Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0497 | 0.0794 |
Echinococcus granulosus | epidermal growth factor receptor | 0.032 | 0.1149 | 0.1714 |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.0532 | 0.085 |
Echinococcus multilocularis | neuroglian | 0.0089 | 0.0169 | 0.0126 |
Echinococcus multilocularis | thymidylate synthase | 0.1452 | 0.5968 | 0.9523 |
Echinococcus granulosus | insulin receptor | 0.0107 | 0.0242 | 0.0244 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0497 | 0.0794 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.24 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1522 | 0.6263 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0071 | 0.0092 | 0.0147 |
Echinococcus granulosus | thymidylate synthase | 0.1452 | 0.5968 | 0.9523 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.032 | 0.1149 | 0.1714 |
Echinococcus multilocularis | insulin receptor | 0.0107 | 0.0242 | 0.0244 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1452 | 0.5968 | 0.953 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0107 | 0.0242 | 0.0244 |
Schistosoma mansoni | nephrin | 0.0089 | 0.0169 | 0.027 |
Brugia malayi | thymidylate synthase | 0.1452 | 0.5968 | 0.9523 |
Onchocerca volvulus | 0.1452 | 0.5968 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.0532 | 0.085 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.032 | 0.1149 | 0.1714 |
Echinococcus granulosus | twitchin | 0.0089 | 0.0169 | 0.0126 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0691 | 0.2728 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0107 | 0.0242 | 0.0244 |
Brugia malayi | hypothetical protein | 0.0691 | 0.2728 | 0.4273 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0175 | 0.0532 | 0.0714 |
Schistosoma mansoni | dihydrofolate reductase | 0.1522 | 0.6263 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0263 | 0.0906 | 0.1319 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0263 | 0.0906 | 0.1319 |
Echinococcus multilocularis | roundabout 2 | 0.0113 | 0.0268 | 0.0286 |
Schistosoma mansoni | tyrosine kinase | 0.0107 | 0.0242 | 0.0387 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0095 | 0.0191 | 0.016 |
Schistosoma mansoni | tyrosine kinase | 0.0107 | 0.0242 | 0.0387 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0071 | 0.0092 | 0.0147 |
Echinococcus multilocularis | 0.0097 | 0.0201 | 0.0177 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.24 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1522 | 0.6263 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0191 | 0.016 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.24 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0497 | 0.0794 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1522 | 0.6263 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1522 | 0.6263 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1522 | 0.6263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0268 | 0.0286 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0175 | 0.0532 | 0.0714 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0107 | 0.0242 | 0.0244 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1452 | 0.5968 | 0.9167 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.24 | 1 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0071 | 0.0092 | 0.0147 |
Schistosoma mansoni | cell adhesion molecule | 0.0095 | 0.0191 | 0.0305 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0175 | 0.0532 | 0.0714 |
Echinococcus granulosus | neuroglian | 0.0089 | 0.0169 | 0.0126 |
Echinococcus granulosus | roundabout 2 | 0.0113 | 0.0268 | 0.0286 |
Brugia malayi | Protein kinase domain containing protein | 0.0107 | 0.0242 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0268 | 0.0286 |
Echinococcus granulosus | dihydrofolate reductase | 0.1522 | 0.6263 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.24 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.032 | 0.1149 | 0.1714 |
Brugia malayi | dihydrofolate reductase family protein | 0.1522 | 0.6263 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.032 | 0.1149 | 0.1835 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1522 | 0.6263 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1522 | 0.6263 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0186 | 0.0581 | 0.0205 |
Loa Loa (eye worm) | thymidylate synthase | 0.1452 | 0.5968 | 0.9523 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.1216 uM | PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.