Detailed information for compound 1413167

Basic information

Technical information
  • TDR Targets ID: 1413167
  • Name: 3,5-dimethoxy-N-[2-(2-methoxyethylcarbamoyl)p henyl]benzamide
  • MW: 358.388 | Formula: C19H22N2O5
  • H donors: 2 H acceptors: 2 LogP: 2.38 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)c1ccccc1NC(=O)c1cc(OC)cc(c1)OC
  • InChi: 1S/C19H22N2O5/c1-24-9-8-20-19(23)16-6-4-5-7-17(16)21-18(22)13-10-14(25-2)12-15(11-13)26-3/h4-7,10-12H,8-9H2,1-3H3,(H,20,23)(H,21,22)
  • InChiKey: WYHOSRXFNHMBJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,5-dimethoxy-N-[2-[(2-methoxyethylamino)-oxomethyl]phenyl]benzamide
  • AH-487/42656701
  • MLS000702065
  • SMR000226574
  • ZINC02140753
  • 3,5-dimethoxy-N-(2-{[(2-methoxyethyl)amino]carbonyl}phenyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0058 0.0547 0.0801
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0245 0.0366
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0204 0.3777 0.5526
Echinococcus multilocularis dna polymerase kappa 0.0118 0.1873 0.2702
Echinococcus granulosus geminin 0.0342 0.6834 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0077 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0338 0.0389
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.1873 0.2701
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0621 0.086
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0902 0.132
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.1873 0.2995
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.02 0.3701 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0859 0.121
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0077 0.0095
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0621 0.086
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0547 0.053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0547 0.0854
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0547 0.0751
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0338 0.0389
Schistosoma mansoni rotamase 0.0035 0.0037 0.0054
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.104 0.1476
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.1017 0.1612
Plasmodium falciparum phd finger protein, putative 0.0059 0.0583 0.5379
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0547 0.0854
Trichomonas vaginalis rotamase, putative 0.0035 0.0037 0.0018
Toxoplasma gondii hypothetical protein 0.0051 0.0389 0.1576
Schistosoma mansoni jumonji domain containing protein 0.0155 0.2688 0.3932
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0902 0.132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0859 0.1257
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0077 0.0095
Brugia malayi jmjC domain containing protein 0.0195 0.3572 0.4107
Loa Loa (eye worm) glutathione reductase 0.0079 0.1017 0.1169
Mycobacterium ulcerans DNA polymerase IV 0.0118 0.1873 0.6306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Plasmodium falciparum glutathione reductase 0.0079 0.1017 1
Giardia lamblia PHD finger protein 15 0.0059 0.0583 0.2814
Toxoplasma gondii thioredoxin reductase 0.0079 0.1017 0.4251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0077 0.025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.018 0.3256 0.8589
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.8697 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.4163 0.4787
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0204 0.3777 0.6069
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.1017 0.1489
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.3572 0.5201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.025 0.0366
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0583 0.067
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0902 0.132
Schistosoma mansoni DNA polymerase IV / kappa 0.0037 0.0077 0.0113
Echinococcus multilocularis peregrin 0.0059 0.0583 0.0803
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0902 0.1037
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.018 0.3256 0.8589
Brugia malayi ImpB/MucB/SamB family protein 0.0118 0.1873 0.2154
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0204 0.3777 0.6069
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0547 0.0629
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0118 0.1873 0.2741
Trypanosoma brucei trypanothione reductase 0.0079 0.1017 0.1612
Trypanosoma brucei unspecified product 0.0081 0.1065 0.169
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Echinococcus granulosus dna polymerase kappa 0.0118 0.1873 0.2702
Brugia malayi ImpB/MucB/SamB family protein 0.0221 0.4163 0.4787
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.025 0.0366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.025 0.0314
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0077 0.025
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.1982 0.2278
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0118 0.1873 0.2995
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Loa Loa (eye worm) hypothetical protein 0.0102 0.1521 0.1749
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0118 0.1873 0.1858
Plasmodium falciparum thioredoxin reductase 0.0079 0.1017 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0902 0.132
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0077 0.0095
Brugia malayi TAR-binding protein 0.0074 0.0902 0.1037
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Trypanosoma brucei unspecified product 0.0118 0.1873 0.2995
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0077 0.0095
Mycobacterium tuberculosis Probable reductase 0.018 0.3256 0.8589
Trypanosoma brucei unspecified product 0.0081 0.1065 0.169
Onchocerca volvulus 0.0061 0.0621 0.0041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.02 0.3701 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1065 0.169
Brugia malayi jmjC domain containing protein 0.0072 0.0859 0.0988
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0204 0.3777 0.4342
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.025 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0547 0.0854
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0621 0.2566
Schistosoma mansoni terminal deoxycytidyl transferase 0.0118 0.1873 0.2741
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0621 0.086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0338 0.0389
Brugia malayi RNA binding protein 0.0074 0.0902 0.1037
Leishmania major DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0621 0.0909
Loa Loa (eye worm) hypothetical protein 0.0157 0.2742 0.3153
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0459 0.0711
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0583 0.0853
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0037 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.6211 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0245 0.0366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.025 0.0314
Echinococcus granulosus transcription factor Dp 1 0.0118 0.1878 0.2709
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.1873 0.2701
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0077 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0859 0.0988
Echinococcus granulosus peregrin 0.0059 0.0583 0.0803
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0089
Schistosoma mansoni ap endonuclease 0.0058 0.0547 0.0801
