TDR Targets

Basic information

Technical information

TDR Targets ID: 1413133
Name: 2-(phenoxy)ethyl [(1,1-dioxothiolan-3-yl)amin o]methanedithioate
MW: 331.474 | Formula: C13H17NO3S3
H donors: 1 H acceptors: 2 LogP: 2.32 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: S=C(NC1CCS(=O)(=O)C1)SCCOc1ccccc1
InChi: 1S/C13H17NO3S3/c15-20(16)9-6-11(10-20)14-13(18)19-8-7-17-12-4-2-1-3-5-12/h1-5,11H,6-10H2,(H,14,18)
InChiKey: UEXGFLKRTHATNV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(1,1-dioxo-3-thiolanyl)amino]methanedithioic acid 2-(phenoxy)ethyl ester
[(1,1-diketothiolan-3-yl)amino]methanedithioic acid 2-(phenoxy)ethyl ester
IFLab1_000084
MLS000712812
SMR000282579
BAS 00533310
AE-848/11244738
STOCK6S-30478
IDI1_008303

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	snurportin 1		No references
Homo sapiens	chemokine (C-X-C motif) ligand 8	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	karyopherin (importin) beta 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Plasmodium falciparum	LCCL domain-containing protein	chemokine (C-X-C motif) ligand 8	99 aa	80 aa	25.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0057	0.1243
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0186	0.0206
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0065	0.0228	0.7923
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0103	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0352	0.1478	0.1631
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0009	0.0061
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0015	0.0011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0015	0.0011	0.0012
Brugia malayi	Carboxylesterase family protein	0.0352	0.1478	0.164
Trypanosoma cruzi	major cysteine proteinase, putative	0.0056	0.0189	0.6499
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0027	0.003
Schistosoma mansoni	amine GPCR	0.0036	0.0103	0.0103
Schistosoma mansoni	glucose transport protein	0.0104	0.0396	0.0396
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0085	0.2762
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0085	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0027	0.003
Brugia malayi	Sugar transporter family protein	0.0104	0.0396	0.0439
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0068	0.215
Plasmodium vivax	PST-A protein	0.0078	0.0285	0.7143
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Plasmodium vivax	vivapain-2	0.0019	0.0027	0.0461
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0078	0.0285	0.1931
Onchocerca volvulus		0.0036	0.0103	0.07
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0078	0.0285	0.1931
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0009	0.0061
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Echinococcus multilocularis	serotonin receptor	0.0036	0.0103	0.0105
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0103	0.0103
Echinococcus multilocularis	acetylcholinesterase	0.2086	0.9014	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0062	0.0214	0.7417
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0036	0.0103	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.0396	0.2679
Schistosoma mansoni	opsin-like receptor	0.0036	0.0103	0.0103
Onchocerca volvulus		0.0036	0.0103	0.07
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0036	0.0103	0.0105
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0093	0.0349	0.0378
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0036	0.0103	0.0115
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0093	0.0349	0.8798
Schistosoma mansoni	hypothetical protein	0.0372	0.1562	0.1562
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0103	0.0105
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0572	0.0635
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.0396	0.043
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0015	0.0009	0.0061
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.0439
Plasmodium falciparum	lysophospholipase, putative	0.0078	0.0285	0.7143
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Onchocerca volvulus		0.0019	0.0027	0.0181
Brugia malayi	G protein-coupled receptor F59B2.13	0.0036	0.0103	0.0115
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.0152	0.0169
Brugia malayi	GnHR receptor homolog	0.0036	0.0103	0.0115
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0009	0.001
Plasmodium vivax	aspartyl proteinase, putative	0.0093	0.0349	0.8798
Onchocerca volvulus		0.0036	0.0103	0.07
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0036	0.0103	0.0103
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0027	0.003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0128	0.4296
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.043
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0186	0.0206
Onchocerca volvulus		0.0015	0.0009	0.0061
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0036	0.0103	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Plasmodium vivax	hexose transporter	0.0104	0.0396	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	MH2 domain containing protein	0.0144	0.0572	0.0635
