Detailed information for compound 141218

Basic information

Technical information
  • TDR Targets ID: 141218
  • Name: (4R,5S,6S,7R)-4,7-dibenzyl-1,3-bis[(3-fluorop henyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-on e
  • MW: 542.616 | Formula: C33H32F2N2O3
  • H donors: 2 H acceptors: 3 LogP: 5.51 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1cccc(c1)CN1[C@H](Cc2ccccc2)[C@H](O)[C@H]([C@H](N(C1=O)Cc1cccc(c1)F)Cc1ccccc1)O
  • InChi: 1S/C33H32F2N2O3/c34-27-15-7-13-25(17-27)21-36-29(19-23-9-3-1-4-10-23)31(38)32(39)30(20-24-11-5-2-6-12-24)37(33(36)40)22-26-14-8-16-28(35)18-26/h1-18,29-32,38-39H,19-22H2/t29-,30-,31+,32+/m1/s1
  • InChiKey: DORNGHWKRMVHHU-ZRTHHSRSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4R,5S,6S,7R)-1,3-bis[(3-fluorophenyl)methyl]-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-diazepan-2-one
  • (4R,5S,6S,7R)-4,7-dibenzyl-1,3-bis(3-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one
  • (4R,5S,6S,7R)-4,7-bis(benzyl)-1,3-bis(3-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one
  • 153182-42-4
  • AIDS-033354
  • AIDS033354
  • 2H-1,3-Diazepin-2-one, 1,3-bis((3-fluorophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
  • 2H-1,3-Diazepin-2-one, 1,3-bis[(3-fluorophenyl)methyl]hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0049 0.0273 0.8994
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0327 0.0474
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.0083 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0059 0.1767
Brugia malayi Trypsin family protein 0.0041 0.0217 0.0669
Brugia malayi Bromodomain containing protein 0.0031 0.0154 0.0473
Loa Loa (eye worm) hypothetical protein 0.0045 0.0248 0.0764
Echinococcus granulosus microtubule associated protein 2 0.1038 0.6778 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0332 0.0326
Schistosoma mansoni patched 1 0.0032 0.0162 0.0156
Schistosoma mansoni loxhd1 0.001 0.0013 0.0006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0032 0.0162 0.0498
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0332 0.1023
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0052 0.0289 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.0038 0.0198 0.0298
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0077 0.2367
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0206 0.1301 0.1296
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1561 0.2696
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0049 0.0273 0.0459
Loa Loa (eye worm) jmjC domain-containing protein 0.0206 0.1301 0.4017
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0042 0.0053
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0482 0.0702
Leishmania major hypothetical protein, conserved 0.0012 0.0031 0.0822
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0059 0.0094
Brugia malayi nuclear hormone receptor 0.0014 0.0039 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0132 0.0821 0.1136
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0039 0.0033
Brugia malayi CXXC zinc finger family protein 0.0037 0.0194 0.0597
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0015 0.0049 0.0063
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0034 0.0172 0.5185
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0342 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0039 0.0119
Brugia malayi TAR-binding protein 0.0032 0.0157 0.0483
Loa Loa (eye worm) hypothetical protein 0.0031 0.0154 0.0474
Plasmodium falciparum enoyl-acyl carrier reductase 0.0728 0.4737 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0342 0.1054
Echinococcus multilocularis Polycystic kidney disease protein 0.001 0.0013 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0039 0.0033
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0034 0.0172 0.5185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0039 0.0119
Loa Loa (eye worm) hypothetical protein 0.006 0.0342 0.1054
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1329 0.2293
Echinococcus multilocularis phd:f box containing protein 0.0054 0.0303 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0039 0.0119
Loa Loa (eye worm) hypothetical protein 0.037 0.238 0.735
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0017 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1329 0.2293
Echinococcus multilocularis RUN 0.001 0.0013 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.0039 0.0119
Schistosoma mansoni phd/f-box containing protein 0.0054 0.0303 0.0297
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0049 0.0273 0.0577
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Brugia malayi Thioredoxin reductase 0.0048 0.0266 0.0819
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0303 0.0935
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0014 0.0039 0.0171
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0049 0.0273 0.8903
Trypanosoma brucei pteridine reductase 1 0.0049 0.0273 0.8994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0039 0.0119
Schistosoma mansoni hypothetical protein 0.0075 0.0445 0.0439
Brugia malayi hypothetical protein 0.0041 0.0217 0.0669
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Schistosoma mansoni hypothetical protein 0.0019 0.0074 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0248 0.0242
Brugia malayi follicle stimulating hormone receptor 0.011 0.0675 0.2083
Loa Loa (eye worm) hypothetical protein 0.0054 0.0303 0.0935
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1099 0.7177 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0046 0.0252 0.8276
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0049 0.0273 0.0459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0039 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0067 0.0107
Loa Loa (eye worm) glutaminase 2 0.05 0.3238 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0185 0.0568
Brugia malayi RNA recognition motif domain containing protein 0.0032 0.0157 0.0483
Loa Loa (eye worm) kap beta 3 protein 0.0009 0.0006 0.0018
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0672 0.131
Schistosoma mansoni zinc finger protein 0.0012 0.0031 0.0024
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0059 0.0094
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0752 0.1073
Schistosoma mansoni flap endonuclease-1 0.0016 0.0052 0.0045
