Detailed information for compound 141291

Basic information

Technical information
  • TDR Targets ID: 141291
  • Name: (11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepi n-6-yl) 2-chloroacetate
  • MW: 330.766 | Formula: C17H15ClN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCC(=O)OC1Cc2ccccc2N(c2c1cccc2)C(=O)N
  • InChi: 1S/C17H15ClN2O3/c18-10-16(21)23-15-9-11-5-1-3-7-13(11)20(17(19)22)14-8-4-2-6-12(14)15/h1-8,15H,9-10H2,(H2,19,22)
  • InChiKey: YGQRITUGYXRHJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloroacetic acid (11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-6-yl) ester
  • (11-aminocarbonyl-5,6-dihydrobenzo[b][1]benzazepin-6-yl) 2-chloroethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Brugia malayi nuclear receptor NHR-88 0.0034 0.0099 0.011
Schistosoma mansoni DNA polymerase eta 0.0046 0.0222 0.0222
Giardia lamblia Kinase, PLK 0.0096 0.0732 0.4245
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0048 0.0243 0.0305
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.014 0.0119
Brugia malayi nuclear hormone receptor 0.0034 0.0099 0.011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.0485 0.0634
Leishmania major thymidine kinase, putative 0.0139 0.1177 0.157
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.0485 0.0485
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.013 0.0104
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Trypanosoma brucei calpain, putative 0.0048 0.0243 0.0305
Echinococcus granulosus FTZ F1 alpha 0.0071 0.0485 0.0461
Mycobacterium ulcerans inorganic polyphosphate/ATP-NAD kinase 0.0189 0.1688 0.5
Onchocerca volvulus 0.0071 0.0485 0.611
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0167
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0099 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0238 0.1274
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0026 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.0485 0.0634
Schistosoma mansoni nuclear receptor 0.0034 0.0099 0.0099
Schistosoma mansoni retinoic acid receptor RXR 0.1001 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0099 0.011
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0416 0.0407
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0732 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0732 0.0732
Schistosoma mansoni hypothetical protein 0.0037 0.013 0.013
Brugia malayi hypothetical protein 0.0034 0.0099 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0232 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.0485 0.0634
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0416 0.0416
Entamoeba histolytica hypothetical protein 0.0037 0.013 0.0141
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0099 0.011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Treponema pallidum hypothetical protein 0.0189 0.1688 0.5
Schistosoma mansoni nuclear receptor 0.0034 0.0099 0.0099
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0026 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0099 0.0099
Echinococcus multilocularis transcription factor Dp 1 0.0433 0.4182 0.4334
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0099 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0485 0.0634
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0416 0.0416
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.0485 0.0485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0232 0.0206
Trichomonas vaginalis thymidine kinase, putative 0.0139 0.1177 0.6926
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.014 0.0167
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0099 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0416 0.0416
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.0485 0.0485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.014 0.014
Echinococcus granulosus NAD kinase 0.0189 0.1688 0.1666
Entamoeba histolytica hypothetical protein 0.0037 0.013 0.0141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.0485 0.0461
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.0485 0.0461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0485 0.0634
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.0485 0.0485
Trichomonas vaginalis thymidine kinase, putative 0.0139 0.1177 0.6926
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0485 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Echinococcus granulosus dna polymerase eta 0.0046 0.0222 0.0196
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0732 0.0707
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0099 0.0099
Leishmania major DNA polymerase eta, putative 0.0046 0.0222 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.0485 0.0634
Trichomonas vaginalis thymidine kinase, putative 0.0139 0.1177 0.6926
Echinococcus multilocularis NAD kinase 0.0189 0.1688 0.1733
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0099 0.011
Giardia lamblia Thymidine kinase 0.0139 0.1177 0.6926
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Brugia malayi nuclear hormone receptor 0.0071 0.0485 0.0634
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0747 0.7403 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.0485 0.0634
Brugia malayi ecdysteroid receptor 0.0071 0.0485 0.0634
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0747 0.7403 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0243 0.0305
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0099 0.011
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0083 0.0089
Brugia malayi Flap endonuclease-1 0.0027 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0099 0.011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0243 0.0305
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0485 0.0634
Schistosoma mansoni kinase 0.0049 0.0251 0.0251
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0732 0.0736
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0099 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0416 0.054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0099 0.0076
Mycobacterium leprae Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) 0.0173 0.1529 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0028 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.0485 0.0634
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Brugia malayi nuclear receptor NHR-88 0.0071 0.0485 0.0634
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.014 0.0167
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.0485 0.611
Plasmodium falciparum flap endonuclease 1 0.0027 0.0026 1
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.0485 0.0634
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.0485 0.0634
Trypanosoma brucei calpain-like protein, putative 0.0048 0.0243 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0026 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Brugia malayi ecdysone receptor 0.0034 0.0099 0.011
Echinococcus granulosus transcription factor Dp 1 0.0433 0.4182 0.4166
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.0485 0.0461
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0167
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0747 0.7403 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.0485 0.0461
Brugia malayi hypothetical protein 0.0038 0.014 0.0167
Echinococcus multilocularis geminin 0.0173 0.1525 0.1564
Schistosoma mansoni coup transcription factor 0.0071 0.0485 0.0485
Trypanosoma brucei thymidine kinase 0.0139 0.1177 0.157
Echinococcus multilocularis dna polymerase eta 0.0046 0.0222 0.0204
Echinococcus multilocularis thyroid hormone receptor alpha 0.0071 0.0485 0.0479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0232 0.0232
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0485 0.0461
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0099 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0732 0.0967
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0099 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0099 0.0073
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0747 0.7403 1
