Detailed information for compound 1412831

Basic information

Technical information
  • TDR Targets ID: 1412831
  • Name: 3-methyl-N-[(4-pyrrolidin-1-ylsulfonylphenyl) carbamothioyl]butanamide
  • MW: 369.502 | Formula: C16H23N3O3S2
  • H donors: 2 H acceptors: 3 LogP: 2.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N1CCCC1)C
  • InChi: 1S/C16H23N3O3S2/c1-12(2)11-15(20)18-16(23)17-13-5-7-14(8-6-13)24(21,22)19-9-3-4-10-19/h5-8,12H,3-4,9-11H2,1-2H3,(H2,17,18,20,23)
  • InChiKey: UIPSCZODVCHHMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methyl-N-[[(4-1-pyrrolidinylsulfonylphenyl)amino]-thioxomethyl]butanamide
  • 3-methyl-N-[(4-pyrrolidin-1-ylsulfonylphenyl)thiocarbamoyl]butyramide
  • ALD-N008971
  • ZINC00677241
  • AN-329/42607813
  • ARONIS007958
  • 3-methyl-N-({[4-(1-pyrrolidinylsulfonyl)phenyl]amino}carbonothioyl)butanamide
  • MLS000862472
  • SMR000300493

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0547 0.205 0.3008
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0255 0.0911 0.3105
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0133 0.0372
Brugia malayi nuclear receptor NHR-88 0.0034 0.0047 0.0046
Echinococcus granulosus tubulin beta 1 chain 0.0609 0.2293 0.2289
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0363 0.0358
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0075 0.0204 0.0293
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.258 1 1
Brugia malayi Guanylate kinase family protein 0.0035 0.005 0.005
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.0025 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0916 0.3124
Brugia malayi Subtilase family protein 0.0056 0.0133 0.0141
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0082 0.0234 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0047 0.0127
Leishmania major C-8 sterol isomerase-like protein 0.0366 0.1344 0.5813
Leishmania major beta tubulin 0.0609 0.2293 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.003 0.0029 0.0011
Echinococcus multilocularis 0.0104 0.0319 0.0314
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0809 0.3076 0.3073
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0068 0.0177 0.0664
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0039 0.0034
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0547 0.205 0.2246
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Plasmodium vivax guanylate kinase, putative 0.0029 0.0027 0.0114
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Brugia malayi YY1-associated factor 2 0.003 0.0029 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0047 0.0061
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0029 0.0027 0.0057
Echinococcus multilocularis Furin 1 0.0312 0.1132 0.1127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0053 0.0071
Echinococcus granulosus g protein coupled receptor 0.0547 0.205 0.2046
Schistosoma mansoni tyrosine kinase 0.0295 0.1066 0.1562
Echinococcus multilocularis guanylate kinase 0.0029 0.0027 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0075 0.0204 0.0199
Echinococcus granulosus peptide allatostatin:somatostatin 0.0547 0.205 0.2046
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Mycobacterium leprae Possible secreted protease 0.0056 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Brugia malayi Transforming growth factor beta like domain containing protein 0.0122 0.039 0.0423
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0034
Onchocerca volvulus 0.0026 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.0547 0.205 0.3008
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0097 0.029 0.0285
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.003 0.0029 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0547 0.205 0.4348
Schistosoma mansoni hypothetical protein 0.003 0.0029 0.0036
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0064 0.006
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0083 0.0236 0.9755
Entamoeba histolytica hypothetical protein 0.0039 0.0064 0.0166
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0547 0.205 0.2046
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0047 0.0061
Echinococcus granulosus guanylate kinase 0.0029 0.0027 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0047 0.0046
Brugia malayi endoprotease bli-4 precursor 0.1228 0.4713 0.517
Loa Loa (eye worm) hypothetical protein 0.0086 0.0249 0.0528
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0047 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Echinococcus granulosus neuroendocrine convertase 2 0.0782 0.2971 0.2967
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0056 0.0133 0.0188
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0362 0.1478
Loa Loa (eye worm) LjBmp2/4b 0.0031 0.0034 0.0072
Giardia lamblia High cysteine membrane protein Group 2 0.0446 0.1654 0.7183
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0039 0.005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0547 0.205 0.3008
Schistosoma mansoni brg-1 associated factor 0.0084 0.0242 0.0349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Leishmania major hypothetical protein, conserved 0.003 0.0029 0.0011
Brugia malayi ORL1-like opioid receptor 0.0547 0.205 0.2246
Echinococcus granulosus tubulin subunit beta 0.0609 0.2293 0.2289
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0047 0.0061
Leishmania major beta tubulin 0.0609 0.2293 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0547 0.205 0.4348
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0047 0.0046
Echinococcus granulosus tachykinin peptides receptor 99D 0.0547 0.205 0.2046
Brugia malayi Guanylate kinase family protein 0.005 0.0106 0.0111
Plasmodium vivax tubulin beta chain, putative 0.0609 0.2293 1
Echinococcus granulosus high voltage activated calcium channel beta 0.0029 0.0027 0.0022
Brugia malayi replication factor A 73 kDa subunit 0.0034 0.0047 0.0046
Echinococcus multilocularis neuropeptides capa receptor 0.0547 0.205 0.2046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0547 0.205 0.3008
Brugia malayi celfurPC protein 0.0972 0.3714 0.4073
Brugia malayi Tachykinin-like peptides receptor 99D 0.1228 0.4714 0.5172
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0038 0.0037
Trichomonas vaginalis tubulin gamma chain, putative 0.0609 0.2293 0.7959
Loa Loa (eye worm) BEN-1 protein 0.0609 0.2293 0.4863
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0029 0.0027 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0034
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0142 0.0466 0.0462
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0547 0.205 0.3008
Onchocerca volvulus Putative endochitinase 0.0073 0.0199 0.0543
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0049
Echinococcus granulosus Tubulin beta 2C chain 0.0609 0.2293 0.2289
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0547 0.205 0.3008
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0097 0.029 0.0285
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0047 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0547 0.205 0.2046
Echinococcus granulosus serotonin receptor 0.0547 0.205 0.2046
Leishmania major beta tubulin 0.0609 0.2293 1
Echinococcus granulosus G protein coupled receptor 139 0.0547 0.205 0.2046
Brugia malayi Protein kinase domain containing protein 0.0026 0.0015 0.0011
