TDR Targets

Basic information

Technical information

TDR Targets ID: 1413137
Name: 6-(2-phenylethenyl)-2-(phenylmethyl)-4,5-dihy dropyridazin-3-one
MW: 290.359 | Formula: C19H18N2O
H donors: 0 H acceptors: 1 LogP: 3.03 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCC(=NN1Cc1ccccc1)/C=C/c1ccccc1
InChi: 1S/C19H18N2O/c22-19-14-13-18(12-11-16-7-3-1-4-8-16)20-21(19)15-17-9-5-2-6-10-17/h1-12H,13-15H2/b12-11+
InChiKey: NNGYRMMDKVLAOO-VAWYXSNFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[(E)-2-phenylethenyl]-2-(phenylmethyl)-4,5-dihydropyridazin-3-one
2-(phenylmethyl)-6-(2-phenylvinyl)-4,5-dihydropyridazin-3-one
2-(phenylmethyl)-6-[(E)-2-phenylvinyl]-4,5-dihydropyridazin-3-one
2-(benzyl)-6-(2-phenylvinyl)-4,5-dihydropyridazin-3-one
2-(benzyl)-6-[(E)-2-phenylvinyl]-4,5-dihydropyridazin-3-one
MLS000706826
SMR000334337
ZINC01383553
Oprea1_073078
10K-325S
2-benzyl-6-styryl-4,5-dihydro-3(2H)-pyridazinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	Smad1	0.001	0.0316	0.0316
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0014	0.0592	0.0624
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0592	0.0624
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.0974	0.149
Brugia malayi	G protein-coupled receptor	0.0014	0.0592	0.0592
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0014	0.0592	0.0624
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	hypothetical protein	0.0014	0.0592	0.0624
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	7tm_1 domain containing protein	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.0974	0.149
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0014	0.0592	0.0624
Schistosoma mansoni	opsin-like receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	g-protein coupled receptor	0.0014	0.0592	0.0624
Plasmodium falciparum	lysophospholipase, putative	0.0081	0.5461	1
Onchocerca volvulus		0.0014	0.0592	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Brugia malayi	jmjC domain containing protein	0.0071	0.4728	0.4728
Brugia malayi	larval opioid receptor	0.0014	0.0592	0.0592
Echinococcus multilocularis	allatostatin A receptor	0.0014	0.0592	0.0624
Brugia malayi	Melatonin receptor type 1A	0.0014	0.0592	0.0592
Echinococcus granulosus	phd:f box containing protein	0.0019	0.0974	0.149
Echinococcus multilocularis	orexin receptor type 2	0.0014	0.0592	0.0624
Brugia malayi	jmjC domain containing protein	0.0019	0.0974	0.0974
Brugia malayi	MH1 domain containing protein	0.001	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Onchocerca volvulus		0.0014	0.0592	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0592	0.0624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Brugia malayi	putative neuropeptide receptor NPR1	0.0014	0.0592	0.0592
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0592	0.0624
Trypanosoma brucei	monoglyceride lipase, putative	0.0081	0.5461	1
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.4728	1
Echinococcus granulosus	serotonin receptor	0.0014	0.0592	0.0624
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Brugia malayi	MH2 domain containing protein	0.001	0.0316	0.0316
Brugia malayi	follicle stimulating hormone receptor	0.0014	0.0592	0.0592
Brugia malayi	sulfakinin receptor protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.0974	0.149
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Brugia malayi	MH1 domain containing protein	0.001	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0974	0.0974
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.0974	0.149
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0014	0.0592	0.0624
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0014	0.0592	0.0592
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.0974	0.149
Schistosoma mansoni	amine GPCR	0.0014	0.0592	0.0624
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.4728	1
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0014	0.0592	0.0624
Brugia malayi	Serotonin receptor	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Onchocerca volvulus		0.0014	0.0592	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.0974	0.149
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	opsin-like receptor	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Onchocerca volvulus		0.0014	0.0592	0.5
Schistosoma mansoni	myosin xvIII	0.0014	0.0592	0.0624
Schistosoma mansoni	amine GPCR	0.0014	0.0592	0.0624
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Brugia malayi	Serotonin receptor	0.0014	0.0592	0.0592
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0014	0.0592	0.0624
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0592	0.0624
Schistosoma mansoni	histamine h1 receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0974	0.149
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0014	0.0592	0.0624
Echinococcus granulosus	orexin receptor type 2	0.0014	0.0592	0.0624
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0974	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0592	0.0624
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0081	0.5461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0014	0.0592	0.0592
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.0974	0.149
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0592	0.0592
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0592	0.0624
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0081	0.5461	0.5
Brugia malayi	putative neuropeptide receptor	0.0014	0.0592	0.0592
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	serotonin receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	neuropeptide s receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus multilocularis	somatostatin receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.0974	0.149
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.0974	0.149
Brugia malayi	RE15519p	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0592	0.0624
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0014	0.0592	0.0592
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Echinococcus granulosus	neuropeptide FF receptor 2	0.0014	0.0592	0.0624
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0974	0.0974
Schistosoma mansoni	neuropeptide f receptor 76f	0.0014	0.0592	0.0624
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.4728	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Brugia malayi	GnHR receptor homolog	0.0014	0.0592	0.0592
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0592	0.0624
Brugia malayi	Dopamine receptor protein 2	0.0014	0.0592	0.0592
Brugia malayi	G protein-coupled receptor F59B2.13	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	7TM GPCR rhodopsin	0.0014	0.0592	0.0624
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0014	0.0592	0.0592
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Mycobacterium ulcerans	lysophospholipase	0.0081	0.5461	0.5
Echinococcus granulosus	hypothetical protein	0.0014	0.0592	0.0624
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0014	0.0592	0.0624
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Mycobacterium ulcerans	hypothetical protein	0.0081	0.5461	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0014	0.0592	0.0592
