Detailed information for compound 1414015

Basic information

Technical information
  • TDR Targets ID: 1414015
  • Name: 2-[4-[5-(furan-2-ylmethylidene)-4-oxo-2-sulfa nylidene-1,3-thiazolidin-3-yl]butanoylamino]b enzoic acid
  • MW: 416.471 | Formula: C19H16N2O5S2
  • H donors: 2 H acceptors: 4 LogP: 3.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1C(=O)O)CCCN1C(=S)S/C(=C\c2ccco2)/C1=O
  • InChi: 1S/C19H16N2O5S2/c22-16(20-14-7-2-1-6-13(14)18(24)25)8-3-9-21-17(23)15(28-19(21)27)11-12-5-4-10-26-12/h1-2,4-7,10-11H,3,8-9H2,(H,20,22)(H,24,25)/b15-11-
  • InChiKey: VNMYZUCXXKBSJZ-PTNGSMBKSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[4-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
  • 2-[4-[5-(2-furylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]butanoylamino]benzoic acid
  • 2-[4-[(5Z)-5-(2-furylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]butanoylamino]benzoic acid
  • 2-[[4-[(5Z)-5-(2-furylmethylene)-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]benzoic acid
  • 2-[[4-[5-(2-furylmethylene)-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]benzoic acid
  • 2-[4-[5-(2-furylmethylene)-4-keto-2-thioxo-thiazolidin-3-yl]butanoylamino]benzoic acid
  • 2-[4-[(5Z)-5-(2-furylmethylene)-4-keto-2-thioxo-thiazolidin-3-yl]butanoylamino]benzoic acid
  • 2-(4-{5-[1-Furan-2-yl-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-butyrylamino)-benzoic acid
  • MLS000778775
  • SMR000415570

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0991 0.0961
Schistosoma mansoni cpg binding protein 0.0037 0.061 0.0578
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.22 0.3239
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0077 0.0044
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0182 0.01
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0383 0.2445
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0598 0.272
Trypanosoma brucei polo-like protein kinase 0.0114 0.22 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0036 0.0594 0.6325
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0233 0.0556
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0795 0.3496
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.1354 0.2018
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0182 0.0247
Loa Loa (eye worm) hypothetical protein 0.0072 0.1326 0.1685
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0991 0.0961
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0324 0.029
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0117 0.0532
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0667 0.2639
Leishmania major importin beta-1 subunit, putative 0.0028 0.0437 0.1536
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0324 0.2736
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0182 0.0828
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0991 0.0961
Trichomonas vaginalis DNA helicase recq1, putative 0.0053 0.0944 0.1398
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.22 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0808 0.0776
Plasmodium falciparum thioredoxin reductase 0.0016 0.0182 0.0863
Brugia malayi Importin beta-1 subunit 0.0035 0.0572 0.0758
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2236 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0324 0.0991
Trichomonas vaginalis DNA helicase recq, putative 0.0053 0.0944 0.1398
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0572 0.054
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0324 0.053
Loa Loa (eye worm) hypothetical protein 0.0158 0.3104 0.4083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.00000000045936
Schistosoma mansoni ap endonuclease 0.0023 0.0324 0.029
Schistosoma mansoni DNA helicase recq5 0.0036 0.0594 0.0562
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.00000000045936
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0991 0.1233
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0182 0.0598
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0795 0.0968
Plasmodium falciparum glutathione reductase 0.0046 0.0795 0.8987
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0324 0.1471
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0182 0.0313
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0019 0.00000000045936
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.4612 0.4594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.00000000045936
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0036 0.0594 0.0562
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0036 0.0594 0.0562
Toxoplasma gondii thioredoxin reductase 0.0046 0.0795 0.6225
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0383 0.3927
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.1326 0.603
Schistosoma mansoni hypothetical protein 0.0372 0.749 0.7482
Schistosoma mansoni cpg binding protein 0.0035 0.0569 0.0537
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1354 0.594
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2236 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0383 0.1279
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0749 0.0718
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.1326 0.1908
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0572 0.2601
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0695 0.0945
Loa Loa (eye worm) glutaminase 0.033 0.6636 0.8847
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0018 0.0219 0.1497
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0749 0.5799
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0695 0.0663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0991 0.0961
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.104 0.1009
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.104 0.1009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0182 0.0828
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0182 0.0164
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0049 0.0872 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1204 0.1519
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1204 0.1174
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.22 0.2863
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0182 0.0828
Brugia malayi Bloom's syndrome protein homolog 0.0053 0.0944 0.1325
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0808 0.0776
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0858 0.3559
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.22 0.2173
Toxoplasma gondii exonuclease III APE 0.0023 0.0324 0.1895
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0383 0.1743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0991 0.0961
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1204 0.1721
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0182 0.0313
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.104 0.1009
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0667 0.2639
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0036 0.0594 0.0697