Brugia malayi	hypothetical protein	0.0093	0.0349	0.0388
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0103	0.0103
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0057	0.174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Plasmodium falciparum	importin beta, putative	0.0035	0.0097	0.2276
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0027	0.003
Onchocerca volvulus		0.0019	0.0027	0.0181
Onchocerca volvulus		0.0093	0.0349	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	larval opioid receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0157	0.0628	0.0697
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.0439
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0036	0.0103	0.0105
Plasmodium falciparum	hexose transporter	0.0104	0.0396	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0009	0.001
Plasmodium falciparum	plasmepsin IX	0.0093	0.0349	0.8798
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0186	0.0186
Brugia malayi	AKH receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0085	0.0577
Loa Loa (eye worm)	fibroinase	0.0019	0.0027	0.003
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0093	0.0349	0.0388
Loa Loa (eye worm)	ctsf protein	0.0019	0.0027	0.003
Schistosoma mansoni	hypothetical protein	0.0036	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma cruzi	cruzipain precursor, putative	0.0071	0.0255	0.8893
Brugia malayi	Carboxylesterase family protein	0.2086	0.9014	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0036	0.0103	0.0115
Leishmania major	cathepsin L-like protease	0.0071	0.0255	0.8893
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0103	0.0105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0085	0.2762
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0069	0.0246	0.1664
Leishmania major	hypothetical protein, conserved	0.0015	0.0011	0.0058
Echinococcus multilocularis	snurportin 1	0.0372	0.1562	0.1724
Loa Loa (eye worm)	carboxylesterase	0.0352	0.1478	0.164
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Echinococcus granulosus	acetylcholinesterase	0.2086	0.9014	1
Schistosoma mansoni	amidase	0.0124	0.0484	0.0484
Mycobacterium ulcerans	amidase	0.0015	0.0011	0.0011
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	7tm_1 domain containing protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0078	0.0285	0.1931
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0352	0.1478	1
Onchocerca volvulus		0.0036	0.0103	0.07
Brugia malayi	Carboxylesterase family protein	0.2086	0.9014	1
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0015	0.0011	0.0011
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0015	0.0011	0.0058
Leishmania major	monoglyceride lipase, putative	0.0078	0.0285	1
Schistosoma mansoni	glucose transport protein	0.0104	0.0396	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0078	0.0285	0.1931
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0103	0.0103
Schistosoma mansoni	sugar transporter	0.0015	0.0009	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Brugia malayi	Pepsin A precursor	0.0093	0.0349	0.0388
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Schistosoma mansoni	neuropeptide f receptor 76f	0.0036	0.0103	0.0103
Echinococcus granulosus	dna polymerase eta	0.0039	0.0117	0.013
Onchocerca volvulus		0.0019	0.0027	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Schistosoma mansoni	acetylcholinesterase	0.0352	0.1478	0.1478
Echinococcus granulosus	serotonin receptor	0.0036	0.0103	0.0115
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0103	0.0103
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0027	0.003
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0027	0.0181
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0103	0.0105
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma cruzi	DNA polymerase eta, putative	0.0039	0.0117	0.3912
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Echinococcus granulosus	acetylcholinesterase	0.2086	0.9014	1
Toxoplasma gondii	aspartyl protease ASP1	0.0093	0.0349	0.8798
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0039	0.0117	0.012
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0057	0.1243
Echinococcus multilocularis	neuropeptide receptor A26	0.0036	0.0103	0.0105
Schistosoma mansoni	fatty-acid amide hydrolase	0.0015	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Leishmania major	cathepsin L-like protease	0.0071	0.0255	0.8893
Echinococcus multilocularis	somatostatin receptor	0.0036	0.0103	0.0105
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0039	0.0117	0.4104
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Mycobacterium ulcerans	amidase	0.0015	0.0011	0.0011
Plasmodium vivax	plasmepsin V, putative	0.0093	0.0349	0.8798
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0085	0.0577
Loa Loa (eye worm)	cysteine protease	0.0019	0.0027	0.003
Onchocerca volvulus		0.0036	0.0103	0.07
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0255	0.8893
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.0152	0.3701