Loa Loa (eye worm) hypothetical protein 0.0049 0.0273 0.0842
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0049 0.0273 0.0459
Entamoeba histolytica HEAT repeat domain containing protein 0.0009 0.0006 0.0011
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0077
Echinococcus multilocularis glycoprotein Antigen 5 0.0041 0.0217 0.0294
Brugia malayi Flap endonuclease-1 0.0017 0.0063 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0739 0.2282
Schistosoma mansoni ran 0.0034 0.0172 0.0166
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0015 0.0049 0.0059
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.008 0.0479 0.1476
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1329 0.2293
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0041 0.0222 0.0384
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0294 0.1818
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Echinococcus multilocularis tar DNA binding protein 0.0032 0.0157 0.021
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0157 0.0151
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0049 0.0273 0.0267
Brugia malayi glutaminase DH11.1 0.05 0.3238 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0041 0.0222 0.7256
Giardia lamblia PHD finger protein 15 0.0058 0.0332 0.0494
Onchocerca volvulus 0.0014 0.0039 0.0171
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0049 0.0665
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0672 0.131
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0077 0.0038
Echinococcus granulosus snurportin 1 0.0492 0.3183 0.4692
Brugia malayi Pre-SET motif family protein 0.0032 0.0157 0.0483
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0332 0.0481
Brugia malayi hypothetical protein 0.0042 0.0225 0.0692
Entamoeba histolytica Flap nuclease, putative 0.0017 0.0063 0.0109
Schistosoma mansoni jumonji/arid domain-containing protein 0.0206 0.1301 0.1296
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0077 0.0031
Loa Loa (eye worm) MBCTL1 0.006 0.0342 0.1054
Echinococcus multilocularis JmjC domain containing protein 4 0.0054 0.0303 0.0414
Brugia malayi kap beta 3 protein 0.0009 0.0006 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0059 0.0111
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1329 0.2293
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0081 0.0248
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0077 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0303 0.0935
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.0039 0.0048
Onchocerca volvulus 0.0041 0.0217 0.1321
Toxoplasma gondii HEAT repeat-containing protein 0.0009 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0149
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.004 0.0047
Schistosoma mansoni glutaminase 0.05 0.3238 0.3234
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0294 0.0288
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0067 0.0107
Loa Loa (eye worm) hypothetical protein 0.0054 0.0303 0.0935
Onchocerca volvulus 0.0032 0.0157 0.0931
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0049 0.0273 0.0459
Echinococcus multilocularis muscleblind protein 0.0433 0.2797 0.3892
Loa Loa (eye worm) follicle stimulating hormone receptor 0.011 0.0675 0.2083
Brugia malayi Doublecortin family protein 0.001 0.0013 0.0037
Onchocerca volvulus 0.0041 0.0217 0.1321
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0157 0.0331
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0059 0.0124
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0017 0.0063 0.0132
Echinococcus multilocularis Niemann Pick C1 protein 0.0075 0.0445 0.0612
Echinococcus multilocularis protein patched 0.0032 0.0162 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0132 0.0821 0.2533
Leishmania major hypothetical protein, conserved 0.0054 0.0303 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0041 0.0217 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0036 0.0185 0.0248
Echinococcus multilocularis lipoxygenase domain containing protein 0.001 0.0013 0.0009
Giardia lamblia Flap structure-specific endonuclease 0.0017 0.0063 0.0024
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0059 0.0017
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Giardia lamblia Fructose-bisphosphate aldolase 0.0886 0.5777 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0185 0.0269
Schistosoma mansoni protein phosphatase 2C 0.0054 0.0303 0.0297
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0049 0.0085
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0327 0.0448
Loa Loa (eye worm) oxidoreductase 0.0049 0.0273 0.0842
Echinococcus granulosus survival motor neuron protein 1 0.037 0.238 0.3505
Schistosoma mansoni alpha-glucosidase 0.0069 0.0405 0.0399
Loa Loa (eye worm) flap endonuclease-1 0.0017 0.0063 0.0192
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0027 0.0127 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0039 0.0119
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0294 0.0401
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0038 0.0198 0.0268
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0148
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0049 0.0273 0.8903
Loa Loa (eye worm) hypothetical protein 0.0135 0.0836 0.258
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0903 0.1556
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0342 0.0495
Echinococcus multilocularis lysine specific demethylase 6a 0.0054 0.0303 0.0414
Brugia malayi MH2 domain containing protein 0.0208 0.1318 0.4068
Toxoplasma gondii exonuclease III APE 0.0019 0.0077 0.0162
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.004 0.005
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Schistosoma mansoni hypothetical protein 0.0027 0.0124 0.0118
Loa Loa (eye worm) hypothetical protein 0.0046 0.0252 0.0777
Onchocerca volvulus 0.0245 0.1561 1
Schistosoma mansoni hypothetical protein 0.0017 0.0059 0.0053
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0059 0.1767
Loa Loa (eye worm) hypothetical protein 0.0084 0.0503 0.1551
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0294
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0248 0.0242
Plasmodium falciparum importin beta, putative 0.0046 0.0252 0.0519
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0041 0.0222 0.0683