Schistosoma mansoni tyrosine kinase 0.0053 0.0119 0.0168
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0075 0.0204 0.0199
Brugia malayi RE15519p 0.0547 0.205 0.2246
Echinococcus multilocularis neuropeptide Y receptor 0.0547 0.205 0.2046
Echinococcus multilocularis growth factor receptor bound protein 2 0.0029 0.0025 0.002
Brugia malayi Dopamine receptor 0.0547 0.205 0.2246
Loa Loa (eye worm) TK/EGFR protein kinase 0.0295 0.1066 0.2262
Echinococcus multilocularis tubulin beta 1 chain 0.0609 0.2293 0.2289
Trypanosoma brucei beta tubulin 0.0609 0.2293 1
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0029 0.0011
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni tyrosine kinase 0.0214 0.0748 0.1094
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0104 0.0319 0.0462
Echinococcus granulosus Tubulin beta 2C chain 0.0609 0.2293 0.2289
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0056 0.0133 1
Brugia malayi GnHR receptor homolog 0.2353 0.9111 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0133 0.0372
Leishmania major beta tubulin 0.0609 0.2293 1
Echinococcus multilocularis tumor protein p63 0.0326 0.1188 0.1184
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0047 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0047 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0029 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0133 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.0025 0.003
Echinococcus granulosus SWI:SNF matrix associated 0.0084 0.0242 0.0237
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0547 0.205 0.2046
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0056 0.0133 0.505
Echinococcus granulosus tyrosine protein kinase ABL1 0.0228 0.0805 0.0801
Loa Loa (eye worm) endoprotease bli-4 0.1228 0.4713 0.9997
Echinococcus granulosus hypothetical protein 0.0547 0.205 0.2046
Echinococcus granulosus neuropeptide Y receptor 0.0547 0.205 0.2046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Onchocerca volvulus 0.0547 0.205 0.5587
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.003 0.0029 0.0027
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0599 0.2254 0.4781
Echinococcus multilocularis 0.0972 0.3714 0.3711
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0047 0.0042
Trypanosoma brucei calpain, putative 0.0115 0.0362 0.1478
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0547 0.205 0.4348
Loa Loa (eye worm) TK/CSK protein kinase 0.0039 0.0064 0.0136
Loa Loa (eye worm) apoptosis regulator protein 0.0142 0.0466 0.0989
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0084 0.0242 0.0949
Loa Loa (eye worm) hypothetical protein 0.1228 0.4713 0.9997
Schistosoma mansoni MAGUK homolog 0.0035 0.005 0.0067
Leishmania major beta tubulin 0.0609 0.2293 1
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Onchocerca volvulus 0.003 0.0029 0.008
Schistosoma mansoni tgf-beta family 0.0031 0.0034 0.0043
Brugia malayi putative neuropeptide receptor 0.0547 0.205 0.2246
Schistosoma mansoni mannosidase endo-alpha 0.0029 0.0027 0.0032
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0034 0.0047 0.0042
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.003 0.0029 0.008
Echinococcus multilocularis beta tubulin 0.0609 0.2293 0.2289
Schistosoma mansoni tyrosine kinase 0.0078 0.0215 0.031
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0064 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0056 0.0133 0.505
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus granulosus tumor protein p63 0.0326 0.1188 0.1184
Onchocerca volvulus 0.0547 0.205 0.5587
Schistosoma mansoni tyrosine kinase 0.0078 0.0215 0.031
Onchocerca volvulus 0.0024 0.0005 0.0013
Schistosoma mansoni MAGUK homolog 0.0036 0.0052 0.007
Brugia malayi brahma associated protein 60 kDa 0.0084 0.0242 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0053 0.0071
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0082 0.0234 0.023
Loa Loa (eye worm) TK/ALK protein kinase 0.0032 0.0036 0.0077
Echinococcus multilocularis tyrosine protein kinase Blk 0.0082 0.0234 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0242 0.0755
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0029 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Echinococcus granulosus 7TM GPCR rhodopsin 0.0547 0.205 0.2046
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0068 0.0177 0.0664
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0049
Echinococcus granulosus Nuclear pore complex protein Nup153 0.003 0.0029 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0047 0.0042
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0029 0.0025 0.0053
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0039 0.0037
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0547 0.205 0.4348
Echinococcus granulosus biogenic amine 5HT receptor 0.0547 0.205 0.2046
Chlamydia trachomatis SWIB complex protein 0.0084 0.0242 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0084 0.0242 0.1052
Brugia malayi Furin-like cysteine rich region family protein 0.0295 0.1066 0.1166
Schistosoma mansoni tgf-beta family 0.0031 0.0034 0.0043
Schistosoma mansoni glutamate receptor NMDA 0.0273 0.098 0.1434
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0047 0.0099
Echinococcus multilocularis GPCR, family 2 0.0032 0.0038 0.0034
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.0199 0.0423
Onchocerca volvulus 0.0547 0.205 0.5587
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0107
Onchocerca volvulus Neuropeptide F receptor homolog 0.0547 0.205 0.5587
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Echinococcus multilocularis epidermal growth factor receptor 0.0295 0.1066 0.1062
Echinococcus granulosus tyrosine protein kinase csk 0.0039 0.0064 0.0059
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Brugia malayi G-protein coupled receptor 0.0547 0.205 0.2246
Loa Loa (eye worm) tubulin beta-2A chain 0.0609 0.2293 0.4863
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0047 0.0046
Trichomonas vaginalis tubulin beta chain, putative 0.0609 0.2293 0.7959
Brugia malayi G protein-coupled receptor F59B2.13 0.0547 0.205 0.2246
Brugia malayi Transforming growth factor beta like domain containing protein 0.0031 0.0034 0.0032
Brugia malayi SRC-1 0.0097 0.029 0.0313
Echinococcus granulosus tm gpcr rhodopsin 0.0547 0.205 0.2046
Toxoplasma gondii subtilisin SUB5 0.0056 0.0133 0.0467
Schistosoma mansoni tyrosine kinase 0.0097 0.029 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0076 0.0211 0.0447
Leishmania major beta tubulin 0.0609 0.2293 1
Loa Loa (eye worm) growth/differentiation factor 10 0.0031 0.0034 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0757 0.2874 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0228 0.0805 0.1708
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0034
Toxoplasma gondii subtilisin SUB11 0.0056 0.0133 0.0467
Trichomonas vaginalis set domain proteins, putative 0.0286 0.103 0.3525
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0025 0.0022
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0103 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0312 0.1132 0.388
Loa Loa (eye worm) hypothetical protein 0.0063 0.0157 0.0333
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.003 0.0029 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0047 0.0042
Leishmania major hypothetical protein, conserved 0.003 0.0029 0.0011