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.749 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0795 0.3256
Schistosoma mansoni cpg binding protein 0.0037 0.061 0.0578
Schistosoma mansoni DNA helicase recq1 0.0036 0.0594 0.0562
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0695 0.0663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0697
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0594 0.4381
Echinococcus multilocularis snurportin 1 0.0372 0.749 0.7482
Trypanosoma brucei unspecified product 0.0028 0.0435 0.1976
Trypanosoma brucei unspecified product 0.0065 0.119 0.5412
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0096 0.0032
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0324 0.0317
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1204 0.1174
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0233 0.02
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0233 0.0556
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.104 0.1551
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1997 0.8922
Loa Loa (eye worm) hypothetical protein 0.0018 0.0233 0.021
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0858 0.3781
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0182 0.0828
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1368 0.1338
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0695 0.0663
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0182 0.0863
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0281 0.1502
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0667 0.3031
Echinococcus multilocularis cpg binding protein 0.0037 0.061 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0776 0.353
Leishmania major DNA polymerase eta, putative 0.0072 0.1326 0.5807
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0749 0.0718
Brugia malayi mbt repeat family protein 0.0058 0.104 0.1471
Loa Loa (eye worm) MBCTL1 0.0066 0.1204 0.1519
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0324 0.3044
Brugia malayi CXXC zinc finger family protein 0.0035 0.0569 0.0754
Schistosoma mansoni ap endonuclease 0.0023 0.0324 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Plasmodium falciparum thioredoxin reductase 0.0046 0.0795 0.8987
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.104 0.1298
Plasmodium falciparum glutathione reductase 0.0016 0.0182 0.0863
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0383 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Echinococcus granulosus importin subunit beta 1 0.0035 0.0572 0.054
Entamoeba histolytica hypothetical protein 0.0043 0.0749 0.2679
Brugia malayi RNA, U transporter 1 0.0099 0.189 0.2767
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0182 0.0313
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0695 0.3042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0182 0.0313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1354 0.594
Schistosoma mansoni hypothetical protein 0.0355 0.7142 0.7132
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2236 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0695 0.0833
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0437 0.1536
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Brugia malayi mbt repeat family protein 0.0058 0.104 0.1471
Loa Loa (eye worm) hypothetical protein 0.0045 0.0776 0.0943
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0324 1
Schistosoma mansoni kinase 0.0058 0.1048 0.1017
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0036 0.0594 0.0562
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.4612 0.4594
Loa Loa (eye worm) glutathione reductase 0.0046 0.0795 0.0968
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1354 0.594
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0383 0.353
Loa Loa (eye worm) RecQ helicase 0.0053 0.0944 0.1169
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1997 0.8922
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0233 0.1063
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.051 0.5797
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0695 0.0663
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.22 0.2173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0437 0.0632
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0598 0.272
Schistosoma mansoni glutaminase 0.033 0.6636 0.6624
Echinococcus multilocularis dna polymerase eta 0.0072 0.1326 0.1297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1206 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0324 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0749 0.3033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0182 0.096
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1204 0.1174
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1354 0.6156
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0077 0.0044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0324 0.0991
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.104 0.1009
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0182 0.0598
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0324 0.0332
Trypanosoma brucei trypanothione reductase 0.0046 0.0795 0.3615
Brugia malayi glutathione reductase 0.0046 0.0795 0.1098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0496 0.3477
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0019 0.00000000045936
Schistosoma mansoni ran 0.0026 0.0383 0.0351
Plasmodium vivax importin-beta 2, putative 0.0035 0.0572 0.6711
Schistosoma mansoni hypothetical protein 0.0043 0.0749 0.0718
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0991 0.1397
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.00000000045936
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0182 0.0863
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.00000000045936
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0383 0.1279
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0598 0.272
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Entamoeba histolytica hypothetical protein 0.0043 0.0749 0.2679
Leishmania major DNA polymerase kappa, putative 0.0049 0.0858 0.3559
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0117 0.0532
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0383 0.1279
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.22 0.2173
Entamoeba histolytica Ran family GTPase 0.0026 0.0383 0.0832
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1997 0.8922
Echinococcus granulosus bloom syndrome protein 0.0053 0.0944 0.0913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0991 0.0961
Entamoeba histolytica hypothetical protein 0.0043 0.0749 0.2679
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0117 0.0532
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1204 0.1174
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0324 0.0461
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1354 0.1898
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0437 0.0632
Giardia lamblia Kinase, PLK 0.0114 0.22 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0568 0.0536