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0103	0.0105
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0103	0.0115
Brugia malayi	Serotonin receptor	0.0036	0.0103	0.0115
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0036	0.0103	0.0105
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0352	0.1478	0.1478
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0255	0.8893
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0349	0.0388
Schistosoma mansoni	opsin-like receptor	0.0036	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0484	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0019	0.0027	0.0181
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Schistosoma mansoni	hypothetical protein	0.0036	0.0103	0.0103
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0097	0.3186
Onchocerca volvulus		0.0015	0.0009	0.0061
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0036	0.0103	0.0115
Brugia malayi	neuropeptide F receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0047	0.0149	0.5069
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0085	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0068	0.0463
Schistosoma mansoni	adenoreceptor	0.0036	0.0103	0.0103
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0009	0.001
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0097	0.2276
Trypanosoma cruzi	amidase, putative	0.0015	0.0011	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0124	0.0484	0.0527
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0036	0.0103	0.07
Brugia malayi	Dopamine receptor protein 1	0.0036	0.0103	0.0115
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0097	0.2276
Onchocerca volvulus		0.0015	0.0009	0.0061
Brugia malayi	Carboxylesterase family protein	0.0352	0.1478	0.164
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Schistosoma mansoni	cathepsin D (A01 family)	0.0093	0.0349	0.0349
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Loa Loa (eye worm)	hypothetical protein	0.2086	0.9014	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.0439
Trypanosoma brucei	DNA polymerase IV, putative	0.0069	0.0246	0.8574
Echinococcus granulosus	dro:myosuppressin receptor	0.0036	0.0103	0.0115
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0085	0.2762
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0103	0.0103
Leishmania major	cathepsin L-like protease	0.0019	0.0027	0.0645
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	Importin beta-1 subunit	0.0035	0.0097	0.0108
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0103	0.0103
Brugia malayi	major facilitator superfamily protein	0.0015	0.0009	0.001
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0036	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.1562	0.1733
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.0396	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0352	0.1478	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0036	0.0103	0.0105
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0124	0.0484	0.0537
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0057	0.174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Schistosoma mansoni	sugar transporter	0.0015	0.0009	0.0009
Onchocerca volvulus		0.0093	0.0349	0.2365
Schistosoma mansoni	glucose transport protein	0.0104	0.0396	0.0396
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0009	0.001
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0103	0.0105
Schistosoma mansoni	hypothetical protein	0.0036	0.0103	0.0103
Onchocerca volvulus	Putative transporter	0.0015	0.0009	0.0061
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0186	0.0206
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0057	0.0063
Plasmodium vivax	plasmepsin IV, putative	0.0093	0.0349	0.8798
Plasmodium falciparum	plasmepsin II	0.0093	0.0349	0.8798
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0027	0.002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0186	0.0196
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0027	0.0461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0027	0.0181
Echinococcus multilocularis	para nitrobenzyl esterase	0.0352	0.1478	0.1631
Onchocerca volvulus		0.0036	0.0103	0.07
Schistosoma mansoni	myosin xvIII	0.0036	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0104	0.0396	0.0396
Schistosoma mansoni	growth hormone secretagogue receptor	0.0036	0.0103	0.0103
Plasmodium falciparum	plasmepsin VIII, putative	0.0093	0.0349	0.8798
Schistosoma mansoni	importin beta-1	0.0035	0.0097	0.0097
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0085	0.2762
Loa Loa (eye worm)	acetylcholinesterase 1	0.2086	0.9014	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0124	0.0484	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma brucei	unspecified product	0.0027	0.0064	0.1987
Mycobacterium ulcerans	amidase	0.0015	0.0011	0.0011
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0103	0.0105
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0009	0.0009
Onchocerca volvulus		0.0015	0.0009	0.0061
