Detailed information for compound 1412350

Basic information

Technical information
  • TDR Targets ID: 1412350
  • Name: [2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoeth yl] 5-nitrofuran-2-carboxylate
  • MW: 360.106 | Formula: C12H7Cl2N3O6
  • H donors: 1 H acceptors: 5 LogP: 2.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ncc(cc1Cl)Cl)COC(=O)c1ccc(o1)[N+](=O)[O-]
  • InChi: 1S/C12H7Cl2N3O6/c13-6-3-7(14)11(15-4-6)16-9(18)5-22-12(19)8-1-2-10(23-8)17(20)21/h1-4H,5H2,(H,15,16,18)
  • InChiKey: FYFKITKMIROERM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(3,5-dichloro-2-pyridyl)amino]-2-oxo-ethyl] 5-nitrofuran-2-carboxylate
  • 5-nitro-2-furancarboxylic acid [2-[(3,5-dichloro-2-pyridyl)amino]-2-oxoethyl] ester
  • 5-nitrofuran-2-carboxylic acid [2-[(3,5-dichloro-2-pyridyl)amino]-2-keto-ethyl] ester
  • [2-[(3,5-dichloropyridin-2-yl)amino]-2-oxo-ethyl] 5-nitrofuran-2-carboxylate
  • Oprea1_532222
  • T0512-6971
  • ZINC05559314

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0021 0.0115
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.1231 0.2413
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0081 0.0447
Loa Loa (eye worm) RNA binding protein 0.0076 0.5035 0.5024
Schistosoma mansoni DNA polymerase eta 0.0023 0.1231 0.2413
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.042 0.0795
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.1741 0.9597
Leishmania major hypothetical protein, conserved 0.003 0.1741 0.9597
Trypanosoma cruzi DNA polymerase eta, putative 0.0007 0.0081 0.0336
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.363
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Leishmania major DNA polymerase eta, putative 0.0007 0.0081 0.0336
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.363
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1741 0.9597
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.042 0.0795
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 0.6968
Entamoeba histolytica Flap nuclease, putative 0.0031 0.1813 1
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0081 0.0336
Leishmania major DNA damage repair protein, putative 0.0007 0.0081 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.1231 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.675
Trypanosoma brucei unspecified product 0.0016 0.0713 0.3864
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.3514 0.6968
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.1231 0.675
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.3864
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.1813 1
Echinococcus granulosus bloom syndrome protein 0.0029 0.1637 0.3223
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1231 0.2413
Brugia malayi hypothetical protein 0.003 0.1741 0.343
Brugia malayi polk-prov protein 0.0007 0.0081 0.012
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.1813 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0795
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.675
Brugia malayi Flap endonuclease-1 0.0031 0.1813 0.3574
Echinococcus multilocularis dna polymerase kappa 0.0023 0.1231 0.2413
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.1813 1
Echinococcus granulosus flap endonuclease 1 0.0031 0.1813 0.3574
Schistosoma mansoni DNA helicase recq1 0.0012 0.042 0.0795
Loa Loa (eye worm) hypothetical protein 0.003 0.1741 0.1723
Echinococcus multilocularis dna polymerase eta 0.0023 0.1231 0.2413
Brugia malayi TAR-binding protein 0.0076 0.5035 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0081 0.0336
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0021 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.1231 0.2413
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1231 1
Entamoeba histolytica exonuclease, putative 0.0006 0.0021 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.1741 0.9602
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1637 0.9019
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0081 0.0336
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.1231 0.675
Echinococcus granulosus dna polymerase eta 0.0023 0.1231 0.2413
Brugia malayi hypothetical protein 0.002 0.0969 0.1891
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0081 0.0336
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.1741 0.9597
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0081 0.0336
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1385 0.7614
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0966 0.5272
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.1231 0.2413
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0949 0.5235
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.1813 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.675
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.1813 0.1796
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.042 0.0795
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.3864
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.675
Leishmania major DNA polymerase eta, putative 0.0023 0.1231 0.675
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0021 0.0115
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1637 0.9019
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1741 0.9597
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.042 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Leishmania major DNA polymerase kappa, putative 0.0007 0.0081 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 0.6968
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0081 0.0336
Schistosoma mansoni hypothetical protein 0.0014 0.054 0.1036
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1637 0.3223
Giardia lamblia DNA damage repair protein 0.0007 0.0081 0.0336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.675
Loa Loa (eye worm) TAR-binding protein 0.0076 0.5035 0.5024
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.042 0.2225
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.1231 0.675
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0081 0.0336
Schistosoma mansoni DNA helicase recq5 0.0012 0.042 0.0795
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.5035 0.5024
Loa Loa (eye worm) hypothetical protein 0.0012 0.042 0.04
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1231 0.2413
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3514 0.6968
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0671 0.3703
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0081 0.0336
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.042 0.0795
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.1231 0.6788
Trypanosoma brucei unspecified product 0.0023 0.1231 0.675
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0081 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 0.6968
Echinococcus granulosus tar DNA binding protein 0.0076 0.5035 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1741 0.9597
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.675
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.1813 1
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.1813 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.363
Brugia malayi RNA binding protein 0.0076 0.5035 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1741 0.9597
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0081 0.0447
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.1231 0.675
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0081 0.0336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.675
Loa Loa (eye worm) hypothetical protein 0.0007 0.0081 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.3864
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0081 0.0336
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.3514 0.3501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3514 0.6968
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0081 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Trypanosoma brucei unspecified product 0.0016 0.0713 0.3864
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.1201 0.2353
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.1231 0.5
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0795
Loa Loa (eye worm) hypothetical protein 0.0023 0.1231 0.1212
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0671 0.363
Giardia lamblia DINP protein human, muc B family 0.0023 0.1231 0.675
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1231 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3514 0.6968
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0081 0.0447
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0081 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3514 0.6968
Echinococcus multilocularis tar DNA binding protein 0.0076 0.5035 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.1231 0.2413
Loa Loa (eye worm) RecQ helicase 0.0029 0.1637 0.162
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.042 0.2225
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0021 0.0115
Plasmodium falciparum flap endonuclease 1 0.0031 0.1813 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.1231 0.2413
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.054 0.1036
Leishmania major DNA polymerase kappa, putative 0.0023 0.1231 0.675
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.2315
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1637 0.3223
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.2315
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.5035 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.1231 0.1212
Schistosoma mansoni flap endonuclease-1 0.0028 0.1597 0.3143
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.054 0.1036
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Echinococcus multilocularis flap endonuclease 1 0.0031 0.1813 0.3574
Entamoeba histolytica exonuclease, putative 0.0006 0.0021 0.0115
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.1231 0.675
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.1813 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0081 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.675
Entamoeba histolytica DNA-repair protein, putative 0.0006 0.0021 0.0115

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 28.32 uM PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0002 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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