Detailed information for compound 1413935

Basic information

Technical information
  • TDR Targets ID: 1413935
  • Name: (4,6-dimethylpyrimidin-2-yl)-[(1,3-dioxoisoin dol-2-yl)methyl]cyanamide
  • MW: 307.307 | Formula: C16H13N5O2
  • H donors: 0 H acceptors: 5 LogP: 2.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN(c1nc(C)cc(n1)C)CN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C16H13N5O2/c1-10-7-11(2)19-16(18-10)20(8-17)9-21-14(22)12-5-3-4-6-13(12)15(21)23/h3-7H,9H2,1-2H3
  • InChiKey: YOGFVGBUYIWYKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4,6-dimethylpyrimidin-2-yl)-[(1,3-dioxoisoindolin-2-yl)methyl]cyanamide
  • (4,6-dimethyl-2-pyrimidinyl)-[(1,3-dioxo-2-isoindolinyl)methyl]cyanamide
  • (1,3-diketoisoindolin-2-yl)methyl-(4,6-dimethylpyrimidin-2-yl)cyanamide
  • AG-205/34704006
  • A0934/0043754
  • Oprea1_325870
  • MLS000080161
  • SMR000036176
  • ZINC00034184

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.0111 0.0097
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0394 0.1759 0.2667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0481 0.2195 0.3423
Onchocerca volvulus 0.0087 0.0219 1
Brugia malayi neuroendocrine convertase 1 precursor 0.1279 0.6203 0.6198
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0394 0.1759 0.2667
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0111 0.0111
Echinococcus multilocularis Furin 1 0.0481 0.2195 0.2736
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0087 0.0219 0.5
Trypanosoma brucei subtilisin peptidase 0.0087 0.0219 0.5
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0087 0.0219 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0481 0.2195 0.3423
Schistosoma mansoni tyrosine kinase 0.0156 0.0564 0.0496
Echinococcus granulosus Furin 1 0.0481 0.2195 0.2195
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0087 0.0219 0.0205
Brugia malayi Muscleblind-like protein 0.018 0.0688 0.0674
Schistosoma mansoni bromodomain containing protein 0.0076 0.0166 0.0095
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0087 0.0219 0.0149
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0111 0.0139
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0071 0.0089
Echinococcus multilocularis muscleblind protein 1 0.018 0.0688 0.0857
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0481 0.2195 0.2139
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0144 0.018
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0087 0.0219 0.5
Toxoplasma gondii subtilisin SUB10 0.0087 0.0219 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Loa Loa (eye worm) endoprotease bli-4 0.2035 1 1
Brugia malayi celfurPC protein 0.1641 0.8024 0.8021
Schistosoma mansoni tyrosine kinase 0.029 0.1238 0.1175
Echinococcus granulosus neuroendocrine convertase 2 0.1279 0.6203 0.6203
Toxoplasma gondii subtilisin SUB11 0.0087 0.0219 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0111 0.0111
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0144 0.0144
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0093 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0085 0.0211 0.0196
Loa Loa (eye worm) hypothetical protein 0.2035 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.029 0.1238 0.1225
Loa Loa (eye worm) MBCTL1 0.0066 0.0111 0.0097
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0087 0.0219 0.0273
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0481 0.2195 0.3423
Brugia malayi mbt repeat family protein 0.0058 0.0071 0.0057
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0087 0.0219 0.5
Trichomonas vaginalis hypothetical protein 0.0394 0.1759 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0071 0.0071
Schistosoma mansoni tyrosine kinase 0.0154 0.0556 0.0488
Toxoplasma gondii subtilisin SUB4 0.0087 0.0219 0.5
Echinococcus granulosus insulin receptor 0.0093 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0798 0.379 0.3781
Brugia malayi proprotein convertase 2 0.1279 0.6203 0.6198
Echinococcus multilocularis geminin 0.0205 0.081 0.1009
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0087 0.0219 0.5
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0087 0.0219 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0922 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Loa Loa (eye worm) hypothetical protein 0.0058 0.0071 0.0057
Schistosoma mansoni hypothetical protein 0.035 0.154 0.1479
Toxoplasma gondii subtilisin SUB9 0.0087 0.0219 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0029 0.0014
Loa Loa (eye worm) proprotein convertase 2 0.0481 0.2195 0.2184
Schistosoma mansoni tyrosine kinase 0.0156 0.0564 0.0496
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0111 0.004
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0087 0.0219 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0564 0.0703
Echinococcus multilocularis insulin receptor 0.0093 0.0247 0.0308
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0481 0.2195 0.3423
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0481 0.2195 0.3423
Schistosoma mansoni tyrosine kinase 0.0154 0.0556 0.0488