Schistosoma mansoni	opsin-like receptor	0.0036	0.0103	0.0103
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0015	0.0011	0.0011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0103	0.0105
Echinococcus granulosus	dna polymerase kappa	0.0069	0.0246	0.0273
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Schistosoma mansoni	amine GPCR	0.0036	0.0103	0.0103
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0015	0.0011	0.0011
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0027	0.002
Trypanosoma brucei	monoglyceride lipase, putative	0.0078	0.0285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Mycobacterium ulcerans	DNA polymerase IV	0.0069	0.0246	0.1613
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Mycobacterium ulcerans	carboxylesterase, LipT	0.0352	0.1478	1
Echinococcus granulosus	carboxylesterase 5A	0.2086	0.9014	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	hypothetical protein	0.0093	0.0349	0.0388
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0027	0.0645
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0036	0.0103	0.0103
Echinococcus granulosus	g-protein coupled receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0124	0.0484	0.0537
Mycobacterium ulcerans	hypothetical protein	0.0078	0.0285	0.1882
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0117	0.0736
Leishmania major	cathepsin L-like protease	0.0019	0.0027	0.0645
Brugia malayi	Carboxylesterase family protein	0.0352	0.1478	0.164
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0057	0.0063
Onchocerca volvulus		0.0036	0.0103	0.07
Echinococcus granulosus	snurportin 1	0.0372	0.1562	0.1733
Leishmania major	cathepsin L-like protease	0.0071	0.0255	0.8893
Brugia malayi	Amidase family protein	0.0015	0.0011	0.0012
Echinococcus multilocularis	cysteine protease	0.0019	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	putative amidase	0.0015	0.0011	0.0012
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0015	0.0011	0.0012
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0036	0.0103	0.0105
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0009	0.001
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Toxoplasma gondii	cathepsin CPL	0.0019	0.0027	0.0461
Schistosoma mansoni	DNA polymerase eta	0.0039	0.0117	0.0117
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.0439
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0027	0.0027
Onchocerca volvulus		0.0015	0.0009	0.0061
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0128	0.4296
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0097	0.3186
Trypanosoma brucei	unspecified product	0.0027	0.0064	0.1987
Echinococcus multilocularis	g-protein coupled receptor	0.0036	0.0103	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0009	0.0061
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0039	0.0117	0.013
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0103	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0085	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0027	0.002
Echinococcus granulosus	allatostatin A receptor	0.0036	0.0103	0.0115
Brugia malayi	neuropeptide F receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0009	0.0061
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0352	0.1478	0.164
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0047	0.0149	0.0954
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0352	0.1478	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0103	0.0105
Echinococcus granulosus	sex peptide receptor	0.0036	0.0103	0.0115
Plasmodium falciparum	plasmepsin X	0.0093	0.0349	0.8798
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0085	0.0577
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0009	0.0061
Brugia malayi	putative neuropeptide receptor NPR1	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0036	0.0103	0.0115
Schistosoma mansoni	sugar transporter	0.0015	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0036	0.0103	0.0105
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0103	0.0115
Brugia malayi	amidase	0.0124	0.0484	0.0537
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0097	0.0098
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.043
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0103	0.0115
Loa Loa (eye worm)	sugar transporter	0.0015	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.013
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0162	0.0648	0.0648
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Trypanosoma brucei	unspecified product	0.0062	0.0214	0.7417
Schistosoma mansoni	ran	0.0026	0.0057	0.0057
Onchocerca volvulus		0.0015	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0108
Plasmodium vivax	aspartyl protease, putative	0.0093	0.0349	0.8798
Plasmodium falciparum	lysophospholipase, putative	0.0078	0.0285	0.7143
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0015	0.0011	0.0041
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0103	0.0105
Brugia malayi	major facilitator superfamily protein	0.0015	0.0009	0.001
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0027	0.0181