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0036 0.0185 0.5999
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0018 0.0067 0.0107
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0049 0.0273 0.0564
Echinococcus granulosus GPCR family 2 0.0027 0.0124 0.0174
Schistosoma mansoni polycystin 1-related 0.001 0.0013 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0042 0.005
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Echinococcus multilocularis lysine specific demethylase 5A 0.0202 0.1277 0.1772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0039 0.0119
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Echinococcus granulosus lipoxygenase domain containing protein 0.001 0.0013 0.0009
Echinococcus multilocularis muscleblind protein 1 0.0433 0.2797 0.3892
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1366 0.4217
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0132 0.0821 0.2533
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0038 0.0198 0.0298
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0038 0.0198 0.0283
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0294 0.0907
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0017 0.0063 0.1898
Plasmodium falciparum glutathione reductase 0.0048 0.0266 0.0548
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.003 0.009
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.0289 0.0492
Loa Loa (eye worm) hypothetical protein 0.0433 0.2797 0.8637
Brugia malayi Trypsin family protein 0.0041 0.0217 0.0669
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0018 0.0067 0.0141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0042 0.0129
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0332 0.0454
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0049 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.0821 0.0815
Leishmania major importin beta-1 subunit, putative 0.0037 0.0195 0.6346
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1029
Schistosoma mansoni hypothetical protein 0.0027 0.0124 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000007131
Brugia malayi Bloom's syndrome protein homolog 0.0015 0.0049 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1329 0.2293
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0342 0.0468
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0059 0.1767
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0049 0.0273 0.0459
Brugia malayi jmjC domain containing protein 0.0054 0.0303 0.0935
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0728 0.4737 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.1682
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0036 0.0185 0.0263
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0039 0.0033
Schistosoma mansoni DNA helicase recq5 0.0015 0.0049 0.0043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0433 0.0915
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0034 0.0172 0.0529
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0039 0.0048
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0049 0.0273 0.0459
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0073 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0089 0.0188
Schistosoma mansoni zinc finger protein 0.0018 0.0068 0.0061
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0041 0.0222 0.0318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000007131
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.004 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0289 0.0492
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0248 0.0357
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0266 0.0442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0039 0.0119
Echinococcus granulosus transmembrane protease serine 3 0.0041 0.0217 0.0311
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0145 0.0903 0.1556
Trichomonas vaginalis DNA helicase recq1, putative 0.0015 0.0049 0.0077
Brugia malayi Trypsin-like protease protein 5 0.0041 0.0217 0.0669
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0049 0.0273 0.0473
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0059 0.0124
Mycobacterium tuberculosis Probable reductase 0.011 0.0672 0.131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.0039 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0077 0.0235
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0032 0.0036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0225 0.0461
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0266 0.0561
Echinococcus multilocularis geminin 0.0439 0.2834 0.3944
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0041 0.0217 0.0294
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0141 0.0188
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0041 0.0222 0.03
Loa Loa (eye worm) hypothetical protein 0.0057 0.0327 0.1007
Echinococcus granulosus geminin 0.0439 0.2834 0.4176
Trypanosoma brucei oxidoreductase-like protein 0.0052 0.0289 0.9527
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0018 0.0067 0.0107
Toxoplasma gondii HEAT repeat-containing protein 0.0046 0.0252 0.0532
Echinococcus granulosus lipoxygenase domain containing protein 0.001 0.0013 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0144 0.0203
Brugia malayi CHE-14 protein 0.0032 0.0162 0.0498
Schistosoma mansoni rab6-interacting 0.001 0.0013 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0124 0.0382
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0672 0.131
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.0039 0.0119
Echinococcus granulosus expressed conserved protein 0.0071 0.0415 0.0603
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0054 0.0303 0.064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0513
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0032 0.0098
Schistosoma mansoni hypothetical protein 0.0041 0.0217 0.0211
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0049 0.0273 0.0459
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.0162
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1777 0.1771
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0067 0.0107
Plasmodium falciparum JmjC domain-containing protein, putative 0.0054 0.0303 0.0627
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0049 0.0149