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0084 0.0242 0.0949
Echinococcus multilocularis tyrosine protein kinase HCK 0.0068 0.0177 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0047 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0916 0.3124
Schistosoma mansoni tubulin subunit beta 0.0609 0.2293 0.3366
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0064 0.0088
Loa Loa (eye worm) guanylate kinase 0.0029 0.0027 0.0057
Echinococcus granulosus disks large 1 0.0029 0.0027 0.0022
Echinococcus multilocularis tyrosine protein kinase Abl 0.0115 0.0362 0.0357
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0033 0.004 0.0046
Schistosoma mansoni serine-type protease inhibitor 0.1762 0.6803 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Schistosoma mansoni apoptosis regulator bax 0.0142 0.0466 0.0679
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0018
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0075 0.0204 0.0199
Echinococcus granulosus dnaJ subfamily B 0.1671 0.6445 0.6444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0047 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Brugia malayi Pre-SET motif family protein 0.0251 0.0895 0.0977
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.004 0.0053
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0039 0.0034
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0064 0.0059
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.029 0.0285
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Plasmodium falciparum tubulin beta chain 0.0609 0.2293 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0177 0.0604 0.0599
Toxoplasma gondii subtilisin SUB10 0.0056 0.0133 0.0467
Echinococcus granulosus disks large 3 0.0035 0.005 0.0046
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0157 0.621
Onchocerca volvulus 0.0198 0.0686 0.187
Echinococcus multilocularis sex peptide receptor 0.0547 0.205 0.2046
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Loa Loa (eye worm) hypothetical protein 0.047 0.1751 0.3714
Brugia malayi Tubulin beta-1 chain 0.0609 0.2293 0.2512
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0547 0.205 0.2046
Echinococcus multilocularis Tubulin beta 2C chain 0.0609 0.2293 0.2289
Brugia malayi beta-tubulin, identical 0.0609 0.2293 0.2512
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.029 0.0285
Trypanosoma brucei RNA helicase, putative 0.0531 0.1987 0.8652
Echinococcus granulosus epidermal growth factor receptor 0.0295 0.1066 0.1062
Schistosoma mansoni biogenic amine receptor 0.0547 0.205 0.3008
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0809 0.3076 0.3073
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0056 0.0133 0.505
Onchocerca volvulus Putative endochitinase 0.0073 0.0199 0.0543
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0062
Echinococcus multilocularis allatostatin A receptor 0.0961 0.3669 0.3666
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni hypothetical protein 0.0142 0.0466 0.0679
Schistosoma mansoni tubulin subunit beta 0.0609 0.2293 0.3366
Onchocerca volvulus 0.0547 0.205 0.5587
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0056 0.0133 0.505
Schistosoma mansoni hypothetical protein 0.0531 0.1987 0.2916
Leishmania major hypothetical protein, conserved 0.003 0.0029 0.0011
Brugia malayi nuclear hormone receptor 0.0034 0.0047 0.0046
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.003 0.0029 0.0027
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0039 0.005
Onchocerca volvulus Putative endochitinase 0.0073 0.0199 0.0543
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0547 0.205 0.2046
Schistosoma mansoni hypothetical protein 0.0084 0.0242 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0064 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0047 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Onchocerca volvulus 0.005 0.0108 0.0294
Echinococcus multilocularis neuropeptide FF receptor 2 0.1228 0.4714 0.4712
Echinococcus granulosus tgf beta family 0.0031 0.0034 0.0029
Echinococcus multilocularis SWI:SNF matrix associated 0.0084 0.0242 0.0237
Loa Loa (eye worm) SRC-1 0.0097 0.029 0.0615
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0106
Echinococcus granulosus epidermal growth factor receptor 0.0085 0.0243 0.0238
Echinococcus granulosus fmrfamide receptor 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Toxoplasma gondii subtilisin SUB6 0.0056 0.0133 0.0467
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Brugia malayi proprotein convertase 2 0.0782 0.2971 0.3257
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0029 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0047 0.0099
Echinococcus granulosus tubulin beta 4A class IVa 0.0609 0.2293 0.2289
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0064 0.006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0047 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0097 0.029 0.0285
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0056 0.0133 0.0141
Schistosoma mansoni growth hormone secretagogue receptor 0.0547 0.205 0.3008
Toxoplasma gondii subtilisin SUB7 0.0056 0.0133 0.0467
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0084 0.0242 0.0237
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0039 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0312 0.1132 0.388
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0053 0.0048
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0035 0.005 0.0046
Echinococcus multilocularis MAGUK p55 subfamily 0.0035 0.005 0.0046
Leishmania major beta tubulin 0.0609 0.2293 1
Schistosoma mansoni fusion 0.003 0.0029 0.0036
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0757 0.2874 0.287
Brugia malayi endochitinase 0.0073 0.0199 0.0214
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0075 0.0204 0.0199
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0177 0.0604 0.1281
Brugia malayi Tyrosine-protein kinase abl-1 0.0115 0.0362 0.0392
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0103 0.0099
Echinococcus granulosus MAGUK p55 subfamily 0.0035 0.005 0.0046
Plasmodium vivax subtilisin-like protease 1 0.0056 0.0133 0.0576
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0047 0.0061
Plasmodium falciparum subtilisin-like protease 2 0.0056 0.0133 0.0467
Echinococcus granulosus tyrosine protein kinase csk 0.0039 0.0064 0.0059
Schistosoma mansoni amine GPCR 0.0547 0.205 0.3008
Echinococcus granulosus neuropeptide receptor 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0547 0.205 0.2046
Brugia malayi ephrin receptor 1 precursor 0.01 0.0305 0.0329
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0547 0.205 0.2046
Brugia malayi Guanylate kinase family protein 0.0029 0.0027 0.0024
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0547 0.205 0.2046
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0024 0.0005 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0312 0.1132 0.388
Schistosoma mansoni alpha-1 adrenergic receptor 0.0547 0.205 0.3008
Trichomonas vaginalis tubulin epsilon chain, putative 0.0609 0.2293 0.7959
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus granulosus furin 0.1228 0.4713 0.471
Loa Loa (eye worm) neuropeptide F receptor 0.0547 0.205 0.4348
Echinococcus granulosus Tubulin beta 2C chain 0.0609 0.2293 0.2289
Brugia malayi ecdysteroid receptor 0.0034 0.0047 0.0046
