Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1366 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1366 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0139 | 0.0139 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1366 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.0139 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1366 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1366 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1366 | 0.1244 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1366 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1366 | 0.1366 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1366 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.5 uM | In vitro reversal of vecuronium-induced block in isolated guinea pig hemi-diaphragm. | ChEMBL. | 12182862 |
EC50 (functional) | = 2.5 uM | In vitro reversal of vecuronium-induced block in isolated guinea pig hemi-diaphragm. | ChEMBL. | 12182862 |
IC50 (binding) | = 0.9 uM | Concentration required for the inhibition of acetylcholinesterase | ChEMBL. | 12182862 |
IC50 (binding) | = 0.9 uM | Concentration required for the inhibition of acetylcholinesterase | ChEMBL. | 12182862 |
S | = 3 mg ml-1 | Aqueous solubility | ChEMBL. | 12182862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.