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0071 0.0071
Brugia malayi Protein kinase domain containing protein 0.0093 0.0247 0.0233
Schistosoma mansoni furin-1 (S08 family) 0.0885 0.4227 0.4185
Toxoplasma gondii subtilisin SUB12 0.0087 0.0219 0.5
Brugia malayi Bromodomain containing protein 0.0091 0.0237 0.0223
Echinococcus multilocularis muscleblind protein 0.018 0.0688 0.0857
Echinococcus multilocularis membrane bound transcription factor site 1 0.0087 0.0219 0.0273
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0087 0.0219 0.5
Toxoplasma gondii subtilisin SUB7 0.0087 0.0219 0.5
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0111 0.0139
Toxoplasma gondii subtilisin SUB2 0.0087 0.0219 0.5
Plasmodium falciparum subtilisin-like protease 1 0.0087 0.0219 0.5
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0087 0.0219 0.0149
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0111 0.0097
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4699 0.5856
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0087 0.0219 0.5
Echinococcus granulosus epidermal growth factor receptor 0.029 0.1238 0.1238
Leishmania major subtilisin-like serine peptidase 0.0087 0.0219 0.5
Giardia lamblia High cysteine membrane protein Group 2 0.0756 0.3579 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0087 0.0219 0.0149
Echinococcus granulosus geminin 0.0205 0.081 0.081
Echinococcus granulosus muscleblind protein 0.018 0.0688 0.0688
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0922 0.1149
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0087 0.0219 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1237 0.5992 1
Brugia malayi mbt repeat family protein 0.0058 0.0071 0.0057
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0087 0.0219 0.5
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0087 0.0219 0.5
Echinococcus multilocularis neuroendocrine convertase 2 0.1279 0.6203 0.7731
Loa Loa (eye worm) subtilase 0.0087 0.0219 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Brugia malayi Subtilase family protein 0.0087 0.0219 0.0205
Echinococcus granulosus membrane bound transcription factor site 1 0.0087 0.0219 0.0219
Plasmodium vivax subtilisin-like protease 2, putative 0.0087 0.0219 0.5
Schistosoma mansoni tyrosine kinase 0.0093 0.0247 0.0177
Schistosoma mansoni hypothetical protein 0.0394 0.1759 0.1699
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0087 0.0219 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0093 0.0247 0.0308
Echinococcus granulosus furin 0.2035 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0219 0.0204
Plasmodium falciparum subtilisin-like protease 2 0.0087 0.0219 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0481 0.2195 0.3423
Echinococcus multilocularis epidermal growth factor receptor 0.029 0.1238 0.1543
Schistosoma mansoni hypothetical protein 0.0205 0.081 0.0744
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1237 0.5992 1
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Plasmodium vivax subtilisin-like serine protease, putative 0.0087 0.0219 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0093 0.0247 0.0233
Schistosoma mansoni tyrosine kinase 0.0154 0.0556 0.0488
Schistosoma mansoni tyrosine kinase 0.0093 0.0247 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.0564 0.0564
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0087 0.0219 0.0219
Toxoplasma gondii subtilisin SUB5 0.0087 0.0219 0.5
Toxoplasma gondii subtilisin SUB1 0.0087 0.0219 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.0688 0.0674
Toxoplasma gondii subtilisin SUB6 0.0087 0.0219 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0564 0.0564
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0071 0.0057
Schistosoma mansoni hypothetical protein 0.0205 0.081 0.0744
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1237 0.5992 0.5992
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0087 0.0219 0.0205
Trypanosoma cruzi subtilisin peptidase 0.0087 0.0219 0.5
Mycobacterium leprae Possible secreted protease 0.0087 0.0219 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0041 0.0026
Schistosoma mansoni site-1 peptidase (S08 family) 0.0087 0.0219 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2035 1 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1237 0.5992 0.7468
Loa Loa (eye worm) hypothetical protein 0.018 0.0688 0.0674
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0071 0.0089
Brugia malayi Furin-like cysteine rich region family protein 0.029 0.1238 0.1225
Trichomonas vaginalis conserved hypothetical protein 0.0394 0.1759 0.2667
Plasmodium vivax subtilisin-like protease 1 0.0087 0.0219 0.5
Echinococcus multilocularis 0.009 0.0233 0.029
Echinococcus multilocularis 0.1641 0.8024 1
Plasmodium falciparum subtilisin-like protease 3 0.0087 0.0219 0.5
Toxoplasma gondii subtilisin SUB8 0.0087 0.0219 0.5
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0394 0.1759 0.2667

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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