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0047 0.0042
Echinococcus multilocularis neuropeptide Y receptor 0.0547 0.205 0.2046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0034
Echinococcus granulosus Tubulin beta 2C chain 0.0609 0.2293 0.2289
Giardia lamblia Beta tubulin 0.0609 0.2293 1
Onchocerca volvulus 0.0961 0.3669 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0053 0.0048
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0036 0.0052 0.0047
Leishmania major beta tubulin 0.0609 0.2293 1
Giardia lamblia Beta tubulin 0.0609 0.2293 1
Echinococcus granulosus neuropeptides capa receptor 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0366 0.1344 0.285
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0547 0.205 0.2046
Brugia malayi neuropeptide F receptor 0.0547 0.205 0.2246
Echinococcus multilocularis somatostatin receptor 0.0547 0.205 0.2046
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Leishmania major hypothetical protein, conserved 0.003 0.0029 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni biogenic amine (5HT) receptor 0.0547 0.205 0.3008
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0177 0.0604 0.0599
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0056 0.0133 0.505
Schistosoma mansoni opsin-like receptor 0.0547 0.205 0.3008
Trichomonas vaginalis tubulin alpha chain, putative 0.0609 0.2293 0.7959
Echinococcus multilocularis fmrfamide receptor 0.0547 0.205 0.2046
Echinococcus multilocularis disks large 1 0.0029 0.0027 0.0022
Schistosoma mansoni opsin-like receptor 0.0547 0.205 0.3008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0053 0.0071
Schistosoma mansoni amine GPCR 0.0547 0.205 0.3008
Onchocerca volvulus 0.0079 0.0223 0.0607
Schistosoma mansoni amine GPCR 0.0547 0.205 0.3008
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.003 0.0029 0.0011
Echinococcus multilocularis high voltage activated calcium channel beta 0.0029 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0029 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0547 0.205 0.2046
Onchocerca volvulus 0.0025 0.0008 0.0023
Echinococcus granulosus neuropeptide receptor A26 0.0547 0.205 0.2046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0084 0.0242 0.0237
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0047 0.0061
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0547 0.205 0.2246
Schistosoma mansoni adapter molecule crk 0.0029 0.0025 0.003
Echinococcus multilocularis g protein coupled receptor 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.021
Schistosoma mansoni ATP-dependent RNA Helicase 0.0035 0.005 0.0067
Toxoplasma gondii subtilisin SUB4 0.0056 0.0133 0.0467
Echinococcus multilocularis g protein coupled receptor 0.0547 0.205 0.2046
Echinococcus multilocularis high voltage activated calcium channel beta 0.0029 0.0027 0.0022
Brugia malayi G-protein coupled receptor 0.0547 0.205 0.2246
Echinococcus granulosus glutamate receptor 2 0.0049 0.0103 0.0099
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0064 0.0059
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0547 0.205 0.3008
Entamoeba histolytica tubulin family protein 0.0609 0.2293 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.005 0.005
Echinococcus multilocularis Tubulin beta 2C chain 0.0609 0.2293 0.2289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0068 0.0176 0.0188
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Toxoplasma gondii subtilisin SUB1 0.0056 0.0133 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0047 0.0042
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0547 0.205 0.2046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Schistosoma mansoni hypothetical protein 0.0255 0.0911 0.1333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0112
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0312 0.1132 0.388
Brugia malayi Calcitonin receptor-like protein seb-1 0.0068 0.0176 0.0188
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus multilocularis NMDA receptor 0.0032 0.0039 0.0034
Entamoeba histolytica tubulin family protein 0.0609 0.2293 1
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Schistosoma mansoni hypothetical protein 0.1671 0.6445 0.9474
Schistosoma mansoni nck2/grb4 0.0029 0.0025 0.003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0103 0.0099
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0115 0.0362 0.1478
Brugia malayi SWIB/MDM2 domain containing protein 0.0084 0.0242 0.026
Brugia malayi Protein kinase domain containing protein 0.0032 0.0036 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0047 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0242 0.1052
Schistosoma mansoni cell polarity protein 0.0035 0.005 0.0067
Loa Loa (eye worm) TK/INSR protein kinase 0.0053 0.0119 0.0252
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0068
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0083 0.0236 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0053 0.0115
Brugia malayi hypothetical protein 0.0025 0.0008 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0047 0.0061
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0097 0.029 0.0285
Loa Loa (eye worm) hypothetical protein 0.1228 0.4714 1
Brugia malayi hypothetical protein 0.0031 0.0034 0.0032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Brugia malayi Transforming growth factor beta like domain containing protein 0.0031 0.0034 0.0032
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0075 0.0206 0.0202
Schistosoma mansoni hypothetical protein 0.0142 0.0466 0.0679
Chlamydia trachomatis DNA topoisomerase I 0.0084 0.0242 1
Schistosoma mansoni neuropeptide F-like receptor 0.0547 0.205 0.3008
Toxoplasma gondii beta-tubulin, putative 0.0609 0.2293 1
Brugia malayi Serotonin receptor 0.0547 0.205 0.2246
Leishmania major beta tubulin 0.0609 0.2293 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0047 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0047 0.0042
Schistosoma mansoni maguk P55 subfamily member 26 0.0029 0.0027 0.0032
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0547 0.205 0.3008
Echinococcus multilocularis epidermal growth factor receptor 0.0085 0.0243 0.0238
Echinococcus multilocularis neuropeptide s receptor 0.0547 0.205 0.2046
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0366 0.1344 0.147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0084 0.0242 0.0949
Toxoplasma gondii PAN domain-containing protein 0.0293 0.1059 0.4556
Schistosoma mansoni hypothetical protein 0.0547 0.205 0.3008
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.003 0.0029 0.0011
Schistosoma mansoni hypothetical protein 0.0084 0.0242 0.0349
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0039 0.0082
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0916 0.3124
Schistosoma mansoni amine GPCR 0.0547 0.205 0.3008
Echinococcus multilocularis SWI:SNF matrix associated 0.0084 0.0242 0.0237
Brugia malayi larval opioid receptor 0.0547 0.205 0.2246
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.003 0.0029 0.0011
Schistosoma mansoni hypothetical protein 0.0547 0.205 0.3008
Echinococcus granulosus orexin receptor type 2 0.0547 0.205 0.2046
Schistosoma mansoni tyrosine kinase 0.0068 0.0177 0.0253
Leishmania major hypothetical protein, conserved 0.003 0.0029 0.0011
Leishmania major beta tubulin 0.0609 0.2293 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0215 0.031