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0592	0.0624
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0014	0.0592	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Plasmodium falciparum	esterase, putative	0.0081	0.5461	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0974	0.149
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0081	0.5461	0.5
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	sex peptide receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Brugia malayi	jmjC domain containing protein	0.0019	0.0974	0.0974
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	serotonin receptor	0.0014	0.0592	0.0624
Trypanosoma cruzi	monoglyceride lipase, putative	0.0081	0.5461	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0014	0.0592	0.0624
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0081	0.5461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0014	0.0592	0.0624
Brugia malayi	Smad1	0.001	0.0316	0.0316
Brugia malayi	AKH receptor	0.0014	0.0592	0.0592
Brugia malayi	neuropeptide F receptor	0.0014	0.0592	0.0592
Brugia malayi	G-protein coupled receptor	0.0014	0.0592	0.0592
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0019	0.0974	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	dro:myosuppressin receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	growth hormone secretagogue receptor	0.0014	0.0592	0.0624
Brugia malayi	jmjC domain containing protein	0.0019	0.0974	0.0974
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0014	0.0592	0.0624
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	hypothetical protein	0.0014	0.0592	0.0624
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0592	0.0624
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.5461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.4728	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0592	0.0624
Echinococcus granulosus	allatostatin A receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0592	0.0624
Trypanosoma brucei	monoglyceride lipase, putative	0.0081	0.5461	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0592	0.0624
Plasmodium falciparum	lysophospholipase, putative	0.0081	0.5461	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Onchocerca volvulus		0.0014	0.0592	0.5
Brugia malayi	Dopamine receptor protein 1	0.0014	0.0592	0.0592
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	adenoreceptor	0.0014	0.0592	0.0624
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0316	0.0316
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	neuropeptide receptor A26	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0014	0.0592	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0014	0.0592	0.0592
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0592	0.0624
Schistosoma mansoni	amine GPCR	0.0014	0.0592	0.0624
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0592	0.0624
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0081	0.5461	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0014	0.0592	0.0624
Plasmodium vivax	PST-A protein	0.0081	0.5461	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0974	0.0974
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.4728	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0014	0.0592	0.0592
Plasmodium falciparum	lysophospholipase, putative	0.0081	0.5461	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.5461	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.4728	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0014	0.0592	0.0624
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0592	0.0624
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0592	0.0624
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0014	0.0592	0.0592
Schistosoma mansoni	hypothetical protein	0.0014	0.0592	0.0624
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.0974	0.149
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0592	0.0624
Brugia malayi	Dopamine receptor	0.0014	0.0592	0.0592
Brugia malayi	MH2 domain containing protein	0.001	0.0316	0.0316
Schistosoma mansoni	amine GPCR	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0592	0.0624
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0081	0.5461	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0014	0.0592	0.0592
Onchocerca volvulus		0.0014	0.0592	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0592	0.0624
Echinococcus granulosus	G protein coupled receptor 139	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0014	0.0592	0.0624
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0316	0.0316
Onchocerca volvulus		0.0014	0.0592	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0081	0.5461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	somatostatin receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	sex peptide receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	fmrfamide receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0592	0.0624
Echinococcus granulosus	dro:myosuppressin receptor	0.0014	0.0592	0.0624
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.4728	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Brugia malayi	neuropeptide F receptor	0.0014	0.0592	0.0592
Brugia malayi	jmjC domain containing protein	0.0071	0.4728	0.4728
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.0974	0.149
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	opsin-like receptor	0.0014	0.0592	0.0624
Brugia malayi	ORL1-like opioid receptor	0.0014	0.0592	0.0592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0014	0.0592	0.0624
Onchocerca volvulus		0.0014	0.0592	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0592	0.0624
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0081	0.5461	0.5
Brugia malayi	jmjC domain containing protein	0.0019	0.0974	0.0974
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0592	0.0592
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0974	0.0974
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0014	0.0592	0.0624
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0019	0.0974	0.5
Schistosoma mansoni	amine GPCR	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0592	0.0624
Leishmania major	monoglyceride lipase, putative	0.0081	0.5461	1
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0592	0.0624
Brugia malayi	G-protein coupled receptor	0.0014	0.0592	0.0592
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0081	0.5461	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.4728	0.4728
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Mycobacterium tuberculosis	Possible lysophospholipase	0.0081	0.5461	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	TYRA-2 protein	0.0014	0.0592	0.0592
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0592	0.0592
Brugia malayi	hypothetical protein	0.0014	0.0592	0.0592
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0592	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0974	0.0974
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.0974	0.149

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.8913 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1549906

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1413137