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.021 0.1329 0.4101
Echinococcus multilocularis transcription factor Dp 1 0.0024 0.0107 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Plasmodium vivax ataxin-2 like protein, putative 0.0042 0.0225 0.0474
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0027 0.0127 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0039 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0157 0.0151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Plasmodium falciparum thioredoxin reductase 0.0048 0.0266 0.0548
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0089 0.0175
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0728 0.4737 1
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.0039 0.0046
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0658 0.0962
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0042 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0037
Echinococcus multilocularis jumonji domain containing 1A 0.0054 0.0303 0.0414
Loa Loa (eye worm) importin-beta domain-containing protein 0.0009 0.0006 0.0018
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.021 0.1329 0.4101
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0266 0.0383
Toxoplasma gondii aldehyde dehydrogenase 0.0038 0.0198 0.0419
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0074 0.0157
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0039 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.0039 0.0119
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0067 0.1313
Echinococcus granulosus transcription factor Dp 1 0.0024 0.0107 0.0148
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0041 0.0217 0.0311
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.0083 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0039 0.0048
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0042 0.005
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Schistosoma mansoni rab6-interacting 0.001 0.0013 0.0006
Schistosoma mansoni hypothetical protein 0.0041 0.0217 0.0211
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0052 0.0289 0.9485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000007131
Brugia malayi glutathione reductase 0.0048 0.0266 0.0819
Trichomonas vaginalis hypothetical protein 0.0009 0.0006 0.0003
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0017 0.0063 0.1898
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0433 0.2796 0.5851
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.1335 0.1962
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Echinococcus granulosus neutral alpha glucosidase AB 0.0018 0.0067 0.0089
Schistosoma mansoni DNA helicase recq1 0.0015 0.0049 0.0043
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0728 0.4737 1
Echinococcus multilocularis transmembrane protease serine 3 0.0041 0.0217 0.0294
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0049 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Echinococcus granulosus lysine specific demethylase 5A 0.0206 0.1301 0.1912
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0041 0.0222 0.0216
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0073
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0041 0.0222 0.0683
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0167 0.0513
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.0083 0.0107
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0037 0.0195 0.0329
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0042 0.0129
Loa Loa (eye worm) CXXC zinc finger family protein 0.0037 0.0194 0.0597
Schistosoma mansoni microtubule-associated protein tau 0.1038 0.6778 0.6776
Echinococcus granulosus phd:f box containing protein 0.0054 0.0303 0.0438
Onchocerca volvulus Glucosylceramidase homolog 0.0138 0.0854 0.5435
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0157 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0208 0.1318 0.4068
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0049 0.0273 0.0577
Brugia malayi hypothetical protein 0.0027 0.0127 0.039
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0036 0.0185 0.0269
Schistosoma mansoni hypothetical protein 0.0027 0.0124 0.0118
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0083 0.0493 0.152
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0058 0.0328 0.0321
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0049 0.0077
Schistosoma mansoni hypothetical protein 0.0323 0.2073 0.2068
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0294 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0132 0.0821 0.1203
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0018 0.0067 0.0204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.0503 0.1551
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0059 0.1029
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0294 0.0401
Schistosoma mansoni alpha glucosidase 0.0018 0.0067 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.0039 0.0048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0672 0.0892
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Echinococcus granulosus FTZ F1 alpha 0.0014 0.0039 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Entamoeba histolytica hypothetical protein 0.0037 0.0195 0.0337
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0015 0.0049 0.0063
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0034 0.0172 0.0529
Brugia malayi jmjC domain containing protein 0.0054 0.0303 0.0935
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0049 0.0273 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0039 0.0119
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0039 0.0033
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0036 0.0185 0.0178
Brugia malayi MH2 domain containing protein 0.0014 0.0042 0.0129
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0049 0.0273 0.0842
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.0303 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.1335 0.1853
Echinococcus multilocularis Mastin 0.0041 0.0217 0.0294
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0018 0.0067 0.0115
Brugia malayi nuclear receptor NHR-88 0.0014 0.0039 0.0119
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Brugia malayi hypothetical protein 0.001 0.0013 0.0037
Schistosoma mansoni hypothetical protein 0.0012 0.0031 0.0024