Loa Loa (eye worm) hypothetical protein 0.0068 0.0176 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0038 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0053 0.0071
Toxoplasma gondii subtilisin SUB9 0.0056 0.0133 0.0467
Schistosoma mansoni tyrosine kinase 0.0085 0.0243 0.0351
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Brugia malayi neuropeptide F receptor 0.0547 0.205 0.2246
Echinococcus multilocularis Tubulin beta 2C chain 0.0609 0.2293 0.2289
Echinococcus granulosus MAGUK p55 subfamily 0.0035 0.005 0.0046
Echinococcus granulosus neuropeptide s receptor 0.0547 0.205 0.2046
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0157 0.621
Entamoeba histolytica hypothetical protein 0.0039 0.0064 0.0166
Brugia malayi G protein-coupled receptor 0.0547 0.205 0.2246
Schistosoma mansoni tyrosine kinase 0.0097 0.029 0.0419
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0104 0.0319 0.0314
Schistosoma mansoni tyrosine kinase 0.0085 0.0243 0.0351
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0157 0.621
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0609 0.2293 0.2289
Echinococcus granulosus GPCR family 2 0.0032 0.0038 0.0034
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0039 0.0082
Loa Loa (eye worm) G-protein coupled receptor 0.0547 0.205 0.4348
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0047 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0047 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0547 0.205 0.3008
Schistosoma mansoni site-1 peptidase (S08 family) 0.0056 0.0133 0.0188
Echinococcus multilocularis G-protein coupled receptor, putative 0.0547 0.205 0.2046
Schistosoma mansoni site-1 peptidase (S08 family) 0.0056 0.0133 0.0188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni hypothetical protein 0.0142 0.0466 0.0679
Onchocerca volvulus 0.0547 0.205 0.5587
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0083 0.0236 0.5
Trichomonas vaginalis tubulin, putative 0.0609 0.2293 0.7959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0047 0.0099
Leishmania major beta tubulin 0.0609 0.2293 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0053 0.0071
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0097 0.029 0.0285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0062
Echinococcus multilocularis bone morphogenetic protein 2 0.0031 0.0034 0.0029
Brugia malayi Dopamine receptor protein 1 0.0547 0.205 0.2246
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0081
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0547 0.205 0.3008
Chlamydia trachomatis glutamine binding protein 0.0083 0.0236 0.9755
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0047 0.0042
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0084 0.0242 0.0949
Loa Loa (eye worm) hypothetical protein 0.0101 0.0306 0.0649
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0039 0.0034
Onchocerca volvulus 0.0031 0.0034 0.0093
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0039 0.0034
Schistosoma mansoni maguk P55 subfamily member 35 0.0035 0.005 0.0067
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0035 0.005 0.0046
Trichomonas vaginalis hypothetical protein 0.0255 0.0911 0.3105
Echinococcus multilocularis c src tyrosine kinase 0.0068 0.0177 0.0172
Plasmodium vivax SET domain protein, putative 0.0036 0.0053 0.0228
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.003 0.0029 0.0027
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0547 0.205 0.4348
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Schistosoma mansoni tubulin subunit beta 0.0609 0.2293 0.3366
Brugia malayi putative neuropeptide receptor NPR1 0.0547 0.205 0.2246
Schistosoma mansoni adenoreceptor 0.0547 0.205 0.3008
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Loa Loa (eye worm) hypothetical protein 0.0961 0.3669 0.7782
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0366 0.1344 0.5813
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Schistosoma mansoni neuropeptide receptor 0.0547 0.205 0.3008
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Loa Loa (eye worm) tubulin beta-4 chain 0.0609 0.2293 0.4863
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0036 0.0052 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus granulosus tm gpcr rhodopsin 0.0547 0.205 0.2046
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0056 0.0133 0.505
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Echinococcus multilocularis membrane bound transcription factor site 1 0.0056 0.0133 0.0128
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0047 0.0046
Brugia malayi steroid hormone receptor 0.0034 0.0047 0.0046
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0083 0.0236 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0547 0.205 0.2046
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0097 0.029 0.0285
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0142 0.0466 0.0507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Echinococcus multilocularis tubulin subunit beta 0.0609 0.2293 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0133 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0916 0.3124
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.0029 0.0027 0.5
Echinococcus multilocularis insulin receptor 0.0053 0.0119 0.0114
Echinococcus granulosus glutamate NMDA receptor subunit 0.0273 0.098 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0133 0.0372
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0547 0.205 0.2046
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0039 0.005
Schistosoma mansoni guanylate kinase 0.0029 0.0027 0.0032
Echinococcus granulosus c src tyrosine kinase 0.0068 0.0177 0.0172
Brugia malayi Sex muscle abnormal protein 5 0.0029 0.0025 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0547 0.205 0.3008
Schistosoma mansoni neuropeptide receptor 0.0547 0.205 0.3008
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0312 0.1132 0.388
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0312 0.1132 0.388
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.029 0.0285
Echinococcus granulosus allatostatin A receptor 0.0961 0.3669 0.3666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0047 0.0099
Loa Loa (eye worm) bone morphogenic protein 6 0.0122 0.039 0.0826
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.029 0.0285
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0547 0.205 0.4348
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0047 0.007
Echinococcus granulosus beta tubulin 0.0609 0.2293 0.2289
Echinococcus granulosus g protein coupled receptor 0.0547 0.205 0.2046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.0025 0.003
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.005
Onchocerca volvulus 0.003 0.0029 0.008
Echinococcus granulosus insulin receptor 0.0053 0.0119 0.0114
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0056 0.0133 0.0128
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0005 0.001
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0056 0.0133 0.0141
Brugia malayi ZU5 domain containing protein 0.0029 0.0027 0.0024
Brugia malayi protein-tyrosine kinase 0.0082 0.0234 0.0252
Echinococcus multilocularis neuropeptides capa receptor 0.0547 0.205 0.2046
Echinococcus multilocularis dnaJ subfamily B 0.1671 0.6445 0.6444