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.2926 0.7541
Trichomonas vaginalis DNA polymerase eta, putative 0.0118 0.1873 0.1858
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.6211 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0583 0.0803
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.104 0.1476
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.1873 0.2995
Leishmania major DNA polymerase eta, putative 0.0221 0.4163 0.6693
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0547 0.5001
Toxoplasma gondii exonuclease III APE 0.0058 0.0547 0.2251
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0547 0.165
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0902 0.1037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0547 0.0751
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.02 0.3701 1
Brugia malayi Bromodomain containing protein 0.0059 0.0583 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1065 0.169
Trypanosoma cruzi DNA damage repair protein, putative 0.0037 0.0077 0.0095
Mycobacterium ulcerans DNA polymerase IV 0.0118 0.1873 0.6306
Echinococcus multilocularis geminin 0.0342 0.6834 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.018 0.3256 0.8589
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0547 0.1406
Leishmania major DNA damage repair protein, putative 0.0037 0.0077 0.0095
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0118 0.1873 0.4204
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0204 0.3777 0.6069
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0547 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.1065 0.169
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0547 0.0854
Leishmania major DNA polymerase eta, putative 0.014 0.2367 0.3792
Echinococcus multilocularis dna polymerase eta 0.0221 0.4163 0.607
Mycobacterium ulcerans hypothetical protein 0.0165 0.2926 1
Onchocerca volvulus 0.0157 0.2742 0.2293
Echinococcus granulosus tar DNA binding protein 0.0074 0.0902 0.1273
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0077 0.0095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0572 0.0787
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.1017 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.025 0.0314
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0118 0.1873 0.2702
Mycobacterium tuberculosis Probable oxidoreductase 0.02 0.3701 1
Schistosoma mansoni hypothetical protein 0.0342 0.6834 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.1873 0.4204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0621 0.0909
Trypanosoma brucei chrX additional, unordered contigs 0.0037 0.0077 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0621 0.0909
Leishmania major DNA polymerase kappa, putative 0.0037 0.0077 0.0095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.3572 0.5201
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0583 0.2402
Brugia malayi polk-prov protein 0.0037 0.0077 0.0089
Toxoplasma gondii ImpB/MucB/SamB family protein 0.014 0.2367 1
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0859 0.121
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0118 0.1873 0.2702
Echinococcus granulosus jumonji domain containing protein 0.0083 0.1097 0.156
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0245 0.0366
Brugia malayi Thioredoxin reductase 0.0079 0.1017 0.1169
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0245 0.0366
Trypanosoma cruzi DNA polymerase eta, putative 0.0221 0.4163 0.6693
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0547 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0583 0.0803
Schistosoma mansoni lipoxygenase 0.0118 0.1873 0.274
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0621 0.0909
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.2554 0.4095
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0902 0.1037
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0547 0.2617
Brugia malayi Pre-SET motif family protein 0.0061 0.0621 0.0714
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0204 0.3777 1
Schistosoma mansoni hypothetical protein 0.0059 0.0583 0.0853
Mycobacterium tuberculosis Probable dehydrogenase 0.018 0.3256 0.8589
Schistosoma mansoni hypothetical protein 0.0342 0.6834 1
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.1097 0.156
Trypanosoma cruzi DNA polymerase eta, putative 0.014 0.2367 0.3792
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0547 0.5001
Leishmania major trypanothione reductase 0.0079 0.1017 0.1612
Plasmodium vivax SET domain protein, putative 0.0061 0.0621 0.5789
Trichomonas vaginalis set domain proteins, putative 0.0485 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0077 0.0095
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0547 0.0629
Trypanosoma brucei DNA damage repair protein, putative 0.0037 0.0077 0.0095
Loa Loa (eye worm) hypothetical protein 0.0059 0.0583 0.067
Echinococcus granulosus dna polymerase eta 0.0221 0.4163 0.607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.025 0.0288
Brugia malayi PHD-finger family protein 0.0059 0.0583 0.067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.025 0.0288
Giardia lamblia DINP protein human, muc B family 0.0118 0.1873 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.6211 1
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0583 0.5379
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.1873 0.2995
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0338 0.0389
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.1017 0.1169
Echinococcus multilocularis transcription factor Dp 1 0.0118 0.1878 0.2709
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0859 0.1257
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0204 0.3777 0.6069
Trypanosoma brucei DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0204 0.3777 0.5502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0118 0.1873 0.2995
Loa Loa (eye worm) hypothetical protein 0.0061 0.0621 0.0714
Plasmodium vivax glutathione reductase, putative 0.0079 0.1017 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0547 0.5
Brugia malayi glutathione reductase 0.0079 0.1017 0.1169
Schistosoma mansoni lipoxygenase 0.0082 0.1089 0.1594
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.2554 0.4095
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0118 0.1873 0.2154
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.018 0.3256 0.8589
Brugia malayi hypothetical protein 0.0157 0.2742 0.3153
Schistosoma mansoni DNA polymerase eta 0.0221 0.4163 0.6091
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0902 0.1273
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.2554 0.4095
Entamoeba histolytica deoxycytidyl transferase, putative 0.0118 0.1873 0.4935
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0902 0.132
Trypanosoma brucei DNA polymerase eta, putative 0.0221 0.4163 0.6693
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.6211 1
Loa Loa (eye worm) RNA binding protein 0.0074 0.0902 0.1037
Brugia malayi Pre-SET motif family protein 0.0426 0.8697 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.025 0.0366
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0204 0.3777 0.5502
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0204 0.3777 0.4342
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0583 0.2402

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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