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0077 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Echinococcus granulosus lysine specific demethylase 6a 0.0054 0.0303 0.0438
Plasmodium falciparum phd finger protein, putative 0.0058 0.0332 0.0688
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0332 0.0701
Entamoeba histolytica Ran family GTPase 0.0034 0.0172 0.0298
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0039 0.0033
Leishmania major GTP-binding protein, putative 0.0034 0.0172 0.5581
Echinococcus granulosus lysosomal alpha glucosidase 0.008 0.0479 0.0697
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1329 0.2293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0039 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0328 0.101
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0752 0.1482
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0051 0.0282 0.0407
Schistosoma mansoni hypothetical protein 0.0439 0.2834 0.283
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.0503 0.1551
Echinococcus multilocularis snurportin 1 0.0492 0.3183 0.4431
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Loa Loa (eye worm) hypothetical protein 0.0042 0.0225 0.0692
Brugia malayi jmjC domain containing protein 0.0206 0.1301 0.4017
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Brugia malayi Glycosyl hydrolases family 31 protein 0.008 0.0479 0.1476
Brugia malayi Glycosyl hydrolases family 31 protein 0.0018 0.0067 0.0204
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0015 0.0049 0.0149
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0658 0.0909
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0041 0.0217 0.0311
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0266 0.0819
Brugia malayi Smad1 0.0014 0.0042 0.0129
Mycobacterium ulcerans glutaminase 0.05 0.3238 0.6796
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.0039 0.0119
Echinococcus multilocularis importin subunit beta 1 0.0046 0.0252 0.0343
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0672 0.131
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0049 0.0273 0.8994
Loa Loa (eye worm) hypothetical protein 0.0037 0.0191 0.0587
Schistosoma mansoni ran 0.0034 0.0172 0.0166
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0059 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0039 0.0119
Schistosoma mansoni alpha-glucosidase 0.0069 0.0405 0.0399
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0049 0.0273 0.0459
Echinococcus granulosus Polycystic kidney disease protein 0.001 0.0013 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0014 0.0039 0.0171
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Leishmania major oxidoreductase-like protein 0.0052 0.0289 0.9527
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0032 0.0038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0037 0.0195 0.0329
Loa Loa (eye worm) glutaminase 0.05 0.3238 1
Echinococcus granulosus flap endonuclease 1 0.0017 0.0063 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1029
Schistosoma mansoni jumonji domain containing protein 0.0054 0.0303 0.0297
Onchocerca volvulus 0.0047 0.0255 0.1567
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0041 0.0222 0.701
Brugia malayi Importin beta-1 subunit 0.0046 0.0252 0.0777
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0063 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0303 0.0935
Onchocerca volvulus 0.0052 0.0294 0.1818
Echinococcus granulosus Niemann Pick C1 protein 0.0075 0.0445 0.0648
Echinococcus multilocularis lysosomal alpha glucosidase 0.008 0.0479 0.0658
Echinococcus granulosus GTP binding nuclear protein Ran 0.0034 0.0172 0.0245
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0752 0.1482
Trichomonas vaginalis ran, putative 0.0034 0.0172 0.029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0157 0.0151
Onchocerca volvulus 0.0041 0.0217 0.1321
Plasmodium falciparum LCCL domain-containing protein 0.001 0.0013 0.0013
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0074 0.0157
Brugia malayi MH1 domain containing protein 0.0014 0.0042 0.0129
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Plasmodium falciparum glutathione reductase 0.0017 0.0059 0.0111
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0728 0.4737 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0039 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.008 0.0476 0.047
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0077 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.0039 0.0119
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0077 0.0038
Schistosoma mansoni smad1 5 8 and 0.0014 0.0042 0.0036
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0148
Plasmodium falciparum thioredoxin reductase 0.0017 0.0059 0.0111
Echinococcus multilocularis Smad4 0.0014 0.0042 0.005
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0054 0.0303 0.064
Trichomonas vaginalis hypothetical protein 0.0728 0.4737 0.8199
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1767
Echinococcus multilocularis sterol regulatory element binding protein 0.0032 0.0162 0.0217
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0041 0.0222 0.7256
Loa Loa (eye worm) hypothetical protein 0.004 0.021 0.0646
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0034 0.0172 0.0231
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0294 0.0425
Brugia malayi MH2 domain containing protein 0.0014 0.0042 0.0129
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0049 0.0273 0.0577
Brugia malayi hypothetical protein 0.001 0.0013 0.0037
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0049 0.0273 0.0459
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0034 0.0172 0.035
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0039 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0124 0.0174
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0332 0.0701
Toxoplasma gondii thioredoxin reductase 0.0048 0.0266 0.0561
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0034 0.0172 0.5581
Loa Loa (eye worm) doublecortin family protein 0.001 0.0013 0.0037
Echinococcus multilocularis GPCR, family 2 0.0027 0.0124 0.0164
Brugia malayi AF-10 protein 0.0019 0.0074 0.0227
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.004 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.0039 0.0119