Loa Loa (eye worm) subtilase 0.0056 0.0133 0.0281
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0029 0.0025 0.003
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus multilocularis disks large 3 0.0035 0.005 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0039 0.005
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0083 0.0236 1
Echinococcus granulosus tyrosine kinase 0.0082 0.0234 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Loa Loa (eye worm) tubulin beta chain 0.0609 0.2293 0.4863
Echinococcus granulosus MAM 0.0025 0.0008 0.0004
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0084 0.0242 0.0513
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0103 0.0099
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0056 0.0133 0.0467
Trypanosoma brucei subtilisin peptidase 0.0056 0.0133 0.0467
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni neuropeptide receptor 0.0547 0.205 0.3008
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0031 0.0033 0.0089
Leishmania major subtilisin-like serine peptidase 0.0056 0.0133 0.0467
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0103 0.0099
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0547 0.205 0.2246
Schistosoma mansoni opsin-like receptor 0.0547 0.205 0.3008
Trypanosoma cruzi beta tubulin, putative 0.0609 0.2293 1
Leishmania major beta tubulin 0.0609 0.2293 1
Brugia malayi SH2 domain containing protein 0.0053 0.0121 0.0128
Echinococcus granulosus Furin 1 0.0312 0.1132 0.1127
Echinococcus multilocularis MAGUK p55 subfamily 0.0035 0.005 0.0046
Toxoplasma gondii subtilisin SUB8 0.0056 0.0133 0.0467
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0039 0.0034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.029 0.0285
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0547 0.205 0.2046
Schistosoma mansoni coup transcription factor 0.0034 0.0047 0.0061
Echinococcus multilocularis Tubulin beta 2C chain 0.0609 0.2293 0.2289
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0005 0.001
Entamoeba histolytica hypothetical protein 0.0039 0.0064 0.0166
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0103 0.0099
Echinococcus granulosus growth factor receptor bound protein 2 0.0029 0.0025 0.002
Brugia malayi Dopamine receptor protein 2 0.0547 0.205 0.2246
Schistosoma mansoni hypothetical protein 0.0084 0.0242 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0604 0.0881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0047 0.0099
Toxoplasma gondii beta tubulin 0.0609 0.2293 1
Schistosoma mansoni biogenic amine receptor 0.0547 0.205 0.3008
Loa Loa (eye worm) SH2 domain-containing protein 0.0046 0.0093 0.0198
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0053
Brugia malayi endochitinase 0.0073 0.0199 0.0214
Brugia malayi Protein kinase domain containing protein 0.0053 0.0119 0.0125
Echinococcus granulosus tyrosine protein kinase Src42A 0.0097 0.029 0.0285
Onchocerca volvulus 0.0056 0.0133 0.0362
Echinococcus multilocularis SWI:SNF matrix associated 0.0084 0.0242 0.0237
Loa Loa (eye worm) tubulin beta-1 chain 0.0609 0.2293 0.4863
Loa Loa (eye worm) hypothetical protein 0.0187 0.0644 0.1366
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0062
Brugia malayi PDZ domain containing protein 0.0076 0.0211 0.0226
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0029 0.0027 0.0057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Echinococcus multilocularis tyrosine protein kinase Srms 0.0082 0.0234 0.023
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0034 0.0047 0.0042
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0097 0.029 0.0285
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0047 0.0046
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0547 0.205 0.2046
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus granulosus dro:myosuppressin receptor 0.0547 0.205 0.2046
Trichomonas vaginalis tubulin epsilon chain, putative 0.0609 0.2293 0.7959
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0255 0.0911 0.3105
Plasmodium falciparum subtilisin-like protease 1 0.0056 0.0133 0.0467
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0049
Leishmania major beta tubulin 0.0609 0.2293 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.003 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Trypanosoma brucei beta tubulin 0.0609 0.2293 1
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus multilocularis dro:myosuppressin receptor 0.0547 0.205 0.2046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0547 0.205 0.2046
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0757 0.2874 0.287
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Schistosoma mansoni serine-type protease inhibitor 0.1762 0.6803 1
Onchocerca volvulus 0.0036 0.0053 0.0144
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0056 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Echinococcus multilocularis guanylate kinase 0.0029 0.0027 0.0022
Toxoplasma gondii beta-1 tubulin, putative 0.0609 0.2293 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0053 0.0048
Echinococcus granulosus tyrosine protein kinase Src64B 0.0097 0.029 0.0285
Schistosoma mansoni neuropeptide F-like receptor 0.0547 0.205 0.3008
Schistosoma mansoni maguk P55 subfamily member 26 0.0035 0.005 0.0067
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0097 0.029 0.0285
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.006 0.0148 0.0143
Schistosoma mansoni tubulin subunit beta 0.0609 0.2293 0.3366
Echinococcus multilocularis ephrin type A receptor 4 A 0.0205 0.0714 0.071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0547 0.205 0.2046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0047 0.0061
Echinococcus granulosus neuropeptide FF receptor 2 0.1228 0.4714 0.4712
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0039 0.0034
Toxoplasma gondii PAN domain-containing protein 0.0293 0.1059 0.4556
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0362 0.1478
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0103 0.0099
Echinococcus granulosus neuropeptide receptor 0.0547 0.205 0.2046
Loa Loa (eye worm) beta-tubulin 0.0609 0.2293 0.4863
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0018
Echinococcus multilocularis orexin receptor type 2 0.0547 0.205 0.2046
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0362 0.1478
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0122 0.039 0.0385
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0255 0.0911 0.3105
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0047 0.0046
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0362 0.1478
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0157 0.0333
Echinococcus granulosus tyrosine protein kinase csk 0.0039 0.0064 0.0059
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1228 0.4713 0.6926
Onchocerca volvulus 0.0547 0.205 0.5587
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Onchocerca volvulus 0.0547 0.205 0.5587
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Onchocerca volvulus 0.0084 0.0242 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0049
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0085 0.0243 0.0238
Brugia malayi map kinase activated protein kinase protein 2 0.0177 0.0604 0.0658
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0103 0.0099
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0547 0.205 0.2046
