Detailed information for compound 1413958

Basic information

Technical information
  • TDR Targets ID: 1413958
  • Name: [2-[2-(5-chloro-2-methoxybenzoyl)hydrazinyl]- 2-oxoethyl] 5-bromofuran-2-carboxylate
  • MW: 431.623 | Formula: C15H12BrClN2O6
  • H donors: 2 H acceptors: 3 LogP: 3.31 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)NNC(=O)COC(=O)c1ccc(o1)Br)Cl
  • InChi: 1S/C15H12BrClN2O6/c1-23-10-3-2-8(17)6-9(10)14(21)19-18-13(20)7-24-15(22)11-4-5-12(16)25-11/h2-6H,7H2,1H3,(H,18,20)(H,19,21)
  • InChiKey: OBDGASRKAUHHCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[N'-(5-chloro-2-methoxy-benzoyl)hydrazino]-2-oxo-ethyl] 5-bromofuran-2-carboxylate
  • 5-bromo-2-furancarboxylic acid [2-[N'-[(5-chloro-2-methoxyphenyl)-oxomethyl]hydrazino]-2-oxoethyl] ester
  • 5-bromofuran-2-carboxylic acid [2-[N'-(5-chloro-2-methoxy-benzoyl)hydrazino]-2-keto-ethyl] ester
  • [2-[2-(5-chloro-2-methoxy-phenyl)carbonylhydrazinyl]-2-oxo-ethyl] 5-bromofuran-2-carboxylate
  • T5277474

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.036 0.0397
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0283 0.0276
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0283 0.0297
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.2551 0.2845
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0019 0.0066
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0111 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0283 0.2946
Loa Loa (eye worm) hypothetical protein 0.0034 0.026 0.088
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.0753
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0105 0.0099
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0083
Schistosoma mansoni zinc finger protein 0.0022 0.0128 0.0276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0088 0.0094
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.1587
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0065 0.0599 0.3486
Brugia malayi Fli-1 protein 0.0222 0.2341 0.8039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0283 0.0957
Trypanosoma brucei trypanothione reductase 0.0047 0.0407 0.4269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0152 0.0375
Trypanosoma cruzi ISWI complex protein 0.0016 0.0061 0.058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0101 0.0108
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0517 0.1143
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0111 0.0238
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0596 0.2033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0599 0.2046
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0152 0.0146
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0013 0.0033 0.0281
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0283 0.0311
Mycobacterium ulcerans beta-lactamase 0.0036 0.0283 0.0276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.142 0.1582
Echinococcus multilocularis muscleblind protein 0.0153 0.157 0.1749
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0111 0.0145
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0111 0.0119
Trypanosoma cruzi ISWI complex protein 0.0016 0.0061 0.058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0111 0.0382
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0288
Schistosoma mansoni lamin 0.0028 0.0194 0.0422
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.1047 0.1414
Plasmodium falciparum thioredoxin reductase 0.0047 0.0407 0.23
Schistosoma mansoni pyruvate kinase 0.0017 0.0079 0.0165
Echinococcus granulosus lysine specific histone demethylase 1A 0.0065 0.0599 0.0807
Brugia malayi Probable ClpP-like protease 0.016 0.1657 0.5691
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0101 0.0347
Schistosoma mansoni pyruvate kinase 0.0034 0.026 0.057
Loa Loa (eye worm) fli-1 protein 0.0222 0.2341 0.8036
Plasmodium falciparum glutathione reductase 0.0016 0.0067 0.021
Mycobacterium ulcerans dehydrogenase 0.0065 0.0599 0.0593
Brugia malayi hypothetical protein 0.0011 0.0005 0.0019
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.321 1
Brugia malayi Ets-domain containing protein 0.0011 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0492
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0066 0.0619 0.3709
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0067 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0111 0.0382
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0517 0.1777
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0283 0.2946
Echinococcus granulosus lamin dm0 0.0028 0.0194 0.0257
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0283 0.0297
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0101 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0111 0.0367
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0398 0.0422
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0013 0.0033 0.0281
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0111 0.0238
Loa Loa (eye worm) carboxylesterase 0.0046 0.0398 0.1355
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0283 0.0786
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0033 0.0281
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.036 0.1222
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0067 0.0645
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.142 0.4877
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0407 0.23
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Leishmania major pyruvate kinase 0.0034 0.026 0.2706
Brugia malayi hypothetical protein 0.0037 0.0296 0.1017
Schistosoma mansoni hypothetical protein 0.0049 0.0431 0.0949
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0086
Onchocerca volvulus 0.0165 0.1705 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0067 0.0645
Mycobacterium tuberculosis Possible oxidoreductase 0.0065 0.0599 0.0638
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0944 0.1274
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Echinococcus multilocularis pyruvate kinase 0.0027 0.0182 0.0198
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0398 0.0534
Onchocerca volvulus 0.002 0.0111 0.0611
