Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0209 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0209 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0209 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.011 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0209 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0209 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0209 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0209 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0209 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.011 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0209 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0209 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0209 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0209 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0209 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0209 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0209 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0209 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.011 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0209 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0209 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0209 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0209 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0209 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0209 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0209 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.011 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.011 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0209 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0209 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0209 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0209 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0209 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0209 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0209 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.011 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0209 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0209 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0209 | 1 | 1 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0209 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0209 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0209 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.011 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0209 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.011 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 14.12537545 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (functional) | = 0.8913 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.