Loa Loa (eye worm) proprotein convertase 2 0.0312 0.1132 0.24
Echinococcus granulosus somatostatin receptor 0.0547 0.205 0.2046
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus granulosus Zinc finger RanBP2 type 0.003 0.0029 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0047 0.0046
Loa Loa (eye worm) chitinase I 0.0073 0.0199 0.0423
Schistosoma mansoni zinc finger protein 0.003 0.0029 0.0036
Onchocerca volvulus 0.003 0.0029 0.008
Toxoplasma gondii subtilisin SUB12 0.0075 0.0207 0.0793
Brugia malayi Pre-SET motif family protein 0.0036 0.0053 0.0053
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0047 0.0046
Loa Loa (eye worm) TYRA-2 protein 0.0547 0.205 0.4348
Echinococcus granulosus membrane bound transcription factor site 1 0.0056 0.0133 0.0128
Schistosoma mansoni neuropeptide receptor 0.0547 0.205 0.3008
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0029 0.0011
Loa Loa (eye worm) hypothetical protein 0.0142 0.0466 0.0989
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0039 0.0034
Entamoeba histolytica protein kinase, putative 0.0068 0.0177 0.0663
Brugia malayi hypothetical protein 0.0029 0.0027 0.0024
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.0029 0.0027 0.0032
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0961 0.3669 0.539
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0072
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Brugia malayi Melatonin receptor type 1A 0.0547 0.205 0.2246
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0047 0.0042
Echinococcus granulosus insulin growth factor 1 receptor beta 0.006 0.0148 0.0143
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0047 0.0042
Trypanosoma brucei hypothetical protein 0.0115 0.0362 0.1478
Echinococcus granulosus rhodopsin orphan GPCR 0.0547 0.205 0.2046
Echinococcus multilocularis zinc finger protein Ran binding 0.003 0.0029 0.0025
Brugia malayi Angiotensin-converting enzyme family protein 0.0599 0.2254 0.247
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0056 0.0133 0.505
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0547 0.205 0.2046
Brugia malayi brahma associated protein 60 kDa 0.0084 0.0242 0.026
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0047 0.0127
Leishmania major chitinase 0.0073 0.0199 0.0761
Onchocerca volvulus 0.0286 0.103 0.2809
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0053 0.0048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0547 0.205 0.3008
Schistosoma mansoni hypothetical protein 0.0547 0.205 0.3008
Plasmodium falciparum subtilisin-like protease 3 0.0056 0.0133 0.0467
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0099 0.0138
Echinococcus granulosus tyrosine protein kinase Blk 0.0082 0.0234 0.023
Echinococcus multilocularis g protein coupled receptor 0.0547 0.205 0.2046
Echinococcus multilocularis NCK adaptor protein 0.0029 0.0025 0.002
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0047 0.0061
Schistosoma mansoni replication factor A 1 rfa1 0.0034 0.0047 0.0062
Leishmania major beta tubulin 0.0609 0.2293 1
Onchocerca volvulus 0.0547 0.205 0.5587
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0033 0.0043 0.0056
Echinococcus granulosus Tubulin beta 2C chain 0.0609 0.2293 0.2289
Onchocerca volvulus 0.0048 0.0099 0.0269
Echinococcus granulosus ring and YY1 binding protein 0.003 0.0029 0.0025
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0056 0.0133 0.0128
Echinococcus granulosus tyrosine protein kinase Lyn 0.0097 0.0292 0.0287
Echinococcus multilocularis MAGUK p55 subfamily 0.0035 0.005 0.0046
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0547 0.205 0.3008
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0048 0.0043
Loa Loa (eye worm) guanylate kinase 0.0035 0.005 0.0107
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0025 0.0022
Brugia malayi neuroendocrine convertase 1 precursor 0.0782 0.2971 0.3257
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0099
Schistosoma mansoni cell polarity protein 0.0044 0.0083 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0018
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0142 0.0466 0.0679
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0432
Brugia malayi AKH receptor 0.0547 0.205 0.2246
Echinococcus granulosus bone morphogenetic protein 2 0.0031 0.0034 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0038 0.0037
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0142 0.0466 0.0462
Schistosoma mansoni tubulin subunit beta 0.0609 0.2293 0.3366
Leishmania major beta tubulin 0.0609 0.2293 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.003 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0047 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0062
Trypanosoma cruzi WLM domain containing protein, putative 0.003 0.0029 0.0011
Brugia malayi Serotonin receptor 0.0547 0.205 0.2246
Loa Loa (eye worm) brahma associated protein 0.0084 0.0242 0.0513
Brugia malayi Tyrosine-protein kinase abl-1 0.0128 0.0411 0.0446
Leishmania major beta tubulin 0.0609 0.2293 1
Echinococcus multilocularis G protein coupled receptor 139 0.0547 0.205 0.2046
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0916 0.1943
Onchocerca volvulus 0.003 0.0029 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0039 0.005
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0122 0.039 0.0385
Echinococcus multilocularis 0.0045 0.0089 0.0084
Echinococcus granulosus zinc finger protein Ran binding 0.003 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Brugia malayi guanylate kinase 0.0029 0.0027 0.0024
Plasmodium vivax subtilisin-like serine protease, putative 0.0056 0.0133 0.0576
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.003 0.0029 0.0011
Onchocerca volvulus 0.0031 0.0034 0.0093
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0547 0.205 0.2046
Schistosoma mansoni tubulin subunit beta 0.0609 0.2293 0.3366
Trypanosoma brucei C-8 sterol isomerase, putative 0.0366 0.1344 0.5813
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0047 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0047 0.0042
Loa Loa (eye worm) TK protein kinase 0.0068 0.0177 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Trypanosoma brucei beta tubulin 0.0609 0.2293 1
Leishmania major beta tubulin 0.0609 0.2293 1
Brugia malayi follicle stimulating hormone receptor 0.0547 0.205 0.2246
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0916 0.3124
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0035 0.005 0.0107
Echinococcus granulosus guanylate kinase 0.0029 0.0027 0.0022
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0362 0.1478
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Onchocerca volvulus 0.0053 0.0121 0.033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Echinococcus granulosus beta tubulin 0.0609 0.2293 0.2289
Echinococcus granulosus NCK adaptor protein 0.0029 0.0025 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0547 0.205 0.2046
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0547 0.205 0.2246
Trypanosoma brucei beta tubulin 0.0609 0.2293 1
Brugia malayi Endochitinase 0.0073 0.0199 0.0214
Echinococcus multilocularis Tubulin beta 2C chain 0.0609 0.2293 0.2289
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0047 0.0046
Brugia malayi sulfakinin receptor protein 0.0547 0.205 0.2246
Loa Loa (eye worm) neuropeptide F receptor 0.0547 0.205 0.4348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0047 0.0099
