Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.7738 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2529 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0312 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0312 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0312 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.9842 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.2529 | 0.2569 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2574 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2529 | 0.2985 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0312 | 0.0317 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2529 | 0.2569 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.7738 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0312 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2529 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.6874 | 0.8837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2529 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.6874 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.6874 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0312 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2529 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.6874 | 0.8837 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.9842 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.7738 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0312 | 0.5 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2529 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.9842 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0312 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.