Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4088 | 0.8541 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1572 | 0.1833 |
Onchocerca volvulus | 0.0035 | 0.4393 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0754 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4088 | 0.8541 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1658 | 0.2532 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4088 | 0.9117 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1658 | 0.2082 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4393 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4088 | 0.4023 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1908 | 0.2804 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4088 | 0.9122 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0634 | 0.0531 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4393 | 0.4331 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4088 | 0.8541 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4088 | 0.9117 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4088 | 0.8541 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4088 | 0.8541 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.4088 | 0.8541 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.4619 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4393 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4088 | 0.4023 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8867 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4088 | 0.4023 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4002 | 0.8868 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1908 | 0.2845 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1572 | 0.1833 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4088 | 0.9117 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4678 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4088 | 0.9122 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1658 | 0.2532 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.