Schistosoma mansoni smad1 5 8 and 0.0014 0.0042 0.0036
Chlamydia trachomatis oxoacy-ACP reductase 0.0049 0.0273 0.0459
Brugia malayi Pre-SET motif family protein 0.0215 0.1366 0.4217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0124 0.0164
Leishmania major trypanothione reductase 0.0048 0.0266 0.874
Brugia malayi jmjC domain containing protein 0.0054 0.0303 0.0935
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0034 0.0172 0.0363
Schistosoma mansoni coup transcription factor 0.0014 0.0039 0.0033
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0042 0.0036
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0039 0.0033
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0148
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0041 0.0217 0.0669
Schistosoma mansoni aldehyde dehydrogenase 0.0038 0.0198 0.0192
Schistosoma mansoni jumonji domain containing protein 0.0283 0.181 0.1805
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0886 0.5777 1
Echinococcus granulosus Smad4 0.0014 0.0042 0.0053
Brugia malayi PHD-finger family protein 0.0022 0.0096 0.0295
Brugia malayi PHD-finger family protein 0.0023 0.0098 0.0302
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0332 0.0701
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.0039 0.0046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Loa Loa (eye worm) trypsin family protein 0.0041 0.0217 0.0669
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0059 0.1767
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.0039 0.0119
Mycobacterium ulcerans hypothetical protein 0.0041 0.0217 0.0339
Echinococcus multilocularis survival motor neuron protein 1 0.037 0.238 0.3311
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.0039 0.0046
Echinococcus granulosus Mastin 0.0041 0.0217 0.0311
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0067 0.0107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000007131
Schistosoma mansoni cpg binding protein 0.0041 0.0218 0.0212
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0049 0.0273 0.0459
Echinococcus multilocularis expressed conserved protein 0.0071 0.0415 0.057
Echinococcus multilocularis lipoxygenase domain containing protein 0.001 0.0013 0.0009
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0015 0.0049 0.009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.0039 0.0048
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0059 0.1767
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.0303 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0059 0.1029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0039 0.0119
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Brugia malayi PHD-finger family protein 0.0058 0.0332 0.1023
Echinococcus multilocularis neutral alpha glucosidase AB 0.0018 0.0067 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0124 0.0382
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0157 0.021
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0077 0.0125
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0322 0.2068 0.2875
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0032 0.0157 0.0483
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0124 0.0164
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0077 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0728 0.4737 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0162 0.0273
Leishmania major hypothetical protein, conserved 0.0042 0.0225 0.7352
Echinococcus multilocularis enteropeptidase 0.0041 0.0217 0.0294
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0075 0.0445 0.1372
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0433 0.2796 0.5651
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0049 0.0273 0.0459
Schistosoma mansoni hypothetical protein 0.0492 0.3183 0.3179
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0225 0.7115
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0039 0.0033
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0124 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0132 0.0821 0.1203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0038 0.0198 0.0298
Echinococcus granulosus tar DNA binding protein 0.0032 0.0157 0.0223
Trypanosoma cruzi importin beta-1 subunit, putative 0.0037 0.0195 0.6018
Brugia malayi ecdysteroid receptor 0.0014 0.0039 0.0119
Mycobacterium tuberculosis Possible oxidoreductase 0.0049 0.0273 0.0459
Onchocerca volvulus Alhambra homolog 0.0058 0.0332 0.2061
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0049 0.0077
Brugia malayi MH1 domain containing protein 0.0014 0.0042 0.0129
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0143 0.0136
Schistosoma mansoni survival motor neuron protein 0.0075 0.0445 0.0439
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.0039 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0039 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Loa Loa (eye worm) hypothetical protein 0.0058 0.0332 0.1023
Loa Loa (eye worm) RNA binding protein 0.0032 0.0157 0.0483
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0039 0.0119
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0034 0.0172 0.0215
Loa Loa (eye worm) TAR-binding protein 0.0032 0.0157 0.0483
Loa Loa (eye worm) hypothetical protein 0.0058 0.0328 0.101
Brugia malayi steroid hormone receptor 0.0014 0.0039 0.0119
Schistosoma mansoni cpg binding protein 0.0041 0.0218 0.0212
Trichomonas vaginalis glutaminase, putative 0.05 0.3238 0.5602
Loa Loa (eye worm) hypothetical protein 0.0032 0.0162 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.0039 0.0119
Brugia malayi hypothetical protein 0.037 0.238 0.735
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0049 0.0273 0.8994
Onchocerca volvulus Bile acid receptor homolog 0.0014 0.0039 0.0171
Plasmodium vivax flap endonuclease 1, putative 0.0017 0.0063 0.0132
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.0039 0.0048
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0302
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1767
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0124 0.0382
Echinococcus multilocularis flap endonuclease 1 0.0017 0.0063 0.0079
Echinococcus multilocularis smad 0.0014 0.0042 0.005
Brugia malayi Cytochrome P450 family protein 0.002 0.0081 0.0248