Echinococcus granulosus	para nitrobenzyl esterase	0.0352	0.1478	0.164
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0057	0.174
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0036	0.0103	0.0115
Trypanosoma brucei	DNA polymerase kappa, putative	0.0035	0.0096	0.3143
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0097	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0285	0.1931
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0015	0.0011	0.0002
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0036	0.0103	0.0105
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Schistosoma mansoni	amine GPCR	0.0036	0.0103	0.0103
Loa Loa (eye worm)	acetyltransferase	0.0162	0.0648	0.0719
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.2086	0.9014	0.9014
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0009	0.001
Brugia malayi	hypothetical protein	0.0015	0.0009	0.001
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0117	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	Melatonin receptor type 1A	0.0036	0.0103	0.0115
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0068	0.215
Onchocerca volvulus		0.0352	0.1478	1
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	somatostatin receptor	0.0036	0.0103	0.0115
Brugia malayi	Serotonin receptor	0.0036	0.0103	0.0115
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0085	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Echinococcus granulosus	orexin receptor type 2	0.0036	0.0103	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Mycobacterium ulcerans	lysophospholipase	0.0078	0.0285	0.1882
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0057	0.3433
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0085	0.2762
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma brucei	DNA polymerase eta, putative	0.0039	0.0117	0.3912
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0078	0.0285	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.003
Onchocerca volvulus		0.0015	0.0009	0.0061
Onchocerca volvulus		0.0019	0.0027	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Leishmania major	cathepsin L-like protease	0.0019	0.0027	0.0645
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Echinococcus multilocularis	allatostatin A receptor	0.0036	0.0103	0.0105
Trypanosoma cruzi	monoglyceride lipase, putative	0.0078	0.0285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0015	0.0009	0.0061
Schistosoma mansoni	histamine h1 receptor	0.0036	0.0103	0.0103
Onchocerca volvulus		0.0015	0.0009	0.0061
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0036	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0015	0.0009	0.001
Brugia malayi	G-protein coupled receptor	0.0036	0.0103	0.0115
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0255	0.8893
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0015	0.0011	0.0011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Onchocerca volvulus		0.0036	0.0103	0.07
Echinococcus multilocularis	General substrate transporter	0.0089	0.0333	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	RE15519p	0.0036	0.0103	0.0115
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0015	0.0011	0.0011
Schistosoma mansoni	cathepsin D (A01 family)	0.0093	0.0349	0.0349
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0103	0.0103
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0036	0.0103	0.0103
Loa Loa (eye worm)	amidase	0.0015	0.0011	0.0012
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0039	0.0117	0.0117
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0036	0.0103	0.0115
Brugia malayi	Carboxylesterase family protein	0.0352	0.1478	0.164
Leishmania major	DNA polymerase eta, putative	0.0039	0.0117	0.3912
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Onchocerca volvulus		0.0352	0.1478	1
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0027	0.094
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.2086	0.9014	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0027	0.003
Echinococcus granulosus	7TM GPCR rhodopsin	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Onchocerca volvulus		0.0015	0.0009	0.0061
Trypanosoma brucei	DNA polymerase kappa, putative	0.0035	0.0096	0.3143
Brugia malayi	Sugar transporter family protein	0.0015	0.0009	0.001
Schistosoma mansoni	amine GPCR	0.0036	0.0103	0.0103
Onchocerca volvulus		0.0352	0.1478	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	solute carrier family 22	0.0015	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Schistosoma mansoni	glucose transporter	0.0015	0.0009	0.0009
Echinococcus granulosus	neuropeptide receptor A26	0.0036	0.0103	0.0115
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0036	0.0103	0.0115
Plasmodium falciparum	plasmepsin I	0.0093	0.0349	0.8798
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0093	0.0349	0.2365
Entamoeba histolytica	Ran family GTPase	0.0026	0.0057	0.2
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0036	0.0103	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Schistosoma mansoni	BC026374 protein (S09 family)	0.0352	0.1478	0.1478