Echinococcus granulosus geminin 0.0173 0.1525 0.1503
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0963 0.9614 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.0485 0.0634
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.0485 0.0479
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0189 0.1688 0.1688
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0222 0.0277
Loa Loa (eye worm) DR-78 0.0034 0.0099 0.011
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0416 0.0416
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0243 0.0305
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0099 0.0076
Brugia malayi nuclear receptor RXR 0.0034 0.0099 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0485 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0485 0.0479
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0222 0.0277
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0416 0.054
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0747 0.7403 0.7403
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.0485 0.0634
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.0485 0.0634
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.013 0.0108
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.0485 0.0634
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0747 0.7403 1
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0189 0.1688 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0026 0.1335
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0416 0.0416
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.0485 0.0485
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.0485 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0485 0.0634
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0747 0.7403 0.7396
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0222 0.0277
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0099 0.0073
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Loa Loa (eye worm) hypothetical protein 0.0046 0.0222 0.0277
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Schistosoma mansoni thyroid hormone receptor 0.0071 0.0485 0.0485
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0099 0.0099
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0732 0.0967
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0026 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.014 0.0167
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0048 0.0243 0.0305
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0099 0.011
Trypanosoma cruzi thymidine kinase, putative 0.0139 0.1177 0.157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.0485 0.0479
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Brugia malayi hypothetical protein 0.0034 0.0099 0.011
Entamoeba histolytica hypothetical protein 0.0037 0.013 0.0141
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0232 0.0291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.0485 0.0479
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.0485 0.0634
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.0485 0.0479
Brugia malayi TAR-binding protein 0.0065 0.0416 0.054
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.014 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0238 0.1274
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0099 0.011
Leishmania major DNA polymerase eta, putative 0.0032 0.0083 0.0089
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0099 0.0073
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0747 0.7403 1
Giardia lamblia Inorganic polyphosphate/ATP-NAD kinase, putative 0.0189 0.1688 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0485 0.0461
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0099 0.011
Brugia malayi nuclear receptor RXR 0.0038 0.014 0.0167
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.0485 0.611
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0189 0.1688 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.0485 0.0634
Loa Loa (eye worm) RNA binding protein 0.0065 0.0416 0.054
Brugia malayi hypothetical protein 0.0038 0.014 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0232 0.0232
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0026 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.0485 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0232 0.0206
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.0485 0.0461
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0634
Mycobacterium tuberculosis Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) 0.0173 0.1529 0.5
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0732 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0732 0.0967
Echinococcus granulosus tar DNA binding protein 0.0065 0.0416 0.0391
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0083 1
Schistosoma mansoni hypothetical protein 0.0173 0.1525 0.1525
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0099 0.0073
Brugia malayi conserved hypotetical protein 0.0034 0.0099 0.011
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.0485 0.611
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0485 0.0634
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.0485 0.0479
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0416 0.054
Brugia malayi tailless protein 0.0034 0.0099 0.011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0232 0.0291
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0732 0.0967
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0167
Brugia malayi nuclear receptor NHR-67 0.0034 0.0099 0.011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0099 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0485 0.0634
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.0485 0.0634
Schistosoma mansoni thyroid hormone receptor 0.0071 0.0485 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0732 0.4245
Brugia malayi steroid hormone receptor 0.0071 0.0485 0.0634
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.0485 0.0479
Schistosoma mansoni hypothetical protein 0.0173 0.1525 0.1525
Trypanosoma brucei polo-like protein kinase 0.0096 0.0732 0.0967
Brugia malayi hypothetical protein 0.0037 0.013 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0243 0.0305
Brugia malayi Cytochrome P450 family protein 0.0027 0.0028 0.0014
Schistosoma mansoni zinc finger protein 0.0034 0.0099 0.0099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.0485 0.0485
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0232 0.0215
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0747 0.7403 0.7695
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.014 0.0115
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.011
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0048 0.0243 0.0305
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0167
Trypanosoma cruzi thymidine kinase, putative 0.0139 0.1177 0.157
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.0485 0.0634
Entamoeba histolytica thymidine kinase, putative 0.0139 0.1177 0.156
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0747 0.7403 1
Entamoeba histolytica hypothetical protein 0.0037 0.013 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0048 0.0243 0.0305
Brugia malayi RNA binding protein 0.0065 0.0416 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.0485 0.0634
Trypanosoma brucei hypothetical protein 0.0048 0.0243 0.0305
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0732 0.0967
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.013 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0232 0.0232
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.0485 0.0485

Activities

Activity type Activity value Assay description Source Reference
Protection (functional) = 0.5 % Compound was tested for anticonvulsant activity against MES-induced seizures in rat ChEMBL. 10411478
Protection (functional) = 0.5 % Compound was tested for anticonvulsant activity against MES-induced seizures in rat ChEMBL. 10411478

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.