Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.338 | 0.374 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.338 | 0.374 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5839 | 0.6459 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0031 | 0.1908 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.338 | 0.374 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5839 | 0.5839 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0114 | 0.9039 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0114 | 0.9039 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0114 | 0.9039 | 0.9039 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5839 | 0.5839 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0114 | 0.9039 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 1 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0031 | 0.1908 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.338 | 0.374 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0031 | 0.1908 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5839 | 0.6459 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Brugia malayi | phosphofructokinase | 0.0114 | 0.9039 | 0.9039 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.9039 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0031 | 0.1908 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5839 | 0.5839 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0114 | 0.9039 | 0.5 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0031 | 0.1908 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.338 | 0.374 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0114 | 0.9039 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0114 | 0.9039 | 0.9039 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0031 | 0.1908 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5839 | 0.6459 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5839 | 0.5839 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5839 | 0.5839 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0114 | 0.9039 | 0.9039 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0114 | 0.9039 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.338 | 0.338 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0031 | 0.1908 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.338 | 0.374 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5839 | 0.6459 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0114 | 0.9039 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5839 | 0.5839 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.338 | 0.338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5839 | 0.6459 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0114 | 0.9039 | 0.9039 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.338 | 0.374 |
Brugia malayi | 6-phosphofructokinase | 0.0114 | 0.9039 | 0.9039 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0114 | 0.9039 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0031 | 0.1908 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5839 | 0.6459 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0031 | 0.1908 | 0.5 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0114 | 0.9039 | 0.5 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0031 | 0.1908 | 0.5 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0114 | 0.9039 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0114 | 0.9039 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5839 | 0.6459 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2643 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 158.4893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.