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0036	0.0103	0.0115
Brugia malayi	aspartic protease BmAsp-1, identical	0.0093	0.0349	0.0388
Brugia malayi	polk-prov protein	0.0042	0.0128	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Plasmodium falciparum	plasmepsin VI	0.0093	0.0349	0.8798
Trichomonas vaginalis	spcc417.12 protein, putative	0.0352	0.1478	1
Echinococcus granulosus	G protein coupled receptor 139	0.0036	0.0103	0.0115
Echinococcus multilocularis	dro:myosuppressin receptor	0.0036	0.0103	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	sugar transporter	0.0104	0.0396	0.0439
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0103	0.0103
Echinococcus granulosus	solute carrier family 22	0.0015	0.0009	0.001
Echinococcus granulosus	neuropeptide FF receptor 2	0.0036	0.0103	0.0115
Plasmodium falciparum	plasmepsin IV	0.0093	0.0349	0.8798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0015	0.0011	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0124	0.0484	0.0484
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Trichomonas vaginalis	DNA polymerase eta, putative	0.0069	0.0246	0.1664
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0078	0.0285	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0036	0.0103	0.0103
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0103	0.0105
Onchocerca volvulus		0.0019	0.0027	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.0152	0.3701
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0349	0.0388
Trypanosoma cruzi	amidase, putative	0.0015	0.0011	0.0058
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0103	0.0103
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.0152	0.3701
Loa Loa (eye worm)	amidase	0.0015	0.0011	0.0012
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0103	0.0103
Onchocerca volvulus		0.0352	0.1478	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0027	0.0461
Onchocerca volvulus		0.0019	0.0027	0.0181
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Brugia malayi	hypothetical protein	0.0015	0.0009	0.001
Mycobacterium tuberculosis	Possible lysophospholipase	0.0078	0.0285	0.1882
Onchocerca volvulus		0.0036	0.0103	0.07
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Mycobacterium ulcerans	peptide amidase, GatA	0.0015	0.0011	0.0011
Echinococcus multilocularis	G protein coupled receptor 139	0.0036	0.0103	0.0105
Brugia malayi	RNA, U transporter 1	0.0099	0.0376	0.0417
Plasmodium vivax	aspartyl protease, putative	0.0093	0.0349	0.8798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0103	0.0103
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0027	0.0461
Brugia malayi	sulfakinin receptor protein	0.0036	0.0103	0.0115
Brugia malayi	Sugar transporter family protein	0.0015	0.0009	0.001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0186	0.0206
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0068	0.0463
Plasmodium falciparum	plasmepsin V	0.0093	0.0349	0.8798
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0015	0.0011	0.0011
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0015	0.0009	0.0061
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1478	0.164
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181
Brugia malayi	Dopamine receptor	0.0036	0.0103	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	dna polymerase eta	0.0039	0.0117	0.012
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0015	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0028	0.0068	0.2398
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0009	0.0061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0027	0.0181
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0352	0.1478	0.1478
Echinococcus granulosus	solute carrier family 22	0.0015	0.0009	0.001
Plasmodium falciparum	plasmepsin VII	0.0093	0.0349	0.8798
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0036	0.0103	0.07
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0093	0.0349	0.0388
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Echinococcus granulosus	fmrfamide receptor	0.0036	0.0103	0.0115
Mycobacterium ulcerans	amidase	0.0015	0.0011	0.0011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Brugia malayi	follicle stimulating hormone receptor	0.0036	0.0103	0.0115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Onchocerca volvulus		0.0036	0.0103	0.07
Leishmania major	glucose transporter, lmgt2	0.0032	0.0085	0.2762
Echinococcus granulosus	solute carrier family 22	0.0015	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0015	0.0011	0.0002
Onchocerca volvulus		0.0036	0.0103	0.07
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0572	0.0635
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0039	0.0117	0.0117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0015	0.0011	0.0041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Trypanosoma brucei	DNA polymerase kappa, putative	0.0035	0.0096	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0103	0.0103
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0103	0.0115