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Echinococcus multilocularis microtubule associated protein 2 0.1038 0.6778 0.9444
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.0039 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0067 0.1313
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0077 0.0235
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0049 0.0273 0.0394
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0059 0.1029
Echinococcus granulosus zinc finger protein 0.0018 0.0068 0.009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0074 0.2284
Schistosoma mansoni dihydropteridine reductase 0.0049 0.0273 0.0267
Brugia malayi jmjC domain containing protein 0.0322 0.2068 0.6384
Echinococcus granulosus enteropeptidase 0.0041 0.0217 0.0311
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.0039 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0039 0.0119
Echinococcus granulosus bloom syndrome protein 0.0015 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0049 0.0273 0.0372
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0124 0.0174
Treponema pallidum fructose-bisphosphate aldolase 0.0886 0.5777 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0054 0.0303 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0059 0.0124
Brugia malayi Muscleblind-like protein 0.0433 0.2797 0.8637
Echinococcus granulosus peregrin 0.006 0.0345 0.0499
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0217 0.0211
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0294 0.0288
Loa Loa (eye worm) glutathione reductase 0.0048 0.0266 0.0819
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0077 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Echinococcus granulosus dnaJ subfamily B 0.0308 0.1977 0.291
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0017 0.0016
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0482 0.0663
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1029
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0148
Echinococcus multilocularis cpg binding protein 0.0041 0.0218 0.0295
Mycobacterium ulcerans oxidoreductase 0.0049 0.0273 0.0459
Schistosoma mansoni hypothetical protein 0.0058 0.0332 0.0326
Echinococcus granulosus sterol regulatory element binding protein 0.0032 0.0162 0.023
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0017 0.0015
Brugia malayi jmjC domain containing protein 0.0054 0.0303 0.0935
Echinococcus granulosus JmjC domain containing protein 4 0.0054 0.0303 0.0438
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0059 0.0124
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0005 0.00000000007131
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0492 0.3183 0.9831
Plasmodium falciparum flap endonuclease 1 0.0017 0.0063 0.0119
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0728 0.4737 1
Echinococcus granulosus jumonji domain containing 1A 0.0054 0.0303 0.0438
Trichomonas vaginalis importin beta-1, putative 0.0037 0.0195 0.0329
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0066
Brugia malayi RNA, U transporter 1 0.0131 0.0811 0.2502
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0049 0.1433
Brugia malayi Bromodomain containing protein 0.0063 0.0364 0.1121
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0073 0.0098
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0074 0.2284
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0294 0.0425
Schistosoma mansoni Smad4 0.0014 0.0042 0.0036
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0322 0.2068 0.3044
Onchocerca volvulus 0.0041 0.0217 0.1321
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0017 0.0063 0.1172
Loa Loa (eye worm) hypothetical protein 0.0433 0.2797 0.8637
Brugia malayi mbt repeat family protein 0.0052 0.0294 0.0907
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0672 0.131
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0038 0.0198 0.6463
Toxoplasma gondii HEAT repeat-containing protein 0.0009 0.0006 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.0503 0.1551
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.003 0.009
Trypanosoma brucei ISWI complex protein 0.0012 0.0031 0.0822
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0289 0.0492
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0342 0.0495
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0059 0.0111
Schistosoma mansoni smad1 5 8 and 0.0014 0.0042 0.0036
Loa Loa (eye worm) bromodomain containing protein 0.0014 0.0043 0.0132
Trypanosoma brucei importin beta-1 subunit, putative 0.0046 0.0252 0.8276
Loa Loa (eye worm) Smad1 0.0014 0.0042 0.0129
Trichomonas vaginalis sucrase-isomaltase, putative 0.0018 0.0067 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0018 0.0067 0.0107
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.007
Onchocerca volvulus 0.0049 0.0273 0.1683
Onchocerca volvulus 0.0041 0.0217 0.1321
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0217 0.0211
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0052 0.0289 0.0492
Echinococcus granulosus RUN 0.001 0.0013 0.0009
Trypanosoma brucei glucosidase, putative 0.0018 0.0067 0.2027
Schistosoma mansoni importin beta-1 0.0046 0.0252 0.0246
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0015 0.0049 0.009
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0059 0.0181
Onchocerca volvulus 0.0075 0.0445 0.2792
Echinococcus multilocularis lysosomal alpha glucosidase 0.008 0.0479 0.0658
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0185 0.0269
Plasmodium vivax glutathione reductase, putative 0.0048 0.0266 0.0561
Loa Loa (eye worm) retinol dehydrogenase 12 0.0049 0.0273 0.0842
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.0039 0.0119
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0049 0.1433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.0821 0.0815
Brugia malayi mbt repeat family protein 0.0052 0.0294 0.0907
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0225 0.7115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0752 0.1482
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0157 0.0151
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0034 0.0172 0.0363
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0049 0.0273 0.8994
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.1029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0018 0.0067 0.0115
