Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ubiquitin specific protease, putative | ubiquitin specific peptidase 2 | 362 aa | 378 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0045 | 0 | 0.5 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0045 | 0 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0288 | 0.6728 | 1 |
Giardia lamblia | Thymidine kinase | 0.0288 | 0.6728 | 0.6728 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0288 | 0.6728 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.