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1511 0.911
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0033 0.0039
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0984 0.2181
Brugia malayi intermediate filament protein 0.0028 0.0194 0.0665
Brugia malayi Carboxylesterase family protein 0.0046 0.0398 0.1368
Loa Loa (eye worm) pip kinase 1 0.0013 0.0033 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.142 0.192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0074 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0101 0.0214
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.1047 0.1121
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0497 0.297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0278
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Brugia malayi PHD-finger family protein 0.0027 0.0189 0.0648
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0051 0.0176
Brugia malayi hypothetical protein 0.0011 0.0005 0.0019
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0398 0.044
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0596 0.1316
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0398 0.044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0517 0.0573
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0152 0.1554
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.026 0.1489
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0111 0.0367
Schistosoma mansoni ap endonuclease 0.0019 0.0101 0.0215
Onchocerca volvulus 0.0036 0.0283 0.1622
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 0.1652
Echinococcus multilocularis pyruvate kinase 0.0034 0.026 0.0286
Echinococcus granulosus muscleblind protein 0.0153 0.157 0.2123
Schistosoma mansoni cpg binding protein 0.0033 0.0251 0.0549
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Loa Loa (eye worm) acetylcholinesterase 1 0.0274 0.2912 1
Brugia malayi Pip kinase protein 1 0.0013 0.0033 0.0113
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0111 0.0367
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0584 0.0786
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0052 0.0459 0.1577
Echinococcus granulosus pyruvate kinase 0.0034 0.026 0.0347
Echinococcus granulosus pyruvate kinase 0.0034 0.026 0.0347
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0033 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0111 0.0145
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0019 0.0066
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0081 0.0104
Echinococcus granulosus Protein patched homolog 1 0.0043 0.036 0.0482
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0111 0.0238
Brugia malayi nuclear receptor RXR 0.0011 0.0005 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0283 0.062
Echinococcus granulosus FTZ F1 alpha 0.002 0.0111 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0101 0.1006
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.026 0.0893
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.321 1
Brugia malayi beta-lactamase 0.0036 0.0283 0.0971
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1461 0.1975
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0067 0.021
Mycobacterium ulcerans lipase LipD 0.0036 0.0283 0.0276
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0957
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0165 0.1705 0.3787
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0067 0.0107
Schistosoma mansoni ap endonuclease 0.0019 0.0101 0.0215
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0852 0.9288 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0111 0.0382
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1205 0.7257
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0517 0.5452
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0111 0.0382
Onchocerca volvulus 0.0036 0.0283 0.1622
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0147 0.0492
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0085 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0111 0.0145
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.026 0.1536
Loa Loa (eye worm) hypothetical protein 0.0028 0.0194 0.0651
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0004 0.0015
Echinococcus multilocularis lamin 0.0028 0.0194 0.0212
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0527 0.3152
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0944 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0916 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0111 0.0238
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0407 0.0546
Entamoeba histolytica hypothetical protein 0.0037 0.0296 0.0828
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.026 0.1489
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0101 0.1006
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0407 0.4269
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0296 0.0395
Brugia malayi RNA binding protein 0.0064 0.0596 0.2045
Loa Loa (eye worm) hypothetical protein 0.0042 0.035 0.119
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0008 0.0026
Echinococcus multilocularis neuroligin 0.0046 0.0398 0.044
Brugia malayi Ets-domain containing protein 0.0073 0.0695 0.2388
Brugia malayi transcription factor E74 isoform 0.0011 0.0004 0.0015
Loa Loa (eye worm) glutathione reductase 0.0047 0.0407 0.1384
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0398 0.115
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0067 0.0065
Leishmania major trypanothione reductase 0.0047 0.0407 0.4269
Mycobacterium leprae Probable lipase LipE 0.0036 0.0283 0.1672
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0067 0.014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0988 0.3006
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0944 0.2091
Echinococcus granulosus intermediate filament protein 0.0028 0.0194 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0152 0.0146
Echinococcus granulosus acetylcholinesterase 0.0274 0.2912 0.3943
Loa Loa (eye worm) carboxylesterase 0.0046 0.0398 0.1355
