Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0029 | 0.0322 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | putative neuropeptide receptor | 0.0029 | 0.0322 | 0.3877 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0528 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Brugia malayi | follicle stimulating hormone receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0831 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | ORL1-like opioid receptor | 0.0029 | 0.0322 | 0.3877 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | GnHR receptor homolog | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | G-protein coupled receptor | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | G-protein coupled receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0831 | 1 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Dopamine receptor | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0029 | 0.0322 | 0.3877 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0528 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0029 | 0.0322 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0029 | 0.0322 | 0.3877 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0831 | 1 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0528 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | RE15519p | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0831 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0831 | 1 |
Brugia malayi | AKH receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Mycobacterium ulcerans | putative regulatory protein | 0.0522 | 0.9877 | 0.9877 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0831 | 1 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | G protein-coupled receptor | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | neuropeptide F receptor | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Dopamine receptor protein 1 | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | larval opioid receptor | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Mycobacterium ulcerans | hypothetical protein | 0.0522 | 0.9877 | 0.9877 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0522 | 0.9877 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0831 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0831 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | sulfakinin receptor protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Onchocerca volvulus | 0.0029 | 0.0322 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Serotonin receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Brugia malayi | Serotonin receptor | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0322 | 0.3877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.