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0049 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0886 0.5777 1
Schistosoma mansoni aldehyde dehydrogenase 0.0038 0.0198 0.0192
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0077 0.0453 0.0447
Loa Loa (eye worm) RecQ helicase 0.0015 0.0049 0.0149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0248 0.0337
Echinococcus granulosus smad 0.0014 0.0042 0.0053
Schistosoma mansoni hypothetical protein 0.0439 0.2834 0.283
Plasmodium vivax SET domain protein, putative 0.0032 0.0157 0.0331
Trichomonas vaginalis maltase-glucoamylase, putative 0.0018 0.0067 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0039 0.0046
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0266 0.0362
Trypanosoma brucei PAB1-binding protein , putative 0.0042 0.0225 0.7352
Brugia malayi Trypsin family protein 0.0041 0.0217 0.0669
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0728 0.4737 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0141 0.0199
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0289 0.0492
Echinococcus multilocularis peregrin 0.006 0.0345 0.0472
Mycobacterium tuberculosis Possible oxidoreductase 0.0049 0.0273 0.0459
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Toxoplasma gondii LsmAD domain-containing protein 0.0042 0.0225 0.0474
Schistosoma mansoni bromodomain containing protein 0.0053 0.0301 0.0295
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0037
Plasmodium vivax JmjC domain containing protein 0.0054 0.0303 0.064
Schistosoma mansoni smad 0.0014 0.0042 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0077 0.1682
Loa Loa (eye worm) hypothetical protein 0.0075 0.0445 0.1372
Echinococcus granulosus Protein patched homolog 1 0.0032 0.0162 0.023
Schistosoma mansoni phosphatidylserine receptor 0.0054 0.0303 0.0297
Brugia malayi Trypsin family protein 0.0041 0.0217 0.0669
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0119
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0039 0.0033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0051 0.0282 0.0384
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0266 0.8627
Echinococcus granulosus glycoprotein Antigen 5 0.0041 0.0217 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0157 0.0151
Leishmania major pteridine reductase 1 0.0052 0.0289 0.9527
Schistosoma mansoni hypothetical protein 0.0308 0.1977 0.1972
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000007131
Echinococcus multilocularis zinc finger protein 0.0018 0.0068 0.0085
Echinococcus multilocularis protein dispatched 1 0.0037 0.0192 0.0259
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.0039 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0005 0.00000000007131
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0157 0.0151
Schistosoma mansoni lipoxygenase 0.0027 0.0127 0.0121
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.0148
Echinococcus multilocularis dnaJ subfamily B 0.0308 0.1977 0.2748
Schistosoma mansoni cpg binding protein 0.0037 0.0194 0.0188
Leishmania major alpha glucosidase II subunit, putative 0.0018 0.0067 0.2027
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0041 0.0222 0.701
Schistosoma mansoni lipoxygenase 0.001 0.0013 0.0006
Plasmodium vivax importin-beta 2, putative 0.0046 0.0252 0.0532
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0132 0.0821 0.1136
Brugia malayi Niemann-Pick C1 protein precursor 0.0075 0.0445 0.1372
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0052
Plasmodium vivax transportin, putative 0.0009 0.0006 0.0014
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Onchocerca volvulus 0.0037 0.0194 0.1171
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0059 0.1767
Onchocerca volvulus 0.0041 0.0217 0.1321
Brugia malayi Bromodomain containing protein 0.006 0.0345 0.1062
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0342 0.0336
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0225 0.0461
Echinococcus multilocularis bloom syndrome protein 0.0015 0.0049 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0138 0.0854 0.1472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.2367
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0886 0.5777 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0669
Echinococcus granulosus importin subunit beta 1 0.0046 0.0252 0.0363
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0006
Brugia malayi RNA binding protein 0.0032 0.0157 0.0483
Schistosoma mansoni hypothetical protein 0.0027 0.0124 0.0118
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.0039 0.0048
Trypanosoma brucei trypanothione reductase 0.0048 0.0266 0.874
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0054 0.0303 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0038 0.0198 0.0298
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0075 0.0445 0.077
Plasmodium vivax multidomain scavenger receptor, putative 0.001 0.0013 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0005 0.00000000007131
Onchocerca volvulus 0.0052 0.0289 0.1786
Echinococcus granulosus muscleblind protein 0.0433 0.2797 0.4121
Echinococcus granulosus cpg binding protein 0.0041 0.0218 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.0821 0.0815
Loa Loa (eye worm) MH2 domain-containing protein 0.0208 0.1318 0.4068
Loa Loa (eye worm) hypothetical protein 0.0052 0.0294 0.0907
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0273 0.0459
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0049 0.0273 0.0459
Mycobacterium ulcerans short chain dehydrogenase 0.0049 0.0273 0.0459
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0015 0.0049 0.0059
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0433 0.2796 0.5851

Activities

Activity type Activity value Assay description Source Reference
IC90 (functional) = 0.71 uM Inhibition of viral infection in HIV-1(RF)-infected MT-2 cells with an oligonucleotide-based sandwich hybridization assay. ChEMBL. 8784449
Ki (binding) = 3 nM Inhibitroy activity against HIV-1 protease ChEMBL. 8784449
Ki (binding) = 3 nM Inhibition of HIV-1 protease ChEMBL. 9925730
Ki (binding) = 3 nM Inhibitroy activity against HIV-1 protease ChEMBL. 8784449
Ki (binding) = 3 nM Inhibition of HIV-1 protease ChEMBL. 9925730

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.