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Echinococcus multilocularis expressed conserved protein 0.0094 0.0922 0.1024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0067 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0283 0.062
Loa Loa (eye worm) hypothetical protein 0.0153 0.157 0.5384
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.026 0.0715
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0988 0.3393
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0085 0.0079
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0162 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Brugia malayi steroid hormone receptor 0.002 0.0111 0.0382
Onchocerca volvulus 0.0099 0.0984 0.5751
Loa Loa (eye worm) hypothetical protein 0.0065 0.0599 0.2046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0152 0.0146
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.2551 0.3454
Loa Loa (eye worm) hypothetical protein 0.0046 0.039 0.1328
Echinococcus granulosus solute carrier family 12 0.0052 0.0459 0.0617
Loa Loa (eye worm) hypothetical protein 0.0065 0.0599 0.2046
Loa Loa (eye worm) hypothetical protein 0.0274 0.2912 1
Chlamydia trachomatis pyruvate kinase 0.0034 0.026 0.1214
Onchocerca volvulus 0.0046 0.0398 0.2302
Schistosoma mansoni hypothetical protein 0.0021 0.0122 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0111 0.0382
Trypanosoma brucei pyruvate kinase 1 0.0034 0.026 0.2706
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0074 0.0073
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1072 0.1148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0111 0.0119
Mycobacterium ulcerans monoamine oxidase 0.0065 0.0599 0.0593
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0111 0.0611
Leishmania major UDP-galactopyranose mutase 0.0065 0.0599 0.6325
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0822 0.8957 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0111 0.0382
Entamoeba histolytica hypothetical protein 0.0037 0.0296 0.0828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0111 0.0367
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0398 0.0877
Loa Loa (eye worm) hypothetical protein 0.0065 0.0599 0.2046
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.026 0.0893
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0013 0.0033 0.0281
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0944 0.323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.142 0.3153
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.142 0.487
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 1
Onchocerca volvulus 0.0046 0.0398 0.2302
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0105 0.0348
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0222 0.0747
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0278
Brugia malayi hypothetical protein 0.0065 0.0599 0.2058
Mycobacterium ulcerans hypothetical protein 0.0024 0.0152 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0005 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1072 0.1148
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0067 0.021
Onchocerca volvulus 0.0028 0.0194 0.1098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0004
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0007 0.0003
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.321 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0596 0.066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0596 0.2033
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.4496 0.5017
Loa Loa (eye worm) hypothetical protein 0.0153 0.157 0.5384
Brugia malayi Pip kinase protein 2 0.0165 0.1705 0.5855
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0065 0.0599 0.1325
Echinococcus granulosus acetylcholinesterase 0.0274 0.2912 0.3943
Leishmania major cytochrome p450-like protein 0.002 0.0105 0.1054
Brugia malayi nuclear hormone receptor 0.002 0.0111 0.0382
Echinococcus multilocularis muscleblind protein 1 0.0153 0.157 0.1749
Brugia malayi Cytochrome P450 family protein 0.0011 0.0007 0.0023
Chlamydia trachomatis protoporphyrinogen oxidase 0.0065 0.0599 0.3346
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0152 0.1554
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0033 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0065 0.0599 0.1325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.142 0.1582
Loa Loa (eye worm) hypothetical protein 0.0063 0.0578 0.1973
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0079 0.0281
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1072 0.1148
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0111 0.0119
Schistosoma mansoni cpg binding protein 0.0033 0.0251 0.0549
Brugia malayi Amino acid permease family protein 0.0052 0.0459 0.1577
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0398 0.0534
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.016 0.1657 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0296 0.0326
Trypanosoma brucei cytochrome P450, putative 0.002 0.0105 0.1054
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0033 0.0159
Plasmodium vivax pyruvate kinase, putative 0.0034 0.026 0.1399
Schistosoma mansoni thyroid hormone receptor 0.002 0.0111 0.0238
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1511 0.162
Brugia malayi Cytochrome P450 family protein 0.002 0.0105 0.0362
Brugia malayi Carboxylesterase family protein 0.0046 0.0398 0.1368
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0101 0.0214
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0632
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0296 0.0325
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0283 0.0377
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0083
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0944 0.5515
Trypanosoma brucei ISWI complex protein 0.0016 0.0061 0.058
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.026 0.1489
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0296 0.065
Onchocerca volvulus 0.0029 0.0211 0.1197
Echinococcus granulosus cpg binding protein 0.0033 0.0251 0.0334
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0497 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.036 0.1028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.142 0.192
