097 0.1744 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0753 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.4562 0.7246
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0029 0.0165
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0029 0.0046
Schistosoma mansoni smad1 5 8 and 0.0033 0.0408 0.0648
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0052 0.0795 0.5
Brugia malayi hypoxia-induced factor 1 0.0148 0.2826 0.2826
Echinococcus granulosus lamin dm0 0.0026 0.026 0.0414
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0938 0.5381
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.3624 0.381
Onchocerca volvulus 0.0304 0.6115 0.6444
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0256 0.1468
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0456 0.0456
Brugia malayi nuclear receptor NHR-88 0.0036 0.0456 0.0456
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0102 0.0163
Brugia malayi intermediate filament protein 0.0026 0.026 0.026
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0052 0.0795 0.1262
Schistosoma mansoni zinc finger protein 0.0017 0.006 0.0095
Brugia malayi RNA recognition motif domain containing protein 0.0313 0.6296 0.6296
Schistosoma mansoni thyroid hormone receptor 0.0158 0.3041 0.4829
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Schistosoma mansoni smad 0.0033 0.0408 0.0648
Schistosoma mansoni thyroid hormone receptor 0.0158 0.3041 0.4829
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.006 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0364 0.0364
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0456 0.0724
Brugia malayi nuclear receptor NHR-67 0.0017 0.006 0.006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0465 0.2668
Brugia malayi MH2 domain containing protein 0.0033 0.0408 0.0408
Brugia malayi PAS domain containing protein 0.0048 0.0715 0.0715
Brugia malayi follicle stimulating hormone receptor 0.0228 0.4506 0.4506
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0304 0.6115 0.9713
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0182 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5058 0.5095
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.006 0.0095
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.006 0.0042
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0029 0.0046
Loa Loa (eye worm) hypothetical protein 0.0186 0.3624 0.3624
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0102 0.0102
Loa Loa (eye worm) DR-78 0.0017 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0052 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0029 0.0046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0029
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0547 0.0868
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0029 0.0165
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.006 0.006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0097 0.1744 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2668
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0456 0.0456
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0456 0.0724
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0616 0.0979
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.4506 0.4506
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0456 0.0724
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0456 0.0724
Onchocerca volvulus 0.0058 0.0938 0.0971
Trypanosoma brucei protein kinase, putative 0.005 0.0753 0.4319
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5058 0.5095
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0456 0.0724
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0029 0.0165
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.006 0.006
Brugia malayi MH1 domain containing protein 0.0018 0.0095 0.0095
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.006 0.0095
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0453 0.0453
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0795 0.4466
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0497 0.0035
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.006 0.0095
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.1207 0.1917
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0097 0.1744 1
Schistosoma mansoni hypothetical protein 0.0114 0.2099 0.3334
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5058 0.5095
Schistosoma mansoni hypothetical protein 0.0245 0.4876 0.7744
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2668
Echinococcus multilocularis sodium and chloride dependent glycine 0.0052 0.0795 0.1262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0938 0.149
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.025
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0256 0.1325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0456 0.0724
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0102 0.0102
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0715 0.1135
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.0795
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0052 0.0795 0.1262
Loa Loa (eye worm) hypothetical protein 0.016 0.3088 0.3088
Trichomonas vaginalis set domain proteins, putative 0.0464 0.9479 1
Brugia malayi Nuclear hormone receptor E75 0.0017 0.006 0.006
Brugia malayi ecdysteroid receptor 0.0036 0.0456 0.0456
Brugia malayi hypothetical protein 0.0017 0.006 0.006
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0465 0.0739
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0408 0.0648