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Plasmodium falciparum	esterase, putative	0.0078	0.0285	0.7143
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0186	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0103	0.0115
Loa Loa (eye worm)	carboxylesterase	0.0352	0.1478	0.164
Brugia malayi	putative neuropeptide receptor	0.0036	0.0103	0.0115
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0135	0.4731
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0022	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0015	0.0009	0.0061
Echinococcus granulosus	BC026374 protein S09 family	0.0352	0.1478	0.164
Onchocerca volvulus		0.0036	0.0103	0.07
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0027	0.003
Onchocerca volvulus		0.0036	0.0103	0.07
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0103	0.0103
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0103	0.0115
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0036	0.0103	0.0115
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0027	0.094
Schistosoma mansoni	ran	0.0026	0.0057	0.0057
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0027	0.003
Echinococcus multilocularis	acetylcholinesterase	0.2086	0.9014	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0093	0.0349	0.0388
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0103	0.0103
Brugia malayi	acetyltransferase, GNAT family protein	0.0162	0.0648	0.0719
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.0152	0.103
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0057	0.0053
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0103	0.0115
Schistosoma mansoni	hypothetical protein	0.0036	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0128	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0085	0.2762
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Echinococcus granulosus	neuropeptide s receptor	0.0036	0.0103	0.0115
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0349	0.0388
Brugia malayi	Dopamine receptor protein 2	0.0036	0.0103	0.0115
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0117	0.013
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0036	0.0103	0.0103
Echinococcus multilocularis	cysteine protease	0.0019	0.0027	0.002
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0103	0.0105
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0057	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Toxoplasma gondii	aspartyl protease ASP3	0.0093	0.0349	0.8798
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Brugia malayi	aspartic protease BmAsp-2, identical	0.0093	0.0349	0.0388
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0036	0.0103	0.07
Trypanosoma cruzi	hexose transporter	0.0032	0.0085	0.2762
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0352	0.1478	0.1631
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0103	0.0103
Schistosoma mansoni	amine GPCR	0.0036	0.0103	0.0103
Onchocerca volvulus		0.0015	0.0009	0.0061
Onchocerca volvulus		0.0036	0.0103	0.07
Echinococcus multilocularis	orexin receptor type 2	0.0036	0.0103	0.0105
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0027	0.003
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0352	0.1478	0.1478
Echinococcus granulosus	neuroligin	0.0352	0.1478	0.164
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.0152	0.103
Echinococcus multilocularis	neuropeptide s receptor	0.0036	0.0103	0.0105
Plasmodium vivax	aspartyl proteinase, putative	0.0093	0.0349	0.8798
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.0396	0.043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0149	0.5069
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0039	0.0117	0.013
Mycobacterium ulcerans	amidase	0.0015	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0255	0.8893
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0036	0.0103	0.0103
Echinococcus granulosus	General substrate transporter	0.0089	0.0333	0.0369
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0078	0.0285	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0078	0.0285	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0093	0.0349	0.8798
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0027	0.0181
Leishmania major	glucose transporter, lmgt3	0.0032	0.0085	0.2762
Loa Loa (eye worm)	carboxylesterase	0.2086	0.9014	1
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0103	0.0105
Loa Loa (eye worm)	melatonin receptor type 1A	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	hypothetical protein	0.0036	0.0103	0.0115
Brugia malayi	ORL1-like opioid receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0162	0.0648	0.071
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0103	0.0105
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Plasmodium falciparum	plasmepsin III	0.0093	0.0349	0.8798
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Brugia malayi	G-protein coupled receptor	0.0036	0.0103	0.0115
Echinococcus multilocularis	carboxylesterase 5A	0.2086	0.9014	1
Schistosoma mansoni	gliotactin	0.0352	0.1478	0.1478