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0101
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0431 0.1478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.142 0.3153
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0398 0.0877
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0281
Brugia malayi Carboxylesterase family protein 0.0046 0.0398 0.1368
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1072 0.1148
Loa Loa (eye worm) hypothetical protein 0.016 0.1657 0.5684
Onchocerca volvulus 0.0036 0.0283 0.1622
Schistosoma mansoni hypothetical protein 0.0172 0.1782 0.3959
Mycobacterium ulcerans pyruvate kinase 0.0034 0.026 0.0254
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0088 0.0114
Toxoplasma gondii hypothetical protein 0.0055 0.0497 0.297
Loa Loa (eye worm) hypothetical protein 0.0065 0.0599 0.2046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0111 0.0367
Schistosoma mansoni thyroid hormone receptor 0.002 0.0111 0.0238
Brugia malayi Muscleblind-like protein 0.0153 0.157 0.5391
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0067 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.142 0.3153
Loa Loa (eye worm) beta-lactamase 0.0036 0.0283 0.0957
Schistosoma mansoni amine oxidase 0.0065 0.0599 0.1325
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0101 0.0102
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0101 0.0212
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0944 0.1049
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0165 0.1705 0.19
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0398 0.0422
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0152 0.0375
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0517 0.0511
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0283 0.0786
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0033 0.0032
Echinococcus multilocularis acetylcholinesterase 0.0274 0.2912 0.3248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0067 0.0645
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0035 0.0042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0517 0.0511
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0162 0.0214
Brugia malayi hypothetical protein 0.0046 0.0398 0.1368
Leishmania major pyruvate kinase 0.0034 0.026 0.2706
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1205 0.1291
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0105 0.0348
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0283 0.2946
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1072 0.6456
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0152 0.0523
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.321 1
Brugia malayi Ets-domain containing protein 0.0073 0.0695 0.2388
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0126
Leishmania major hypothetical protein, conserved 0.0016 0.0061 0.058
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0067 0.006
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0517 0.055
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0065 0.0599 0.3486
Loa Loa (eye worm) pip kinase 2 0.0165 0.1705 0.5849
Schistosoma mansoni gliotactin 0.0046 0.0398 0.0877
Toxoplasma gondii histone lysine-specific demethylase 0.0065 0.0599 0.359
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0067 0.0645
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Schistosoma mansoni lamin 0.0028 0.0194 0.0422
Schistosoma mansoni hypothetical protein 0.0418 0.4496 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Echinococcus multilocularis protein dispatched 1 0.0049 0.0426 0.0471
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0052 0.0459 0.1013
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0165 0.1705 0.3787
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0085 0.0085
Echinococcus multilocularis cpg binding protein 0.0033 0.0251 0.0275
Loa Loa (eye worm) hypothetical protein 0.0099 0.0984 0.3368
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0111 0.0238
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Brugia malayi Bromodomain containing protein 0.0039 0.0323 0.1108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0278
Echinococcus granulosus lysine specific histone demethylase 1A 0.0065 0.0599 0.0807
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0081 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.0019
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0101 0.0214
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0944 1
Onchocerca volvulus 0.0028 0.0194 0.1098
Brugia malayi Bromodomain containing protein 0.0079 0.0758 0.2604
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0079 0.0281
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0101 0.0418
Loa Loa (eye worm) hypothetical protein 0.004 0.0323 0.1097
Loa Loa (eye worm) pyruvate kinase 0.0034 0.026 0.088
Schistosoma mansoni survival motor neuron protein 0.0049 0.0431 0.0949
Mycobacterium tuberculosis Conserved protein 0.0036 0.0283 0.0297
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0067 0.021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0283 0.0971
Brugia malayi CHE-14 protein 0.0043 0.036 0.1235
Onchocerca volvulus 0.0049 0.0431 0.2492
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1072 0.1148
Plasmodium falciparum thioredoxin reductase 0.0016 0.0067 0.021
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0004
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0398 0.044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0004
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0013 0.0033 0.0281
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0283 0.0297
Schistosoma mansoni peptidase Clp (S14 family) 0.016 0.1657 0.3681
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0067 0.0366
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0101 0.1006
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0033 0.0159
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0111 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0101 0.1006
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0398 0.0422
