Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3713 | 0.8229 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4331 | 0.4331 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.1265 | 0.1796 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4331 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3713 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4619 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8854 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4331 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0839 | 0.0754 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4619 | 0.4619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4619 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.1265 | 0.1796 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4331 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1265 | 0.1265 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4619 | 0.4619 |
Brugia malayi | hypothetical protein | 0.002 | 0.214 | 0.376 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0839 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0531 | 0.0531 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.3713 | 0.8239 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.