Echinococcus granulosus alpha 1A adrenergic receptor 0.0547 0.205 0.2046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0363 0.0358
Giardia lamblia Beta tubulin 0.0609 0.2293 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0547 0.205 0.2046
Brugia malayi abnormal cell lineage protein 2 0.0029 0.0027 0.0024
Loa Loa (eye worm) TK/EPH protein kinase 0.0259 0.0926 0.1965
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Brugia malayi hypothetical protein 0.0039 0.0064 0.0065
Leishmania major beta tubulin 0.0609 0.2293 1
Trypanosoma brucei calpain-like protein, putative 0.0115 0.0362 0.1478
Echinococcus multilocularis serotonin receptor 0.0547 0.205 0.2046
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0075 0.0204 0.0199
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0039 0.005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.004 0.0053
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0034 0.0047 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.029 0.0285
Schistosoma mansoni hypothetical protein 0.0035 0.005 0.0067
Echinococcus multilocularis serotonin receptor 0.0547 0.205 0.2046
Entamoeba histolytica chitinase, putative 0.0073 0.0199 0.0761
Schistosoma mansoni tyrosine kinase 0.0053 0.0119 0.0168
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0047 0.0042
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0312 0.1132 0.1658
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.003 0.0029 0.0011
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.003 0.0029 0.0027
Echinococcus multilocularis ring and YY1 binding protein 0.003 0.0029 0.0025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0895 0.1898
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Giardia lamblia Furin precursor putative serine protease 0.0255 0.0911 0.3902
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0115 0.0362 0.1478
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0571 0.1556
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0547 0.205 0.5587
Echinococcus granulosus tyrosine protein kinase HCK 0.0068 0.0177 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0606 0.2036
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0547 0.205 0.3008
Trypanosoma cruzi WLM domain containing protein, putative 0.003 0.0029 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0362 0.1478
Echinococcus multilocularis g-protein coupled receptor 0.0547 0.205 0.2046
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0606 0.2036
Echinococcus granulosus MAGUK p55 subfamily 0.0035 0.005 0.0046
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus granulosus sex peptide receptor 0.0547 0.205 0.2046
Schistosoma mansoni neuropeptide f receptor 76f 0.0547 0.205 0.3008
Entamoeba histolytica hypothetical protein 0.0039 0.0064 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Schistosoma mansoni myosin xvIII 0.0547 0.205 0.3008
Onchocerca volvulus 0.0036 0.0054 0.0147
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0363 0.0358
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0103 0.0099
Echinococcus multilocularis tgf beta family 0.0031 0.0034 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0757 0.2874 1
Schistosoma mansoni ephrin receptor 0.0205 0.0714 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Loa Loa (eye worm) G-protein coupled receptor 0.0547 0.205 0.4348
Brugia malayi hypothetical protein 0.0547 0.205 0.2246
Schistosoma mansoni amine GPCR 0.0547 0.205 0.3008
Onchocerca volvulus 0.0547 0.205 0.5587
Echinococcus granulosus tyrosine protein kinase Src42A 0.0075 0.0206 0.0202
Echinococcus multilocularis neuropeptide receptor 0.0547 0.205 0.2046
Onchocerca volvulus Putative endochitinase 0.0073 0.0199 0.0543
Onchocerca volvulus Putative endochitinase 0.0073 0.0199 0.0543
Echinococcus multilocularis MAM 0.0025 0.0008 0.0004
Schistosoma mansoni histamine h1 receptor 0.0547 0.205 0.3008
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0228 0.0805 0.0801
Echinococcus granulosus g protein coupled receptor 0.0547 0.205 0.2046
Schistosoma mansoni RNA binding protein 0.003 0.0029 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0547 0.205 0.2046
Toxoplasma gondii ran binding protein 0.003 0.0029 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Schistosoma mansoni TRABID protein (C64 family) 0.003 0.0029 0.0036
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0068 0.0177 0.0664
Echinococcus multilocularis neuropeptide receptor 0.0547 0.205 0.2046
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0056 0.0133 0.0188
Schistosoma mansoni furin-1 (S08 family) 0.0527 0.1972 0.2894
Loa Loa (eye worm) hypothetical protein 0.0056 0.0133 0.0281
Schistosoma mansoni tyrosine kinase 0.0036 0.0053 0.0071
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0916 0.1001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0547 0.205 0.2046
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0273 0.098 0.0975
Plasmodium vivax subtilisin-like protease 2, putative 0.0056 0.0133 0.0576
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0916 0.3124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0047 0.0046
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0047 0.007
Echinococcus multilocularis beta tubulin 0.0609 0.2293 0.2289
Echinococcus granulosus ephrin type A receptor 4 A 0.0205 0.0714 0.071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0072
Toxoplasma gondii subtilisin SUB2 0.0056 0.0133 0.0467
Schistosoma mansoni hypothetical protein 0.0039 0.0064 0.0088
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0039 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0547 0.205 0.2046
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0198 0.0686 0.1455
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0047 0.0042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0547 0.205 0.2246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0133 0.0372
Brugia malayi Peripheral plasma membrane protein CASK 0.005 0.0106 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0255 0.0911 0.3105
Echinococcus granulosus high voltage activated calcium channel beta 0.0029 0.0027 0.0022
Onchocerca volvulus 0.0034 0.0047 0.0127
Brugia malayi hypothetical protein 0.0031 0.0034 0.0032
Loa Loa (eye worm) BEN-1 protein 0.0609 0.2293 0.4863
Echinococcus granulosus g-protein coupled receptor 0.0547 0.205 0.2046
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.003 0.0029 0.0011
Echinococcus multilocularis neuroendocrine convertase 2 0.0782 0.2971 0.2967
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0103 0.0145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0047 0.0061
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0047 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0547 0.205 0.3008
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0571 0.1911
Loa Loa (eye worm) hypothetical protein 0.0547 0.205 0.4348
Loa Loa (eye worm) TK protein kinase 0.0082 0.0234 0.0497
Schistosoma mansoni biogenic amine receptor 0.0547 0.205 0.3008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0068 0.0176 0.0374
Schistosoma mansoni septate junction protein 0.0028 0.0023 0.0027
Trypanosoma cruzi subtilisin peptidase 0.0056 0.0133 0.0467

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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