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0074 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0111 0.0382
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.1657 1
Onchocerca volvulus 0.0046 0.0398 0.2302
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0111 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0088 0.0186
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0944 0.324
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0067 0.0107
Schistosoma mansoni hypothetical protein 0.0172 0.1782 0.3959
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0065 0.0599 0.359
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0584 0.0648
Echinococcus multilocularis tumor protein p63 0.0679 0.7379 0.8238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0111 0.0611
Schistosoma mansoni coup transcription factor 0.002 0.0111 0.0238
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1222
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.026 0.2706
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0067 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0596 0.1316
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0596 0.1316
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0085 0.0114
Echinococcus multilocularis acetylcholinesterase 0.0274 0.2912 0.3248
Toxoplasma gondii ABC1 family protein 0.0036 0.0283 0.1672
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0065 0.0599 0.3486
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0152 0.0146
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0599 0.3486
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0067 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0957
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0033 0.0064
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 0.5059
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0111 0.0238
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0475 0.1619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0111 0.0382
Schistosoma mansoni intermediate filament proteins 0.0028 0.0194 0.0422
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0596 0.1316
Brugia malayi Carboxylesterase family protein 0.0274 0.2912 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.1047 0.1165
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0111 0.0145
Mycobacterium tuberculosis Conserved protein 0.0036 0.0283 0.0297
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0111 0.0145
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0122 0.0404
Loa Loa (eye worm) CYP4Cod1 0.002 0.0105 0.0348
Echinococcus multilocularis musashi 0.0028 0.0194 0.0212
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.016 0.1657 0.2241
Echinococcus granulosus lamin 0.0028 0.0194 0.0257
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0033 0.0113
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0194 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.041 0.1187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0957
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0088 0.0186
Mycobacterium tuberculosis Conserved protein 0.0036 0.0283 0.0297
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0101 0.0094
Schistosoma mansoni zinc finger protein 0.0016 0.0061 0.0126
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0695 0.0937
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.1047 0.1121
Schistosoma mansoni hypothetical protein 0.0037 0.0296 0.065
Brugia malayi CXXC zinc finger family protein 0.0029 0.0211 0.0723
Echinococcus multilocularis protein patched 0.0043 0.036 0.0397
Plasmodium falciparum protoporphyrinogen oxidase 0.0065 0.0599 0.3486
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0695 0.2377
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0283 0.0786
Echinococcus granulosus dnaJ subfamily B 0.0418 0.4496 0.609
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0111 0.0238
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1205 0.1291
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0067 0.006
Entamoeba histolytica hypothetical protein 0.0037 0.0296 0.0828
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0065 0.0599 0.3486
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0599 0.3486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0111 0.0382
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0152 0.1554
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.0753
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0398 0.0534
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0398 0.0877
Echinococcus multilocularis geminin 0.0172 0.1782 0.1986
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1511 0.1505
Mycobacterium tuberculosis Probable reductase 0.0107 0.1072 0.1148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0957
Echinococcus granulosus geminin 0.0172 0.1782 0.2411
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Plasmodium vivax glutathione reductase, putative 0.0047 0.0407 0.23
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0033 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0152 0.0146
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2415 0.2595
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0296 0.0396
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0067 0.0085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0085 0.0321
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0101 0.0418
Giardia lamblia Pyruvate kinase 0.0017 0.0079 0.0143
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0152 0.0157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1005 0.2229
Echinococcus granulosus expressed conserved protein 0.0094 0.0922 0.1244
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0211 0.071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0067 0.0366
Brugia malayi beta-lactamase family protein 0.0036 0.0283 0.0971
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0398 0.0877
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0398 0.0877
Schistosoma mansoni amine oxidase 0.0065 0.0599 0.1325
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0497 0.2856
Giardia lamblia Pyruvate kinase 0.0034 0.026 0.0715