Echinococcus granulosus tar DNA binding protein 0.0313 0.6296 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0914 0.0914
Onchocerca volvulus 0.0052 0.0795 0.0819
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0804 0.1277
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0465 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.3218 0.3054
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Loa Loa (eye worm) hypothetical protein 0.0245 0.4876 0.4876
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2826 0.2826
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0938 0.149
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0029 0.0046
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0029 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0313 0.6296 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0052 0.0795 0.1262
Brugia malayi bZIP transcription factor family protein 0.0083 0.1447 0.1447
Leishmania major protein kinase, putative 0.0022 0.0161 0.0921
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.5058 0.5058
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0029 0.0046
Schistosoma mansoni jun-related protein 0.0067 0.1121 0.178
Echinococcus granulosus survival motor neuron protein 1 0.023 0.4562 0.7246
Schistosoma mansoni sodium-dependent amino acid transporter 0.0052 0.0795 0.1262
Loa Loa (eye worm) solute carrier family 6 member 4 0.0304 0.6115 0.6115
Brugia malayi jmjC domain containing protein 0.0015 0.0029 0.0029
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0097 0.1744 1
Onchocerca volvulus 0.0035 0.0453 0.0457
Toxoplasma gondii isocitrate dehydrogenase 0.0097 0.1744 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.002 0.002
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0753 0.1196
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0753 0.4319
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Echinococcus multilocularis GPCR, family 2 0.0114 0.2099 0.3334
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.5058 0.5058
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0456 0.046
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0052 0.0795 0.1262
Echinococcus granulosus sodium and chloride dependent glycine 0.0052 0.0795 0.1262
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0052 0.0795 0.1262
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.002 0.002
Brugia malayi Pre-SET motif family protein 0.0407 0.8292 0.8292
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Brugia malayi Pax transcription factor protein 2 0.0249 0.4952 0.4952
Onchocerca volvulus 0.0047 0.0697 0.0716
Schistosoma mansoni inositol monophosphatase 0.0036 0.0465 0.0739
Schistosoma mansoni hypothetical protein 0.0114 0.2099 0.3334
Echinococcus granulosus single minded 2 0.0039 0.0522 0.0829
Echinococcus granulosus Smad4 0.0033 0.0408 0.0648
Brugia malayi jmjC domain containing protein 0.0057 0.0914 0.0914
Brugia malayi ecdysone receptor 0.0017 0.006 0.006
Echinococcus multilocularis sodium and chloride dependent glycine 0.0052 0.0795 0.1262
Echinococcus granulosus GPCR family 2 0.0114 0.2099 0.3334
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0304 0.6115 0.6115
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0182 0.3903
Brugia malayi Cytochrome P450 family protein 0.0023 0.0182 0.0182
Schistosoma mansoni Smad4 0.0015 0.002 0.0032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0097 0.1744 0.2769
Brugia malayi isocitrate dehydrogenase 0.0097 0.1744 0.1744
Brugia malayi RNA binding protein 0.0313 0.6296 0.6296
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0182 0.0182
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0753 0.4319
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0753 0.0319
Loa Loa (eye worm) hypothetical protein 0.0359 0.7268 0.7268
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0753 0.1196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0914 0.1452
Echinococcus multilocularis musashi 0.0026 0.026 0.0414
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.026 0.026
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.006 0.0095
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0052 0.0795 0.4557
Loa Loa (eye worm) TAR-binding protein 0.0313 0.6296 0.6296
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0456 0.0456
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.2099 0.3334
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0097 0.1744 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.006 0.006
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0097 0.1744 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0938 0.149
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0938 0.149
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0256 0.1468
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0097 0.1744 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.2099 0.3334
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0029 0.0046
Schistosoma mansoni hypothetical protein 0.0067 0.1121 0.178
Loa Loa (eye worm) Smad1 0.0033 0.0408 0.0408
Brugia malayi N-terminal motif family protein 0.0186 0.3624 0.3624
Onchocerca volvulus 0.0017 0.006 0.0042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0359 0.7268 0.7268
Loa Loa (eye worm) RNA binding protein 0.0313 0.6296 0.6296
Brugia malayi Smad1 0.0033 0.0408 0.0408
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0097 0.1744 0.2769
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0009 0.0014
Brugia malayi Fli-1 protein 0.0216 0.4262 0.4262

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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