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1017 0.1508
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0324 0.0991
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0594 0.4381
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0036 0.0594 0.0562
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.22 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0324 0.0461
Trichomonas vaginalis DNA helicase recq, putative 0.0039 0.0667 0.0979
Entamoeba histolytica recQ family DNA helicase 0.0018 0.0233 0.0072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0182 0.0149
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.1354 0.2018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0182 0.01
Brugia malayi polk-prov protein 0.0045 0.0776 0.107
Leishmania major trypanothione reductase 0.0046 0.0795 0.3256
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0569 0.0663
Loa Loa (eye worm) glutaminase 2 0.033 0.6636 0.8847
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0695 0.2403
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.22 1
Echinococcus granulosus snurportin 1 0.0372 0.749 0.7482
Loa Loa (eye worm) hypothetical protein 0.0182 0.3604 0.4758
Plasmodium falciparum importin beta, putative 0.0035 0.0572 0.6032
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0117 0.0532
Entamoeba histolytica hypothetical protein 0.0028 0.0437 0.1102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1354 0.594
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.104 0.1009
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0324 0.0379
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0182 0.5
Brugia malayi hypothetical protein 0.0043 0.0749 0.1028
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1354 0.6156
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.22 0.5371
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Entamoeba histolytica recQ family helicase, putative 0.0039 0.0667 0.2262
Brugia malayi hypothetical protein 0.0182 0.3604 0.5379
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0182 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1997 0.8922
Brugia malayi glutaminase DH11.1 0.033 0.6636 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1326 0.5807
Loa Loa (eye worm) hypothetical protein 0.0058 0.104 0.1298
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1997 0.8922
Trichomonas vaginalis ran, putative 0.0026 0.0383 0.0551
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0324 0.0991
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0383 0.0351
Giardia lamblia Sgs1 DNA helicase, putative 0.0036 0.0594 0.2292
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0096 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0182 0.096
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0182 0.0729
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0594 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0776 0.353
Trichomonas vaginalis glutaminase, putative 0.033 0.6636 1
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.104 0.1009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0749 0.0718
Entamoeba histolytica hypothetical protein 0.0043 0.0749 0.2679
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0572 0.2601
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.00000000045936
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0991 0.0961
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0324 0.1367
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0182 0.0313
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1204 0.1174
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0858 0.3902
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.104 0.1009
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0437 0.0632
Brugia malayi Thioredoxin reductase 0.0046 0.0795 0.1098
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0383 0.0471
Onchocerca volvulus 0.0058 0.104 0.1551
Echinococcus multilocularis dna polymerase kappa 0.0073 0.1354 0.1324
Echinococcus granulosus cpg binding protein 0.0037 0.061 0.0578
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1354 0.1898
Giardia lamblia DINP protein human, muc B family 0.0049 0.0858 0.3559
Echinococcus granulosus dna polymerase eta 0.0072 0.1326 0.1297
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0182 0.0313
Schistosoma mansoni hypothetical protein 0.0494 1 1
Schistosoma mansoni ran 0.0026 0.0383 0.0351
Echinococcus granulosus dna polymerase kappa 0.0073 0.1354 0.1324
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0572 0.4178
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.119 0.5412
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0324 0.029
Onchocerca volvulus 0.0182 0.3604 1
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0117 0.0532
Schistosoma mansoni DNA polymerase eta 0.0072 0.1326 0.1297
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Mycobacterium tuberculosis Probable reductase 0.0104 0.1997 0.8922
Plasmodium vivax glutathione reductase, putative 0.0046 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0572 0.0667
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0594 0.0792
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0383 0.0351
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0182 0.0313
Treponema pallidum ATP-dependent DNA helicase 0.0018 0.0233 0.3587
Leishmania major DNA polymerase eta, putative 0.0043 0.0749 0.3033
Trypanosoma brucei unspecified product 0.0028 0.0435 0.1976
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0117 0.0083
Leishmania major GTP-binding protein, putative 0.0026 0.0383 0.1279
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.22 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.22 0.3296
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1354 0.6156
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0182 0.0149
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0182 0.0149
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0182 0.0247
Echinococcus multilocularis bloom syndrome protein 0.0053 0.0944 0.0913
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2236 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1017 0.1508
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0795 1
Mycobacterium ulcerans glutaminase 0.033 0.6636 1
Schistosoma mansoni importin beta-1 0.0035 0.0572 0.054

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 86.02 um PUBCHEM_BIOASSAY: Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU). Secondary screen. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 102.31 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.3587 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485292] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.1821 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 24.1489 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2549 (qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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