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0283 0.1672
Schistosoma mansoni kinase 0.0049 0.0424 0.0934
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0111 0.0119
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0274 0.2912 0.6475
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0407 0.0431
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.036 0.0482
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.026 0.0273
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.2362
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0517 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0111 0.0382
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0033 0.0039
Echinococcus granulosus tar DNA binding protein 0.0064 0.0596 0.0802
Brugia malayi Cytochrome P450 family protein 0.002 0.0105 0.0362
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1564
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.1657 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0101 0.0107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0152 0.0882
Brugia malayi beta-lactamase family protein 0.0036 0.0283 0.0971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0111 0.0367
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0407 0.1384
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0283 0.0297
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0033 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0067 0.0645
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0988 0.1099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0509
Giardia lamblia Kinase, PLK 0.0096 0.0944 0.2866
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0111 0.0382
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0509
Brugia malayi cytochrome P450 0.0011 0.0007 0.0023
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0497 0.2856
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0398 0.115
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0281
Brugia malayi ecdysteroid receptor 0.002 0.0111 0.0382
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0111 0.0367
Loa Loa (eye worm) cytochrome P450 0.0011 0.0007 0.0008
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0944 0.2866
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0152 0.0146
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0152 0.0882
Echinococcus multilocularis pyruvate kinase 0.0034 0.026 0.0286
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.026 0.0715
Loa Loa (eye worm) RNA binding protein 0.0064 0.0596 0.2033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0067 0.0645
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0086
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0111 0.0238
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0033 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0111 0.0382
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 1
Echinococcus granulosus neuroligin 0.0046 0.0398 0.0534
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0281
Brugia malayi Thioredoxin reductase 0.0047 0.0407 0.1396
Onchocerca volvulus 0.0024 0.0152 0.0853
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0509
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0105 0.1054
Mycobacterium ulcerans oxidoreductase 0.0065 0.0599 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0111 0.0367
Schistosoma mansoni patched 1 0.0043 0.036 0.0791
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0152 0.0146
Brugia malayi TAR-binding protein 0.0064 0.0596 0.2045
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0152 0.0523
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0033 0.0281
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0162 0.0351
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0957
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.016 0.1657 0.1846
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0005 0.0002
Echinococcus multilocularis protoporphyrinogen oxidase 0.0065 0.0599 0.0665
Trypanosoma brucei polo-like protein kinase 0.0096 0.0944 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0596 0.1316
Trypanosoma cruzi UDP-galactopyranose mutase 0.0065 0.0599 0.6325
Trypanosoma cruzi UDP-galactopyranose mutase 0.0065 0.0599 0.6325
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Loa Loa (eye worm) carboxylesterase 0.0274 0.2912 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0378 0.1284
Mycobacterium ulcerans hypothetical protein 0.0036 0.0283 0.0276
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0101 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0067 0.0231
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0944 1
Brugia malayi Carboxylesterase family protein 0.0274 0.2912 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0944 0.2866
Brugia malayi hypothetical protein 0.0241 0.2551 0.8761
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0407 0.0449
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0988 0.1334
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0283 0.0276
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1461 0.1627
Leishmania major hypothetical protein, conserved 0.0036 0.0283 0.2946
Onchocerca volvulus 0.0046 0.0398 0.2302
Brugia malayi Carboxylesterase family protein 0.0046 0.0398 0.1368
Loa Loa (eye worm) hypothetical protein 0.0065 0.0599 0.2046
Loa Loa (eye worm) hypothetical protein 0.01 0.0988 0.3383
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1205 0.1291
Entamoeba histolytica hypothetical protein 0.0037 0.0296 0.0828
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0152 0.0157
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0083
Onchocerca volvulus 0.0046 0.0398 0.2302
Echinococcus multilocularis lamin dm0 0.0028 0.0194 0.0212
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.0753
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0081 0.0171
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.0753
Schistosoma mansoni pyruvate kinase 0.0034 0.026 0.057
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0695 0.0772
Loa Loa (eye worm) amino acid permease 0.0052 0.0459 0.1564