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0285	0.1931
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0246	0.8574
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0027	0.003
Onchocerca volvulus		0.0036	0.0103	0.07
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0186	0.0186
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0085	0.0577
Onchocerca volvulus		0.0352	0.1478	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Brugia malayi	Amidase family protein	0.0015	0.0011	0.0012
Plasmodium vivax	vivapain-2	0.0019	0.0027	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Onchocerca volvulus		0.0015	0.0009	0.0061
Leishmania major	GTP-binding protein, putative	0.0026	0.0057	0.174
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0085	0.2762
Echinococcus granulosus	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0027	0.002
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0057	0.1243
Leishmania major	glucose transporter, lmgt1	0.0032	0.0085	0.2762
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0103	0.0115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0027	0.0181
Plasmodium falciparum	lysophospholipase, putative	0.0078	0.0285	0.7143
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0068	0.0463
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0186	0.0196
Echinococcus multilocularis	neuroligin	0.0352	0.1478	0.1631
Onchocerca volvulus		0.0015	0.0009	0.0061
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0036	0.0103	0.0105
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0352	0.1478	1
Echinococcus multilocularis	dna polymerase kappa	0.0069	0.0246	0.0263
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0103	0.0103
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0103	0.0105
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0085	0.2762
Loa Loa (eye worm)	aspartyl protease 6	0.0093	0.0349	0.0388
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Mycobacterium ulcerans	DNA polymerase IV	0.0069	0.0246	0.1613
Trypanosoma brucei	DNA polymerase IV, putative	0.0069	0.0246	0.8574
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0027	0.003
Brugia malayi	hypothetical protein	0.0352	0.1478	0.164
Echinococcus granulosus	cathepsin l1	0.0019	0.0027	0.003
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0103	0.0105
Onchocerca volvulus		0.0036	0.0103	0.07
Trypanosoma brucei	monoglyceride lipase, putative	0.0078	0.0285	1
Echinococcus multilocularis	sex peptide receptor	0.0036	0.0103	0.0105
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0085	0.0577
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0078	0.0285	0.1931
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0027	0.094
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Loa Loa (eye worm)	TYRA-2 protein	0.0036	0.0103	0.0115
Schistosoma mansoni	sugar transporter	0.0015	0.0009	0.0009
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.002	0.0031	0.0565
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0027	0.0645
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0093	0.0349	0.0388
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0015	0.0011	0.5
Giardia lamblia	DINP protein human, muc B family	0.0047	0.0149	1
Leishmania major	cathepsin L-like protease	0.0019	0.0027	0.0645
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0352	0.1478	1
Leishmania major	DNA polymerase kappa, putative	0.0047	0.0149	0.5069
Plasmodium vivax	aspartyl protease, putative	0.0093	0.0349	0.8798
Brugia malayi	G protein-coupled receptor	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Echinococcus multilocularis	serotonin receptor	0.0036	0.0103	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0009	0.0061
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0027	0.0027
Toxoplasma gondii	aspartyl protease	0.0093	0.0349	0.8798
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0135	0.3256
Leishmania major	cathepsin L-like protease	0.0019	0.0027	0.0645
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0349	0.0349
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0036	0.0103	0.0103
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0103	0.0105
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0135	0.8995
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0103	0.0105
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0103	0.0115
Trichomonas vaginalis	ran, putative	0.0026	0.0057	0.0386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0027	0.0181

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	3.07 uM	PubChem BioAssay. Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	3.66 uM	PubChem BioAssay. Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	> 66 uM	PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	> 66 uM	PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.9285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	4.1095 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	33.5875 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1549646

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1413133