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0573 0.1267
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0194 0.0651
Echinococcus multilocularis solute carrier family 12 0.0052 0.0459 0.0508
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0004
Loa Loa (eye worm) pyruvate kinase 0.0034 0.026 0.088
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0596 0.2045
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0101
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0088 0.0288
Echinococcus multilocularis carboxylesterase 5A 0.0274 0.2912 0.3248
Brugia malayi Cytochrome P450 family protein 0.003 0.0222 0.0761
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0111 0.0119
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.1047 0.6305
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0013 0.0033 0.0281
Trichomonas vaginalis esterase, putative 0.0036 0.0283 0.0786
Brugia malayi glutathione reductase 0.0047 0.0407 0.1396
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0194 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0111 0.0382
Toxoplasma gondii thioredoxin reductase 0.0047 0.0407 0.2423
Schistosoma mansoni ets-related 0.0222 0.2341 0.5203
Schistosoma mansoni gabp alpha 0.0073 0.0695 0.1539
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0283 0.0297
Loa Loa (eye worm) hypothetical protein 0.0241 0.2551 0.8759
Loa Loa (eye worm) pyruvate kinase 0.0034 0.026 0.088
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0051 0.0162
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0013 0.0033 0.0281
Brugia malayi SWIRM domain containing protein 0.0065 0.0599 0.2058
Echinococcus multilocularis zinc finger protein 0.0022 0.0128 0.0138
Schistosoma mansoni acetylcholinesterase 0.0046 0.0398 0.0877
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0599 0.0638
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0152 0.0523
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.0019
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0147 0.036
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0065 0.0599 0.0665
Schistosoma mansoni bromodomain containing protein 0.0067 0.0625 0.1382
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0005 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0105 0.1054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0645
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0013 0.0033 0.0281
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0067 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0111 0.0382
Loa Loa (eye worm) hypothetical protein 0.0274 0.2912 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.026 0.2706
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0398 0.0392
Schistosoma mansoni cytochrome P450 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0165 0.1705 0.5849
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0152 0.0375
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0033 0.0281
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0005 0.0004
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0079 0.0436
Echinococcus granulosus tumor protein p63 0.0679 0.7379 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0283 0.0297
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0111 0.0145
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0278
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.1657 0.1652
Schistosoma mansoni cpg binding protein 0.0029 0.0211 0.0459
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0033 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.321 1
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0013 0.0033 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.041 0.1187
Plasmodium falciparum pyruvate kinase 0.0034 0.026 0.1399
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0111 0.0611
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0165 0.1705 0.2306
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0081 0.0171
Echinococcus multilocularis 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0957
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0101 0.0214
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0283 0.0786
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0013 0.0033 0.0159
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0065 0.0599 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0111 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0367
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0283 0.0786
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1355
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0033 0.0032
Toxoplasma gondii exonuclease III APE 0.0019 0.0101 0.0571
Onchocerca volvulus 0.0065 0.0599 0.3486
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.026 0.1536
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0111 0.0119
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0111 0.0119
Brugia malayi amine oxidase, flavin-containing family protein 0.0065 0.0599 0.2058
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0283 0.0297
Plasmodium falciparum glutathione reductase 0.0047 0.0407 0.23
Echinococcus multilocularis 0.0065 0.0599 0.0665
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0074 0.0073
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0101
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0106
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0067 0.0107
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0283 0.1537
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0111 0.0119
Echinococcus granulosus zinc finger protein 0.0022 0.0128 0.0168
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0111 0.0119
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.016 0.1657 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0111 0.0238
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0111 0.0382
Echinococcus granulosus carboxylesterase 5A 0.0274 0.2912 0.3943
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0111 0.0238
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.026 0.2706

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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